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61. 发明申请

US20120225463A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US20120225463A1
公开(公告)日：2012-09-06
申请号：US13361799
申请日：2012-01-30
申请人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12P7/18 , C12N1/19 , C12N1/15 , C12N1/21
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

62. 发明授权

US08178327B2 Microorganisms for the production of 1,4-butanediol 有权
公开(公告)号：US08178327B2
公开(公告)日：2012-05-15
申请号：US13009813
申请日：2011-01-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
IPC分类号： C12P7/18 , C12N1/21
CPC分类号： C12P7/18 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/12 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/70 , C12N15/81 , C12Y101/01157 , C12Y402/01055
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

63. 发明申请

US20110217742A1 MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE 有权
标题翻译：共聚1,4-丁二醇和γ-丁内酯的微生物和方法
公开(公告)号：US20110217742A1
公开(公告)日：2011-09-08
申请号：US12940021
申请日：2010-11-04
申请人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
发明人： Jun Sun , Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Wei Niu , John D. Trawick , Robert Haselbeck
IPC分类号： C12P17/04
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
摘要翻译：本发明提供包含1,4-丁二醇（14-BDO）和γ-丁内酯（GBL）途径的非天然存在的微生物生物，其包含至少一种编码14-BDO和GBL途径酶的外源核酸，其以足够的量表达，生产14-BDO和GBL。本发明另外提供了使用这种微生物生物来生产14-BDO和GBL的方法。

64. 发明授权

US09175297B2 Microorganisms for the production of 1,4-Butanediol 有权
标题翻译：用于生产1,4-丁二醇的微生物
公开(公告)号：US09175297B2
公开(公告)日：2015-11-03
申请号：US13449187
申请日：2012-04-17
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
IPC分类号： C12P7/18 , C12N9/04 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/70 , C12N15/81
CPC分类号： C12P7/18 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/12 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/70 , C12N15/81 , C12Y101/01157 , C12Y402/01055
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，该途径包含至少一种编码足够数量产生BDO的BDO途径酶的外源核酸。本发明还提供了使用这种微生物生产BDO的方法。

65. 发明授权

US08129169B2 Microorganisms for the production of 1,4-butanediol and related methods 有权
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：US08129169B2
公开(公告)日：2012-03-06
申请号：US12794700
申请日：2010-06-04
申请人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12N1/21
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化用于BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

66. 发明申请

US20110281337A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL 有权
公开(公告)号：US20110281337A1
公开(公告)日：2011-11-17
申请号：US13009813
申请日：2011-01-19
申请人： Mark J. BURK , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
发明人： Mark J. BURK , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N1/00
CPC分类号： C12P7/18 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/12 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/70 , C12N15/81 , C12Y101/01157 , C12Y402/01055
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

67. 发明申请

US20120329111A1 Microorganisms for Producing Cyclohexanone and Methods Related Thereto 审中-公开
标题翻译：用于生产环己酮的微生物及其相关方法
公开(公告)号：US20120329111A1
公开(公告)日：2012-12-27
申请号：US13528541
申请日：2012-06-20
申请人： Anthony Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Anthony Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/21 , C12P7/26
CPC分类号： C12P7/26 , C12N15/52
摘要： Provided herein is a non-naturally occurring microbial organism having a cyclohexanone pathway and comprising at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. Also provided herein is a method for producing cyclohexanone, including culturing these non-naturally occurring microbial organisms.
摘要翻译：本文提供的是具有环己酮途径并且包含至少一种编码环己酮途径酶的外源核酸的非天然存在的微生物生物。本文还提供了生产环己酮的方法，包括培养这些非天然存在的微生物。

68. 发明授权

US08420375B2 Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol 有权
标题翻译：微生物和MEK和2-丁醇的碳有效生物合成方法
公开(公告)号：US08420375B2
公开(公告)日：2013-04-16
申请号：US12813469
申请日：2010-06-10
申请人： Robin E. Osterhout , Wei Niu , Anthony P. Burgard
发明人： Robin E. Osterhout , Wei Niu , Anthony P. Burgard
IPC分类号： C12N1/20 , C12N1/00 , C12N9/00 , C12P7/26 , C12P7/16 , C12P21/06 , C07H21/04
CPC分类号： C12P7/26 , C12N15/52 , C12P7/16 , Y02E50/10
摘要： A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
摘要翻译：非天然存在的微生物有至少一种编码MEK途径酶的外源核酸，其表达量足以产生MEK。 MEK途径包括选自乙酰乙酰辅酶A脱氢酶（双功能），乙酰乙酰辅酶A醛脱氢酶，3-氧代丁醛还原酶，3-氧代丁醇脱水酶，MEK氧化还原酶，3-氧代丁醛氨基转移酶，4-氨基丁酸 -2-酮脱氨酶，2-氨基-4-酮戊酸酯（AKP）硫解酶，AKP氨基转移酶，2,4-二氧代戊酸脱羧酶，AKP脱氨酶，乙酰丙酸酯脱羧酶，AKP脱羧酶，谷氨酸脱氢酶，氧化丁醛氧化还原酶（胺化）和AKP氧化还原酶（胺化）。 2-丁醇途径还包括MEK还原酶。包括生产MEK或2-丁醇的方法包括在条件和足够的时间内培养这些生物体以产生MEK或2-丁醇。

