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    • 65. 发明授权
    • In situ photodynamic therapy
    • 原位光动力疗法
    • US5257970A
    • 1993-11-02
    • US865918
    • 1992-04-09
    • Thomas J. Dougherty
    • Thomas J. Dougherty
    • A61K9/127A61K31/40A61K31/50A61K31/66A61K41/00A61N1/30
    • A61K9/127A61K31/40A61K31/50A61K31/66A61K41/0057A61K41/0071
    • The process of photodynamic therapy (PDT) is conducted by the step of:1) separately encapsulating at least one activation component for said photodynamic therapy process in a liposome;2) injecting a photosensitizer into a human or animal host;3) injecting the liposome encapsulated components systemically into the same human or animal host; and4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components.The mixing of the activation components can result in:a) energy transfer to the previously injected photosensitizer;b) emission of light and absorption of said light by the previously injected photosensitizer; andc) direct formation of at least one cytotoxic species that functions against the tumor.The heating of the site of the tumor is accomplished by one of the following methods: laser, ultra sound, radio-frequency or microwave frequency. Photofrin photosensitizer is a preferred photosensitizer.
    • 光动力学治疗(PDT)的过程是通过以下步骤进行的:1)在脂质体中分别封装所述光动力学治疗过程的至少一种活化成分; 2)将光敏剂注入人或动物宿主; 3)将脂质体包封的组分全身注入相同的人或动物宿主中; 和4)加热肿瘤部位以熔化脂质体包封的组分以允许活化组分的混合。 活化组分的混合可导致:a)能量转移到先前注射的光敏剂; b)通过先前注射的光敏剂发射光和吸收所述光; 和c)直接形成对肿瘤起作用的至少一种细胞毒性物质。 通过以下方法之一实现肿瘤部位的加热:激光,超声,射频或微波频率。 Photofrin光敏剂是优选的光敏剂。
    • 66. 发明授权
    • Bacteriochlorophyll-a derivatives useful in photodynamic therapy
    • 细菌叶绿素a衍生物可用于光动力学治疗
    • US5173504A
    • 1992-12-22
    • US638172
    • 1991-01-03
    • Thomas J. Dougherty
    • Thomas J. Dougherty
    • A61K41/00C07D487/22
    • C07D487/22A61K41/0071
    • Compounds of formula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, Sn.sup.+2, and Zn.sup.+2, or represents 2 H.sup.30 each H.sup.+ bonded to one of the N atoms connected by the solid lines;R.sup.1 is a saturated of unsaturated hydrocarbyl residue of 8-25 C.;each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, andX is COOR.sup.3, wherein R.sup.3 is alkyl (1-C);are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.
    • (1)或式(2)的化合物:其中M是选自Mg + 2,Sn + 2和Zn + 2的非顺磁性金属,或表示2 H30每个H +与通过实线连接的N个原子之一键合; R1是饱和的8-25℃的不饱和烃基残基。 每个R 2独立地选自乙烯基,乙基,乙酰基和1-羟乙基,X是COOR 3,其中R 3是烷基(1-C); 可用于光动力疗法和诊断。 这些化合物对目标生物底物进行光敏照射,用这些敏化剂处理所述底物,然后照射导致生物底物的损伤或破坏。 当全身施用时,这些化合物积聚在不需要的靶生物底物中。 也可以在体外使用这些化合物,例如以破坏用于输血的血液中的感染性细胞或病毒。
    • 67. 发明授权
    • Switched emergency battery system
    • 开关式应急电池系统
    • US5002840A
    • 1991-03-26
    • US365084
    • 1989-06-12
    • Alan J. KlebenowThomas J. DoughertyEdward N. MrotekDavid A. ThuerkMaurice G. Michaud
    • Alan J. KlebenowThomas J. DoughertyEdward N. MrotekDavid A. ThuerkMaurice G. Michaud
    • H01M2/02H01M2/20H01M2/30H01M2/34H01M10/12H01M10/42
    • H01M10/4207H01M10/122H01M2/0242H01M2/20H01M2/305H01M2/34Y02E60/126
    • The invention provides a vehicle battery system including a main and a reserve battery disposed within a battery housing (10) having conventional external dimensions and battery terminal locations. An illustrated embodiment includes a main battery, comprising a series of thin, flat cells (38) disposed along a first axis, and a reserve battery, comprising a series of cells (42) diposed along a second axis transverse to the first axis. An electrical circuit facilitates selective communication between the reserve battery and the vehicle starter in accordance with the position of a switch assembly (100). The circuit illustratively includes a diode (110) configured to permit current flow into the reserve battery (104) during recharging, but which prevents reserve battery drain during normal vehicle operation. A variable resistor (112) is disposed in series with the diode to limit the amount of power, and hence the amount of heat, dissipated by the diode. When the main battery becomes drained, switch assembly (100) is actuated to bring the reserve battery (104) into parallel with the main battery (102).
