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61. 发明授权

US5610626A Multiple-tone display system 失效
标题翻译：多色调显示系统
公开(公告)号：US5610626A
公开(公告)日：1997-03-11
申请号：US486291
申请日：1995-06-07
申请人： Naruhiko Kasai , Hiroyuki Mano , Shigeyuki Nishitani , Isao Takita , Kohji Takahashi
发明人： Naruhiko Kasai , Hiroyuki Mano , Shigeyuki Nishitani , Isao Takita , Kohji Takahashi
IPC分类号： G09G3/36 , G02F1/133 , G09G3/20 , H04N5/66
CPC分类号： G09G3/2011 , G09G3/3648 , G09G3/3688 , G09G3/3696 , G09G2310/027 , G09G2320/0242 , G09G2320/0271 , G09G2320/0276 , G09G3/2025
摘要： A dot matrix display system for multiple-tone displays, including a display device in which pixels are arrayed in a matrix shape, an LC (liquid-crystal) drive signal generator which converts color display data into LC display data, an 8-level data driver which selects one of 8-level voltages in accordance with the LC display data and then delivers the selected voltage, and an 8-level applied LC voltage generator by which the 8-level voltages to be applied to the pixels are produced so as to substantially make uniform color differences between the respectively adjacent tones of the multiple-tone displays. Owing to the substantially uniform color differences between the respectively adjacent tones, multiple-tone displays which are uniformly seen by the human eye can be obtained.
摘要翻译：一种用于多色调显示器的点阵显示系统，包括其中像素排列成矩阵形状的显示装置，将彩色显示数据转换为LC显示数据的LC（液晶）驱动信号发生器，8级数据驱动器，其根据LC显示数据选择8级电压中的一个，然后传送所选择的电压;以及8级施加的LC电压发生器，通过该电压产生要施加到像素的8电平电压，以便在多色调显示器的相邻相邻色调之间基本上使均匀的色差。由于相邻相邻色调之间的色差基本均匀，可以获得人眼均匀观看的多色调显示。

62. 发明授权

US5298912A Multi-tone display device 失效
标题翻译：多色显示设备
公开(公告)号：US5298912A
公开(公告)日：1994-03-29
申请号：US844965
申请日：1992-02-28
申请人： Hiroyuki Mano , Kiyokazu Nishioka , Toshio Futami , Kiyoshige Kinugawa
发明人： Hiroyuki Mano , Kiyokazu Nishioka , Toshio Futami , Kiyoshige Kinugawa
IPC分类号： G02F1/133 , G09G3/20 , G09G3/36
CPC分类号： G09G3/2011 , G09G3/3685 , G09G2310/027 , G09G2310/0297
摘要： This specification discloses a novel multi-tone display matrix display device. The matrix display device according to an embodiment of the present invention comprises a matrix display panel having a matrix composed of plural X direction signal lines and plural Y direction signal lines lying at right angles thereto, intersecting points on the matrix being pixels of an image to be displayed, an X direction driving section for sequentially scanning the X direction signal lines to provide image signals, a Y direction driving section for driving the Y direction signal lines in synchronism with the scanning of the X direction signal lines to sequentially provide select signals to the Y direction signal lines, an A-D converter section for receiving an analog signal and converting it into a digital signal, a voltage generating section for generating signals at plural voltage levels, and a selector section for selecting an output signal from the voltage generating section in accordance with the output from A-D converter section and providing it to the X direction driving section as an image signal.
摘要翻译：本说明书公开了一种新颖的多色调显示矩阵显示装置。根据本发明的实施例的矩阵显示装置包括矩阵显示面板，其具有由多个X方向信号线和与其成直角的多个Y方向信号线构成的矩阵，矩阵的矩阵显示面是矩阵上的相交点，显示X方向驱动部分，用于顺序扫描X方向信号线以提供图像信号; Y方向驱动部分，用于与X方向信号线的扫描同步地驱动Y方向信号线，以顺序地提供选择信号 Y方向信号线，用于接收模拟信号并将其转换为数字信号的AD转换器部分，用于产生多个电压电平的信号的电压产生部分和用于从电压产生部分选择输出信号的选择器部分根据AD转换器部分的输出并将其提供给X方向驱动部分作为图像信号。

