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61. 发明授权

US5061435A High-temperature reactor 失效
标题翻译：高温反应釜
公开(公告)号：US5061435A
公开(公告)日：1991-10-29
申请号：US553088
申请日：1990-07-17
申请人： Jasbir Singh , Heiko Barnert , Hans Hohn
发明人： Jasbir Singh , Heiko Barnert , Hans Hohn
IPC分类号： G21C1/07 , G21C15/02 , G21C15/18
CPC分类号： G21C15/18 , G21C15/02 , Y02E30/40
摘要： High temperature reactor with residual-heat transfer system comprises a cooling gas intake at the bottom and cooling gas outlet at the top so that a cooling gas can flow from the bottom to the top through the reactor core. In order to assure reliable heat transfer a bypass duct is provided with a lower end communicating with the cooling gas intake and the upper end communicating with the cooling gas outlet. The bypass duct is arranged parallel to the reactor core and passing a partial flow of cooling gas from the bottom to the top. This partial flow of cooling gas heats up only trivially. This partial flow of cooling gas is further cooled by the cooler. The upward flow of the comparatively cold cooling gas in the bypass duct stops and by itself reverses because the cooling gas in the bypass duct is drawn toward the reactor core on account of the natural convection. This natural convection is maintained itself automatically in the reactor core with the required downflow inspite of the raised temperature of the cooling gas.
摘要翻译：具有残余热传递系统的高温反应器包括底部的冷却气体入口和顶部的冷却气体出口，使得冷却气体可以从底部通过反应堆堆芯流到顶部。为了确保可靠的热传递，旁路管道设置有与冷却气体入口连通的下端，并且与冷却气体出口连通的上端。旁路管道平行于反应堆堆芯布置，并将部分冷却气体流从底部传递到顶部。冷却气体的这种部分流动仅仅是微小的加热。该冷却气体的这种部分流动被冷却器进一步冷却。由于旁路管道中的冷却气体由于自然对流而被拉向反应堆堆芯，所以旁路管道中较冷的冷却气体的向上流动停止并且自身反转。这种自然对流本身自动保持在反应堆堆芯中，并具有冷却气体升高温度所需的下降流动。

62. 发明授权

US08750805B2 Systems and method for spur supression in a multiple radio SoC 有权
标题翻译：多重无线电SoC中的支路抑制系统和方法
公开(公告)号：US08750805B2
公开(公告)日：2014-06-10
申请号：US12969800
申请日：2010-12-16
申请人： Vivek Singhal , Senthilkannan Chandrasekaran , Sumanth Poddutur , Jasbir Singh
发明人： Vivek Singhal , Senthilkannan Chandrasekaran , Sumanth Poddutur , Jasbir Singh
IPC分类号： H04B1/00
CPC分类号： H03K3/017 , H04B2215/067
摘要： A digital system includes a spur calculator that computes harmonics of a frequency of a digital clock signal and that identities a harmonic that lies in a frequency band of operation of a radio frequency circuit. A duty cycle computation module receives the harmonic and computes a duty cycle for the harmonic. Further, a clock generator that is coupled to the duty cycle computation block generates a digital clock signal of the frequency and with the duty cycle such that amplitude of spur caused due to the harmonic is suppressed.
摘要翻译：数字系统包括一个辅助计算器，其计算数字时钟信号的频率的谐波，并且识别位于射频电路的操作频带中的谐波。占空比计算模块接收谐波并计算谐波的占空比。此外，耦合到占空比计算块的时钟发生器产生频率和占空比的数字时钟信号，从而抑制由谐波引起的杂散振幅。

63. 发明申请

US20120169138A1 NON-MOVING PART OR STATIC ELECTRIC GENERATOR 审中-公开
标题翻译：非移动部件或静态电力发电机
公开(公告)号：US20120169138A1
公开(公告)日：2012-07-05
申请号：US13395633
申请日：2011-01-14
申请人： Jasbir Singh
发明人： Jasbir Singh
IPC分类号： H01F38/00 , H02N11/00
CPC分类号： H02K53/00
摘要： A static or non-moving part electric power generator achieved by a changing (fluctuating) magnetic field (flux) by passing a pulsating direct current (DC) through a coil of wire wound on either a magnet or any material capable of producing a magnetic field, which in turn induces an alternating current (AC) in an adjacent secondary coil winding, and wherein a portion of the AC produced is used in recharging a DC source.
摘要翻译：通过使脉动直流（DC）通过缠绕在磁体上的线圈或能够产生磁场的任何材料的线圈通过变化（波动的）磁场（磁通）而实现的静态或非移动部分发电机，其又在相邻次级线圈绕组中引起交流电（AC），并且其中所产生的AC的一部分用于对DC源再充电。

