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61. 发明授权

US09406146B2 Quantitative perfusion analysis 有权
标题翻译：定量灌注分析
公开(公告)号：US09406146B2
公开(公告)日：2016-08-02
申请号：US13380610
申请日：2010-06-23
申请人： Rafael Wiemker , Thomas Buelow
发明人： Rafael Wiemker , Thomas Buelow
IPC分类号： G06K9/00 , G06T7/40 , G06T7/20 , G06T7/00
CPC分类号： G06T7/401 , G06T7/0016 , G06T7/20 , G06T7/41 , G06T2207/10096 , G06T2207/20104 , G06T2207/30104
摘要： A system is disclosed for quantitative analysis of perfusion images comprising image elements having intensity values associated therewith. The system comprises a frequency distribution computing subsystem (1) for computing a plurality of frequency distributions of the intensity values of at least part of the images. The system comprises a perfusion information extractor (2) for extracting information relating to perfusion from the plurality of frequency distributions. The perfusion information extractor (2) comprises a shift detector (3) for detecting a shift of the intensity values of the frequency distribution. The perfusion information extractor (2) is arranged for extracting the information relating to perfusion, based on the detected shift. A user interface element (8) enables a user to indicate a boundary between the core region and the rim region by a single degree of freedom. A vesselness subsystem (9) associates a vesselness value with an image element.
摘要翻译：公开了一种用于定量分析包括具有与其相关联的强度值的图像元素的灌注图像的系统。该系统包括用于计算至少部分图像的强度值的多个频率分布的频率分布计算子系统（1）。该系统包括用于从多个频率分布中提取与灌注相关的信息的灌注信息提取器（2）。灌注信息提取器（2）包括用于检测频率分布的强度值的偏移的移位检测器（3）。灌注信息提取器（2）被布置为基于检测到的移位来提取与灌注有关的信息。用户界面元件（8）使得用户能够通过单个自由度来指示核心区域和边缘区域之间的边界。容器子系统（9）将容器值与图像元素相关联。

62. 发明授权

US08805044B2 Segmenting pulmonary arteries 有权
标题翻译：分段肺动脉
公开(公告)号：US08805044B2
公开(公告)日：2014-08-12
申请号：US12937289
申请日：2009-04-14
申请人： Thomas Buelow , Rafael Wiemker
发明人： Thomas Buelow , Rafael Wiemker
IPC分类号： G06K9/00
CPC分类号： G06T7/162 , G06T7/33 , G06T2207/10081 , G06T2207/20016 , G06T2207/20072 , G06T2207/30061 , G06T2207/30101
摘要： A method of identifying at least part of a pulmonary artery tree (402) comprises receiving (102) a bronchial tree structure (500) and receiving (104) a pulmonary vessel structure (400). A pair of a first bronchial segment (602) and a first vessel segment (604) is identified (106), wherein the first bronchial segment and the first vessel segment are adjacent with respect to position and orientation. The first vessel segment is identified (108) as arterial segment of the pulmonary artery tree. A spatial transformation is applied (110) such that the first bronchial segment and the first vessel segment substantially coincide (602′). Respective further vessel segments (606, 608) are identified (112) adjacent to bronchial segments (610, 612), wherein the bronchial segments are comprised in the bronchial tree.
摘要翻译：识别肺动脉树（402）的至少一部分的方法包括接收（102）支气管树结构（500）并接收（104）肺血管结构（400）。识别出一对第一支气管段（602）和第一血管段（604）（106），其中第一支气管区段和第一血管区段相对于位置和取向相邻。识别第一血管段（108）作为肺动脉树的动脉段。应用空间变换（110）使得第一支气管段和第一血管段基本上重合（602'）。识别与支气管段（610,612）相邻的另外的血管段（606,608），其中支气管段包括在支气管树中。

