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61. 发明授权

US06901180B2 MEMS optical switch on a single chip and method 失效
标题翻译： MEMS光开关单芯片及方法
公开(公告)号：US06901180B2
公开(公告)日：2005-05-31
申请号：US09768723
申请日：2001-01-24
申请人： Nan Zhang , Hong Zhang
发明人： Nan Zhang , Hong Zhang
IPC分类号： G02B6/35 , G02B26/08 , G02B6/26
CPC分类号： G02B6/352 , G02B6/3548 , G02B6/355 , G02B6/357 , G02B26/0841
摘要： The present invention provides for a 1×N optical switch having a switching component, an input, and a plurality of outputs formed in a single substrate. The switching component includes a pair of mirrors which are operated such that by changing the position of at least one of the mirrors, the output of the switch changes.
摘要翻译：本发明提供一种1xN光开关，其具有形成在单个基板中的开关部件，输入端和多个输出端。切换部件包括一对反射镜，其操作使得通过改变至少一个反射镜的位置，开关的输出改变。

62. 发明申请

US20050065167A1 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents 失效
标题翻译： 6-芳基-7-卤代 - 咪唑并[1,2-a]嘧啶作为抗癌剂
公开(公告)号：US20050065167A1
公开(公告)日：2005-03-24
申请号：US10950542
申请日：2004-09-24
申请人： Nan Zhang , Semiramis Ayral-Kaloustian
发明人： Nan Zhang , Semiramis Ayral-Kaloustian
IPC分类号： A61K31/519 , A61P35/00 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些6-芳基-7-卤代咪唑并[1,2-a]嘧啶或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于通过促进微管聚合治疗哺乳动物的癌症。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在有需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。

63. 发明授权

US06689772B1 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors 失效
标题翻译： 3-氰基喹啉，3-氰基-1,6-萘啶和3-氰基-1,7-萘啶作为蛋白激酶抑制剂
公开(公告)号：US06689772B1
公开(公告)日：2004-02-10
申请号：US10318213
申请日：2002-12-12
申请人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： A61K3133
CPC分类号： C07D401/04 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
摘要翻译：本发明提供式（I）化合物，其具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4，和n在本文中定义，或其药学上可接受的盐，其可用作抗肿瘤剂并用于治疗骨质疏松症和多囊肾病。

64. 发明授权

US06526197B2 MEMS optical balanced path switch 失效
标题翻译： MEMS光学平衡路径开关
公开(公告)号：US06526197B2
公开(公告)日：2003-02-25
申请号：US09829212
申请日：2001-04-09
申请人： Nan Zhang
发明人： Nan Zhang
IPC分类号： G02B626
CPC分类号： G02B6/3518
摘要： An optical switch formed on a substrate with receiving channels defined by alignment grooves formed in the substrate that are offset from alignment grooves that form the inputting channels. The offset receiving channels reduce the output power differentiation from an optical switch in which there is no offset.
摘要翻译：一种形成在基板上的光学开关，其具有由形成在基板中的对准槽限定的接收通道，该对准槽与形成输入通道的对准槽偏移。偏移接收通道减少与没有偏移的光开关的输出功率微分。

