会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 63. 发明授权
    • Combination thrust bearing and journal bearing, and method for distributing fluid to same
    • 组合推力轴承和轴颈轴承,以及将流体分配到其中的方法
    • US06739756B2
    • 2004-05-25
    • US10320592
    • 2002-12-16
    • William H. Miller
    • William H. Miller
    • F16C1703
    • F16C32/0629F16C17/03F16C17/06F16C32/0666F16C33/1075F16C33/108
    • A thrust bearing tilting pad has face with a border region including an engagement surface and defining a pocket with generally longitudinal sidebars and a bottom. The pad has leading and trailing portions, with the face extending generally longitudinally therebetween. The leading and trailing portions can be positioned upstream and downstream, respectively, relative to a direction of movement of a runner. The pad is pivotally supported by (e.g., mechanical and/or hydrostatic) pivot and can cooperate with one or more other pads and fluid within a housing to hydrodynamically and mechanically support the runner in an axial position. In another embodiment, the pad tilts free of mechanical engagement with other pads. The leading portion can define an entrance to the pocket and the sidebars can converge along the direction of motion of the runner. The pocket hydrodynamically increases pressure on the runner during rotation, and generates pressure effecting on the face counteraction force about the pivot and upstream relative to the rotation direction in order to counteract spragging force. The pocket can also have a generally tapered profile or an abrupt step.
    • 止推轴承倾斜垫具有包括接合表面的边界区域并且限定具有大体上纵向的侧边条和底部的口袋。 垫具有前后部分,其表面大致纵向延伸。 前导部分和尾部部分可以相对于流道的运动方向分别位于上游和下游。 该垫由(例如机械和/或静液压)枢轴枢轴支撑,并且可以与壳体内的一个或多个其它垫和流体配合以在轴向位置上流体动力地和机械地支撑流道。 在另一个实施例中,垫片与其它垫片没有倾斜的机械接合。 引导部分可以限定到口袋的入口,并且侧杆可以沿着跑步者的运动方向收敛。 口袋在旋转期间流体动力地增加流道上的压力,并且相对于旋转方向产生影响围绕枢轴和上游的表面反作用力的压力,以便抵消上翘力。 口袋也可以具有大致锥形的轮廓或突然的台阶。
    • 64. 发明授权
    • Fab I inhibitors
    • Fab I抑制剂
    • US06503903B1
    • 2003-01-07
    • US09959172
    • 2001-10-18
    • William H. MillerKenneth A. NewlanderMark A. Seefeld
    • William H. MillerKenneth A. NewlanderMark A. Seefeld
    • A61K3155
    • C07D403/12
    • Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: wherein: R1 is H, C1-6alkyl or Ar—C0-6alkyl; R2 is H, C1-6alkyl, Ar—C0-6alkyl, HO—(CH2)n— or R′OC(O)—(CH2)n—; R3 is A—C0-4alkyl, A—C2-4alkenyl, A—C2-4alkynyl, A—C3-4oxoalkenyl, A—C3-4oxoalkynyl, A—C1-4aminoalkyl, A—C3-4aminoalkenyl, A—C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R10 or R7; R5 is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R7 is —COR8, —COCR′2R9, —C(S)R8, —S(O)kOR′, —S(O)kNR′R″, —PO(OR′), —PO(OR′)2, —B(OR′)2, —NO2, or