63. 发明授权

US5206635A Method and apparatus for multi-level tone display for liquid crystal apparatus 失效
标题翻译：用于液晶显示器的液晶显示器的方法和装置
公开(公告)号：US5206635A
公开(公告)日：1993-04-27
申请号：US472306
申请日：1990-01-30
申请人： Tatsuhiro Inuzuka , Hiroyuki Mano , Kazuhiro Fujisawa , Satoshi Konuma , Kiyoshige Kinugawa , Satoru Tsunekawa
发明人： Tatsuhiro Inuzuka , Hiroyuki Mano , Kazuhiro Fujisawa , Satoshi Konuma , Kiyoshige Kinugawa , Satoru Tsunekawa
IPC分类号： G02F1/133 , G09G3/20 , G09G3/36 , H04N3/12
CPC分类号： G09G3/3622 , G09G3/3611 , H04N3/127 , G09G3/2018 , G09G3/3614
摘要： A liquid crystal display apparatus including a liquid crystal panel of a plurality of dots, an X drive circuit for supplying display information of at least one line to the liquid crystal panel and a Y drive circuit for selecting one-dot data for each line of the liquid crystal panel, the X drive circuit and the Y drive circuit enabling energization of the liquid crystal panel. A plurality of memories are provided for receiving a plurality of bits of information data and for storing at least M dot display information data so as to enable display of a respective line of the liquid crystal panel, M being an integer. A selection arrangement is provided for selecting one bit of display information data out of a plurality of bits of display information data to be read out of the memories and a selection controller is provided for specifying the one bit of display information data to be selected by the selection arrangement so as to enable read out of each one bit of the plurality of bits in a predetermined time sequence corresponding to one horizontal perioid divided by N for display, where N is an integer of at least two. The X drive circuit is supplied one dot information at leat two times during the one horizontal period so that one dot is controlled for display at least two times during the one horizontal period to enable multi-level tone display.
摘要翻译：一种液晶显示装置，包括多个点的液晶面板，用于向液晶面板提供至少一条线路的显示信息的X驱动电路和用于选择每一行的单点数据的Y驱动电路液晶面板，X驱动电路和Y驱动电路，使液晶面板通电。提供多个存储器用于接收多个位的信息数据，并且用于存储至少M个点显示信息数据，以便能够显示液晶面板的各个行，M是整数。提供了一种选择装置，用于从要从存储器中读出的显示信息数据的多个位中选择一位显示信息数据，并提供选择控制器，用于指定要由该存储器选择的一位显示信息数据选择装置，以使得能够以对应于除以N的一个水平眼旁侧的预定时间序列读出多个比特的每一比特以进行显示，其中N是至少两个的整数。在一个水平周期期间，X驱动电路提供一个点信息，两次，使得在一个水平周期期间，一个点被控制至少两次，以启用多级色调显示。

64. 发明授权

US5038139A Half tone display driving circuit for crystal matrix panel and half tone display method thereof 失效
标题翻译：晶体矩阵面板的半色调显示驱动电路及其半色调显示方法
公开(公告)号：US5038139A
公开(公告)日：1991-08-06
申请号：US395595
申请日：1989-08-18
申请人： Kazuhiro Fujisawa , Hiroyuki Mano , Satoru Tsunekawa , Kiyoshige Kinugawa , Satoshi Konuma , Tatsuhiro Inuzuka
发明人： Kazuhiro Fujisawa , Hiroyuki Mano , Satoru Tsunekawa , Kiyoshige Kinugawa , Satoshi Konuma , Tatsuhiro Inuzuka
IPC分类号： G09G3/20 , G09G3/36
CPC分类号： G09G3/3622 , G09G3/3611 , G09G3/3685 , G09G2310/027 , G09G3/2014
摘要： In a half tone display driving circuit for a liquid crystal matrix panel, a pulse for half tone display is phase modulated so that pulse signals which are out of phase relative to each other are applied to adjacent columns of the liquid crystal matrix panel, or from the phase-modulated pulse a gray scale pulse (tone pulse) is prepared in which the frequency of occurrence of voltage edges is decreased. The dephased pulse signals or the gray scale pulse (tone pulse) is used to prevent a decrease in brightness of display when the liquid crystal matrix panel is driven for half tone display.
摘要翻译：在用于液晶矩阵面板的半色调显示驱动电路中，用于半色调显示的脉冲被相位调制，使得相对于彼此相位的脉冲信号被施加到液晶矩阵面板的相邻列，或者从准备了相位调制脉冲，其中电压边缘的出现频率降低了的灰阶脉冲（音调脉冲）。当使用液晶矩阵面板进行半色调显示时，使用去相位脉冲信号或灰度脉冲（音调脉冲）来防止显示亮度降低。

