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61. 发明授权

US09089326B2 Dual staple cartridge for surgical stapler 有权
标题翻译：手术吻合器双重钉仓
公开(公告)号：US09089326B2
公开(公告)日：2015-07-28
申请号：US13267922
申请日：2011-10-07
申请人： David T. Krumanaker , Robert J. Simms , Edit Goldberg , Thomas A. Osborne
发明人： David T. Krumanaker , Robert J. Simms , Edit Goldberg , Thomas A. Osborne
IPC分类号： A61B17/068 , A61B17/072 , A61B17/064 , A61B17/29
CPC分类号： A61B17/072 , A61B17/07292 , A61B2017/0645 , A61B2017/07228 , A61B2017/07271 , A61B2017/2927 , F04C2270/041
摘要： A surgical stapler includes and end effector configured to receive an upper staple cartridge and a lower staple cartridge. The lower staple cartridge includes staple drivers disposed at a non-perpendicular or oblique angle. The staple drivers may be oppositely angled relative to the perpendicular. The staple drivers may further be coupled to an actuation member that pivots the staple drivers to the perpendicular prior to stapling. The actuation members may be actuated by the firing bar and/or by a wedge sled. The upper staple cartridge may also include angled staple drivers that are pivotable to the perpendicular. The upper staple cartridge and/or the lower staple cartridge may also include staple forming pockets. Alternatively, one staple driver may be perpendicular and second staple driver may be at a non-perpendicular angle. The second staple driver may be actuated into an angled stamped recess.
摘要翻译：外科缝合器包括和末端执行器，其构造成接纳上钉仓和下钉仓。下钉仓包括以非垂直或倾斜角设置的钉驱动器。订书钉驱动器可以相对于垂直线相对成角度。订书钉驱动器可以进一步联接到在装订之前将订书钉驱动器枢转到垂直的致动构件。致动构件可以由击发杆和/或楔形滑轨致动。上钉仓还可以包括可枢转到垂直线的成角度的钉驱动器。上钉仓和/或下钉仓还可以包括钉形成袋。或者，一个订书钉驱动器可以是垂直的，并且第二订书钉驱动器可以处于非垂直的角度。第二订书钉驱动器可以被致动成成角度的冲压凹部。

62. 发明授权

US08808351B2 Stretchable prosthesis fenestration 有权
标题翻译：伸展假体开窗
公开(公告)号：US08808351B2
公开(公告)日：2014-08-19
申请号：US10962632
申请日：2004-10-12
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/061 , A61F2002/075 , A61F2002/821
摘要： A prosthesis (10) having a variable size or stretchable fenestration (14) in the graft material (37) of a biocompatible tubular graft (11). An expandable frame (16) is disposed about the fenestration, and a portion (17) of the graft material about the fenestration is folded back over the frame to cover the frame. Additional grafts or prosthesis of varying size can be inserted through the frame and fenestration with the stretched frame and folded portion compressing on the inserted graft forming a seal therewith.
摘要翻译：在生物相容的管状移植物（11）的移植材料（37）中具有可变尺寸或可拉伸的开窗（14）的假体（10）。围绕开窗设置可膨胀框架（16），围绕开窗的移植材料的一部分（17）被折回到框架上以覆盖框架。可以通过框架插入不同尺寸的附加移植物或假体，并用拉伸的框架进行开窗，并且在插入的移植物上的折叠部分压缩形成与其的密封。

63. 发明授权

US08709060B2 Prosthesis deployment system 有权
标题翻译：假体部署系统
公开(公告)号：US08709060B2
公开(公告)日：2014-04-29
申请号：US12158400
申请日：2006-12-22
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/9511 , A61F2002/9517 , A61F2002/9665
摘要： A trigger wire release mechanism is disclosed that includes a control member for selectively releasing a trigger wire (22, 44) from a prosthesis retaining device. The control member includes an elongate body member (36) and a guide member (24, 25, 93, 94) slidably disposed on the elongate body member. The trigger wire 1 (22, 44) includes a distal end coupled to the prosthesis retaining device and a proximal end coupled to the guide member. The guide member (24, 25, 93, 94) can be moved from a distal end of the elongate body (36) to a proximal end of the elongate body, thereby disengaging the trigger wire (22, 44) from the retaining device. The control member may include a locking mechanism (120) for limiting the axial position of the guide member (24, 25, 93, 94) along the elongate body member (36). A prosthesis control member (81) is also disclosed. The prosthesis control member (81) is adapted to control the position of the prosthesis during deployment.
摘要翻译：公开了一种触发线释放机构，其包括用于从假体保持装置选择性地释放触发线（22,44）的控制构件。控制构件包括细长主体构件（36）和可滑动地设置在细长主体构件上的引导构件（24,25,93,94）。触发线1（22,44）包括联接到假体保持装置的远端和联接到引导构件的近端。引导构件（24,25,93,94）可以从细长体（36）的远端移动到细长体的近端，从而使触发线（22,44）与保持装置分离。控制构件可以包括用于限制引导构件（24,25,93,94）沿着细长主体构件（36）的轴向位置的锁定机构（120）。还公开了假体控制构件（81）。假体控制构件（81）适于在展开期间控制假体的位置。