63. 发明申请

US20140219534A1 INTERACTIVE LIVE SEGMENTATION WITH AUTOMATIC SELECTION OF OPTIMAL TOMOGRAPHY SLICE 有权
标题翻译：具有自动选择最佳胃肠切片的交互式活体分期
公开(公告)号：US20140219534A1
公开(公告)日：2014-08-07
申请号：US14342553
申请日：2012-09-03
申请人： Rafael Wiemker , Harald Sepp Heese , Andre Goossen , Klaus Erhard
发明人： Rafael Wiemker , Harald Sepp Heese , Andre Goossen , Klaus Erhard
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/187 , G06T2200/24 , G06T2207/20101 , G06T2207/30068
摘要： An apparatus for automatic selection of optimal tomography slices by executing a number of tentative segmentations using the same interactively provided in-slice seed point on some or all available tomography slices. The appropriate segmentation boundaries are then marked and the slice with the best segmentation goodness value (figure of merit) is presented to the user via a viewer. The steps are repeated when the user changes the seed point. The optimal segmentation boundary is displayed on top of a single simulated mammography image, fused from all tomography slice images.
摘要翻译：一种用于通过在一些或所有可用的断层摄影切片上使用相同交互式提供的切片种子点执行多个临时分割来自动选择最佳断层摄影切片的装置。然后标记适当的分割边界，并且经由观察者向用户呈现具有最佳分割优点值（品质因数）的切片。当用户更改种子点时，重复这些步骤。最佳分割边界显示在单个模拟乳房X射线摄影图像的顶部，融合于所有断层摄影切片图像。

64. 发明授权

US08718341B2 Synopsis of multiple segmentation results for breast lesion characterization 有权
标题翻译：乳腺病变特征的多个分割结果的概要
公开(公告)号：US08718341B2
公开(公告)日：2014-05-06
申请号：US13131140
申请日：2009-11-16
申请人： Thomas Buelow , Rafael Wiemker , Martin Bergtholdt , Lina Arbash Meinel
发明人： Thomas Buelow , Rafael Wiemker , Martin Bergtholdt , Lina Arbash Meinel
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/136 , G06T2207/10096 , G06T2207/30096
摘要： When characterizing a tumor or lesion as malignant or benign, a system (10) receives an image of the lesion volume (50), employs a processor (12) to perform a raw segmentation of the image, the results of which are stored to memory (14). Then processor then executes a hole-filling procedure to fill in dark areas in the image of the lesion representing necrotic tissue that absorbed little or no contrast agent, and optionally a leakage removal procedure to remove image voxels associated with non-lesion tissue, e.g., blood vessels, in which the contrast agent was present during imaging, to generate a complete lesion volume. A voxel analyzer (18) assesses a number of voxels included in the raw segmentation of the lesion image, and the final segmentation (e.g., after filling and optional leakage removal). A segmentation comparator (20) computes a ratio of dark area voxels related to necrotic tissue detected after the raw segmentation to total voxels detected in the final image segmentation. The ratio is then used to determine a likelihood of malignancy, with a higher ratio indicating a higher likelihood.
摘要翻译：当将肿瘤或病变描绘为恶性或良性时，系统（10）接收病变体积（50）的图像，使用处理器（12）执行图像的原始分割，其结果存储到存储器（14）。然后，处理器然后执行填充填充程序以填充代表坏死组织的损伤图像中的暗区域，其吸收很少或没有造影剂，以及可选地泄漏去除程序以去除与非损伤组织相关联的图像体素，在成像期间存在造影剂的血管，以产生完整的病变体积。体素分析器（18）评估包括在损伤图像的原始分割中的多个体素，以及最终分割（例如在填充和可选的泄漏移除之后）。分割比较器（20）计算与原始分割之后检测到的坏死组织相关的暗区域体素与在最终图像分割中检测到的总体素的比率。然后将该比率用于确定恶性肿瘤的可能性，其中较高的比率表明更高的可能性。

65. 发明申请

US20130236124A1 IMAGE PROCESSING APPARATUS 有权
标题翻译：图像处理设备
公开(公告)号：US20130236124A1
公开(公告)日：2013-09-12
申请号：US13988770
申请日：2011-11-22
申请人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
发明人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
IPC分类号： G06T11/60
CPC分类号： G06T11/60 , G06T11/00
摘要： Image processing apparatus (100) for creating an overlaid presentation of a first input image (101) and a second input image (102) in an output image (108), the first input image comprising input values, the output image comprising vectors of output values, the vectors of output values representing colors of the output image, and the apparatus comprising an input (110) for obtaining the first input put image and the second input image, a rendering unit (140) configured for rendering the first input image in the output image by using a first mapping function for representing the input values in the vectors of output values, a predictor (120) configured for predicting the second input image from the first input image for obtaining a predicted second input image (104), a residual calculator (130) configured for calculating a residual image (106) from the second input image and the predicted second input image, the residual image comprising residual values representing prediction errors of the predicted second input image, and the rendering unit being further configured for rendering the residual image in the output image by using a second mapping function for representing the residual values in the vectors of output values, the second mapping function being different from the first mapping function for distinguishing the residual image from the first input image.
摘要翻译：用于在输出图像（108）中创建第一输入图像（101）和第二输入图像（102）的叠加呈现的图像处理装置（100），所述第一输入图像包括输入值，所述输出图像包括输出矢量值，表示输出图像的颜色的输出值的矢量，以及包括用于获得第一输入放映图像和第二输入图像的输入（110）的装置，被配置为将第一输入图像呈现在通过使用用于表示输出值的向量中的输入值的第一映射函数的输出图像，配置用于从第一输入图像预测第二输入图像以获得预测的第二输入图像的预测器（120），剩余计算器（130），被配置为从所述第二输入图像和所述预测的第二输入图像计算残差图像（106），所述残差图像包括表示预测误差的残差值所述预测的第二输入图像和所述绘制单元还被配置为通过使用用于表示所述输出值的向量中的残差的第二映射函数来呈现所述输出图像中的残差图像，所述第二映射函数不同于所述第一映射用于区分残差图像与第一输入图像的功能。

