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61. 发明授权

US5586812A Railway braking apparatus 失效
标题翻译：铁路制动装置
公开(公告)号：US5586812A
公开(公告)日：1996-12-24
申请号：US477470
申请日：1995-06-07
申请人： Wajih Kanjo , Eric Smith , Thomas J. Demoise , Michael Girotti , Thomas McCabe , Charles B. Fessler , Scott Natschke
发明人： Wajih Kanjo , Eric Smith , Thomas J. Demoise , Michael Girotti , Thomas McCabe , Charles B. Fessler , Scott Natschke
IPC分类号： B60T7/18 , B60T13/40 , B60T17/22 , B61H13/02 , B60T13/00
CPC分类号： B60T7/18 , B60T13/406 , B60T17/228 , B61H13/02
摘要： Apparatus for indicating the condition of hand brakes on railway cars and for applying and releasing railway car parking or hand brakes automatically in response to predetermined conditions including movement of a train, wayside conditioning apparatus, wayside operating mechanism, a signal controlled by an operator and performance of predetermined railway operating procedures, such as completion of an air brake test procedure. The apparatus may respond to mechanical, electrical and electronic signals and may operate on pneumatic or electric power provided from the service air brake system of a train or from a source of power outside of such air brake system.
摘要翻译：用于指示铁路车辆上的手制动器的状况的装置，以及响应于包括列车的移动，路边调节装置，路旁操作机构，由操作者控制的信号和性能的预定条件自动地施加和释放铁路停车场或手刹预定的铁路操作程序，如完成空气制动测试程序。该装置可以响应机械，电气和电子信号，并且可以对从列车的服务空气制动系统或从这种空气制动系统外部的动力源提供的气动或电力进行操作。

62. 发明公开

US20240177557A1 SYSTEM AND METHOD FOR MANAGING A CASINO-STYLE BATTLESHIPS GAME 审中-公开
公开(公告)号：US20240177557A1
公开(公告)日：2024-05-30
申请号：US18071527
申请日：2022-11-29
申请人： Eric Smith
发明人： Eric Smith
IPC分类号： G07F17/32
CPC分类号： G07F17/322 , G07F17/3265 , G07F17/3293
摘要： A System and method for managing a game of casino battleships comprising a plurality of game grids, a plurality of game tokens and a plurality of game cards. Each game grid has a plurality of predefined game positions upon which to place the game tokens, each position has a unique identifier code corresponding to a unique identifier code of game card. The apparatus has sensors for detecting placement of tokens and a scanner for scanning the game cards. The apparatus has at least one processor and a memory, the memory storing instructions executed by the processor for directing the sensors, the scanner, at least one rule set for winning the game and an output device to indicate winner of the game.

63. 发明公开

US20240066667A1 Extendable Pronged Pair Of Mandibles Device 审中-公开
公开(公告)号：US20240066667A1
公开(公告)日：2024-02-29
申请号：US17895782
申请日：2022-08-25
申请人： Eric Smith
发明人： Eric Smith
IPC分类号： B25B9/00
CPC分类号： B25B9/00
摘要： An extendable pronged pair of mandibles device for removing animal nests includes a handle base having a top surface, a bottom surface, a pair of side surfaces, a shaft surface, and a button surface. A handle protrudes out from the bottom surface of the handle base. Additionally, a shaft protrudes out from the shaft surface of the handle base. The shaft has a tubular body for nesting an arm with a pair of mandibles having a plurality of teeth for providing grip upon an animal nest. The pair of mandibles further includes a non-magnetic variation for engaging with the animal nest and a magnetic variation for engaging with a plurality of magnetic elements. A trigger is positioned proximate to the handle of the handle base and is a lever being an actuator for the pair of mandibles when pulled towards the handle.

64. 发明授权

US10051847B1 Fishing lures and fishing lure production methods and uses 有权
公开(公告)号：US10051847B1
公开(公告)日：2018-08-21
申请号：US14737055
申请日：2015-06-11
申请人： Eric Smith
发明人： Eric Smith
IPC分类号： A01K69/00 , A01K85/18 , A01K99/00
CPC分类号： A01K85/18 , A01K85/16 , A01K99/00
摘要： Artificial fish for use as a fishing lure are provided that can include a body about a frame, the body defining fish attributes and the frame supporting the body and defining a recess configured to receive an end of a weighted rod. Other lures can include at least two frame components articulated in relation to one another. Methods for manufacturing an artificial fish for use as a fishing lure are provided. Methods for using an artificial fish lure are provided. Artificial fish for use as fishing lure kits are provided.