64. 发明授权

US08246650B2 Removable vena cava filter 有权
标题翻译：可移动的腔静脉过滤器
公开(公告)号：US08246650B2
公开(公告)日：2012-08-21
申请号：US12714761
申请日：2010-03-01
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/0078 , A61F2230/008
摘要： A removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends connected to each other to define a central axis of the filter. Each primary strut has a curved member extending from the central axis and terminates at an anchoring hook to engage the blood vessel at a first axial plane. The filter further comprises a plurality of secondary struts connected to the curved members of the primary struts and extending therefrom to a free end at a second axial plane to centralize the filter in the blood vessel.
摘要翻译：用于在血管中捕获血栓的可移除的过滤器。过滤器包括多个主支柱，其具有彼此连接以限定过滤器的中心轴线的第一端。每个主支柱具有从中心轴线延伸的弯曲构件，并终止于锚定钩以在第一轴向平面处接合血管。过滤器还包括连接到主支柱的弯曲构件并从其延伸到第二轴向平面处的自由端的多个次撑杆，以将过滤器集中在血管中。

65. 发明授权

US07972353B2 Removable vena cava filter with anchoring feature for reduced trauma 有权
标题翻译：可拆卸的腔静脉过滤器具有锚固功能，减少创伤
公开(公告)号：US07972353B2
公开(公告)日：2011-07-05
申请号：US11108246
申请日：2005-04-18
申请人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
发明人： Per Hendriksen , Allan G. Hemmingsen , Arne Molgaard-Nielsen , Thomas A. Osborne
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2002/8483 , A61F2230/005 , A61F2230/008
摘要： The present invention involves a removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of struts having first ends attached together along a longitudinal axis of the filter. Each strut has a body member extending from the first end along the longitudinal axis to an anchoring hook defining a strut axis. Each strut is configured to move along a strut path relative to the longitudinal axis between an expanded state for engaging with the blood vessel and a collapsed state for filter delivery or retrieval. Each anchoring hook has an angle of up to about 90 degrees relative to the strut axis.
摘要翻译：本发明涉及用于在血管中捕获血栓的可移除过滤器。过滤器包括多个支柱，其具有沿着过滤器的纵向轴线连接在一起的第一端。每个支柱具有主体构件，其从第一端沿着纵向轴线延伸到限定支柱轴线的定位钩。每个支柱构造成在与血管接合的扩张状态和用于过滤器输送或回收的折叠状态之间相对于纵向轴线沿支柱路径移动。每个锚定钩相对于支柱轴线具有高达约90度的角度。

66. 发明授权

US07918882B2 Implantable vascular device comprising a bioabsorbable frame 有权
标题翻译：可植入血管装置，其包括生物可吸收框架
公开(公告)号：US07918882B2
公开(公告)日：2011-04-05
申请号：US11185272
申请日：2005-07-19
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12172 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/005 , A61F2230/0058 , A61F2230/0095
摘要： A multiple-sided valve for implantation within a body vessel comprising a frame comprising a bioabsorbable material is provided. The devices can be pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material, or a bioabsorbable material, including a collagen-based material such as small intestinal submucosa (SIS), may be attached to the frame to form an occlusion device, a graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：提供了用于植入体内容器的多侧阀，其包括包含生物可吸收材料的框架。装置可以从输送导管推入管道或容器的内腔中，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料或包括基于胶原的材料如小肠粘膜下层（SIS）的生物可吸收材料的全部或部分覆盖物可以附接到框架上以形成闭塞装置，移植物或植入物，腔内瓣膜，如用于矫正小腿和脚部无力静脉。

67. 发明授权

US07901453B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07901453B2
公开(公告)日：2011-03-08
申请号：US11932113
申请日：2007-10-31
申请人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
发明人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上，至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是优选构造为冠状动脉支架。多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

