专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US5665726A Benzo[5,6]cycloheptapyridines, compositions and methods of use 失效
标题翻译：苯并[5,6]环庚吡啶，组合物和使用方法
公开(公告)号：US5665726A
公开(公告)日：1997-09-09
申请号：US433300
申请日：1995-05-03
申请人： John J. Piwinski , Ashit K. Ganguly , Michael J. Green , Jesse Wong
发明人： John J. Piwinski , Ashit K. Ganguly , Michael J. Green , Jesse Wong
IPC分类号： C07D221/04 , C07D401/04 , C07D401/14 , A61K31/445
CPC分类号： C07D221/04 , C07D401/04 , C07D401/14
摘要： Derivatives of benzo[5,6]cyclohepta pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.
摘要翻译：公开了苯并[5,6]环庚吡啶的衍生物及其药学上可接受的盐和溶剂合物，其具有抗过敏和抗炎活性。还描述了制备和使用化合物的方法。

62. 发明授权

US5185334A 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use 失效
标题翻译： 2,2-二取代的甘油和甘油样化合物，组合物和使用方法
公开(公告)号：US5185334A
公开(公告)日：1993-02-09
申请号：US758448
申请日：1991-09-06
申请人： Daniel Solomon , James J. Kaminski , Steven K. White , Laura S. Lehman de Gaeta , Ashit K. Ganguly
发明人： Daniel Solomon , James J. Kaminski , Steven K. White , Laura S. Lehman de Gaeta , Ashit K. Ganguly
IPC分类号： C07C219/16 , C07C271/12 , C07C271/16 , C07C271/20 , C07C279/08 , C07D213/06 , C07D213/20 , C07D213/65 , C07D213/74 , C07D233/54 , C07D233/88 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/82 , C07D285/12 , C07D285/135 , C07D295/088 , C07D521/00 , C07F9/10 , C07F9/58 , C07F9/6506 , C07F9/6539
CPC分类号： C07D213/20 , C07C219/16 , C07C271/12 , C07C271/16 , C07C271/20 , C07C279/08 , C07D213/06 , C07D213/65 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/88 , C07D249/08 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/82 , C07D285/135 , C07D295/088 , C07F9/10 , C07F9/581 , C07F9/65061 , C07F9/6539
摘要： Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.
摘要翻译：公开了用作抗过敏和抗炎化合物的新型2,2-二取代的甘油样化合物。这些化合物是血小板活化因子（“PAF”）的拮抗剂。还公开了合成和使用本发明化合物的方法及其药物组合物。化合物具有式（I）其中R 1，R 2，R 3和R 4如说明书中所定义。

63. 发明授权

US5034531A Fused polycyclic pyranyl compounds as antiviral agents 失效
标题翻译：稠合多环吡喃基化合物作为抗病毒剂
公开(公告)号：US5034531A
公开(公告)日：1991-07-23
申请号：US289285
申请日：1988-12-23
申请人： Richard J. Friary , John H. Schwerdt , Ashit K. Ganguly
发明人： Richard J. Friary , John H. Schwerdt , Ashit K. Ganguly
IPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D491/052 , C07D491/147
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14
摘要： Novel polycyclic pyranyl compounds, pharmaceutical compositions, and their use as anti-viral agents are disclosed.
摘要翻译：公开了新型多环吡喃基化合物，药物组合物及其作为抗病毒剂的用途。

64. 发明授权

US4027016A Everninomicin antibacterial derivatives, electrochemical method for their manufacture, method for their use as antibacterial agents, and pharmaceutical compositions useful therefor 失效
标题翻译： Everninomicin抗菌衍生物，其制备的电化学方法，其用作抗菌剂的方法和用于其的药物组合物
公开(公告)号：US4027016A
公开(公告)日：1977-05-31
申请号：US650081
申请日：1976-01-19
申请人： Peter Kabasakalian , Sami Y. Kalliney , Ashit K. Ganguly , Anita Westcott
发明人： Peter Kabasakalian , Sami Y. Kalliney , Ashit K. Ganguly , Anita Westcott
IPC分类号： C07H19/01 , C25B3/04 , A61K31/715
CPC分类号： C07H19/01 , C25B3/04
摘要： Everninomicin derivatives devoid of a nitro group and having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or salts thereof in an aprotic anhydrous solvent in the absence of carbon dioxide. A preferred starting compound is everninomicin D whereby is produced a product mixture of antibacterial agents identified as desevernitrose everninomicin D, everninomicin D-3, and everninomicin D-7, respectively.
摘要翻译：没有硝基并具有抗菌活性的Everninomicin衍生物通过在不存在二氧化碳的情况下在非质子无水溶剂中电化学还原具有硝基官能团的相应的everninomicin或其盐来制备。优选的起始化合物是伊维菌素D，由此产生分别被鉴定为脱乙酰壳多糖依维诺霉素D，依维诺米星D-3和依维霉素D-7的抗菌剂的产物混合物。