66. 发明申请

US20120230563A1 SCAN PLAN FIELD OF VIEW ADJUSTOR, DETERMINER, AND/OR QUALITY ASSESSOR 有权
标题翻译：查看计划视野调查员，决定者和/或质量评估员
公开(公告)号：US20120230563A1
公开(公告)日：2012-09-13
申请号：US13508370
申请日：2010-10-14
申请人： Torbjorn Vik , Jorg Bredno , Rafael Wiemker , Mark E. Olszewski
发明人： Torbjorn Vik , Jorg Bredno , Rafael Wiemker , Mark E. Olszewski
IPC分类号： G06K9/46 , G06K9/34
CPC分类号： G06T7/0012 , A61B5/0037 , A61B5/055 , A61B5/7207 , A61B6/032 , A61B6/12 , A61B6/488 , A61B6/5264 , G06T7/32 , G06T7/344 , G06T2207/10081 , G06T2207/30004
摘要： A method includes using a pre-scan image to define a scan field of view for a region of interest of a patient to be scanned for at least one image acquisition of a series of image acquisitions of a scan plan, performing an image acquisition of the series based on a corresponding scan field of view for the image acquisition, and determining, via a processor (120), a next field of view for a next image acquisition of the series based on available image related data.
摘要翻译：一种方法包括使用预扫描图像来定义要扫描的患者的感兴趣区域的扫描视场，用于对扫描计划的一系列图像采集的至少一次图像采集，执行扫描图像的图像采集基于用于图像获取的相应的扫描视野的系列，以及基于可用的图像相关数据，经由处理器（120）确定用于下一次图像采集的下一个视场。

67. 发明申请

US20110194742A1 ONE-CLICK CORRECTION OF TUMOR SEGMENTATION RESULTS 审中-公开
标题翻译：一次性修正肿瘤分期结果
公开(公告)号：US20110194742A1
公开(公告)日：2011-08-11
申请号：US13123042
申请日：2009-10-06
申请人： Thomas Buelow , Rafael Wiemker
发明人： Thomas Buelow , Rafael Wiemker
IPC分类号： G06K9/00
CPC分类号： G06T7/11 , G06T2200/04 , G06T2200/24 , G06T2207/20092 , G06T2207/30096
摘要： When adjusting parameters of a segmentation protocol for segmenting a volume of interest in an anatomical image, a user selects a superparameter (50) that includes multiple internal parameters (52) for adjusting a raw segmentation of the volume interest. As a weight of the selected superparameter is adjusted, weights of the internal parameters associated with the superparameter are adjusted according to a superparameter segmentation adjustment algorithm (20). The volume of interest is iteratively re-segmented after each internal parameter adjustment, transparently to the user, until a predetermined amount of change has been effected in the volume of interest segmentation, at which time the re-segmented volume of interest is displayed to the user.
摘要翻译：当调整分割协议的参数以分解解剖图像中的感兴趣体积时，用户选择包括多个内部参数（52）的超参数（50），以调整体积兴趣的原始分割。当调整所选超参数的权重时，根据超参数分段调整算法（20）调整与超参数相关联的内部参数的权重。在每个内部参数调整之后，对用户透明地重新分段感兴趣的体积，直到感兴趣区段的体积中已经实现了预定量的变化，此时将重新分割的感兴趣体积显示给用户。

