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61. 发明申请

US20090221699A1 Fab I Inhibitors 有权
标题翻译： Fab I抑制剂
公开(公告)号：US20090221699A1
公开(公告)日：2009-09-03
申请号：US11767967
申请日：2007-06-25
申请人： Walter J. Burgess , Dalia Jakas , William F. Huffman , William H. Miller , Kenneth A. Newlander , Mark A. Seefeld , Irene N. Uzinskas
发明人： Walter J. Burgess , Dalia Jakas , William F. Huffman , William H. Miller , Kenneth A. Newlander , Mark A. Seefeld , Irene N. Uzinskas
IPC分类号： A61K31/343 , C07D307/87 , A61P31/04
CPC分类号： C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
摘要翻译：公开了作为Fab I抑制剂并且可用于治疗细菌感染的化合物。

62. 发明申请

US20090097922A1 APPARATUS, SYSTEM, AND METHOD FOR CONCURRENTLY LAYING MULTIPLE PIPELINES 失效
标题翻译：用于同时铺设多管道的装置，系统和方法
公开(公告)号：US20090097922A1
公开(公告)日：2009-04-16
申请号：US12249895
申请日：2008-10-10
申请人： Beverly A. Miller , William H. Miller , Christopher S. Shannon
发明人： Beverly A. Miller , William H. Miller , Christopher S. Shannon
IPC分类号： F16L1/024
CPC分类号： F16L1/036 , F16L1/065 , F16L9/20
摘要： An apparatus, system, and method are disclosed for concurrently forming a plurality of pipelines. The apparatus includes a support chassis coupled to at least one transportation facilitation member. The transportation facilitation member facilities the movement of the support chassis along a surface. A first pipe fuser is disposed on the support chassis and is configured to fuse a first section of pipe to a first pipeline. A second pipe fuser may also be disposed on the support chassis. The second pipe fuser may be configured to independently fuse a second section of pipe to a second pipeline. The first pipe fuser fuses the first section of pipe to the first pipeline with the support chassis in a stationary position. The second pipe fuser fuses the second section of pipe to the second pipeline with the support chassis in the same stationary position.
摘要翻译：公开了用于同时形成多条管道的装置，系统和方法。该装置包括联接到至少一个运输促进构件的支撑底盘。运输便利化装置可以使支撑底盘沿着表面运动。第一管道定影器设置在支撑底盘上并且被配置为将第一部分管道熔合到第一管道。第二管定影器也可以设置在支撑底盘上。第二管定影器可以被配置为独立地将第二部分管熔合到第二管道。第一个管道定影器将管道的第一部分熔化到第一管道，支撑底盘处于静止位置。第二管道定影器将第二部分管道熔化到第二管道，其中支撑底盘处于相同的固定位置。

63. 发明授权

US07287878B2 LED sign cover and method of manufacture 有权
标题翻译： LED标志盖和制造方法
公开(公告)号：US07287878B2
公开(公告)日：2007-10-30
申请号：US10869305
申请日：2004-06-16
申请人： William H. Miller
发明人： William H. Miller
IPC分类号： F21V11/02
CPC分类号： G09F9/33 , G09F27/008 , Y10S362/812
摘要： A cover for a LED sign is manufactured from a stainless steel sheet that is dimensionally larger than the array of light emitting diodes comprising the LED sign. The stainless steel sheet is laser cut and then bent to simultaneously form a plurality of apertures and a corresponding plurality of louvers each extending adjacent one of the apertures. The apertures facilitate viewing of the LED sign and the louvers shield the light emitting diodes comprising the LED sign from excessive light.
摘要翻译：用于LED符号的盖由不同于尺寸大于包括LED符号的发光二极管阵列的不锈钢板制造。不锈钢板被激光切割，然后弯曲以同时形成多个孔和相应的多个百叶窗，每个百叶窗都相邻于一个孔延伸。这些孔便于观察LED标志，并且百叶窗屏蔽包含LED标志的发光二极管过多的光。