65. 发明授权

US06469361B2 Semiconductor wafer 失效
标题翻译：半导体晶圆
公开(公告)号：US06469361B2
公开(公告)日：2002-10-22
申请号：US09946390
申请日：2001-09-04
申请人： Nan Zhang
发明人： Nan Zhang
IPC分类号： H01L2900
CPC分类号： H01L21/32139 , G03F7/095 , G03F7/16 , H01L21/0274 , H01L21/31144
摘要： Techniques for etching a wafer layer using multiple layers of the same photoresistant material and structures formed using such techniques are provided. In a method, first, multiple layers of the same photoresist material are formed over the wafer layer to form a composite photoresist layer. The composite photoresist layer is patterned and developed to form a patterned photoresist layer. Exposed portions of the wafer layer are then removed using the pattern photoresist layer. Each of the multiple layers of photoresist may, for example, be formed to a maximum rated thickness for the photoresist material. Structures formed using this process may have relatively small dimensions (e.g., widths of 5 microns or less or a spacing or pitch of 5 microns or less). In addition, structures may also have sidewalls which are relatively long, smooth, and/or vertical.
摘要翻译：提供了使用相同光致抗蚀剂材料的多层蚀刻晶片层的技术和使用这些技术形成的结构。在一种方法中，首先在晶片层上形成多层相同的光致抗蚀剂材料以形成复合光致抗蚀剂层。将复合光致抗蚀剂层图案化并显影以形成图案化的光致抗蚀剂层。然后使用图案光致抗蚀剂层去除晶片层的暴露部分。例如，可以将多层光致抗蚀剂中的每一层形成为光致抗蚀剂材料的最大额定厚度。使用该方法形成的结构可以具有相对小的尺寸（例如，5微米或更小的宽度或5微米或更小的间距或间距）。此外，结构还可以具有相对长，平滑和/或垂直的侧壁。

66. 发明授权

US06229640B1 Microelectromechanical optical switch and method of manufacture thereof 有权
标题翻译：微机电光开关及其制造方法
公开(公告)号：US06229640B1
公开(公告)日：2001-05-08
申请号：US09372265
申请日：1999-08-11
申请人： Nan Zhang
发明人： Nan Zhang
IPC分类号： G02B2600
CPC分类号： G02B6/357 , B81B2201/033 , B81B2201/045 , B81C1/00182 , B81C2201/0109 , B81C2203/0136 , G02B6/3514 , G02B6/3518 , G02B6/3544 , G02B6/3584 , H02N1/008
摘要： A MEMS-based optical switch having improved characteristics and methods for manufacturing the same are provided. In accordance with one embodiment, an optical switch includes a single comb drive actuator having a deflecting beam structure and a mirror coupled to the actuator. The mirror is capable of being moved between an extended position interposed between waveguide channels and a retracted position apart from the waveguide channels. The actuator applies a force capable of deflecting the beam structure and moving the mirror to one of the extended positions or the retracted position and the beam structure returns the mirror to the other of the extended position or the retracted position in the absence of the application of force.
摘要翻译：提供了具有改进的特性的MEMS基光开关及其制造方法。根据一个实施例，光学开关包括具有偏转梁结构的单个梳状驱动致动器和耦合到致动器的反射镜。镜子能够在介于波导通道之间的延伸位置与离开波导通道的缩回位置之间移动。致动器施加能够使梁结构偏转并且将反射镜移动到延伸位置或缩回位置中的一个的力，并且梁结构在没有应用的情况下将反射镜返回到延伸位置或缩回位置中的另一个力。

67. 发明授权

US5908840A Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents 失效
标题翻译：杂环芳基吡啶并喹唑啉酮衍生物作为抗癌剂
公开(公告)号：US5908840A
公开(公告)日：1999-06-01
申请号：US965217
申请日：1997-11-06
申请人： Michael P. Trova , Nan Zhang
发明人： Michael P. Trova , Nan Zhang
IPC分类号： C07D471/04 , A61K31/505 , A61K31/55
CPC分类号： C07D471/04
摘要： This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of H, (C.sub.1 -C.sub.4) straight-chain alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.5 and R.sub.6 are alkyl moieties which are taken together to form a 4-7 membered ring;or a pharmaceutically acceptable salt thereof which is useful as an antineoplastic agent.
摘要翻译：本发明提供具有下式的化合物：其中：（A）n = 2-4; （B）R 1和R 2相同或不同，选自H，（C 1 -C 3）烷基，-CH 2 CH 2 OH，-CH 2 CH 2 NH 2和-CH 2 CH 2 N（CH 3）2或R 1和R 2为被取代的烷基部分一起形成4-至7-元环; （C）R 3选自H，-CH 3，-CH 2 CH 3和-CH 2 CH 2 NH 2; （D）Y是位于吡啶并喹啉酮核的2-或3-位的具有5-14个原子的杂环基，其中1-3个杂环环原子独立地是氮，氧或硫; 其中Y可任选被-OR 4，-NR 5 R 6，-CO 2 H，-CO 2 R 4或苯基单，二或三取代; R4是H或（C1-C4）直链烷基; R5和R6相同或不同，选自H，（C1-C4）直链烷基，-CH2CH2OH，-CH2CH2NH2和-CH2CH2N（CH3）2或R5和R6是烷基部分，它们是一起形成4-7元环; 或其药学上可接受的盐，其可用作抗肿瘤剂。