tetrazolyl; R8 is —OR′, —NR′R″, —NR′SO2R′, —NR′OR′, or —OCR′2CO(O)R′; R9 is —OR′, —CN, —S(O)rR′, —S(O)kNR′2, —C(O)R′, C(O)NR′2, or —CO2R′; R10 is H, halo, —OR11, —CN, —NR′R11, —NO2, —CF3, CF3S(O)r—, —CO2R′, —CONR′2, A—C0-6alkyl-, A—C1-6oxoalkyl-, A—C2-6alkenyl-, A—C2-6alkynyl-, A—C0-6alkyloxy-, A—C0-6alkylamino- or A—C0-6alkyl —S(O)r—; R11 is R′, —C(O)R′, —C(O)NR′2, —C(O)OR′, —S(O)kR′, or —S(O)kNR′2; R′ is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; R″ is R′, —C(O)R′ or —C(O)OR′; R′″ is H, C1-6alkyl, Ar—C0-6alkyl, HO-(CH2)2—, R′C(O)—, (R′)2NC(O)CH2— or R′S(O)2—; X is H, C1-4alkyl, OR′, SR′, C1-4alkylsulfonyl, C1-4alkylsulfoxyl, —CN, N(R′)2, CH2N(R′)2, —NO2, —CF3, —CO2R′, —CON(R′)2, —COR′, —NR′C(O)R′, F, Cl, Br, I, or CF3S(O)r—; k is 1 or 2; m is 1, 2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
    • 公开了式(I)化合物,其为FabI抑制剂并且可用于治疗细菌感染:其中:R1为H,C1-6烷基或Ar-C0-6烷基; R2为H,C1-6烷基,Ar-C0- C 1-6烷基,HO-(CH 2)n或R'OC(O) - (CH 2)n - ; R 3是A-C 0-4烷基,A-C 2-4链烯基,A-C 2-4亚烷基, 任选地被R 10或R 7中的一个或多个的任何可接近的组合取代的C 3-4氧代炔基,A-C 1-4氨基烷基,A-C 3-4氨基烯基,A-C 3-8氨基炔基,R 5是H,C 1-6烷基, C 1-6烷基或C 3-6环烷基-C 0-6烷基; A是H,C 3-6环烷基,Het或Ar; R 7是-COR 8,-COCR 2 R 9,-C(S)R 8,-S(O)k OR' O)kNR'R“,-PO(OR'),-PO(OR')2,-B(OR')2,-NO 2或四唑基; R8是-OR',-NR'R” -NR'SO2R',-NR'OR'或-OCR'2CO(O)R'; R9是-OR',-CN,-S(O)rR',-S(O)kNR'2, C(O)R',C(O)NR'2或-CO 2 R'; R 10是H,卤素,-OR 11,-CN,-NR'R 11,-NO 2,-CF 3,CF 3 S(O) -CO 2 R',-CONR'2,A-C0-6烷基 - ,A-C1-6氧代烷基 - ,A-C2-6烯基 - ,A-C2-6炔基 - ,A-C10-烷氧基 - ,A-C10-烷基氨基 - 或A-C0-6烷基-S(O)r-; R11是R',-C(O)R', -C(O)NR'2,-C(O)OR',-S(O)kR'或-S(O)kNR'2; R'是H,C1-6烷基,Ar-C0-6烷基或 C3-6环烷基-C0-6烷基; R“是R',-C(O)R'或-C(O)OR'; R”'是H,C1-6烷基,Ar-C0-6烷基, (CH 2)2 - ,R'C(O) - ,(R')2 NC(O)CH 2 - 或R'S(O)2 - ; X是H,C 1-4烷基,OR',SR',C 1-4烷基磺酰基, C 1-4烷基亚磺酰基,-CN,N(R')2,CH 2 N(R')2,-NO 2,-CF 3,-CO 2 R',-CON(R')2,-COR',-NR'C R',F,Cl,Br,I或CF 3 S(O)r - ; k为1或2; m为1,2或3; n为1至6; 和r为0,1或2;或其药学上可接受的盐。
    • 65. 发明授权
    • Integrin receptor antagonists
    • 整合素受体拮抗剂
    • US6008213A
    • 1999-12-28
    • US722095
    • 1997-12-19
    • William E. BondinellWilliam H. Miller
    • William E. BondinellWilliam H. Miller
    • C07D211/26C07D213/74C07D235/14C07D235/16C07D235/04C07D211/06C07D213/02C07D235/06
    • C07D213/74C07D211/26C07D235/14C07D235/16
    • Compounds of formula (I) ##STR1## wherein A.sub.1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R.sup.3 or R.sup.4 ; X.sup.1 --X.sup.2 is CHR.sup.1 --CH, CR.sup.1 .dbd.CH, NR.sup.1 --CH, S(O).sub.u --CH or O--CH; X.sup.3 is CR.sup.5 R.sup.5 ', NR.sup.5, S(O).sub.u or O; R.sup.2 is --OR', --NR'R", --NR'SO.sub.2 R'", --NR'OR', --OCR'.sub.2 C(O)OR', --OCR'.sub.2 OC(O)--R', --OCR'.sub.2 C(O)NR'.sub.2, CF.sub.3 or --COCR'.sub.2 