64. 发明授权

US06881736B1 Vitronectin receptor antagonists 失效
标题翻译： Vitronectin受体拮抗剂
公开(公告)号：US06881736B1
公开(公告)日：2005-04-19
申请号：US10070057
申请日：2000-09-07
申请人： Peter J. Manley , William H. Miller , Irene N. Uzinskas
发明人： Peter J. Manley , William H. Miller , Irene N. Uzinskas
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/444 , C07D213/74 , C07D413/08 , C07D413/12 , C07D417/08 , C07D417/12 , C07D471/04
CPC分类号： C07D213/74 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: wherein R1 is Het or Ar R2 is or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了式（I）的化合物，其是玻连蛋白受体拮抗剂，可用于治疗骨质疏松症：其中R 1是Het或Ar R 2或其药学上可接受的盐其可接受的盐。

65. 发明授权

US06846819B1 Fab I inhibitors 有权
标题翻译： Fab I抑制剂
公开(公告)号：US06846819B1
公开(公告)日：2005-01-25
申请号：US10089755
申请日：2000-10-06
申请人： William H. Miller , Kenneth A. Newlander , Mark A. Seefeld , Irene N. Uzinskas , Walter E. DeWolf, Jr. , Dalia R. Jakas
发明人： William H. Miller , Kenneth A. Newlander , Mark A. Seefeld , Irene N. Uzinskas , Walter E. DeWolf, Jr. , Dalia R. Jakas
IPC分类号： G01N33/50 , A61K31/381 , A61K31/4045 , A61K31/407 , A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61P31/04 , A61P43/00 , C07D209/14 , C07D209/52 , C07D213/73 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , G01N33/15 , A61K31/4375
CPC分类号： C07D213/75 , A61K31/381 , A61K31/4436 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/506 , A61K31/5365 , C07D209/14 , C07D209/52 , C07D239/42 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D495/04 , Y02A50/473
摘要： Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
摘要翻译：公开了式（I）的化合物，其是Fab I抑制剂并且可用于治疗细菌感染。

66. 发明授权

US06739756B2 Combination thrust bearing and journal bearing, and method for distributing fluid to same 失效
标题翻译：组合推力轴承和轴颈轴承，以及将流体分配到其中的方法
公开(公告)号：US06739756B2
公开(公告)日：2004-05-25
申请号：US10320592
申请日：2002-12-16
申请人： William H. Miller
发明人： William H. Miller
IPC分类号： F16C1703
CPC分类号： F16C32/0629 , F16C17/03 , F16C17/06 , F16C32/0666 , F16C33/1075 , F16C33/108
摘要： A thrust bearing tilting pad has face with a border region including an engagement surface and defining a pocket with generally longitudinal sidebars and a bottom. The pad has leading and trailing portions, with the face extending generally longitudinally therebetween. The leading and trailing portions can be positioned upstream and downstream, respectively, relative to a direction of movement of a runner. The pad is pivotally supported by (e.g., mechanical and/or hydrostatic) pivot and can cooperate with one or more other pads and fluid within a housing to hydrodynamically and mechanically support the runner in an axial position. In another embodiment, the pad tilts free of mechanical engagement with other pads. The leading portion can define an entrance to the pocket and the sidebars can converge along the direction of motion of the runner. The pocket hydrodynamically increases pressure on the runner during rotation, and generates pressure effecting on the face counteraction force about the pivot and upstream relative to the rotation direction in order to counteract spragging force. The pocket can also have a generally tapered profile or an abrupt step.
摘要翻译：止推轴承倾斜垫具有包括接合表面的边界区域并且限定具有大体上纵向的侧边条和底部的口袋。垫具有前后部分，其表面大致纵向延伸。前导部分和尾部部分可以相对于流道的运动方向分别位于上游和下游。该垫由（例如机械和/或静液压）枢轴枢轴支撑，并且可以与壳体内的一个或多个其它垫和流体配合以在轴向位置上流体动力地和机械地支撑流道。在另一个实施例中，垫片与其它垫片没有倾斜的机械接合。引导部分可以限定到口袋的入口，并且侧杆可以沿着跑步者的运动方向收敛。口袋在旋转期间流体动力地增加流道上的压力，并且相对于旋转方向产生影响围绕枢轴和上游的表面反作用力的压力，以便抵消上翘力。口袋也可以具有大致锥形的轮廓或突然的台阶。