65. 发明授权

US08836287B2 Time-domain multiplexing of power and data 有权
标题翻译：电源和数据的时域复用
公开(公告)号：US08836287B2
公开(公告)日：2014-09-16
申请号：US13286982
申请日：2011-11-01
申请人： Eric Smith , Bryan R. Hinch , Tommee So
发明人： Eric Smith , Bryan R. Hinch , Tommee So
IPC分类号： H02J7/00
CPC分类号： H02J7/007 , G06F1/263 , Y10T307/858
摘要： Circuits, methods, and apparatus that may allow an electronic device to control a power adapter. One example may provide an electronic system where an electronic device may control a power adapter through a communication channel. Data transferred in the communication channel may include the temperature of the power adapter, the charging capability of the adapter, and other types of data. In one example, power and data may share the same two wires, and the power and data may be time-division multiplexed. That is, the two wires may convey power and data at different times. Another example may include circuitry to detect a connection between the electronic device and the power adapter. Once a connection is detected, power may be transferred from the power adapter to the electronic device. This power transfer may be interrupted on occasion to transfer data between the power adapter to the electronic device.
摘要翻译：可允许电子设备控制电源适配器的电路，方法和设备。一个示例可以提供电子系统，其中电子设备可以通过通信信道来控制电力适配器。在通信信道中传送的数据可以包括电源适配器的温度，适配器的充电能力以及其他类型的数据。在一个示例中，功率和数据可以共享相同的两条线，并且功率和数据可以被时分复用。也就是说，两条线可以在不同时间传输电力和数据。另一示例可以包括用于检测电子设备和电源适配器之间的连接的电路。一旦检测到连接，电源可能会从电源适配器传输到电子设备。这种电力传输有时可能会在电源适配器与电子设备之间传输数据。

66. 发明授权

US08583910B2 Method and apparatus for device detection and multi-mode security in a control network 有权
公开(公告)号：US08583910B2
公开(公告)日：2013-11-12
申请号：US12549305
申请日：2009-08-27
申请人： Eric Smith , James Gist
发明人： Eric Smith , James Gist
IPC分类号： H04L29/06
CPC分类号： H04L12/2803 , H04L12/2809 , H04L12/281 , H04L63/0428 , H04L63/061 , H04L2012/2841 , H04L2012/285 , H04W12/02 , H04W12/04
摘要： A method and apparatus for device discovery and multi-mode security in a wired and/or wireless control network are described. A controlled device is configured with discovery-level instructions and application-level control instructions. The controlled device includes a user-configurable parameter for selecting between multiple security modes. In one or more security modes, the controlled device may ignore application-level messages until encrypted communications are established with a controller. In one mode, the encrypted communication is established with an encryption key exchange using a predetermined security key. In another mode, a specific key is manually entered into the controller by the user/administrator to facilitate the encryption key exchange. Additionally, for control applications where security is not important, an unencrypted security mode may be implemented. A driver ID provided by the controlled device facilitates loading of a preferred device driver by the controller.

67. 发明授权

US08568721B2 Method of treating rheumatoid arthritis with an anti-IL-6R antibody 有权
标题翻译：用抗IL-6R抗体治疗类风湿性关节炎的方法
公开(公告)号：US08568721B2
公开(公告)日：2013-10-29
申请号：US13462938
申请日：2012-05-03
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译：本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。

68. 发明授权

US08298271B2 Instruments and methods for holding a bone plate 有权
标题翻译：用于固定骨板的仪器和方法
公开(公告)号：US08298271B2
公开(公告)日：2012-10-30
申请号：US12562536
申请日：2009-09-18
申请人： Michael Jacene , Jonathan Fanger , Eric Smith , Eric Kolb
发明人： Michael Jacene , Jonathan Fanger , Eric Smith , Eric Kolb
IPC分类号： A61B17/88
CPC分类号： A61B17/808 , A61B17/1757 , A61B17/8023 , Y10S606/915
摘要： An instrument for insertion and placement of dynamic spinal fixation plates is provided. In general, the instrument is a clip that holds the plate at its maximum extension for implantation.
摘要翻译：提供了一种插入和放置动态脊柱固定板的仪器。通常，仪器是将板保持在其用于植入的最大延伸的夹子。

69. 发明授权

US08192741B2 Method of treating rheumatoid arthritis with an anti-IL-6R antibody 有权
标题翻译：用抗IL-6R抗体治疗类风湿性关节炎的方法
公开(公告)号：US08192741B2
公开(公告)日：2012-06-05
申请号：US13286261
申请日：2011-11-01
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译：本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。

70. 发明申请

US20120003697A1 HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR 有权
标题翻译：人类IL-6受体的高亲和力抗体
公开(公告)号：US20120003697A1
公开(公告)日：2012-01-05
申请号：US13230081
申请日：2011-09-12
申请人： Sean STEVENS , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean STEVENS , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： C12P21/00 , C12N1/21 , C12N5/10 , C07H21/00 , C12N15/63
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：提供了以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并且以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

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