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61. 发明申请

US20080190926A1 DETECTION DEVICE FOR VEHICLES 有权
标题翻译：车辆检测装置
公开(公告)号：US20080190926A1
公开(公告)日：2008-08-14
申请号：US12028544
申请日：2008-02-08
申请人： Fabio Nebbia , Paolo Colombo , Domenico Cantarelli
发明人： Fabio Nebbia , Paolo Colombo , Domenico Cantarelli
IPC分类号： B60K15/05 , B65D55/14 , B60R25/10
CPC分类号： B60K15/0409 , B60K15/0406 , B60K2015/03197 , B60K2015/03434 , G01R33/07 , Y10T70/5571 , Y10T70/558
摘要： A removable cap for fuel tanks of vehicles includes a gripping portion and a locking portion, operatively set between which is a key-operated locking device. In the closing condition of the device, a rotation movement imparted manually upon the gripping portion is not transferred to the locking portion, while in the opening condition of the device a rotation movement imparted manually upon the first part is transferred to the clamping portion. In the closing condition at least one component of the locking device is rotatable together with the gripping portion, and switching with the key of the locking device between the conditions of closing and opening causes an angular movement of the component with respect to the gripping portion, between a first pre-defined angular position and a second pre-defined angular position. The cap further includes a circuit arrangement that includes at least one sensor configured for detecting the relative angular movement between the component of the locking device and the gripping portion.
摘要翻译：用于车辆的燃料箱的可移除盖包括夹紧部分和锁定部分，其可操作地设置在其之间，是钥匙操作的锁定装置。在装置的关闭状态下，手动地向握持部分施加的旋转运动不会转移到锁定部分，而在装置的打开状态下，手动地将第一部件上的旋转运动传递到夹紧部分。在关闭状态下，锁定装置的至少一个部件与抓握部分一起旋转，并且在关闭和打开条件之间用锁定装置的钥匙切换导致部件相对于抓握部分的角运动，在第一预定义角位置和第二预定义角位置之间。帽还包括电路装置，其包括至少一个传感器，该传感器被配置为检测锁定装置的部件与夹持部分之间的相对角度运动。

62. 发明申请

US20050008700A1 Modular systems for the controlled release of a substance with space and time control 审中-公开
标题翻译：用于控制释放具有空间和时间控制的物质的模块化系统
公开(公告)号：US20050008700A1
公开(公告)日：2005-01-13
申请号：US10496327
申请日：2002-11-20
申请人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Catellani
发明人： Paolo Colombo , Ruggero Bettini , Patrizia Santi , Pier Catellani
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22
CPC分类号： A61K9/0065 , A61K9/2009 , A61K9/2054 , A61K9/2072 , A61K9/2086
摘要： The present invention concerns an innovative pharmaceutical form for controlled drug release. In particular, the present invention refers to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
摘要翻译：本发明涉及用于受控药物释放的创新药物形式。特别地，本发明涉及通过组装各个释放模块获得的系统，其中在时间和空间上释放药物的能力取决于模块组装的方式。模块化结构提供了很高的制造再现性和释放的灵活性。

63. 发明授权

US06730664B1 Formulations for parenteral use of estramustine phosphate and sulfoalkyl ether cyclodextrins 失效
标题翻译：胃肠外使用雌激素磷酸盐和磺烷基醚环糊精的制剂
公开(公告)号：US06730664B1
公开(公告)日：2004-05-04
申请号：US10070416
申请日：2002-03-15
申请人： Lorena Muggetti , Paolo Colombo , Alessandro Martini , Giovanni Buzzi
发明人： Lorena Muggetti , Paolo Colombo , Alessandro Martini , Giovanni Buzzi
IPC分类号： A61K31724
CPC分类号： A61K9/0019 , A61K31/661 , A61K45/06 , A61K47/40 , A61K2300/00
摘要： A pharmaceutical formulation which comprises a parenterally acceptable carrier or diluent, estramustine phosphate and a sulfoalkyl ether cyclodextrin. The formulation can be administered according to a combined chemotherapy regimen in association with one or more chemotherapeutic agents. The formulation also enables estramustin phosphate to be administered with no side effects at the site of injection.
摘要翻译：一种药物制剂，其包含肠胃外可接受的载体或稀释剂，雌莫司汀磷酸盐和磺基烷基醚环糊精。该制剂可以根据与一种或多种化学治疗剂联合的联合化疗方案施用。该制剂还能够在注射部位施用没有副作用的磷酸雌莫司汀。