65. 发明授权

US09109259B2 Detection method for novel ROS1 fusions 有权
标题翻译：新型ROS1融合检测方法
公开(公告)号：US09109259B2
公开(公告)日：2015-08-18
申请号：US13805513
申请日：2011-06-22
申请人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
发明人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/574
CPC分类号： C12Q1/6886 , C12P19/34 , C12Q1/68 , C12Q2600/156 , G01N33/57484
摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.
摘要翻译：阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

66. 发明授权

US09029521B2 EML4-ALK fusion gene 有权
标题翻译： EML4-ALK融合基因
公开(公告)号：US09029521B2
公开(公告)日：2015-05-12
申请号：US13468730
申请日：2012-05-10
申请人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
发明人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
IPC分类号： C07K14/435 , C12N9/12 , C07K14/47 , A61K31/506 , C12N15/113 , C12Q1/48 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/506 , C07K14/47 , C07K2319/00 , C12N9/1205 , C12N2310/14 , C12Q1/485 , C12Q1/6886
摘要： The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.
摘要翻译：本发明人发现存在于某些癌症患者中的融合基因是癌基因。本发明涉及作为新型融合蛋白的多肽，编码多肽的多核苷酸，包含多核苷酸的载体，包含载体的转化细胞，检测融合蛋白或多核苷酸的方法，用于筛选治疗剂的方法癌症和治疗癌症的方法，所述方法显示为融合基因呈阳性。此外，本发明涉及可用于检测癌症的试剂盒，引物组和探针，其对于融合基因显示为阳性。

67. 发明申请

US20130158095A1 EML4-ALK FUSION GENE 审中-公开
标题翻译： EML4-ALK融合基因
公开(公告)号：US20130158095A1
公开(公告)日：2013-06-20
申请号：US13468730
申请日：2012-05-10
申请人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
发明人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
IPC分类号： C12N9/12 , C12N15/113 , A61K31/506 , C12Q1/68 , C12Q1/48
CPC分类号： C12N15/1137 , A61K31/506 , C07K14/47 , C07K2319/00 , C12N9/1205 , C12N2310/14 , C12Q1/485 , C12Q1/6886
摘要： The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.
摘要翻译：本发明人发现存在于某些癌症患者中的融合基因是癌基因。本发明涉及作为新型融合蛋白的多肽，编码多肽的多核苷酸，包含多核苷酸的载体，包含载体的转化细胞，检测融合蛋白或多核苷酸的方法，用于筛选治疗剂的方法癌症和治疗癌症的方法，所述方法显示为融合基因呈阳性。此外，本发明涉及可用于检测癌症的试剂盒，引物组和探针，其对于融合基因显示为阳性。

