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61. 发明申请

US20140093496A1 Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY 审中-公开
标题翻译： Fc-γ-RIIb-SPECIFIC Fc抗体
公开(公告)号：US20140093496A1
公开(公告)日：2014-04-03
申请号：US14001218
申请日：2012-02-24
申请人： Futa Mimoto , Taichi Kuramochi , Tomoyuki Igawa , Hitoshi Katada , Shojiro Kadono
发明人： Futa Mimoto , Taichi Kuramochi , Tomoyuki Igawa , Hitoshi Katada , Shojiro Kadono
IPC分类号： C07K16/18 , C07K16/08
CPC分类号： C07K16/2866 , C07K16/08 , C07K16/18 , C07K16/303 , C07K2317/524 , C07K2317/72
摘要： An objective of the present invention is to provide a polypeptide containing an Fc region having maintained or decreased binding activities towards both allotypes of FcγRIIa, types H and R, and having enhanced FcγRIIb-binding activity in comparison with a parent polypeptide; a pharmaceutical composition containing the polypeptide; an agent for treating or preventing immunological inflammatory diseases that includes the pharmaceutical composition; a production method thereof; and a method for maintaining or decreasing binding activities towards both allotypes of FcγRIIa and enhancing the FcγRIIb-binding activity. Specifically, it is found that a polypeptide containing an antibody Fc region that has an alteration of substituting Pro at position 238 (EU numbering) with Asp or Leu at position 328 (EU numbering) with Glu enhances FcγRIIb-binding activity, and maintains or decreases binding activities towards both allotypes of FcγRIIa, types H and R. It is also found that a polypeptide containing an antibody Fc region that contains an alteration of substituting Pro at position 238 (EU numbering) with Asp and several other alterations, enhances FcγRIIb-binding activity, and maintains or decreases binding activities towards both allotypes of FcγRIIa, types H and R.
摘要翻译：本发明的目的是提供一种多肽，其含有与亲本多肽相比具有增强的FcγRIIb结合活性的FcγRIIa，H型和R型两种的同种异型的具有维持或降低的结合活性的Fc区; 含有该多肽的药物组合物; 用于治疗或预防包括该药物组合物的免疫性炎性疾病的药剂; 其制造方法; 以及用于维持或减少对FcγRIIa的同种异型的结合活性并增强FcγRIIb结合活性的方法。具体地说，发现含有在位置238上用Asp或Leu取代第238位（EU编号）的抗体Fc区的多肽与Glu的EU编号增强FcγRIIb结合活性，维持或减少对H型和R型FcγRIIa的两种同种异型的结合活性。还发现含有抗体Fc区的多肽含有替换Pro位于第238位（EU编号）与Asp和其他几种改变增强FcγRIIb结合活动，并维持或减少对类型H和R的两种同种异型的结合活性。

62. 发明授权

US10022319B2 Stabilized antibody-containing liquid formulations 有权
公开(公告)号：US10022319B2
公开(公告)日：2018-07-17
申请号：US13522848
申请日：2011-01-20
申请人： Tomoyuki Igawa , Chifumi Moriyama
发明人： Tomoyuki Igawa , Chifumi Moriyama
IPC分类号： A61K39/395 , A61K9/00 , A61K47/12 , A61K47/18
摘要： An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.

63. 发明申请

US20140080153A1 METHOD FOR IMPROVING PHYSICAL PROPERTIES OF ANTIBODY 审中-公开
标题翻译：改善抗体物理性质的方法
公开(公告)号：US20140080153A1
公开(公告)日：2014-03-20
申请号：US13978232
申请日：2012-01-06
申请人： Tomoyuki Igawa , Yukiko Nishida
发明人： Tomoyuki Igawa , Yukiko Nishida
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , A61K39/39591 , A61K2039/505 , C07K16/36 , C07K2317/31 , C07K2317/56 , C07K2317/94
摘要： The present inventors discovered that physicochemical properties of a polypeptide can be improved by reducing the extracellular matrix-binding activity of the polypeptide.
摘要翻译：本发明人发现通过降低多肽的细胞外基质结合活性可以改善多肽的物理化学性质。