R.sup.2 '; R.sup.3, R.sup.4 and R.sup.7 are independently H, halo, --OR.sup.12, --SR.sup.12, --CN, --NR'R.sup.12, --NO.sub.2, --CF.sub.3, CF.sub.3 S(O).sub.r --, --CO.sub.2 R', --CONR'.sub.2, R.sup.14 --C.sub.0-6 alky-, R.sup.14 --C.sub.1-6 oxoalkyl-, R.sup.14 --C.sub.2-6 alkenyl-, R.sup.14 --C.sub.2-6 alkynyl-, R.sup.14 --C.sub.0-6 alkyloxy-, R.sup.14 --C.sub.0-6 alkylamino- or R.sup.14 --C.sub.0-6 alkyl--S(O).sub.r --; R.sup.6 is W--(CR'.sub.2).sub.q --Z--(CR'R.sup.10)--U--(CR'.sub.2).sub.s --V-- or W'--(CR'.sub.2).sub.q --U--(CR'.sub.2).sub.s -- U and V are absent or CO, CR'.sub.2, C(.dbd.CR.sup.15.sub.2), S(O).sub.n, O, NR.sup.15, CR.sup.15 'OR.sup.15, CR'(OR")CR'.sub.2, CR'.sub.2 CR'(OR") C(O)CR'.sub.2, CR.sup.15.sub.2 C(O), CONR.sup.15, NR.sup.15 CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR.sup.15, NR.sup.15 C(S), SO.sub.2 NR.sup.15, NR.sup.15 SO.sub.2, N.dbd.N, NR.sup.15 NR.sup.15, NR.sup.15 CR.sup.15.sub.2, NR.sup.15 CR.sup.15.sub.2, CR.sup.15.sub.2 O, OCR.sup.15.sub.2, C$(m)ZC, CR.sup.15 .dbd.CR.sup.15, Het, or Ar, provided that U and V are not simultaneously absent, and W and W' are a nitrogen-containing substituent, and integrin receptor antagonists.
    • PCT No.PCT / US96 / 11108 Sec。 371 1997年12月19日第 102(e)1997年12月19日PCT PCT 1996年6月28日PCT公布。 出版物WO97 / 01540 日期1997年1月16日其中A1为C或N的式(I)化合物; E是任选被R 3或R 4取代的五元或六元杂芳族或六元芳环; X1-X2是CHR1-CH,CR1 = CH,NR1-CH,S(O)u-CH或O-CH; X3是CR5R5',NR5,S(O)u或O; R2是-OR',-NR'R“,-NR'SO2R”',-NR'OR',-OCR'2C(O)OR',-OCR'2OC(O)-R',-OCR '2C(O)NR'2,CF 3或-COCR'2R2'; R3,R4和R7独立地是H,卤素,-OR12,-SR12,-CN,-NR'R12,-NO2,-CF3,CF3S(O)r-,-CO2R',-CONR'2,R14-C0 烷基 - ,R14-C 1-6氧基烷基 - ,R 14 -C 2-6烯基 - ,R 14 -C 2-6炔基 - ,R 14 -C 0-6烷氧基 - ,R 14 -C 0-6烷基氨基 - 或R 14 -C 0-6烷基-S(O)r - ; R6是W-(CR'2)qZ-(CR'R10)-U-(CR'2)sV-或W' - (CR'2)qU-(CR'2)s- U和V不存在 CO,CR'2,C(= CR152),S(O)n,O,NR15,CR15'OR15,CR'(OR“)CR'2,CR'2CR'(OR” CR(O),CONR 15,NR 15 CO,OC(O),C(O)O,C(S)O,OC(S),C(S)NR 15,NR 15 C(S),SO 2 NR 15,NR 15 SO 2, N = N,NR15NR15,NR15CR152,NR15CR152,CR152O,OCR152,C $(m)ZC,CR15 = CR15,Het或Ar,条件是U和V不同时不存在,W和W' 取代基和整联蛋白受体拮抗剂。
    • 66. 发明授权
    • Metering apparatus having a screw member
    • 具有螺纹构件的计量装置
    • US5609275A
    • 1997-03-11
    • US422746
    • 1995-04-14
    • Robert L. BrownWilliam H. MillerDavid E. Baxter
    • Robert L. BrownWilliam H. MillerDavid E. Baxter
    • B05C11/10B29C47/38G01F11/20
    • B29C47/38B05C11/1002B29C47/003