67. 发明授权

US06503903B1 Fab I inhibitors 有权
标题翻译： Fab I抑制剂
公开(公告)号：US06503903B1
公开(公告)日：2003-01-07
申请号：US09959172
申请日：2001-10-18
申请人： William H. Miller , Kenneth A. Newlander , Mark A. Seefeld
发明人： William H. Miller , Kenneth A. Newlander , Mark A. Seefeld
IPC分类号： A61K3155
CPC分类号： C07D403/12
摘要： Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: wherein: R1 is H, C1-6alkyl or Ar—C0-6alkyl; R2 is H, C1-6alkyl, Ar—C0-6alkyl, HO—(CH2)n— or R′OC(O)—(CH2)n—; R3 is A—C0-4alkyl, A—C2-4alkenyl, A—C2-4alkynyl, A—C3-4oxoalkenyl, A—C3-4oxoalkynyl, A—C1-4aminoalkyl, A—C3-4aminoalkenyl, A—C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R10 or R7; R5 is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R7 is —COR8, —COCR′2R9, —C(S)R8, —S(O)kOR′, —S(O)kNR′R″, —PO(OR′), —PO(OR′)2, —B(OR′)2, —NO2, or tetrazolyl; R8 is —OR′, —NR′R″, —NR′SO2R′, —NR′OR′, or —OCR′2CO(O)R′; R9 is —OR′, —CN, —S(O)rR′, —S(O)kNR′2, —C(O)R′, C(O)NR′2, or —CO2R′; R10 is H, halo, —OR11, —CN, —NR′R11, —NO2, —CF3, CF3S(O)r—, —CO2R′, —CONR′2, A—C0-6alkyl-, A—C1-6oxoalkyl-, A—C2-6alkenyl-, A—C2-6alkynyl-, A—C0-6alkyloxy-, A—C0-6alkylamino- or A—C0-6alkyl —S(O)r—; R11 is R′, —C(O)R′, —C(O)NR′2, —C(O)OR′, —S(O)kR′, or —S(O)kNR′2; R′ is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; R″ is R′, —C(O)R′ or —C(O)OR′; R′″ is H, C1-6alkyl, Ar—C0-6alkyl, HO-(CH2)2—, R′C(O)—, (R′)2NC(O)CH2— or R′S(O)2—; X is H, C1-4alkyl, OR′, SR′, C1-4alkylsulfonyl, C1-4alkylsulfoxyl, —CN, N(R′)2, CH2N(R′)2, —NO2, —CF3, —CO2R′, —CON(R′)2, —COR′, —NR′C(O)R′, F, Cl, Br, I, or CF3S(O)r—; k is 1 or 2; m is 1, 2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了式（I）化合物，其为FabI抑制剂并且可用于治疗细菌感染：其中：R1为H，C1-6烷基或Ar-C0-6烷基; R2为H，C1-6烷基，Ar-C0- C 1-6烷基，HO-（CH 2）n或R'OC（O） - （CH 2）n - ; R 3是A-C 0-4烷基，A-C 2-4链烯基，A-C 2-4亚烷基，任选地被R 10或R 7中的一个或多个的任何可接近的组合取代的C 3-4氧代炔基，A-C 1-4氨基烷基，A-C 3-4氨基烯基，A-C 3-8氨基炔基，R 5是H，C 1-6烷基， C 1-6烷基或C 3-6环烷基-C 0-6烷基; A是H，C 3-6环烷基，Het或Ar; R 7是-COR 8，-COCR 2 R 9，-C（S）R 8，-S（O）k OR' O）kNR'R“，-PO（OR'），-PO（OR'）2，-B（OR'）2，-NO 2或四唑基; R8是-OR'，-NR'R” -NR'SO2R'，-NR'OR'或-OCR'2CO（O）R'; R9是-OR'，-CN，-S（O）rR'，-S（O）kNR'2， C（O）R'，C（O）NR'2或-CO 2 R'; R 10是H，卤素，-OR 11，-CN，-NR'R 11，-NO 2，-CF 3，CF 3 S（O） -CO 2 R'，-CONR'2，A-C0-6烷基 - ，A-C1-6氧代烷基 - ，A-C2-6烯基 - ，A-C2-6炔基 - ，A-C10-烷氧基 - ，A-C10-烷基氨基 - 或A-C0-6烷基-S（O）r-; R11是R'，-C（O）R'， -C（O）NR'2，-C（O）OR'，-S（O）kR'或-S（O）kNR'2; R'是H，C1-6烷基，Ar-C0-6烷基或 C3-6环烷基-C0-6烷基; R“是R'，-C（O）R'或-C（O）OR'; R”'是H，C1-6烷基，Ar-C0-6烷基，（CH 2）2 - ，R'C（O） - ，（R'）2 NC（O）CH 2 - 或R'S（O）2 - ; X是H，C 1-4烷基，OR'，SR'，C 1-4烷基磺酰基， C 1-4烷基亚磺酰基，-CN，N（R'）2，CH 2 N（R'）2，-NO 2，-CF 3，-CO 2 R'，-CON（R'）2，-COR'，-NR'C R'，F，Cl，Br，I或CF 3 S（O）r - ; k为1或2; m为1,2或3; n为1至6; 和r为0,1或2;或其药学上可接受的盐。

