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61. 发明授权

US5216478A Doppler velocity meter 失效
标题翻译：多普勒速度仪
公开(公告)号：US5216478A
公开(公告)日：1993-06-01
申请号：US839708
申请日：1992-02-24
申请人： Hidejiro Kadowaki , Ken Tsuchii , Makoto Takamiya , Kosuke Yamamoto , Masafumi Wataya , Toshiyuki Yanaka , Haruhiko Takahashi , Hiroshi Sugiyama , Yasuhiko Ishida
发明人： Hidejiro Kadowaki , Ken Tsuchii , Makoto Takamiya , Kosuke Yamamoto , Masafumi Wataya , Toshiyuki Yanaka , Haruhiko Takahashi , Hiroshi Sugiyama , Yasuhiko Ishida
IPC分类号： B41J2/125 , G01S7/481 , G01S17/58
CPC分类号： B41J2/125 , G01S17/58 , G01S7/4811 , B41J11/007 , B41J11/42
摘要： A Doppler velocity meter has a radiation source for emitting a radiation beam the wavelength of which fluctuates, such as a laser; an optical system for directing the radiation beam to an object at an incident angle .theta. and a detector for detecting scattered beam generated from the object by directing the radiation beam. The optical system has a diffraction grating which serves to change the incident angle .theta. in accordance with a change in the wavelength .lambda. of the radiation beam in such a manner as to maintain the value of sin .theta./.lambda. substantially constant. The velocity meter can accurately detect the velocity of movement of the object regardless of any change in the wavelength .lambda., because the diffraction grating serves to substantially compensate for any change in the frequency of the scattered beam caused by the change in the wavelength.
摘要翻译：多普勒速度计具有用于发射其波长波动的辐射束的辐射源，例如激光; 用于将辐射束以入射角θ引导到物体的光学系统和用于通过引导辐射束来检测从物体产生的散射光束的检测器。光学系统具有衍射光栅，其用于根据辐射束的波长λ的变化改变入射角θ，以保持sinθ/λ的值基本上恒定。由于衍射光栅用于基本上补偿由波长变化引起的散射光束的频率的任何变化，所以速度计可以精确地检测物体的移动速度，而不管波长λ的任何变化。

62. 发明授权

US4770552A Printing apparatus for accentuating the outline portion of a printed character 失效
标题翻译：用于突出打印字符的轮廓部分的打印装置
公开(公告)号：US4770552A
公开(公告)日：1988-09-13
申请号：US27826
申请日：1987-03-19
申请人： Takeo Nishijima , Kazuhide Takahama , Hiroshi Sugiyama
发明人： Takeo Nishijima , Kazuhide Takahama , Hiroshi Sugiyama
IPC分类号： B41J2/325 , B41J2/355 , B41J2/485 , B41J2/505 , B41J3/407 , B41J3/12
CPC分类号： B41J2/5058 , B41J2/355
摘要： A printing device comprising a character generator storing items of character data, each constituted by a plurality of printing dot data, a first memory for storing the character data read out from the character generator, a printer, and a control unit for driving the printer such that the printer prints the characters represented by the character data, accentuating the outline portions of each character. The printing device further comprises a second memory. The control unit derives, from the character data stored in the first memory, outline-image data representing the outline portions of the characters represented by the character data, and writes the outline-image data into the second memory. It drives the printer in accordance with the character data stored in the first memory and also with the outline-image data stored in the second memory, thereby printing, with a first printing energy, those dots specified by both the character data and the outline-image data, and printing, with a second printing energy, less than the first printing energy, those dots specified by the outline-image data.
摘要翻译：一种打印装置，包括：一个字符发生器，存储由多个打印点数据构成的字符数据项;存储从字符发生器读出的字符数据的第一存储器，打印机和用于驱动打印机的控制单元，打印机打印由字符数据表示的字符，强调每个字符的轮廓部分。打印装置还包括第二存储器。控制单元从存储在第一存储器中的字符数据导出表示由字符数据表示的字符的轮廓部分的轮廓图像数据，并将轮廓图像数据写入第二存储器。它根据存储在第一存储器中的字符数据以及与存储在第二存储器中的轮廓图像数据一起驱动打印机，从而以第一打印能量打印由字符数据和轮廓图形二者指定的那些点，图像数据和打印，具有小于第一打印能量的第二打印能量，由轮廓图像数据指定的那些点。