68. 发明申请

US20110015520A1 PERFUSION IMAGING 审中-公开
标题翻译：灌注成像
公开(公告)号：US20110015520A1
公开(公告)日：2011-01-20
申请号：US12920483
申请日：2009-02-25
申请人： Kirsten Meetz , Ingwer Carlsen , Heinrich Schulz , Rafael Wiemker , Stewart Young
发明人： Kirsten Meetz , Ingwer Carlsen , Heinrich Schulz , Rafael Wiemker , Stewart Young
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： G06F19/321 , A61B6/481 , A61B6/504 , A61B6/507 , G06T7/0012 , G06T2207/10072 , G06T2207/30016 , G06T2207/30101 , G16H40/63 , G16H50/20 , G16H50/50
摘要： A perfusion analysis system includes a perfusion modeller (120) and a user interface (122). The perfusion modeller (120) generates a patient specific perfusion model based on medical imaging perfusion data for the patient, a general perfusion model, and a quantification of one or more identified pathologies of the patient that affect perfusion in the patient. The user interface (122) accepts an input indicative of a modification to the quantification of the one or more identified pathologies. In response, the perfusion modeller (120) updates the patient specific perfusion model based on the medical imaging perfusion data for the patient, the general perfusion model, and the quantification of the one or more identified pathologies of the patient, including the modification thereto.
摘要翻译：灌注分析系统包括灌注建模器（120）和用户界面（122）。灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和影响患者灌注的患者的一个或多个鉴定的病理学的定量产生患者特异性灌注模型。用户界面（122）接受指示对所述一个或多个识别的病理学的量化的修改的输入。作为响应，灌注建模器（120）基于患者的医学成像灌注数据，一般灌注模型和患者的一个或多个鉴定的病理学的定量（包括其修改）来更新患者特异性灌注模型。

69. 发明申请

US20100278409A1 HARDWARE TUMOR PHANTOM FOR IMPROVED COMPUTER-AIDED DIAGNOSIS 审中-公开
标题翻译：硬件肿瘤细胞改进计算机辅助诊断
公开(公告)号：US20100278409A1
公开(公告)日：2010-11-04
申请号：US12746552
申请日：2008-12-12
申请人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
发明人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B6/03 , A61B6/583 , G06T7/41 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/20104 , G06T2207/30096 , G09B23/30
摘要： An imaging system (1) includes at least one hardware phantom (52, 54, 56, 58) which includes structural features (s, 82, 92) that mimic different structural features of tumors. A scanner (10) acquires image data for a subject (14) in a region of interest (40) and the at least one hardware phantom. A reconstruction processor (32) processes the image data to generate reconstructed image data representative of the region of interest and of the hardware phantom.
摘要翻译：成像系统（1）包括至少一个硬件体模（52,54,56,58），其包括模拟肿瘤的不同结构特征的结构特征（s，82,92）。扫描器（10）获取感兴趣区域（40）中的对象（14）的图像数据和至少一个硬件体模。重建处理器（32）处理图像数据以产生表示感兴趣区域和硬件体模的重建图像数据。

70. 发明申请

US20100260392A1 CONSISTENCY METRIC BASED IMAGE REGISTRATION 审中-公开
标题翻译：一致性公制图像注册
公开(公告)号：US20100260392A1
公开(公告)日：2010-10-14
申请号：US12746179
申请日：2008-12-12
申请人： Rafael Wiemker , Sven Kabus , Thomas Buelow , Roland Opfer
发明人： Rafael Wiemker , Sven Kabus , Thomas Buelow , Roland Opfer
IPC分类号： G06T7/00 , G06K9/60
CPC分类号： G06K9/32 , G06F19/321 , G06K2209/05 , G06T7/337 , G06T2207/10081 , G06T2207/30004
摘要： A method includes registering a first sub-portion of a first image with a corresponding second sub-portion of a second image, and registering the second sub-portion of the second image with a corresponding third sub-portion of the first image. The first sub-portion encompasses a first object of interest, and the third sub-portion encompasses a third object of interest. The method further includes reducing a size of the first sub-portion when the first and third objects of interest are substantially similar. The method further includes repeating the steps of registering the first sub-portion, registering the second sub-portion, and reducing the size of the first sub-portion until the first and third objects are not substantially similar.
摘要翻译：一种方法包括：将第一图像的第一子部分与第二图像的对应的第二子部分对齐，并且将第二图像的第二子部分与第一图像的对应的第三子部分进行登记。第一子部分包含第一感兴趣对象，第三子部分包含第三感兴趣对象。所述方法还包括当所述第一和第三感兴趣对象基本相似时减小所述第一子部分的大小。该方法还包括重复登记第一子部分，登记第二子部分以及减小第一子部分的大小，直到第一和第三对象基本不相似的步骤。

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