68. 发明授权

US07887576B2 Endoluminal device with extracellular matrix material and methods 有权
标题翻译：腔内装置与细胞外基质材料及方法
公开(公告)号：US07887576B2
公开(公告)日：2011-02-15
申请号：US12468383
申请日：2009-05-19
申请人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
发明人： Clinton D. Bahler , Michael P. DeBruyne , Neal E. Fearnot , Alan R. Leewood , Jason A. Mead , Thomas A. Osborne , Jichao Sun , Lal Ninan
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/0077 , A61F2/848 , A61F2/89 , A61F2/915 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0065
摘要： An endoluminal device comprises a stent and a tubular graft supported by the stent. The graft has a proximal and a distal opening and comprises a synthetic material and a bioremodelable material. The bioremodelable material is disposed on an exterior surface in at least one band adjacent at least one of the proximal and distal openings.
摘要翻译：腔内装置包括支架和由支架支撑的管状移植物。移植物具有近端和远端开口，并且包括合成材料和生物可重构材料。生物可重塑材料设置在邻近近端和远端开口中的至少一个的至少一个带中的外表面上。

69. 发明申请

US20080306509A1 Patent Foramen Ovale Closure Device and Method 有权
标题翻译：专利孔封闭装置及方法
公开(公告)号：US20080306509A1
公开(公告)日：2008-12-11
申请号：US12159829
申请日：2007-01-09
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61B17/068 , A61B17/064
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/0684 , A61B2017/00349 , A61B2017/00353 , A61B2017/00575
摘要： A device for closure of a patent foramen ovale. The device includes at least one elongated tissue anchor at the distal end of the device. A distal end portion of the tissue anchor is selectively deployable between a closed position in which the distal end portion of the tissue anchor is capable of penetrating the septum and the flap, and a radially extensible position in which the distal end portion of the tissue anchor is capable of engaging the septum or flap so that the septum and flap may be urged into registry. A deployment member is associated with the tissue anchor for selectively deploying the distal end portion of the tissue anchor between the closed position and the radially extensible position. A closure element is disposed at the distal end of the device. The closure element is engageable with the septum and the flap when the septum and flap are in registry, for maintaining such registry. An actuator is associated with the closure element for selectively engaging the closure element with the septum and flap.
摘要翻译：用于闭合卵孔卵泡的设备。该装置包括在装置的远端处的至少一个细长的组织锚。组织锚固件的远端部分可选择性地展开在关闭位置，组合锚固件的远端部分能够穿过隔膜和瓣部之间的封闭位置以及组织锚固件的远端部分的径向可伸展位置能够接合隔膜或瓣片，使得隔膜和皮瓣可被推入注册。展开构件与组织锚固件相关联，用于选择性地将组织锚的远端部分展开在关闭位置和可径向延伸位置之间。闭合元件设置在装置的远端。当隔膜和襟翼处于注册状态时，封闭元件可与隔膜和襟翼接合，以保持这种注册。致动器与闭合元件相关联，用于选择性地将闭合元件与隔膜和瓣片接合。

70. 发明申请

US20080288044A1 Composite Stent Graft 有权
标题翻译：复合支架移植
公开(公告)号：US20080288044A1
公开(公告)日：2008-11-20
申请号：US12092120
申请日：2006-10-31
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/826 , A61F2002/828 , A61F2220/0075 , A61F2230/0054 , A61F2250/0056
摘要： A composite prosthesis (19, 99, 199) and method are disclosed herein. This endoluminal prosthesis is constructed by separately deploying a first prosthesis (9, 201) and a second prosthesis (14, 208), wherein the first prosthesis is deployed and secured to the interior surface of a body lumen (260). In a subsequent step, the second prosthesis is deployed substantially within and secured to the first prosthesis. Although additional prostheses may be deployed within the second prosthesis, in a preferred configuration the first and second prostheses combine to provide all of the necessary attributes associated with a functioning endoluminal prosthesis. Thus, one of the first and second prostheses is permeable to blood and exerts sufficient radial force to cause the composite prosthesis to securely engage an interior surface of the body lumen at one or both of the composite prosthesis's proximal and distal ends, while the other of the first and second prostheses is impermeable to blood flow.
摘要翻译：本文公开了一种复合假体（19,99,199）和方法。该腔内假体通过分开展开第一假体（9,201）和第二假体（14,208）来构造，其中第一假体展开并固定到体腔（260）的内表面。在随后的步骤中，第二假体基本上部署在第一假体内并固定到第一假体。虽然附加的假体可以部署在第二假体内，但是在优选的构造中，第一和第二假体组合以提供与功能性腔内假体相关联的所有必要属性。因此，第一和第二假体中的一个可渗透血液并施加足够的径向力，以使复合假体在复合假体的近端和远端中的一个或两个处牢固地接合体腔的内表面，而另一个第一和第二假体是不透血的。

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