63. 发明授权

US4592759A Production of aqueous coal slurries having high coal contents 失效
标题翻译：生产含煤量高的含水煤浆
公开(公告)号：US4592759A
公开(公告)日：1986-06-03
申请号：US581455
申请日：1984-02-17
申请人： Akihiro Naka , Tominobu Mayuzumi , Hiroshi Sugiyama
发明人： Akihiro Naka , Tominobu Mayuzumi , Hiroshi Sugiyama
IPC分类号： C10L1/32
CPC分类号： C10L1/326 , Y10S516/01 , Y10S516/07
摘要： Coarse coal particles are pulverized to at least 70% passing through a standard 200 mesh screen in the presence of water in an amount to form aqueous coal slurries having a coal concentration from 60 to 80% by weight. The pulverization is carried out also in the presence of polyether typed polyoxyalkylene adducts having a high molecular weight with polyols having at least three active hydrogen atoms, phenol/aldehyde condensates of polyalkyleneimines, or derivatives of these adducts.
摘要翻译：将粗煤颗粒粉碎至至少70％，在水的存在下通过标准的200目筛，以形成煤浓度为60至80重量％的水煤浆。在具有高分子量的聚醚型聚氧化烯加成物与具有至少三个活性氢原子的多元醇，聚亚烷基亚胺的苯酚/醛缩合物或这些加合物的衍生物的存在下也进行粉碎。

64. 发明授权

US4014268A Steering control mechanism 失效
标题翻译：转向控制机构
公开(公告)号：US4014268A
公开(公告)日：1977-03-29
申请号：US604781
申请日：1975-08-14
申请人： Yukiyoshi Hatori , Hiroshi Sugiyama
发明人： Yukiyoshi Hatori , Hiroshi Sugiyama
IPC分类号： B61B13/00 , B62D1/26 , B61B12/02
CPC分类号： B62D1/265
摘要： A guide arm is mounted via a ball joint to a support structure. A guide linkage, connected to the arm and foldable at its mid point, is also connected by a ball joint to the support structure. A second guide linkage guides the arm to a near vertical storage position when a motor folds the first linkage.
摘要翻译：引导臂通过球窝接头安装到支撑结构上。连接到臂上并在其中点可折叠的导向连杆也通过球形接头连接到支撑结构。当电动机折叠第一连杆时，第二引导连杆将臂引导到近垂直的存储位置。

65. 发明授权

US08821606B2 Metal bonded grinding stone, and method of manufacturing the same 有权
标题翻译：金属粘结磨石及其制造方法
公开(公告)号：US08821606B2
公开(公告)日：2014-09-02
申请号：US13384676
申请日：2010-07-21
申请人： Masato Ujihashi , Toshiya Hirata , Kazuhiko Kitanaka , Naohide Unno , Hiroshi Sugiyama , Noriyuki Namba
发明人： Masato Ujihashi , Toshiya Hirata , Kazuhiko Kitanaka , Naohide Unno , Hiroshi Sugiyama , Noriyuki Namba
IPC分类号： B24D3/00 , B24D11/00 , B24D18/00 , C09K3/14 , B24D3/02 , C09C1/68 , B24D3/06
CPC分类号： B24D3/06 , B24B33/086 , B24D3/08 , B24D18/0009
摘要： A metal bonded grinding stone is manufactured by heating and pressurizing a material including abrasive grains, a cobalt, a tungsten disulfide and a copper tin alloy to obtain a sintered product, and rapid-cooling the sintered product.
摘要翻译：通过对包括磨粒，钴，二硫化钨和铜锡合金的材料进行加热加压来制造金属粘结研磨石以获得烧结产品，并快速冷却烧结产品。