69. 发明申请

US20110008858A1 MICROORGANISMS AND METHODS FOR CARBON-EFFICIENT BIOSYNTHESIS OF MEK AND 2-BUTANOL 有权
标题翻译：用于碳氢化合物和2-丁醇的高效生物合成的微生物和方法
公开(公告)号：US20110008858A1
公开(公告)日：2011-01-13
申请号：US12813469
申请日：2010-06-10
申请人： Robin E. Osterhout , Wei Niu , Anthony P. Burgard
发明人： Robin E. Osterhout , Wei Niu , Anthony P. Burgard
IPC分类号： C12P7/26 , C12N1/00 , C12P7/16
CPC分类号： C12P7/26 , C12N15/52 , C12P7/16 , Y02E50/10
摘要： A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
摘要翻译：非天然存在的微生物有至少一种编码MEK途径酶的外源核酸，其表达量足以产生MEK。 MEK途径包括选自乙酰乙酰辅酶A脱氢酶（双功能），乙酰乙酰辅酶A醛脱氢酶，3-氧代丁醛还原酶，3-氧代丁醇脱水酶，MEK氧化还原酶，3-氧代丁醛氨基转移酶，4-氨基丁苯 -2-酮脱氨酶，2-氨基-4-酮戊酸酯（AKP）硫解酶，AKP氨基转移酶，2,4-二氧代戊酸脱羧酶，AKP脱氨酶，乙酰丙酸酯脱羧酶，AKP脱羧酶，谷氨酸脱氢酶，氧化丁醛氧化还原酶（胺化）和AKP氧化还原酶（胺化）。 2-丁醇途径还包括MEK还原酶。包括生产MEK或2-丁醇的方法包括在条件和足够的时间内培养这些生物体以产生MEK或2-丁醇。

70. 发明申请

US20110124911A1 SEMI-SYNTHETIC TEREPHTHALIC ACID VIA MICROORGANISMS THAT PRODUCE MUCONIC ACID 审中-公开
标题翻译：通过生产肌酸的微生物的半合成的正十二酸
公开(公告)号：US20110124911A1
公开(公告)日：2011-05-26
申请号：US12851478
申请日：2010-08-05
申请人： Mark J. Burk , Robin E. Osterhout , Jun Sun
发明人： Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C07C63/26 , C12N1/21 , C12P7/44
CPC分类号： C12P7/44 , C12N9/88 , C12Y402/01002
摘要： The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.
摘要翻译：本发明提供了一种非天然存在的微生物，其具有一种具有至少一种外源核酸的粘蛋白途径的微生物生物，所述外源核酸编码以足够量表达的粘蛋白途径酶以产生粘蛋白。所述粘蛋白途径包括选自β-酮硫解酶，β-酮己二酰辅酶A水解酶，β-酮己二酰辅酶A转移酶，β-酮己二酰辅酶A连接酶，2-富马酰乙酸酯还原酶，2- 富马酰乙酸脱氢酶，反式-3-羟基-4-己二酸脱水酶，2-富马酸乙酯氨基转移酶，2-富马酸乙酯胺化氧化还原酶，反式-3-氨基-4-己烯酸脱氨酶，β-酮己二酸烯醇内酯水解酶，粘蛋白内酯异构酶，粘蛋白环异构酶，β-酮己二酰辅酶A脱氢酶，3-羟基己二酰辅酶A脱水酶，2,3-脱氢阿迪普基-CoA转移酶，2,3-脱氢阿迪普基-CoA水解酶，2,3-脱氢阿迪普酯 - CoA连接酶，粘蛋白还原酶，2-马来酰乙酸酯还原酶，2-马来酰乙酸酯脱氢酶，顺式-3-羟基-4-己二酸脱水酶，2-马来酰乙酸氨基转移酶，2-马来酰乙酸胺胺化氧化还原酶，顺式-3-氨基 -4-十六酸脱氨酶和粘蛋白顺式/反式异构酶。还提供了其它粘蛋白途径酶。另外提供了生产粘蛋白的方法。

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