64. 发明授权

US06706286B1 Process for the preparation of granular and porous sucralfate dry gel 有权
标题翻译：粒状和多孔硫糖铝干凝胶的制备方法
公开(公告)号：US06706286B1
公开(公告)日：2004-03-16
申请号：US09744869
申请日：2001-01-29
申请人： Giorgio Zagnoli , Paolo Colombo , Loretta Maggi , Fabrizio Cudazzo
发明人： Giorgio Zagnoli , Paolo Colombo , Loretta Maggi , Fabrizio Cudazzo
IPC分类号： A61K914
CPC分类号： A61K9/145 , A61K9/0056 , A61K9/209
摘要： Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titre of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.
摘要翻译：处于干燥状态的蔗糖凝胶以粒径分布为100至1000μm的多孔颗粒形式，粉末床的表观密度为0.7至0.9g / ml，沉降指数为5至15％，和残余湿度在5至15％之间，以及相应的制备方法，其包括用粉状硫糖铝凝胶的稀释溶液的微波处理，硫糖铝滴定剂为20至70重量％。％。该固体产品可有利地用于制备含有它作为单一活性成分的固体药物组合物，或者作为活性成分含有可能引起胃粘膜损害的物质的固体组合物的包衣。

65. 发明授权

US5549913A Multilayer matrix systems for the controlled release of active principles 失效
标题翻译：用于控制释放有源原理的多层矩阵系统
公开(公告)号：US5549913A
公开(公告)日：1996-08-27
申请号：US153437
申请日：1993-11-16
申请人： Paolo Colombo , Antonio C. Cardona , Giorgio Pifferi
发明人： Paolo Colombo , Antonio C. Cardona , Giorgio Pifferi
IPC分类号： A61J3/10 , A61K9/20 , A61K9/24 , A61K9/48 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42
CPC分类号： A61K9/2086 , A61K9/209
摘要： This invention concerns systems for the release of active principles which are capable of releasing active principle(s) into an aqueous medium at a controlled rate.More precisely, the invention concerns a monolithic system for the controlled release of active principles, consisting of:a) at least one swelling layer containing one or more active principles, in a matrix of swellable, hydrophilic polymers;b) at least one erodible and/or soluble layer comprising excipients and/or water soluble polymers, possibly containing one or more active principles, either the same or different from those present in the layer a), the said erodible and/or soluble layer being in contact with the swelling layer(s) a).
摘要翻译：本发明涉及释放能够以受控速率将有效原理释放到水性介质中的活性原理的系统。更准确地说，本发明涉及用于控制释放活性成分的整体系统，其包括：a）在可溶胀亲水性聚合物基质中含有一种或多种活性成分的至少一种溶胀层; b）至少一个包含赋形剂和/或水溶性聚合物的可侵蚀和/或可溶性层，其可能含有一个或多个与层a）中存在的活性成分相同或不同的活性成分，所述可侵蚀和/或可溶层与膨胀层a）接触。

66. 发明授权

US5422123A Tablets with controlled-rate release of active substances 失效
标题翻译：具有控制释放活性物质的片剂
公开(公告)号：US5422123A
公开(公告)日：1995-06-06
申请号：US123982
申请日：1993-09-21
申请人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
发明人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
IPC分类号： A61K9/24 , A61K9/20 , A61K9/22 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/36 , A61K9/32
CPC分类号： A61K9/2086
摘要： Tablets with zero order controlled-rate of release of the active substances, consisting of a core of defined geometrical form containing the active substance, polymer substances which swell on contact with aqueous liquids and polymer substances with gelling properties, and a support applied to said core to partly cover its surface, the support consisting of polymer substances which are slowly soluble and/or slowly gellable in aqueous liquids, plasticizing substances, and possibly substances with an adjuvant function.
摘要翻译：含有活性物质的零级控制速率的片剂，由含有活性物质的限定几何形式的核心组成，与水性液体接触时膨胀的聚合物物质和具有胶凝性质的聚合物物质，以及用于所述核心为了部分地覆盖其表面，载体由在水性液体中缓慢溶解和/或缓慢凝胶化的聚合物物质，增塑物质和可能具有佐剂功能的物质组成。

67. 发明授权

US5246697A Use of sucralfate humid gel as vehicle for drugs having topic activity and for cosmetics 失效
标题翻译：用作具有主题活性和化妆品的药物的SUCCALFATE HUMID GEL的用途
公开(公告)号：US5246697A
公开(公告)日：1993-09-21
申请号：US538739
申请日：1990-06-15
申请人： Ubaldo Conte , Paolo Colombo , Giorgio Zagnoli , Carla Caramella
发明人： Ubaldo Conte , Paolo Colombo , Giorgio Zagnoli , Carla Caramella
IPC分类号： A61K9/06 , A61K8/02 , A61K8/60 , A61K8/73 , A61K8/92 , A61K9/00 , A61K9/70 , A61K31/70 , A61K47/26 , A61Q19/00
CPC分类号： A61K47/26 , A61K31/70 , A61K8/0212 , A61K8/042 , A61K8/60 , A61K9/0014 , A61Q19/00 , Y10S514/887 , Y10S514/944
摘要： The use of sucralfate humid gel is described as vehicle for the applicationf drugs having topic activity (dermic and mucosal) and as basis for the formulation of beauty masks and other cosmetic preparations. Therapeutic and cosmetic formulations are described in the form of creams, ointments, aqueous dispersions comprising sucralfate humid gel.

