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61. 发明申请

US20040259111A1 Automated system and method for preparing an assay ready biological sample 审中-公开
标题翻译：用于制备测定准备好的生物样品的自动化系统和方法
公开(公告)号：US20040259111A1
公开(公告)日：2004-12-23
申请号：US10734063
申请日：2003-12-10
申请人： Rosetta Inpharmatics LLC
发明人： Jon Carl Marlowe , Elizabeth Anne West , Hienthuc Phan , Emily Ruth Schultz
IPC分类号： C12Q001/68 , G01N033/53 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： G01N35/0099
摘要： Once a binding assay design and sample is received from a scientist, an experiment design is automatically prepared for generating a binding-ready biological sample to be used by the binding assay. Materials usage and plate layout is then automatically optimized for generating the binding-ready biological sample. A robot method is chosen for generating the binding-ready biological sample and work instructions generated for preparing the binding-ready biological sample. The work instructions are based on the experiment design and the robot method. The work instructions are then transmitted towards a controller for execution by robot stations. From the robot method it is then determined whether pooling and/or splitting needs to occur. If pooling and/or splitting needs to occur, a worklist containing a set of instructions for pooling and splitting is generated and transmitted towards the controller for execution by the robot stations.
摘要翻译：一旦从科学家接收到结合测定设计和样品，则自动制备实验设计用于产生要通过结合测定使用的结合准备的生物样品。然后自动优化材料使用和板材布局，以生成结合准备的生物样品。选择机器人方法用于产生结合准备的生物样品和为制备结合准备的生物样品而生成的工作说明书。工作指导是基于实验设计和机器人的方法。然后将工作指令发送到控制器以由机器人站执行。从机器人方法，然后确定是否需要进行池化和/或拆分。如果需要进行池化和/或拆分，则生成包含用于池化和拆分的一组指令的工作列表，并向控制器发送并由机器人站执行。

62. 发明申请

US20040161791A1 Gene discovery using microarrays 审中-公开
标题翻译：使用微阵列的基因发现
公开(公告)号：US20040161791A1
公开(公告)日：2004-08-19
申请号：US10813506
申请日：2004-03-29
申请人： Rosetta Inpharmatics LLC.
发明人： Daniel D. Shoemaker , Stewart Scherer , Steven J. Altschuler , Lani F. Wu , Christopher D. Armour
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： C12Q1/6837 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , C12Q1/6809 , C40B40/06 , G16B20/00 , G16B25/00
摘要： The invention relates to methods and systems (e.g., computer systems and computer program products) for identifying and characterizing genes using microarrays. In particular, the invention provides for improved, robust methods for detecting genes through the use of microarrays to analyze the expression state of the genome. Genes which are expressed can be mapped to their respective positions in the genome, and the structure of such genes can be determined.
摘要翻译：本发明涉及用于使用微阵列识别和表征基因的方法和系统（例如，计算机系统和计算机程序产品）。特别地，本发明提供了用于通过使用微阵列检测基因以分析基因组的表达状态的改进的，鲁棒的方法。可以将表达的基因映射到其在基因组中的相应位置，并且可以确定这些基因的结构。

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