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61. 发明申请

US20140363465A1 MYCOBACTERIAL VACCINE VECTORS AND METHODS OF USING THE SAME 审中-公开
标题翻译： MYCOBACTERIAL VACCINE VECTORS及其使用方法
公开(公告)号：US20140363465A1
公开(公告)日：2014-12-11
申请号：US14009376
申请日：2012-04-04
申请人： Norman L Letvin , Michael W. Panas , Geoff Gillard
发明人： Norman L Letvin , Michael W. Panas , Geoff Gillard
IPC分类号： A61K39/00 , A61K39/12 , A61K39/02
CPC分类号： A61K39/0002 , A61K39/0003 , A61K39/0011 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/21 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C12N2710/10343 , C12N2740/15034
摘要： Mycobacterium bovis BCG is a potent stimulator of the cellular immune response and has potential as a recombinant vaccine vector. Disclosed are BCG strains that generate greater MHC class I presentation of a transgenic protein, relative to the unmutated parental strain, and that improve a recipient's CD8+ T cell response against the transgenic protein following vaccination. The mycobacterial constructs and their respective t/ansposon mutant BCG strains exhibit increased immunogenicity that is several times greater than responses generated by the parental strain and other existing modified rBCG strains. Furthermore, upon introducing the SIV gag gene into these novel strains, we observed that these strains primed for increased CD8+ T cell responses in a heterologous prime/boost regimen, comparable to levels generated by plasmid DNA vaccines. Creation of a second generation rBCG vector that may be utilized as a vaccine vector for immunizing against a variety of pathogens.
摘要翻译：牛分枝杆菌BCG是细胞免疫应答的有效刺激物，并且具有作为重组疫苗载体的潜力。公开了相对于未突变的亲本菌株产生更大的转基因蛋白质MHC I类呈递的BCG菌株，并且在接种疫苗后改善接受者对转基因蛋白质的CD8 + T细胞应答。分枝杆菌构建体及其各自的t / ansposon突变体BCG菌株表现出增加的免疫原性，其是亲本菌株和其他现有修饰的rBCG菌株产生的响应的数倍。此外，在将SIV gag基因导入这些新型菌株后，我们观察到这些菌株用异源原始/加强方案引发增加的CD8 + T细胞应答，与质粒DNA疫苗产生的水平相当。创建第二代rBCG载体，其可以用作用于免疫各种病原体的疫苗载体。

62. 发明申请

US20140349314A1 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING INFLAMMATORY DISEASE 审中-公开
标题翻译：用于检测和治疗炎症疾病的方法和组合物
公开(公告)号：US20140349314A1
公开(公告)日：2014-11-27
申请号：US14280179
申请日：2014-05-16
申请人： Beth Israel Deaconess Medical Center, Inc.
发明人： Detlef SCHUPPAN , Yury Popov , Miroslaw Kornek
IPC分类号： G01N33/576 , G01N33/68
CPC分类号： G01N33/5767 , A61K35/15 , A61K38/1774 , G01N33/5094 , G01N33/6872 , G01N2333/70514 , G01N2333/70517 , G01N2800/085 , G01N2800/24 , G01N2800/7095
摘要： The invention features methods of diagnosing inflammatory disease based on the elevated presence microparticles (MP) expressing certain receptors. The invention also features methods of decreasing fibrosis in the liver by administering MP to subjects with liver fibrosis.
摘要翻译：本发明的特征在于基于表达某些受体的升高的存在微粒（MP）来诊断炎性疾病的方法。本发明还具有通过向具有肝纤维化的受试者施用MP来减少肝脏纤维化的方法。

63. 发明申请

US20140303251A1 Methods Of Treating Acute Kidney Injury With Retinoic Acid 审中-公开
标题翻译：用视黄酸治疗急性肾损伤的方法
公开(公告)号：US20140303251A1
公开(公告)日：2014-10-09
申请号：US13981802
申请日：2012-01-31
申请人： Terry B. Strom , Savithri Balasubramanian , Benjamin D. Humphreys
发明人： Terry B. Strom , Savithri Balasubramanian , Benjamin D. Humphreys
IPC分类号： A61K31/203 , A61K45/06
CPC分类号： A61K31/203 , A61K31/07 , A61K31/43 , A61K31/519 , A61K31/52 , A61K31/573 , A61K38/063 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The present invention provides, in one embodiment, a method of inhibiting apoptosis in kidney epithelial cells after acute injury by modulating/inhibiting Nur77 induction/expression or function/activity in the cells. The invention further provides a method of preventing or treating an acute kidney injury in a subject in need thereof, comprising administering to the subject an effective amount of a retinoic acid or retinoic acid derivative, and a method of preserving a kidney for transplant, comprising contacting the kidney with a solution that comprises a retinoic acid or a, retinoic acid derivative.
摘要翻译：本发明在一个实施方案中提供了通过调节/抑制细胞中Nur77诱导/表达或功能/活性来抑制急性损伤后肾上皮细胞凋亡的方法。本发明还提供一种在有需要的受试者中预防或治疗急性肾损伤的方法，其包括对受试者施用有效量的视黄酸或视黄酸衍生物，以及保存用于移植的肾的方法，包括接触肾中含有视黄酸或视黄酸衍生物的溶液。