64. 发明授权

US07648978B2 Small molecule modulators of cytokine activity 有权
标题翻译：细胞因子活性的小分子调节剂
公开(公告)号：US07648978B2
公开(公告)日：2010-01-19
申请号：US11238285
申请日：2005-09-28
申请人： David E. Zembower , Jasbir Singh , Rama K. Mishra
发明人： David E. Zembower , Jasbir Singh , Rama K. Mishra
IPC分类号： A61P25/00 , A61K31/55 , C07D403/02
CPC分类号： C07D401/10 , C07D237/32 , C07D401/14 , C07D403/10 , C07D403/14
摘要： The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
摘要翻译：本发明提供具有式（I）或（II）的化合物及其药学上可接受的衍生物，其中m，p，R 1，R 2，R 3和R 4如本文中一般和本领域和亚类所述，并另外提供其药物组合物及其用于治疗与HGF / SF或其他细胞因子活性相关的许多疾病，病症或病症中的任何一种的方法。

65. 发明申请

US20090136473A1 BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：用于治疗肺动脉和心脏病的BIARYL PDE4抑制剂
公开(公告)号：US20090136473A1
公开(公告)日：2009-05-28
申请号：US12275152
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
IPC分类号： A61K31/44 , C07D231/12 , C07D213/64 , C07D239/42 , C07D213/79 , C07C275/28 , C07D285/135 , A61K31/433 , A61K31/4439 , A61P1/00 , A61P11/00 , A61P35/00 , A61P9/00 , A61K31/122 , A61K31/4353 , A61K31/435 , A61K31/4427 , A61K31/437 , A61K31/4545 , C07D401/06 , C07D471/04 , C07D213/72 , A61K31/415 , A61K31/4412 , A61K31/495
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is
摘要翻译：本发明涉及含有至少一个其它环的联芳基化合物属。该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。化合物具有通式Ia，Ib，Ic或Id：具体实施方案是

66. 发明申请

US20090130076A1 SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：替代苯扎唑PDE4抑制剂治疗肺动脉和心脏病
公开(公告)号：US20090130076A1
公开(公告)日：2009-05-21
申请号：US12275164
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao
IPC分类号： A61K31/122 , C07D417/08 , A61K31/4965 , A61P35/00 , A61K31/4439 , C07D417/14
CPC分类号： C07D417/14 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/06 , C07D498/04 , C07D513/04
摘要： The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is
摘要翻译：本发明涉及用于治疗中风，心肌梗塞和心血管炎症状况的可用于治疗中风，心肌梗死和心血管炎症状况的苯环的吡啶和嘧啶环的取代苯并唑和其对应物与包含这些化合物的药物组合物的方法，治疗哺乳动物的中风，心肌梗死和心血管炎症状况。化合物具有通式I：其中A和B是碳环或杂环。一个特定的实施例是

67. 发明申请

US20070270594A1 PROCESS FOR PREPARING 7-(ACRYLOYL)INDOLES 失效
标题翻译：制备7-（丙烯酸）吲哚的方法
公开(公告)号：US20070270594A1
公开(公告)日：2007-11-22
申请号：US11748858
申请日：2007-05-15
申请人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
发明人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
IPC分类号： C07D409/02
CPC分类号： C07D409/12 , C07D209/08
摘要： The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
摘要翻译：本发明涉及制备取代的吲哚的方法，例如涉及两个顺序的交叉偶联反应的DTSI。

68. 发明授权

US07288650B2 Cyclic substituted fused pyrrolocarbazoles and isoindolones 有权
标题翻译：环状取代的稠合吡咯并咔唑和异吲哚酮
公开(公告)号：US07288650B2
公开(公告)日：2007-10-30
申请号：US11346524
申请日：2006-02-02
申请人： Robert L. Hudkins , Dandu R. Reddy , Jasbir Singh , Rabindranath Tripathy , Ted Underiner
发明人： Robert L. Hudkins , Dandu R. Reddy , Jasbir Singh , Rabindranath Tripathy , Ted Underiner
IPC分类号： C07D487/02 , C07D237/00 , A61K31/407
CPC分类号： C07D487/04 , C07D209/94
摘要： The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.
摘要翻译：本发明涉及环状取代的稠合吡咯并咔唑和异吲哚酮。本发明还涉及制备和使用环状取代的稠合吡咯并咔唑和异吲哚酮的方法。

