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61. 发明授权

US5197976A Manually separable multi-lumen vascular graft 失效
标题翻译：手动分离多腔血管移植
公开(公告)号：US5197976A
公开(公告)日：1993-03-30
申请号：US760716
申请日：1991-09-16
申请人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
发明人： Steve A. Herweck , Theodore Karwoski , Paul Martakos
IPC分类号： A61F2/00 , A61F2/04 , A61F2/06 , A61L27/16 , A61L27/54 , A61L27/56
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/54 , A61F2/04 , A61F2002/065 , A61F2250/0067 , A61L2300/00
摘要： A vascular prosthesis has a plurality of tubular structures, each of which is manually separable from the others. Each tube structure has a biocompatible exterior surface and a lumen of predetermine diameter. Fluid, such as blood, is channelled through the lumina upon implantation in an arterial or venous pathway. Each of the tube structures is separable from the others over at least a portion of the axial extent of the exterior surface.
摘要翻译：血管假体具有多个管状结构，每个管状结构可手动地分离。每个管结构具有生物相容的外表面和预定直径的内腔。流体，如血液，植入动脉或静脉通路时通过管腔引导。每个管结构在外表面的轴向范围的至少一部分上可与其他管结构分离。

62. 发明授权

US09012506B2 Cross-linked fatty acid-based biomaterials 有权
标题翻译：交联脂肪酸基生物材料
公开(公告)号：US09012506B2
公开(公告)日：2015-04-21
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

63. 发明授权

US08308684B2 Method of coating a folded medical device 有权
标题翻译：折叠式医疗装置的涂敷方法
公开(公告)号：US08308684B2
公开(公告)日：2012-11-13
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译：以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

64. 发明申请

US20110213302A1 METHOD OF COATING A FOLDED MEDICAL DEVICE 有权
标题翻译：涂敷折叠医疗器械的方法
公开(公告)号：US20110213302A1
公开(公告)日：2011-09-01
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
IPC分类号： A61L29/16 , B05D5/10
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译：以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

65. 发明授权

US07947015B2 Application of a therapeutic substance to a tissue location using an expandable medical device 有权
标题翻译：使用可扩张医疗装置将治疗物质施用于组织位置
公开(公告)号：US07947015B2
公开(公告)日：2011-05-24
申请号：US11804478
申请日：2007-05-18
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M37/00
CPC分类号： A61M25/1027 , A61L29/085 , A61L29/146 , A61L29/16 , A61L2300/22 , A61L2300/606 , A61M2025/1075 , A61M2025/1088 , C08L27/18
摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.
摘要翻译：应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。输送装置使用充气流体的压力膨胀。在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

66. 发明申请

US20100034867A1 DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
标题翻译：用于医疗设备的药物输送涂料和治疗血管损伤的方法
公开(公告)号：US20100034867A1
公开(公告)日：2010-02-11
申请号：US11919363
申请日：2006-04-28
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
IPC分类号： A61L27/54 , A61K31/436 , A61K38/13 , A61K47/12 , A61P9/00 , A61L29/16
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of medical devices coated with a therapeutic coating comprising a mTOR targeting compound and a calcineurin inhibitor, and methods of applying said coatings. In various aspects, the therapeutic coating comprises a bio-absorbable carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译：本发明提供涂覆有包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗性涂层的医疗器械的各种实施方案，以及施用所述涂层的方法。在各个方面，治疗性包衣包含至少部分由细胞吸收抑制剂和细胞摄取增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分。在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

67. 发明申请

US20090181937A1 CROSS-LINKED FATTY ACID-BASED BIOMATERIALS 有权
标题翻译：交联的基于脂肪酸的生物材料
公开(公告)号：US20090181937A1
公开(公告)日：2009-07-16
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/395 , A61P41/00
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

68. 发明申请

US20080113001A1 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US20080113001A1
公开(公告)日：2008-05-15
申请号：US11980155
申请日：2007-10-30
申请人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
发明人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

69. 发明申请

US20080109017A1 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

70. 发明申请

US20080015500A1 Application of a therapeutic substance to a tissue location using an expandable medical device 有权
标题翻译：使用可扩张医疗装置将治疗物质施用于组织位置
公开(公告)号：US20080015500A1
公开(公告)日：2008-01-17
申请号：US11804478
申请日：2007-05-18
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M29/02
CPC分类号： A61M25/1027 , A61L29/085 , A61L29/146 , A61L29/16 , A61L2300/22 , A61L2300/606 , A61M2025/1075 , A61M2025/1088 , C08L27/18
摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.
摘要翻译：应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。输送装置使用充气流体的压力膨胀。在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

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