68. 发明授权

US08197818B2 EML4-ALK fusion gene 有权
标题翻译： EML4-ALK融合基因
公开(公告)号：US08197818B2
公开(公告)日：2012-06-12
申请号：US13086245
申请日：2011-04-13
申请人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
发明人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
IPC分类号： A61K39/00 , C07H21/04
CPC分类号： C12N15/1137 , A61K31/506 , C07K14/47 , C07K2319/00 , C12N9/1205 , C12N2310/14 , C12Q1/485 , C12Q1/6886
摘要： The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.
摘要翻译：本发明人发现存在于某些癌症患者中的融合基因是癌基因。本发明涉及作为新型融合蛋白的多肽，编码多肽的多核苷酸，包含多核苷酸的载体，包含载体的转化细胞，检测融合蛋白或多核苷酸的方法，用于筛选治疗剂的方法癌症和治疗癌症的方法，所述方法显示为融合基因呈阳性。此外，本发明涉及可用于检测癌症的试剂盒，引物组和探针，其对于融合基因显示为阳性。

69. 发明授权

US07964710B2 EML4-ALK fusion gene 有权
标题翻译： EML4-ALK融合基因
公开(公告)号：US07964710B2
公开(公告)日：2011-06-21
申请号：US12466920
申请日：2009-05-15
申请人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
发明人： Hiroyuki Mano , Sadao Kuromitsu , Nobuaki Shindo , Takatoshi Soga , Takashi Furutani
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： C12N15/1137 , A61K31/506 , C07K14/47 , C07K2319/00 , C12N9/1205 , C12N2310/14 , C12Q1/485 , C12Q1/6886
摘要： The present inventors found that a fusion gene present in some cancer patients is an oncogene. The present invention relates to a polypeptide as a novel fusion protein, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, a transformed cell comprising the vector, a method for detecting the fusion protein or polynucleotide, a method for screening a therapeutic agent for cancer, and a method for treating cancer that is shown to be positive for the fusion gene. Further, the present invention relates kit, primer set, and probe useful in the detection of cancer that is shown to be positive for the fusion gene.
摘要翻译：本发明人发现存在于某些癌症患者中的融合基因是癌基因。本发明涉及作为新型融合蛋白的多肽，编码多肽的多核苷酸，包含多核苷酸的载体，包含载体的转化细胞，检测融合蛋白或多核苷酸的方法，用于筛选治疗剂的方法癌症和治疗癌症的方法，所述方法显示为融合基因呈阳性。此外，本发明涉及可用于检测癌症的试剂盒，引物组和探针，其对于融合基因显示为阳性。

70. 再颁专利

USRE40916E1 Liquid crystal driver and liquid crystal display device using the same 有权
标题翻译：液晶驱动器和液晶显示装置使用相同
公开(公告)号：USRE40916E1
公开(公告)日：2009-09-15
申请号：US11980700
申请日：2007-10-31
申请人： Hiroyuki Nitta , Hiroyuki Mano , Tsutomu Furuhashi , Isao Takita , Satoru Tsunekawa , Toshio Futami , Makiko Ikeda
发明人： Hiroyuki Nitta , Hiroyuki Mano , Tsutomu Furuhashi , Isao Takita , Satoru Tsunekawa , Toshio Futami , Makiko Ikeda
IPC分类号： G09G3/36
CPC分类号： G09G3/2011 , G09G3/3614 , G09G3/3655 , G09G3/3688 , G09G3/3696 , G09G2310/0248 , G09G2310/027 , G09G2310/0281 , G09G2310/0289 , G09G2310/0297 , G09G2330/023
摘要： A liquid crystal driver includes a voltage generator for generating gray scale voltages on the basis of reference voltages, and an output device for selecting one gray scale voltage from the generated gray scale voltages in accordance with display data, for applying inversion/non-inversion control to the selected gray scale voltage with respect to an inversion reference voltage on the basis of the selected gray scale voltage, an AC switching signal and the inversion reference voltage, and for outputting different liquid crystal supply voltages for one and the same display data to a liquid crystal panel.
摘要翻译：液晶驱动器包括：基于参考电压产生灰度电压的电压发生器;以及用于根据显示数据从产生的灰度级电压中选择一个灰度级电压的输出装置，用于施加反相/非反相控制基于所选择的灰度级电压，AC开关信号和反转参考电压相对于反转参考电压的所选择的灰度级电压，并且将用于一个和相同显示数据的不同液晶电源电压输出到液晶面板。

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