66. 发明授权

US07888516B2 TGF-β gene expression inhibitor 有权
标题翻译： TGF- 基因表达抑制剂
公开(公告)号：US07888516B2
公开(公告)日：2011-02-15
申请号：US11658475
申请日：2005-08-02
申请人： Noboru Fukuda , Takahiro Ueno , Hiroshi Sugiyama
发明人： Noboru Fukuda , Takahiro Ueno , Hiroshi Sugiyama
IPC分类号： C07D233/00
CPC分类号： C07D403/12
摘要： A TGF-β gene expression inhibitor containing a pyrrole-immidazole polyamide comprising an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a γ-aminobutyric acid unit which can be folded into an U-shaped conformation at the above-described γ-aminobutyric acid unit site in a minor groove of a double-stranded region (hereinafter referred to as the target region) containing a part or the whole of the following base sequence (SEQ ID NO: 2) corresponding to −450 to −310 of human transforming growth factor β1 (hereinafter also referred to as h TGF-β1) promoter and a strand complementary thereto and in which a Py/Im pair, an Im/Py pair and a PY/Py pair correspond respectively to a C-G base pair, a G-C base pair and an A-T base pair and a T-A base pair.
摘要翻译：转化生长因子含有N-甲基吡咯单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸单元的基因表达抑制剂，其可以折叠成在上述γ-氨基丁酸单元位置的双链区（以下称为靶区）的小槽中的U型构象，其含有部分或全部以下碱基序列（SEQ ID NO： 2）对应于-450至-310的人转化生长因子＆bgr; 1（以下也称为h TGF-β1）启动子和与其互补的链，并且其中Py / Im对，Im / Py对并且PY / Py对分别对应于CG碱基对，GC碱基对和AT碱基对和TA碱基对。

67. 发明授权

US07807844B2 TGF-β gene expression inhibitor 有权
标题翻译： TGF- 基因表达抑制剂
公开(公告)号：US07807844B2
公开(公告)日：2010-10-05
申请号：US10570159
申请日：2004-09-03
申请人： Noboru Fukuda , Hirofumi Kishioka , Hiroshi Sugiyama
发明人： Noboru Fukuda , Hirofumi Kishioka , Hiroshi Sugiyama
IPC分类号： C00D403/02 , C07D233/00 , C07D487/04 , C07D233/34
CPC分类号： C07D403/14
摘要： A TGF-β gene expression inhibitor containing a pyrrole-imidazole polyamide having N-methylimidazole unit (hereinafter also referred to as Py), N-methylimidazole unit (hereinafter also referred to as Im) and γ-aminobutyrate unit which can be holded into an U-shaped conformation at the γ-aminobutyrate unit in the minor groove in a double helix region (hereinafter referred to as the target region) containing a complementary chain corresponding to the sequence at the −557 to −536 in the base sequence of a human transforming growth factor β1 (hereinafter also referred to as hTGF-β1) promoter, either as a whole or a part thereof: TAAAGGAGAGCAATTCT-TACAG (SEQ ID NO: 1) wherein a Py/Im pair corresponds to a C-G base pair, an Im/Py pair corresponds to a G-C base pair, and Py/Py pairs correspond respectively to an A-A base pair and a T-A base pair.
摘要翻译：转化生长因子含有具有N-甲基咪唑单元（以下也称为Py）的吡咯 - 咪唑聚酰胺，N-甲基咪唑单元（以下也称为Im）和γ-氨基丁酸酯单元的基因表达抑制剂，其可以被保持为U形构象在双螺旋区域（以下称为靶区域）的小沟槽中的γ-氨基丁酸酯单元中含有对应于人转化生长因子碱基序列中的-557至-536处的序列的互补链 ; 1（以下也称为hTGF-＆bgr; 1）启动子，其全部或部分：TAAAGGAGAGCAATTCT-TACAG（SEQ ID NO：1），其中Py / Im对对应于CG碱基对， / Py对对应于GC碱基对，Py / Py对分别对应于AA碱基对和TA碱基对。

68. 发明申请

US20090171097A1 AUTOMATED SOLID PHASE SYNTHESIS OF PYRROLE-IMIDAZOLE POLYAMIDE 审中-公开
标题翻译：自由基固相合成吡咯并吡唑聚酰胺
公开(公告)号：US20090171097A1
公开(公告)日：2009-07-02
申请号：US12093651
申请日：2006-11-14
申请人： Hiroshi Sugiyama , Chikara Dohno , Noboru Fukuda
发明人： Hiroshi Sugiyama , Chikara Dohno , Noboru Fukuda
IPC分类号： C07D403/14
CPC分类号： C07D403/14 , C07D409/14
摘要： A synthesis method for pyrrole-imidazole polyamide is automated at a higher level and can produce a product with a high yield in a more stable manner. In a solid phase synthesis method, the automated synthesis of a polyimide can be promoted by using HCTU as a condensation-activator, the yield of a product can be increased by charging a monomer in a solid form, and a pyrrole-imidazole polyamide having any sequence can be synthesis by combining the synthesis method with a manual synthesis with an acid chloride.
摘要翻译：吡咯 - 咪唑聚酰胺的合成方法在更高的水平上自动化，并且可以以更稳定的方式产生高产率的产物。在固相合成方法中，通过使用HCTU作为缩合活化剂可以促进聚酰亚胺的自动合成，通过加入固体形式的单体可以提高产物的产率，并且可以使用具有任意形式的吡咯 - 咪唑聚酰胺可以通过将合成方法与手性合成与酰氯组合来合成序列。