68. 发明授权

US4865849A Tablet for pharmaceutical use able to release active substances at successive times 失效
标题翻译：用于制药的片剂能够连续释放活性物质
公开(公告)号：US4865849A
公开(公告)日：1989-09-12
申请号：US139635
申请日：1987-12-30
申请人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
发明人： Ubaldo Conte , Aldo La Manna , Paolo Colombo
IPC分类号： A61K9/20 , A61K9/24
CPC分类号： A61K9/2072 , A61K9/209
摘要： A tablet for pharmaceutical use able to release active substances at successive times, comprising at least; a first layer containing a portion of the active substance with suitable excipients, a barrier layer of polymer material gellable and/or soluble in water and/or aqueous liquids, which is interposed between said first layer and a third layer containing the remaining portion of active substance with suitable excipients, said barrier layer and said third layer being housed in a casing consisting of polymer material impermeable and insoluble in water or soluble in an alkaline environment.That part of the active substance not inserted in the casing is immediately available for dissolving, whereas the part inserted in the casing is available only after dissolution or rupture of the barrier layer and/or after solubilization of the casing.

69. 发明授权

US08535680B2 Anti-LPS factor from Parietaria judaica and methods of use thereof 失效
标题翻译：芍药的抗LPS因子及其使用方法
公开(公告)号：US08535680B2
公开(公告)日：2013-09-17
申请号：US12933390
申请日：2009-03-19
申请人： Paolo Colombo , Angela Bonura , Francesco Di Blasi
发明人： Paolo Colombo , Angela Bonura , Francesco Di Blasi
IPC分类号： A61K38/00 , A61K39/00 , C07K1/00 , C07K2/00
CPC分类号： C07K14/415 , A61K38/00
摘要： The present invention falls within the field of molecular biology, and in particular it refers to peptides, polypeptides, protein molecules, uses, methods, processes, systems and compositions for minimizing the presence of molecules in a material and/or interfering with effects associated to such molecules. In particular, the present invention can appear in the form of anti-septic shock pharmacological composition and systems of purification from bacterial endotoxins.
摘要翻译：本发明属于分子生物学领域，特别是指多肽，多肽，蛋白质分子，用途，方法，方法，系统和组合物，用于最小化材料中分子的存在和/或干扰与这样的分子。特别地，本发明可以以抗败血性休克药理学组成和细菌内毒素净化系统的形式出现。

70. 发明申请

US20120237402A1 DETECTION DEVICE 审中-公开
标题翻译：检测装置
公开(公告)号：US20120237402A1
公开(公告)日：2012-09-20
申请号：US13514507
申请日：2010-12-10
申请人： Domenico Cantarelli , Enrico Chiesa , Paolo Colombo
发明人： Domenico Cantarelli , Enrico Chiesa , Paolo Colombo
IPC分类号： G01M15/10 , B01D53/94
CPC分类号： F02D41/1448 , F02D41/1441 , F02D41/1446 , F02D2041/1468 , F02D2200/0418 , G01K1/08 , G01K13/02 , G01K2205/04 , G01L19/0092
摘要： A detection device for internal combustion engines exhaust gases post-treatment systems has a casing (2, 3) housing a circuit arrangement (21, 31) including humidity sensor means (32), for measuring the humidity of the gas. The circuit arrangement further comprises temperature sensor means (33) and pressure sensor means (22), for detecting a gas temperature value and a gas pressure value, respectively. The gas temperature value can be used for compensating the humidity value obtained through the humidity sensor means (32) and the pressure value can be used for deducing the clogging degree of a filter of the post-treatment system. Preferably the pressure sensor means (22) are housed in a first chamber (8) of the casing (2-3) while the humidity sensor means (32) and the temperature sensor means (33) are housed in a second chamber (10b) of the casing (2, 3).
摘要翻译：一种用于内燃机废气后处理系统的检测装置，具有壳体（2,3），其容纳包括用于测量气体湿度的湿度传感器装置（32）的电路装置（21,31）。电路装置还包括分别用于检测气体温度值和气体压力值的温度传感器装置（33）和压力传感器装置（22）。气体温度值可以用于补偿通过湿度传感器装置（32）获得的湿度值，并且压力值可以用于推断后处理系统的过滤器的堵塞度。优选地，压力传感器装置（22）容纳在壳体（2-3）的第一室（8）中，同时湿度传感器装置（32）和温度传感器装置（33）容纳在第二室（10b）中，（2,3）。

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