    • A metering apparatus 10 for continuously supplying a specified amount of fluid material F to a desired surface. The apparatus 10 includes a reservoir 14 for maintaining a supply of fluid material, a housing 16 having a central bore 22 therethrough, a receiving opening 24 for receiving fluid material from the reservoir 14 to central bore 22, and an exit opening 26 through which fluid material exits the housing 16. A rotatable screw member 28 is provided engaged through the housing 16 within said central bore 22, and a driver 37 engaged with the screw member for rotating the screw member within the bore at between approximately 1 rpm to 2,700 rpm, and preferably approximately 1,750 rpm, in order to continuously supply fluid to the exit opening 26. At this operating level, fluid material is provided from the exit opening 26 at a flow rate of between approximately 1 to 23 grams/min, and in a thickness of approximately 0.001 to 8 mils. The reservoir 14 includes a tank 50 for the fluid material, and a motor 68 for agitating the fluid during operation of the apparatus 10. The housing 16 is secured adjacent the tank 50 to provide the fluid material from the tank to the receiving opening 24.
    • 用于将特定量的流体材料F连续地供给到期望的表面的计量装置10。 设备10包括用于维持流体材料供应的储存器14,具有穿过其中的中心孔22的壳体16,用于将流体材料从储存器14接收到中心孔22的接收开口24和流体 材料离开壳体16.通过壳体16在所述中心孔22内接合的可旋转的螺纹构件28和与螺钉构件接合的驱动器37,用于在大约1rpm至2,700rpm之间旋转孔内的螺杆构件, 并且优选地为约1,750rpm,以便将流体连续地供应到出口26。在该操作水平下,流体材料以约1至23克/分钟之间的流速从出口26提供,并且以厚度 约0.001至8密耳。 储存器14包括用于流体材料的罐50和用于在装置10的操作期间搅拌流体的马达68.壳体16被固定在罐50附近,以将流体材料从罐提供到接收开口24。
    • 67. 发明授权
    • Handling system and method for curved extrusions
    • 弯曲挤压的处理系统和方法
    • US5562875A
    • 1996-10-08
    • US715026
    • 1991-06-13
    • William H. MillerJames F. Stevenson
    • William H. MillerJames F. Stevenson
    • B29C47/00B29C47/12B29C47/26B29C47/34B29C47/24
    • B29C47/0035B29C47/003B29C47/0866B29C47/12B29C47/26B29C47/34B29C47/0019B29C47/025
    • An assembly and method for processing extrudate material containing curves or angles into a predetermined overall configuration, including having a die assembly for an extruder which assembly controls the cross-sectional shape or profile of the extrudate and selectively varies the path of the extrudate as it leaves the die assembly. A support member is provided which has a predetermined overall configuration and profile to receive the extrudate and maintain its configuration. A driving apparatus is also provided for continuously driving either the support member or the die assembly relative to the other while the extrudate is being received in the support member, and until the entire predetermined overall configuration has been completed. The path of the extrudate is variably directed by the die assembly as it leaves the extruder in coordination with the relative speeds involved to conform the extrudate configuration to the predetermined overall configuration of the support member.