    • 本发明提供了一种车辆电池系统,其包括设置在具有常规外部尺寸和电池端子位置的电池壳体(10)内的主电池和备用电池。 所示实施例包括主电池,其包括沿着第一轴设置的一系列薄的扁平电池(38)和备用电池,其包括沿着横向于第一轴线的第二轴线浸入的一系列电池(42)。 电路有助于根据开关组件(100)的位置在储备电池和车辆启动器之间进行选择性通信。 该电路示例性地包括二次管(110),其被配置为在再充电期间允许电流流入备用电池(104),但是这防止在正常车辆操作期间备用电池漏极。 可变电阻器(112)与二极管串联布置以限制二极管消耗的功率量,因此限制热量。 当主电池耗尽时,开关组件(100)被致动以使备用电池(104)与主电池(102)平行。
    • 68. 发明授权
    • Method and apparatus for sealing a battery terminal post
    • 密封电池端子柱的方法和装置
    • US4775604A
    • 1988-10-04
    • US80154
    • 1987-07-29
    • Thomas J. DoughertyRichard A. HamannMatthias Geibl
    • Thomas J. DoughertyRichard A. HamannMatthias Geibl
    • H01M2/06H01M2/08H01M2/02
    • H01M2/08H01M2/06
    • The interface between the plastic cover of a battery container and the lead or other metal terminal post which extends therethrough is sealed with a rubber bushing which is compressed and extruded along the terminal post during installation and locked tightly in its compressed and extruded state. The bushing preferably has a pair of oppositely angled intersecting frustoconical surfaces on its exterior surface which are adapted to cooperate with mating surfaces surrounding the opening in the cover and on a locking retainer. The assembly provides a flexible seal which will accommodate the inevitable vertical movement of the terminal post as a result of battery element expansion. Most importantly, the assembly provides an extremely effective barrier to the migration of electrolyte along the terminal post to prevent outer terminal corrosion. The rubber bushing is preferably impregnated with silicone oil which, when the bushing is installed, fills the surface voids in the cast terminal post which otherwise provide paths for electrolyte migration. The silicone oil also provides a lubricant for the controlled compression and extrusion of the bushing.
    • 电池容器的塑料盖和延伸穿过其的导线或其他金属端子柱之间的界面用橡胶衬套密封,橡胶衬套在安装期间沿着端子柱压缩和挤出并且紧密地锁定在其压缩和挤压状态。 套管优选地在其外表面上具有一对相对角度的相交的截头圆锥形表面,其适于与围绕盖中的开口的配合表面和锁定保持器协作。 组件提供了柔性密封,其将适应由于电池元件膨胀而导致的端子柱的不可避免的垂直运动。 最重要的是,该组件为电极沿着端子柱的迁移提供了非常有效的屏障,以防止外部端子腐蚀。 橡胶衬套优选地浸渍有硅油,当安装衬套时,填充铸造端子柱中的表面空隙,否则其提供用于电解质迁移的路径。 硅油还提供润滑剂用于受控压缩和挤压衬套。
    • 69. 发明授权
    • Automatic battery analyzer
    • 自动电池分析仪
    • US4193025A
    • 1980-03-11
    • US863925
    • 1977-12-23
    • Charles E. FrailingThomas J. Dougherty
    • Charles E. FrailingThomas J. Dougherty
    • G01R31/36G01N27/42
    • G01R31/3662G01R31/3627G01R31/3668Y10S320/12
    • Apparatus for automatically testing automotive-type, lead acid storage batteries are disclosed in which three separate tests are made and the results thereof compared to predetermined standards in a specified order to maximize the information obtained about the battery. The three tests measure (1) whether the battery meets its cold cranking rating by drawing a predetermined load current therefrom for a predetermined period of time and determining whether the battery terminal voltage is above a specified level at the end of that period, (2) whether the battery terminal voltage is above another specified level at the end of a predetermined period of time following the completion of the first test, and (3) whether the internal resistance is acceptably low. If the battery passes the first test, it is known to be acceptable. If the battery fails the first test and passes the second test, it is known to be unacceptable. If the battery fails the first and second tests, the third test is performed. If the battery then passes the third test, it is known to be acceptable but to require a recharge, whereas if the battery then fails the third test the acceptability of the battery is then not yet determined and it must be recharged and retested.
    • 公开了用于自动测试汽车型铅酸蓄电池的装置,其中进行三次分开的测试,并且其结果以规定的顺序与预定标准进行比较,以最大限度地获得关于电池的信息。 三个测试测量(1)电池是否通过从预定的时间段内抽出预定的负载电流来满足其冷起动额定值,并确定电池端电压是否在该期间结束时高于规定的电平;(2) 电池端子电压是否在第一次测试完成后的预定时间段结束时高于另一个指定电平,以及(3)内部电阻是否可接受地低。 如果电池通过第一次测试,则已知可以接受。 如果电池第一次测试失败并通过第二次测试,则已知不能接受。 如果电池第一次和第二次测试失败,则进行第三次测试。 如果电池通过第三次测试,则已知可以接受但要求充电,而如果电池在第三次测试中失败,则电池的可接受性尚未确定,并且必须重新充电并重新测试。