68. 发明授权

US5609275A Metering apparatus having a screw member 失效
标题翻译：具有螺纹构件的计量装置
公开(公告)号：US5609275A
公开(公告)日：1997-03-11
申请号：US422746
申请日：1995-04-14
申请人： Robert L. Brown , William H. Miller , David E. Baxter
发明人： Robert L. Brown , William H. Miller , David E. Baxter
IPC分类号： B05C11/10 , B29C47/38 , G01F11/20
CPC分类号： B29C47/38 , B05C11/1002 , B29C47/003
摘要： A metering apparatus 10 for continuously supplying a specified amount of fluid material F to a desired surface. The apparatus 10 includes a reservoir 14 for maintaining a supply of fluid material, a housing 16 having a central bore 22 therethrough, a receiving opening 24 for receiving fluid material from the reservoir 14 to central bore 22, and an exit opening 26 through which fluid material exits the housing 16. A rotatable screw member 28 is provided engaged through the housing 16 within said central bore 22, and a driver 37 engaged with the screw member for rotating the screw member within the bore at between approximately 1 rpm to 2,700 rpm, and preferably approximately 1,750 rpm, in order to continuously supply fluid to the exit opening 26. At this operating level, fluid material is provided from the exit opening 26 at a flow rate of between approximately 1 to 23 grams/min, and in a thickness of approximately 0.001 to 8 mils. The reservoir 14 includes a tank 50 for the fluid material, and a motor 68 for agitating the fluid during operation of the apparatus 10. The housing 16 is secured adjacent the tank 50 to provide the fluid material from the tank to the receiving opening 24.
摘要翻译：用于将特定量的流体材料F连续地供给到期望的表面的计量装置10。设备10包括用于维持流体材料供应的储存器14，具有穿过其中的中心孔22的壳体16，用于将流体材料从储存器14接收到中心孔22的接收开口24和流体材料离开壳体16.通过壳体16在所述中心孔22内接合的可旋转的螺纹构件28和与螺钉构件接合的驱动器37，用于在大约1rpm至2,700rpm之间旋转孔内的螺杆构件，并且优选地为约1,750rpm，以便将流体连续地供应到出口26。在该操作水平下，流体材料以约1至23克/分钟之间的流速从出口26提供，并且以厚度约0.001至8密耳。储存器14包括用于流体材料的罐50和用于在装置10的操作期间搅拌流体的马达68.壳体16被固定在罐50附近，以将流体材料从罐提供到接收开口24。