    • 一种用于将包含曲线或角度的挤出物材料加工成预定的总体构造的组件和方法,包括具有用于挤出机的模具组件,其组装控制挤出物的横截面形状或轮廓,并且当挤出物离开时选择性地改变挤出物的路径 模具组件。 提供了一种支撑构件,其具有预定的整体构造和轮廓以接收挤出物并保持其构型。 还提供一种驱动装置,用于当挤出物被容纳在支撑构件中时,并且直到整个预定的整体构型完成为止,连续地驱动支撑构件或模具组件相对于另一个。 挤出物的路径可随模头组件可变地引导,因为它与所涉及的相对速度协调地离开挤出机,以使挤出物构型符合支撑构件的预定整体构型。
    • 68. 发明授权
    • Multiple axis transducer mounting collar
    • 多轴传感器安装环
    • US5520061A
    • 1996-05-28
    • US107326
    • 1993-08-16
    • Scott E. ThibaultWilliam H. MillerWarren R. BrookTimothy P. Mannix
    • Scott E. ThibaultWilliam H. MillerWarren R. BrookTimothy P. Mannix
    • G01H1/00G01H1/10G01H13/00G01N29/12G01N29/22G10K11/00G01N29/26
    • G01H13/00G01H1/003G01H1/10G01N29/12G01N29/223G01N29/225G10K11/004G01N2291/105
    • An improved apparatus and method for determining the existence and severity of a crack in a shaft system is provided. The apparatus includes means for mounting multiple vibration responsive output transducers around an outer circumference of the shaft system, allowing simultaneous measurements of vibrational response of the shaft system when multiple vibration responsive output transducers are mounted to the mounting means. In a first approach, the mounting means comprises a collar having two connected arcuate members, with drilled milled and tapped apertures for mounting radial input and output transducers. Torsional input and output transducers may also be mounted tangentially on the collar in drilled milled and tapped heads of bolts used to connect the two arcuate members. In a second approach, the mounting means comprises a plurality of support blocks disposed substantially symmetrically around and protruding outward from the outer collar circumference with each of the blocks orienting at least one transducer in a radial direction and at least one transducer in a tangential direction. Each block may further orient another transducer in an axial direction.
    • 提供了一种用于确定轴系中的裂纹的存在和严重性的改进的装置和方法。 该装置包括用于在轴系的外周安装多个响应振动的输出换能器的装置,当多个响应振动的输出换能器安装到安装装置时,允许同时测量轴系的振动响应。 在第一种方法中,安装装置包括具有两个连接的弓形构件的套环,其具有用于安装径向输入和输出换能器的钻孔和螺纹孔。 扭转输入和输出传感器也可以切向地安装在用于连接两个弓形构件的钻孔的研磨和螺纹螺栓头部的套环上。 在第二种方法中,安装装置包括多个支撑块,这些支撑块基本上对称地设置在外围环周围并且从外环周向外突出,其中每个块沿径向定向至少一个换能器,并且沿切线方向定向至少一个换能器。 每个块可以进一步沿轴向方向定向另一个换能器。
    • 69. 发明授权
    • Rotor with hollow cylindrical permanent magnet
    • 转子采用中空圆柱形永久磁铁
    • US5317227A
    • 1994-05-31
    • US986675
    • 1992-12-08
    • Rodolfo PalmaWilliam H. Miller
    • Rodolfo PalmaWilliam H. Miller
    • H02K1/22H02K1/27H02K21/18H02K21/20H02K21/12
    • H02K1/2713H02K21/20
    • A rotor for a dynamoelectric machine, without windings and rotatable about a central longitudinal axis, having an axially extending rotatable body and a toroidal magnet coaxially mounted on the body is constructed to provide magnetic exitation for the rotor. The rotatable body contains a first set of circumferentially spaced axially extending salient poles with circumferentially spaced recesses therebetween and a second set of similar poles at an opposite axial location. The toroidal magnet is coaxially mounted on the body between the first and second set of salient poles. A second toroidal magnet may also be mounted on the body and a magnetic spacer placed in between both toroidal magnets.
    • 具有轴向延伸的可旋转主体和同轴地安装在本体上的环形磁体的用于电动机的转子,不具有绕组并且围绕中心纵向轴线可旋转的转子被构造成为转子提供磁力排出。 可旋转体包含第一组周向间隔开的轴向延伸的凸极,并且在相对的轴向位置处具有周向间隔开的凹部和第二组相似的极。 环形磁体同轴地安装在第一组和第二组凸极之间的主体上。 第二环形磁体也可以安装在主体上,并且磁隔离件放置在两个环形磁体之间。