65. 发明授权

US3998708A Electrochemical process for preparing hydroxylaminoeverninomicins 失效
标题翻译：制备羟基氨基炔诺酮的电化学方法
公开(公告)号：US3998708A
公开(公告)日：1976-12-21
申请号：US650082
申请日：1976-01-19
申请人： Peter Kabasakalian , Sami Y. Kalliney , Ashit K. Ganguly , Anita Westcott
发明人： Peter Kabasakalian , Sami Y. Kalliney , Ashit K. Ganguly , Anita Westcott
IPC分类号： C07H19/01 , C25B3/04 , C07D325/00 , C07H15/00
CPC分类号： C07H19/01 , C25B3/04
摘要： Hydroxylaminoeverninomicins having antibacterial activity are prepared by electrochemically reducing the corresponding everninomicin having a nitro function or the corresponding nitrosoeverninomicin in an aqueous miscible organic solvent under an inert atmosphere or in an anhydrous aprotic solvent in the presence of carbon dioxide. Additionally, nitrosoeverninomicins, upon electrochemical reduction in an aprotic solvent under an inert atmosphere, are converted to the corresponding hydroxylaminoeverninomicins. Preferred starting compounds are everninomicins B, C and D whereby are obtained hydroxylaminoeverninomicins B, C and D, respectively. Particularly useful is the electrochemical reduction of everninomicin D in anhydrous dimethylformamide in the presence of carbon dioxide to obtain hydroxylaminoeverninomicin D of excellent purity in high yields.
摘要翻译：具有抗菌活性的羟基氨基炔诺酮通过在二氧化碳存在下，在惰性气氛或无水质子惰性溶剂中，在含水混溶性有机溶剂中，电化学还原具有硝基官能团的相应的伊维菌素或相应的亚硝吗啉。另外，在非质子溶剂中在惰性气氛下电化学还原时，亚硝基毒素被转化为相应的羟基氨基炔诺酮。优选的起始化合物是乙酰丙酮蛋白B，C和D，分别得到羟基氨基炔诺酮B，C和D。特别有用的是在二氧化碳存在下在无水二甲基甲酰胺中电解还原everninomicin D，以高产率获得优异的纯度的羟基氨基炔诺酮D。

66. 发明授权

US5449680A 2,2 disubstituted glycerol and glycerol-like compounds, compositions and methods of use 失效
标题翻译： 2,2二取代甘油和甘油样化合物，组合物和使用方法
公开(公告)号：US5449680A
公开(公告)日：1995-09-12
申请号：US955784
申请日：1992-10-02
申请人： Daniel Solomon , James J. Kaminski , Steven K. White , Laura S. Lehman de Gaeta , Ashit K. Ganguly
发明人： Daniel Solomon , James J. Kaminski , Steven K. White , Laura S. Lehman de Gaeta , Ashit K. Ganguly
IPC分类号： C07C219/16 , C07C271/12 , C07C271/16 , C07C271/20 , C07C279/08 , C07D213/06 , C07D213/20 , C07D213/65 , C07D213/74 , C07D233/54 , C07D233/88 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/82 , C07D285/12 , C07D285/135 , C07D295/088 , C07D521/00 , C07F9/10 , C07F9/58 , C07F9/6506 , C07F9/6539 , A61K31/425
CPC分类号： C07D213/20 , C07C219/16 , C07C271/12 , C07C271/16 , C07C271/20 , C07C279/08 , C07D213/06 , C07D213/65 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/88 , C07D249/08 , C07D249/14 , C07D277/04 , C07D277/06 , C07D277/18 , C07D277/22 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/82 , C07D285/135 , C07D295/088 , C07F9/10 , C07F9/581 , C07F9/65061 , C07F9/6539
摘要： Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.
摘要翻译：公开了用作抗过敏和抗炎化合物的新型2,2-二取代的甘油样化合物。这些化合物是血小板活化因子（“PAF”）的拮抗剂。还公开了合成和使用本发明化合物的方法及其药物组合物。化合物具有式（I）其中R 1，R 2，R 3和R 4如说明书中所定义。