69. 发明授权

US5562875A Handling system and method for curved extrusions 失效
标题翻译：弯曲挤压的处理系统和方法
公开(公告)号：US5562875A
公开(公告)日：1996-10-08
申请号：US715026
申请日：1991-06-13
申请人： William H. Miller , James F. Stevenson
发明人： William H. Miller , James F. Stevenson
IPC分类号： B29C47/00 , B29C47/12 , B29C47/26 , B29C47/34 , B29C47/24
CPC分类号： B29C47/0035 , B29C47/003 , B29C47/0866 , B29C47/12 , B29C47/26 , B29C47/34 , B29C47/0019 , B29C47/025
摘要： An assembly and method for processing extrudate material containing curves or angles into a predetermined overall configuration, including having a die assembly for an extruder which assembly controls the cross-sectional shape or profile of the extrudate and selectively varies the path of the extrudate as it leaves the die assembly. A support member is provided which has a predetermined overall configuration and profile to receive the extrudate and maintain its configuration. A driving apparatus is also provided for continuously driving either the support member or the die assembly relative to the other while the extrudate is being received in the support member, and until the entire predetermined overall configuration has been completed. The path of the extrudate is variably directed by the die assembly as it leaves the extruder in coordination with the relative speeds involved to conform the extrudate configuration to the predetermined overall configuration of the support member.
摘要翻译：一种用于将包含曲线或角度的挤出物材料加工成预定的总体构造的组件和方法，包括具有用于挤出机的模具组件，其组装控制挤出物的横截面形状或轮廓，并且当挤出物离开时选择性地改变挤出物的路径模具组件。提供了一种支撑构件，其具有预定的整体构造和轮廓以接收挤出物并保持其构型。还提供一种驱动装置，用于当挤出物被容纳在支撑构件中时，并且直到整个预定的整体构型完成为止，连续地驱动支撑构件或模具组件相对于另一个。挤出物的路径可随模头组件可变地引导，因为它与所涉及的相对速度协调地离开挤出机，以使挤出物构型符合支撑构件的预定整体构型。

70. 发明授权

US5520061A Multiple axis transducer mounting collar 失效
标题翻译：多轴传感器安装环
公开(公告)号：US5520061A
公开(公告)日：1996-05-28
申请号：US107326
申请日：1993-08-16
申请人： Scott E. Thibault , William H. Miller , Warren R. Brook , Timothy P. Mannix
发明人： Scott E. Thibault , William H. Miller , Warren R. Brook , Timothy P. Mannix
IPC分类号： G01H1/00 , G01H1/10 , G01H13/00 , G01N29/12 , G01N29/22 , G10K11/00 , G01N29/26
CPC分类号： G01H13/00 , G01H1/003 , G01H1/10 , G01N29/12 , G01N29/223 , G01N29/225 , G10K11/004 , G01N2291/105
摘要： An improved apparatus and method for determining the existence and severity of a crack in a shaft system is provided. The apparatus includes means for mounting multiple vibration responsive output transducers around an outer circumference of the shaft system, allowing simultaneous measurements of vibrational response of the shaft system when multiple vibration responsive output transducers are mounted to the mounting means. In a first approach, the mounting means comprises a collar having two connected arcuate members, with drilled milled and tapped apertures for mounting radial input and output transducers. Torsional input and output transducers may also be mounted tangentially on the collar in drilled milled and tapped heads of bolts used to connect the two arcuate members. In a second approach, the mounting means comprises a plurality of support blocks disposed substantially symmetrically around and protruding outward from the outer collar circumference with each of the blocks orienting at least one transducer in a radial direction and at least one transducer in a tangential direction. Each block may further orient another transducer in an axial direction.
摘要翻译：提供了一种用于确定轴系中的裂纹的存在和严重性的改进的装置和方法。该装置包括用于在轴系的外周安装多个响应振动的输出换能器的装置，当多个响应振动的输出换能器安装到安装装置时，允许同时测量轴系的振动响应。在第一种方法中，安装装置包括具有两个连接的弓形构件的套环，其具有用于安装径向输入和输出换能器的钻孔和螺纹孔。扭转输入和输出传感器也可以切向地安装在用于连接两个弓形构件的钻孔的研磨和螺纹螺栓头部的套环上。在第二种方法中，安装装置包括多个支撑块，这些支撑块基本上对称地设置在外围环周围并且从外环周向外突出，其中每个块沿径向定向至少一个换能器，并且沿切线方向定向至少一个换能器。每个块可以进一步沿轴向方向定向另一个换能器。

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