64. 发明授权

US08852120B2 Devices and methods for tissue transplant and regeneration 有权
标题翻译：用于组织移植和再生的装置和方法
公开(公告)号：US08852120B2
公开(公告)日：2014-10-07
申请号：US11698290
申请日：2007-01-25
申请人： Roger J. Laham , Joanna J. Wykrzykowska
发明人： Roger J. Laham , Joanna J. Wykrzykowska
IPC分类号： A61B10/00 , A61M5/178 , A61B17/34 , A61M25/00 , A61B10/02 , A61B17/00 , A61B18/00
CPC分类号： A61B17/3468 , A61B10/02 , A61B10/0266 , A61B17/00234 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2017/00292 , A61B2017/00323 , A61B2017/00969 , A61B2018/00392 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/407 , A61M25/0102 , A61M25/0662 , A61M2025/0042
摘要： Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and/or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.
摘要翻译：用于移植组织以用于再生的装置和方法，用于治疗患有心肌组织的患者和/或通过细胞再生长改善心脏功能。更具体地，装置和方法避免了对细胞改变的需要。这些装置包括具有尖锐远端的中空管，在中空管内设置和移动的探针以及限制探针的运动的止动装置。所述方法包括从哺乳动物器官的第一区域去除完整的组织并将组织植入同一器官的第二区域。

65. 发明申请

US20140199781A1 NON-INVASIVE METHODS FOR DIAGNOSING CHRONIC ORGAN TRANSPLANT REJECTION 审中-公开
标题翻译：用于诊断慢性移植物移植物的非侵入性方法
公开(公告)号：US20140199781A1
公开(公告)日：2014-07-17
申请号：US14003313
申请日：2012-03-08
申请人： David M. Briscoe , Kevin P. Daly , Ananth Karumanchi , Michael Seifert
发明人： David M. Briscoe , Kevin P. Daly , Ananth Karumanchi , Michael Seifert
IPC分类号： G01N33/536
CPC分类号： G01N33/536 , G01N33/6893 , G01N2333/475 , G01N2333/515 , G01N2333/52 , G01N2333/522 , G01N2333/96433 , G01N2800/245 , G01N2800/50 , G01N2800/60
摘要： Presented herein are methods of diagnosing or assessing an individual at increased risk of developing chronic rejection, or chronic allograft vasculopathy, based on analysis the individual's biomarker profile.
摘要翻译：这里提出的是基于分析个体的生物标志物概况来诊断或评估增加发生慢性排斥或慢性同种异体移植血管病变风险的个体的方法。

66. 发明授权

US08699773B2 Method for image reconstruction using low-dimensional-structure self-learning and thresholding 有权
标题翻译：使用低维结构自学习和阈值的图像重建方法
公开(公告)号：US08699773B2
公开(公告)日：2014-04-15
申请号：US12909313
申请日：2010-10-21
申请人： Mehmet Akcakaya , Reza Nezafat
发明人： Mehmet Akcakaya , Reza Nezafat
IPC分类号： G06K9/00
CPC分类号： G06T5/002 , G06T5/10 , G06T11/008 , G06T2200/12 , G06T2207/10081 , G06T2207/10088 , G06T2207/20056 , G06T2207/30004
摘要： A method for reconstructing an image of a subject from undersampled image data that is acquired with an imaging system, such as a magnetic resonance imaging system or computed tomography system, is provided. From the acquired undersampled image data, an image of the subject is reconstructed and used to guide further image reconstruction. For example, a low resolution image is reconstructed from a portion of the undersampled image data, such as from a portion corresponding to the center of k-space when MRI is used. From this image, a number of similarity clusters are produced and processed. The processing may be by hard thresholding, Wiener filtering, principal component pursuit, or other similar techniques. These processed similarity clusters are then used to reconstruct a final, target image of the subject using, for example, a weighted average combination of the similarity clusters.
摘要翻译：提供了一种用于使用诸如磁共振成像系统或计算机断层摄影系统的成像系统获取的欠采样图像数据来重建被摄体图像的方法。从获取的欠采样图像数据中，重建对象的图像并用于指导进一步的图像重建。例如，低分辨率图像从欠采样图像数据的一部分重建，例如从使用MRI时与k空间的中心相对应的部分。从该图像中，生成并处理了许多相似性簇。处理可以是通过硬阈值，维纳滤波，主成分追踪或其他类似技术。然后使用这些处理的相似性群体使用例如相似性群集的加权平均组合来重建受试者的最终目标图像。