67. 发明授权

US4810708A Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives 失效
标题翻译：多环喹啉，萘啶和吡嗪并吡啶衍生物
公开(公告)号：US4810708A
公开(公告)日：1989-03-07
申请号：US17027
申请日：1987-02-17
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/113 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22 , A61K31/435 , C07D491/044 , C07D491/056
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
摘要翻译：公开了可用于治疗过敏反应，炎症，消化性溃疡，高血压和过度增生性皮肤病以及抑制哺乳动物免疫应答的新型多环喹啉，萘啶和吡嗪并吡啶衍生物。还公开了制备所述化合物的方法。

68. 发明授权

US4373095A Macrolide antibacterial AR-5 components 失效
标题翻译：大环内酯抗菌AR-5成分
公开(公告)号：US4373095A
公开(公告)日：1983-02-08
申请号：US244541
申请日：1981-03-17
申请人： Ashit K. Ganguly , Olga Sarre , Yi-Tsung Liu
发明人： Ashit K. Ganguly , Olga Sarre , Yi-Tsung Liu
IPC分类号： C07H17/08 , C12P19/48 , C12P19/62 , C07H17/06
CPC分类号： C07H17/08 , C12P19/48 , C12P19/62 , C12R1/29
摘要： Desmycinosyl derivatives of 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 1 and 12,13-desepoxy-12,13-dehydro antibiotic AR-5 component 2 are useful antibacterial agents and may be converted to other such agents by processes analogous to those generally known in the art.
摘要翻译： 12,13-去环氧-12,13-脱氢抗菌素AR-5组分1和12,13-去环氧-12,13-脱氢抗生素AR-5组分2的去霉霉素衍生物是有用的抗菌剂，并且可以转化成其它这样的试剂通过与本领域中通常已知的方法类似的方法。

69. 发明授权

US4279896A Novel 20-imino macrolide antibacterial agents 失效
标题翻译：新型20-imino大环内酯抗菌剂
公开(公告)号：US4279896A
公开(公告)日：1981-07-21
申请号：US161947
申请日：1980-06-23
申请人： Ashit K. Ganguly , Yi-Tsung Liu
发明人： Ashit K. Ganguly , Yi-Tsung Liu
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , A61K31/71
CPC分类号： C07H17/08
摘要： Rosaramicin and 12,13-desepoxy-12,13-dehydrorosaramicin form novel 20-imino-20-deoxy derivatives having substantial antibacterial activity. Methods for preparing such compounds are also disclosed.
摘要翻译：异恶唑烷酮和12,13-去环氧-12,13-脱氢罗丹霉素形成具有显着抗菌活性的新型20-亚氨基-20-脱氧衍生物。还公开了制备这些化合物的方法。

70. 发明授权

US06914122B2 Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties 失效
标题翻译：丙型肝炎病毒的大环NS-3丝氨酸蛋白酶抑制剂包含烷基和芳基丙氨酸P2部分
公开(公告)号：US06914122B2
公开(公告)日：2005-07-05
申请号：US09836636
申请日：2001-04-17
申请人： Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
发明人： Srikanth Venkatraman , Kevin X. Chen , Ashok Arasappan , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly , Tin-Yau Chan , Brian Alexander Mc Kittrick , Nanhua Hugh Yao , Andrew Joseph Prongay , Vincent Stewart Madison
IPC分类号： A61K45/00 , A61K31/7052 , A61K38/00 , A61K38/21 , A61P31/12 , A61P31/14 , A61P43/00 , C07D273/00 , C07K5/02 , C07K7/02 , C07K7/64 , C07K7/50
CPC分类号： C07K5/0202 , A61K38/00 , C07K7/02
摘要： The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型大环化合物及其制备方法。在另一个实施方案中，本发明公开了包含这种大环化合物的药物组合物以及使用它们治疗与HCV蛋白酶相关的病症的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式