64. 发明申请

US20130022625A1 Stabilized Antibody-Containing Liquid Formulations 有权
标题翻译：含稳定抗体的液体制剂
公开(公告)号：US20130022625A1
公开(公告)日：2013-01-24
申请号：US13522848
申请日：2011-01-20
申请人： Tomoyuki Igawa , Chifumi Moriyama
发明人： Tomoyuki Igawa , Chifumi Moriyama
IPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , C07K1/00
CPC分类号： A61K9/0019 , A61K9/19 , A61K39/395 , A61K39/39591 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/26
摘要： An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.
摘要翻译：本发明的目的是提供适用于皮下给药的稳定的含抗体制剂，并且在长期保存期间抑制聚集形成。本发明人发现通过使用酸性氨基酸，天冬氨酸或谷氨酸作为组氨酸缓冲液或三（羟甲基）氨基甲烷中的抗衡离子物质，特别是通过使用组氨酸 - 天冬氨酸缓冲液或组氨酸 - 谷氨酸盐缓冲液，或三（羟甲基）氨基甲烷 - 天冬氨酸盐或三（羟甲基）氨基甲烷 - 谷氨酸盐缓冲液。本发明人还发现，通过使用酸性氨基酸，天冬氨酸或谷氨酸，作为对离子种类与碱性氨基酸如精氨酸，特别是使用精氨酸 - 天冬氨酸或精氨酸 - 谷氨酸，实现了显着的稳定化效果。

65. 发明申请

US20090285802A1 HIGHLY CONCENTRATED STABILIZED IGM SOLUTION 有权
标题翻译：高浓度稳定的IGM解决方案
公开(公告)号：US20090285802A1
公开(公告)日：2009-11-19
申请号：US12509075
申请日：2009-07-24
申请人： Tomoyuki Igawa , Yasuo Sekimori
发明人： Tomoyuki Igawa , Yasuo Sekimori
IPC分类号： A61K39/395
CPC分类号： C07K16/3084 , A61K9/0019 , A61K9/0095 , A61K31/198 , A61K31/7016 , A61K39/39558 , A61K39/39591 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/26 , C07K2317/21 , C07K2317/52 , A61K2300/00
摘要： The present inventors discovered that stable and highly concentrated IgM solutions can be prepared by using, as an additive, a compound comprising a polyvalent cationic ion, such as magnesium chloride or arginine hydrochloride, to suppress IgM aggregation in solutions.
摘要翻译：本发明人发现，通过使用包含多价阳离子离子如氯化镁或精氨酸盐酸盐的化合物作为添加剂，可以制备稳定且高度浓缩的IgM溶液，以抑制溶液中的IgM聚集。

66. 发明申请

US20070249812A1 Methods for Stabilizing Protein Solutions 有权
标题翻译：稳定蛋白质溶液的方法
公开(公告)号：US20070249812A1
公开(公告)日：2007-10-25
申请号：US10574827
申请日：2004-10-08
申请人： Akira Hayasaka , Tomoyuki Igawa , Yasuo Sekimori
发明人： Akira Hayasaka , Tomoyuki Igawa , Yasuo Sekimori
IPC分类号： C07K16/00
CPC分类号： A61K9/08 , A61K47/12 , C07K16/00
摘要： The present inventors examined use of citric acid buffers for suppressing cryoprecipitation of IgM at a pH range and salt concentration suitable for storing IgM. As a result, the present inventors discovered that citric acid buffers significantly suppress cryoprecipitation.
摘要翻译：本发明人研究了柠檬酸缓冲液在pH范围和用于储存IgM的盐浓度下抑制IgM的冷沉淀的用途。结果，本发明人发现柠檬酸缓冲液显着抑制冷沉淀。

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