68. 外观设计

USD1031180S1 Dog bed 有权
公开(公告)号：USD1031180S1
公开(公告)日：2024-06-11
申请号：US29927915
申请日：2024-02-07
申请人： Nan Zhang
设计人： Nan Zhang
摘要： FIG. 1 is a top perspective view of a dog bed showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof; and,
FIG. 8 is a rear perspective view thereof.
The broken lines in the figures illustrate portions of the dog bed that form no part of the claimed design.

69. 发明授权

US09048575B2 Temperature controller, cable device, and temperature control unit 有权
标题翻译：温度控制器，电缆设备和温度控制单元
公开(公告)号：US09048575B2
公开(公告)日：2015-06-02
申请号：US13380754
申请日：2011-03-16
申请人： Takahito Mizue , Nan Zhang
发明人： Takahito Mizue , Nan Zhang
IPC分类号： H01R24/00 , H01R13/627 , G05D23/22 , H01R12/71 , H01R13/74 , H01R13/447
CPC分类号： H01R13/6273 , G05D23/1909 , G05D23/22 , H01R12/714 , H01R13/447 , H01R13/743
摘要： A temperature controller for adjusting temperature includes a substrate side contact portion formed on a surface on one side of a circuit substrate for processing an input signal. The substrate side contact portion is configured to be brought into contact with a cable device.
摘要翻译：用于调节温度的温度控制器包括形成在电路基板的一侧的表面上用于处理输入信号的基板侧接触部分。基板侧接触部构造成与电缆装置接触。

70. 发明授权

US08735836B2 Positron emission tomography block detector interconnect 有权
标题翻译：正电子发射断层摄影块检测器互连
公开(公告)号：US08735836B2
公开(公告)日：2014-05-27
申请号：US13229797
申请日：2011-09-12
申请人： James Frank Caruba , Niraj K Doshi , John W Young , Nan Zhang
发明人： James Frank Caruba , Niraj K Doshi , John W Young , Nan Zhang
IPC分类号： G01T1/164
CPC分类号： G01T1/1648
摘要： Using standard or “off the shelf” cable to interconnect between the PET block detector and the detector circuit may save substantial costs given the number of PMTs in a PET system. Given space constraints, simple maintenance with reduced risk of disturbing cabling is desired, making ongoing use of standard cabling without adding further cabling desired. To implement digital gain control, a further communication is provided between the PET detector block and the detector circuit. Since the standard cable may not have additional wires for such communications and to reduce timing degradation, the PMT signals are combined, such as generating position and energy signals at the PET detector block. The four PMT signals are reduced to three signals without reduction in function, allowing a fourth twisted pair of wires in a CAT5 cable to be used for digital gain control.
摘要翻译：使用标准或“现成”电缆在PET块检测器和检测器电路之间进行互连可以节省大量成本，因为PET系统中PMT的数量。鉴于空间限制，需要简单的维护，减少干扰布线的风险，不断增加布线需求，不断使用标准布线。为了实现数字增益控制，在PET检测器块和检测器电路之间提供进一步的通信。由于标准电缆可能没有用于这种通信的附加电线并且减少定时劣化，所以组合PMT信号，例如在PET检测器块处产生位置和能量信号。四个PMT信号减少到三个信号而不减少功能，允许CAT5电缆中的第四根双绞线用于数字增益控制。

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