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61. 发明申请

US20060073476A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060073476A1
公开(公告)日：2006-04-06
申请号：US10233134
申请日：2002-08-29
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C07K14/47 , C07K14/435 , C12N9/00 , C12N2510/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

62. 发明申请

US20060051777A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060051777A1
公开(公告)日：2006-03-09
申请号：US11084792
申请日：2005-03-18
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68 , C12P21/06 , C12N9/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

63. 发明申请

US20060003355A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060003355A1
公开(公告)日：2006-01-05
申请号：US11122524
申请日：2005-05-04
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

64. 发明申请

US20050202526A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20050202526A1
公开(公告)日：2005-09-15
申请号：US10180554
申请日：2002-06-25
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C07H21/04 , C07K14/435 , C07K16/18 , C12N5/06 , C12N9/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

65. 发明申请

US20050202496A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20050202496A1
公开(公告)日：2005-09-15
申请号：US11110520
申请日：2005-04-19
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K17/00 , C12N5/06 , C12N9/00 , C12N9/02 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

66. 发明申请

US20050202475A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20050202475A1
公开(公告)日：2005-09-15
申请号：US11038328
申请日：2005-01-18
申请人： Kevin Baker , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood
发明人： Kevin Baker , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood
IPC分类号： C07H21/04 , C07K14/435 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

67. 发明申请

US20050176104A1 Compositions and methods for the treatment of tumor 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：US20050176104A1
公开(公告)日：2005-08-11
申请号：US11052503
申请日：2005-02-04
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Margaret Roy , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C07H21/04 , C07K14/82 , C07K16/30 , C07K16/40 , C12N5/06 , C12N5/16 , C12N15/00 , C12P21/02 , C12P21/04
CPC分类号： C07K16/30
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

68. 发明申请

US20050170467A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20050170467A1
公开(公告)日：2005-08-04
申请号：US11050559
申请日：2005-02-02
申请人： Napoleone Ferrara , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood
发明人： Napoleone Ferrara , Audrey Goddard , Paul Godowski , Austin Gurney , William Wood
IPC分类号： C07H21/04 , C07K14/47 , C12N9/99 , C12N15/09
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

69. 发明申请

US20050153396A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
标题翻译：分泌和跨膜多肽和编码其的核酸
公开(公告)号：US20050153396A1
公开(公告)日：2005-07-14
申请号：US10955952
申请日：2004-09-29
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K17/00 , C12N5/06 , C12N9/00 , C12N9/02 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention used to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含用于异源多肽序列的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体和本发明的多肽的制备方法发明。

70. 发明申请

US20070238150A1 PRO4356 POLYPEPTIDES 有权
公开(公告)号：US20070238150A1
公开(公告)日：2007-10-11
申请号：US10187595
申请日：2002-07-01
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C07K14/47 , A61K38/17 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C07K14/47 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/28 , C07K2319/30 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5082 , G01N33/5308 , G01N33/574 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2500/00 , C12Q2563/131 , C12Q2527/137
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

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