69. 发明授权

US07550581B2 Guanosine derivatives and use thereof 失效
标题翻译：鸟苷衍生物及其用途
公开(公告)号：US07550581B2
公开(公告)日：2009-06-23
申请号：US10546107
申请日：2004-02-23
申请人： Hiroshi Sugiyama , Yan Xu , Reiko Ikeda
发明人： Hiroshi Sugiyama , Yan Xu , Reiko Ikeda
IPC分类号： C07H21/00 , C07H19/04
CPC分类号： C07H19/167
摘要： It is intended to provide a novel monomer unit by which Z type DNA can be more effectively stabilized, a reagent for integrating this monomer unit into an oligonucleotide, and a method of stabilizing Z type DNA by using the reagent. Namely, a guanosine derivative represented by the following general formula [1]: wherein R1 represents acyl; R2 represents lower alkyl; R3 represents tri-substituted silyloxy or tetrahedropyranyloxy; and R4 represents cyanoethyl or allyl; a reagent for stabilizing Z type DNA which contains the guanosine derivative; and a method of stabilizing Z type DNA by using the guanosine derivative. It is also intended to provide a method of transferring guanosine having lower alkyl at the 8-position into an oligonucleotide by using the guanosine derivative; and an oligonucleotide carrying guanosine having lower alkyl at the 8-position transferred thereinto.
摘要翻译：旨在提供可以更有效地稳定Z型DNA的新单体单元，将该单体单元整合到寡核苷酸中的试剂，以及使用该试剂来稳定Z型DNA的方法。即，由以下通式[1]表示的鸟苷衍生物：其中R1表示酰基; R2代表低级烷基; R3表示三取代的甲硅烷氧基或四氢吡喃氧基; R4代表氰基乙基或烯丙基; 用于稳定含有鸟苷衍生物的Z型DNA的试剂; 以及使用鸟苷衍生物稳定Z型DNA的方法。还提供通过使用鸟苷衍生物将在8-位具有低级烷基的鸟苷转移到寡核苷酸中的方法; 和携带转移到其中的8-位具有低级烷基的鸟苷的寡核苷酸。

70. 发明授权

US07378237B2 Development of method for screening physiologically active pyrrole imidazole derivative 失效
标题翻译：开发用于筛选生理活性吡咯咪唑衍生物的方法
公开(公告)号：US07378237B2
公开(公告)日：2008-05-27
申请号：US10285030
申请日：2002-11-01
申请人： Hiroshi Sugiyama , Isao Saito , Hirokazu Iida
发明人： Hiroshi Sugiyama , Isao Saito , Hirokazu Iida
IPC分类号： C12Q1/68 , A61K49/00 , A61K31/70 , A61K39/395
CPC分类号： G01N33/5011
摘要： A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance containing DNA or RNA by using one or more chemical species represented by the following general formula (I) which are capable of recognizing a DNA base sequence; a kit therefor; and a plate to be used therein: B-L-A (I) wherein B represents a chemical structure containing an non-natural base capable of recognizing a DNA base sequence; A represents a chemical structure having an interaction with DNA; and L represents a linker whereby the chemical structures A and B can be linked together.
摘要翻译：通过使用人造化学物质筛选片段A（化学物质A）对含有DNA或RNA的物质（例如细胞）的影响的方法。即，通过使用能够识别DNA碱基序列的由以下通式（I）表示的一种或多种化学物质来检测或鉴定含有DNA或RNA的物质上的化学物质A的功能的方法; 一套工具; 和其中使用的板：B-L-A（I）其中B表示含有能够识别DNA碱基序列的非天然碱基的化学结构; A表示与DNA相互作用的化学结构; L表示连接物，化学结构A和B可以连接在一起。

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