69. 发明授权

US06831075B2 Heterocyclic substituted pyrazolones 有权
标题翻译：杂环取代的吡唑啉酮
公开(公告)号：US06831075B2
公开(公告)日：2004-12-14
申请号：US10225670
申请日：2002-08-22
申请人： Jasbir Singh , Rabindranath Tripathy
发明人： Jasbir Singh , Rabindranath Tripathy
IPC分类号： A61K3133
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.
摘要翻译：本发明涉及新颖的杂环取代的吡唑啉酮，包括药物组合物，诊断试剂盒，测定标准品或含有它们的试剂，以及使用它们作为治疗剂的方法。本发明还涉及制备这些新化合物的中间体和方法。

70. 发明授权

US5677283A .alpha.-heteroaryloxymethyl ketones as interleukin - 1 .beta. converting enzyme inhibitors 失效
标题翻译： α-杂环氧基甲基酮作为白细胞介素-1β转换酶抑制剂
公开(公告)号：US5677283A
公开(公告)日：1997-10-14
申请号：US732173
申请日：1996-10-16
申请人： Roland E. Dolle , Jasbir Singh , David A. Whipple , Catherine Prouty , Prasad V. Chaturvedula , Stanley J. Schmidt , Mohamed M. A. Awad , Denton W. Hoyer , Tina Morgan Ross
发明人： Roland E. Dolle , Jasbir Singh , David A. Whipple , Catherine Prouty , Prasad V. Chaturvedula , Stanley J. Schmidt , Mohamed M. A. Awad , Denton W. Hoyer , Tina Morgan Ross
IPC分类号： C12N9/99 , A61K31/397 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K38/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07D205/04 , C07D207/38 , C07D209/12 , C07D215/14 , C07D217/16 , C07D223/08 , C07D231/20 , C07D231/22 , C07D261/12 , C07D263/06 , C07D265/06 , C07D265/30 , C07D311/46 , C07D311/50 , C07D311/56 , C07D401/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D453/02 , C07D471/04 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/09 , C07K5/097 , C07D231/04 , C07K5/00
CPC分类号： C07D401/12 , C07D207/38 , C07D231/20 , C07D231/22 , C07D261/12 , C07D311/46 , C07D311/56 , C07D409/12 , C07D413/04 , C07D417/12 , C07D453/02 , C07K5/0202 , A61K38/00
摘要： Compounds which Inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is Independently L-valine or L-alanine; R.sub.1 is selected from the group consisting of N-�4(N,N-dimethylaminomethyl)!benzoyl, N-benzoyloxycarbonyl, N-methyl-N-�4-(pyridyl)methyl!, N-�4-(pyddyl)methyl!carbonyl, N-3-(piperidinopropionyl), N-�4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyddyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-�2-(4-pyridyl)ethyl!carbonyl, and N-(N-phenylpiperazino) carbonyl; and R.sub.8, R.sub.9 and R.sub.10 are as defined below.
摘要翻译：提供了抑制白细胞介素-1β蛋白酶活性的化合物，含有这些化合物的药物组合物和使用该化合物的方法。化合物具有式（1）其中n为0-2; 每个AA是独立的L-缬氨酸或L-丙氨酸; R1选自N- [4（N，N-二甲基氨基甲基）]苯甲酰基，N-苯甲酰氧基羰基，N-甲基-N- [4-（吡啶基）甲基]，N- [4-（吡啶基）甲基 ]羰基，N-3-（哌啶基丙酰基），N- [4-（吗啉代乙氧基）苯甲酰基，N-2-（奎宁环基）羰基，N-（3-吡啶基）甲氧基羰基，N-（2- N-甲基-N-苄基羰基，N-甲基-N- [2-（4-吡啶基）乙基]羰基和N-（N-苯基哌嗪基）羰基; 并且R 8，R 9和R 10如下所定义。

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