67. 发明授权

US08697950B2 Vacuolar pyrophosphatases and uses in plants 有权
标题翻译：真空焦磷酸酶及其在植物中的应用
公开(公告)号：US08697950B2
公开(公告)日：2014-04-15
申请号：US11890795
申请日：2007-08-07
申请人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
发明人： Roberto A. Gaxiola , Gerald R. Fink , Seth L. Alper
IPC分类号： A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8259 , C12N15/8261 , C12N15/8273 , Y02A40/146
摘要： The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The present invention also relates to a transgenic plant with increased Pi uptake, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described.
摘要翻译：本发明涉及对盐具有耐受性的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。本发明还涉及具有增加的Pi摄取的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。本发明还包括本文所述的转基因植物的转基因后代和种子。还描述了从种子生长的后代转基因植物。

68. 发明申请

US20140093497A1 ANTI-CD40 ANTIBODIES AND USES THEREOF 有权
标题翻译：抗CD40抗体及其用途
公开(公告)号：US20140093497A1
公开(公告)日：2014-04-03
申请号：US14004552
申请日：2012-03-12
申请人： Keith A. Reimann , Rijian Wang , Christian P. Larsen
发明人： Keith A. Reimann , Rijian Wang , Christian P. Larsen
IPC分类号： A61K39/395 , A61K45/06 , C07K16/18
CPC分类号： A61K39/3955 , A61K31/436 , A61K38/13 , A61K39/39541 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K2317/24 , C07K2317/33 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/423 , A61K2300/00
摘要： The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also relates to fragments of these antibodies, uses of the antibodies for reduction or treatment of transplant rejection and graft-versus-host disease, and methods for making the antibodies.
摘要翻译：本发明涉及对CD40上的特定表位有特异性的抗体以及结合CD40并具有特定功能特征的抗体。本发明还涉及这些抗体的片段，抗体用于减少或治疗移植排斥反应和移植物抗宿主病的用途，以及制备抗体的方法。

69. 发明授权

US08685393B2 Methods and compositions for the treatment and diagnosis of systemic anthrax infection 有权
标题翻译：用于治疗和诊断系统性炭疽感染的方法和组合物
公开(公告)号：US08685393B2
公开(公告)日：2014-04-01
申请号：US12934430
申请日：2009-03-23
申请人： Samir M. Parikh
发明人： Samir M. Parikh
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： G01N33/56911 , A61K38/179 , A61K38/1891 , A61K38/4866 , C07K16/22 , C12Q1/689 , G01N2333/32 , G01N2333/515 , G01N2800/52 , G01N2800/56 , A61K2300/00 , A61K38/00
摘要： The present invention features methods and kits that utilize Ang-2 antagonists for the treatment, inhibition, and prevention of a systemic anthrax infection. The invention described herein also features methods for the diagnosis of a systemic anthrax infection by detecting elevated levels of Ang-2 in the serum of a subject.
摘要翻译：本发明的特征在于利用Ang-2拮抗剂治疗，抑制和预防全身性炭疽感染的方法和试剂盒。本文描述的发明还具有通过检测受试者血清中Ang-2水平升高来诊断系统性炭疽感染的方法。

70. 发明申请

US20140088449A1 MULTILEAD ECG TEMPLATE-DERIVED RESIDUA FOR ARRHYTHMIA RISK ASSESSMENT 有权
标题翻译：多雷达心电图模板残疾人风险评估
公开(公告)号：US20140088449A1
公开(公告)日：2014-03-27
申请号：US13624544
申请日：2012-09-21
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： Bruce D. NEARING , Richard L. Verrier
IPC分类号： A61B5/04 , A61B5/0456 , A61B5/0472 , A61B5/0452
CPC分类号： A61B5/04012 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0472 , A61B5/7246 , A61B5/7275 , A61B5/7278 , G06F19/00
摘要： A method and system for predicting the onset of heart arrhythmias more accurately observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and the baseline measurement is subtracted from the second set of ECG signals on a beat-to-beat basis. Afterwards, a residuum signal is generated for each lead based on the subtraction. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals.
摘要翻译：用于预测心律不齐发作的方法和系统更准确地观察心电图（ECG）的异常或病理形态的趋势。从患者监测第一组ECG信号。从监测的第一组ECG信号产生基线测量，以在每个引线中包含非病理ECG形态。从患者监测第二组ECG信号，并且基于每搏输出从第二组ECG信号中减去基线测量值。然后，基于减法产生每个引线的残留信号。基于产生的残留信号量化了R波异质性，T波异质性，P波异质性或ST段异质性或其他心律失常风险或心肌缺血指标。

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