专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US07727982B2 Benzamides and related inhibitors of factor Xa 失效
标题翻译：苯甲酰胺和相关因子Xa抑制剂
公开(公告)号：US07727982B2
公开(公告)日：2010-06-01
申请号：US11488455
申请日：2006-07-17
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D243/02 , C07D401/02 , A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compound and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。化合物和组合物可用于体外或体内用于预防或治疗凝血障碍。

62. 发明授权

US06844367B1 Benzamides and related inhibitors of factor Xa 有权
标题翻译：苯甲酰胺和相关因子Xa抑制剂
公开(公告)号：US06844367B1
公开(公告)日：2005-01-18
申请号：US09663420
申请日：2000-09-15
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/166 , G07C233/64
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：公开了与哺乳动物因子Xa有活性的新型苯甲酰胺化合物，其盐和与其有关的组合物。该化合物在体外或体内可用于预防或治疗凝血障碍。

63. 发明授权

US08377974B2 Factor Xa inhibitors 有权
公开(公告)号：US08377974B2
公开(公告)日：2013-02-19
申请号：US13213927
申请日：2011-08-19
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , C07D233/64 , C07D231/12 , C07D207/34
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

64. 发明申请

US20120149688A1 PLATELET ADP RECEPTOR INHIBITORS 有权
标题翻译： PLATELET ADP受体抑制剂
公开(公告)号：US20120149688A1
公开(公告)日：2012-06-14
申请号：US13270193
申请日：2011-10-10
申请人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles K. Marlowe , Kim A. Kane-Maguire
发明人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles K. Marlowe , Kim A. Kane-Maguire
IPC分类号： A61K31/55 , C07D471/04 , C07D487/04 , A61K31/4725 , A61K31/517 , A61P9/10 , A61K31/519 , A61K31/4709 , A61K31/404 , A61K31/5513 , A61P7/02 , A61P9/00 , C07D409/12 , A61K31/4745
CPC分类号： C07D487/04 , C07D209/48 , C07D239/22 , C07D239/48 , C07D239/50 , C07D239/96 , C07D333/34 , C07D333/62 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D521/00
摘要： Novel compounds of formulae (I) and (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）和（VIII）的新型化合物，其更具体地包括作为有效血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰基氰胍基衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I）至（VIII）化合物或其药学上可接受的盐的步骤。

65. 发明申请

US20100197929A1 METHODS OF SYNTHESIZING PHARMACEUTICAL SALTS OF A FACTOR XA INHIBITOR 有权
标题翻译：合成XA抑制剂的药物盐的方法
公开(公告)号：US20100197929A1
公开(公告)日：2010-08-05
申请号：US12446954
申请日：2007-11-01
申请人： Robert M. Scarborough , Carroll Scarborough , James P. Kanter , Keiko Sujino , Sharique Sami Zuberi
发明人： Robert M. Scarborough , Carroll Scarborough , James P. Kanter , Keiko Sujino , Sharique Sami Zuberi
IPC分类号： C07D213/75
CPC分类号： C07D213/90 , C07D213/75
摘要： Novel methods of preparing a compound of Formula I which is an inhibitor of Factor Xa and its maleate salt, are described herein.
摘要翻译：本文描述了制备作为因子Xa及其马来酸盐的抑制剂的式I化合物的新方法。

66. 发明授权

US06689786B2 Platelet ADP receptor inhibitors 有权
标题翻译：血小板ADP受体抑制剂
公开(公告)号：US06689786B2
公开(公告)日：2004-02-10
申请号：US10350883
申请日：2003-01-23
申请人： Robert M. Scarborough , Wolin Huang
发明人： Robert M. Scarborough , Wolin Huang
IPC分类号： C07D41712
CPC分类号： C07D239/22 , C07D239/48 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）至（VI）的新型化合物，其更具体地包括作为有效的血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰基氰胍基衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I） - （VI）化合物或其药学上可接受的盐的步骤。

67. 发明授权

US06548517B2 Oxindole inhibitors of factor Xa 失效
标题翻译：因子Xa的羟吲哚抑制剂
公开(公告)号：US06548517B2
公开(公告)日：2003-04-15
申请号：US09816782
申请日：2001-03-26
申请人： Charles K. Marlowe , Kim A. Kane-Maguire , Bing-Yan Zhu , Robert M. Scarborough
发明人： Charles K. Marlowe , Kim A. Kane-Maguire , Bing-Yan Zhu , Robert M. Scarborough
IPC分类号： A61K31445
CPC分类号： C07D401/12
摘要： Novel compounds of formula I: including its pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa is described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
摘要翻译：描述了新颖的式I化合物：包括其具有抗哺乳动物因子Xa活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。化合物和组合物可用于体外或体内用于预防或治疗特征在于不希望的血栓形成的哺乳动物的状况。

68. 发明授权

US06525076B1 Selective factor Xa inhibitors 失效
公开(公告)号：US06525076B1
公开(公告)日：2003-02-25
申请号：US09500231
申请日：2000-02-08
申请人： Bing-Yan Zhu , Robert M. Scarborough
发明人： Bing-Yan Zhu , Robert M. Scarborough
IPC分类号： C07D41712
CPC分类号： C07D413/14 , A61K38/00 , C07D417/12 , C07D417/14 , C07F5/025 , C07K5/06026 , C07K5/0821
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

69. 发明授权

US06369080B2 Selective factor Xa inhibitors 失效
标题翻译：选择因子Xa抑制剂
公开(公告)号：US06369080B2
公开(公告)日：2002-04-09
申请号：US08948664
申请日：1997-10-10
申请人： Bing-Yan Zhu , Robert M. Scarborough
发明人： Bing-Yan Zhu , Robert M. Scarborough
IPC分类号： C07D41706
CPC分类号： C07D213/76 , C07D413/12 , C07D417/12
摘要： Novel compounds of formula I: including its pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
摘要翻译：描述了新颖的式I化合物：包括其药学上可接受的异构体，盐，水合物，溶剂合物和具有抗哺乳动物因子Xa活性的前药衍生物。还描述了含有这些化合物的组合物。化合物和组合物可用于体外或体内用于预防或治疗特征在于不希望的血栓形成的哺乳动物的状况。

70. 发明授权

US06291469B1 Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation 有权
标题翻译：螺环化合物作为纤维蛋白原依赖性血小板聚集的抑制剂
公开(公告)号：US06291469B1
公开(公告)日：2001-09-18
申请号：US09043846
申请日：1998-10-05
申请人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
发明人： Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
IPC分类号： C07D22120
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.
摘要翻译：本发明涉及由碱式和酸性官能团取代的某些螺环化合物，如式（I）所示：其中Q，L，Ai，Bj，R 0，R 3，R 10，m，n，p和q如可用于抑制血小板聚集。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式