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61. 发明申请

US20120070416A1 Macrocyclic Proline Derived HCV Serine Protease Inhibitors 有权
标题翻译：大环脯氨酸衍生的HCV丝氨酸蛋白酶抑制剂
公开(公告)号：US20120070416A1
公开(公告)日：2012-03-22
申请号：US13237120
申请日：2011-09-20
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
IPC分类号： A61K38/12 , A61P31/14 , A61K38/21 , A61K38/46 , A61P37/02 , A61K38/48 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , C07K7/56 , A61K38/45
CPC分类号： C07K5/123 , A61K38/00 , A61K38/12 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0823 , C07K5/0827 , C07K14/811
摘要： The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

62. 发明授权

US08129403B2 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US08129403B2
公开(公告)日：2012-03-06
申请号：US11816374
申请日：2006-02-15
申请人： Michelle Lamb , Tao Wang , Dingwei Yu , Peter Mohr , Bin Wang
发明人： Michelle Lamb , Tao Wang , Dingwei Yu , Peter Mohr , Bin Wang
IPC分类号： A61K31/44 , C07D513/02 , C07D515/02
CPC分类号： C07D473/32 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物; 及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

63. 发明申请

US20120049500A1 Dual Stage Pretensioning and High Pay-In Capacity Pretensioning Retractor 审中-公开
标题翻译：双阶段预张紧和高支付能力预张紧牵引器
公开(公告)号：US20120049500A1
公开(公告)日：2012-03-01
申请号：US12872285
申请日：2010-08-31
申请人： Bin Wang , Frank Kiiskila , Daniel K. Webb , Jon E. Burrow , Kurt W. Schulz , Chad E. Moore , Gerald J. Keller
发明人： Bin Wang , Frank Kiiskila , Daniel K. Webb , Jon E. Burrow , Kurt W. Schulz , Chad E. Moore , Gerald J. Keller
IPC分类号： B60R22/46
CPC分类号： B60R22/4628 , B60R2022/4642 , B60R2022/4657
摘要： A seat belt retractor for use in seat belt restraint systems. The retractor incorporates dual rotopretensioner units and adaptive load limiting characteristics. Preferably, the rotopretensioners are positioned on opposite ends of a retractor spool for driving the spool for pretensioning rotation. A first pretensioner may be activated alone to provide pretensioning rotation. In one embodiment of the invention, if the second pretensioner is not activated, the system will be engaged to provide a given belt load limiting characteristic. A second rotopretensioner may be fired either after the first pretensioner is fired to increase pay-in capacity or to activate a different load limiting characteristic for the retractor.
摘要翻译：一种用于安全带约束系统的安全带卷收器。牵开器包含双重旋转陀螺仪单元和自适应负载限制特性。优选地，旋转拉伸器位于卷收器卷轴的相对端上，用于驱动卷轴以预张紧旋转。可以单独激活第一预紧器以提供预张紧旋转。在本发明的一个实施例中，如果第二预紧器没有被激活，系统将被接合以提供给定的带负载限制特性。在第一预张紧器被点火之后，可以发射第二个陀螺仪，以增加收费能力或激活牵开器的不同负载限制特性。

64. 发明申请

US20110238789A1 ENHANCED BLOCK-REQUEST STREAMING SYSTEM USING SIGNALING OR BLOCK CREATION 有权
标题翻译：使用信号或块创建的增强块请求流程系统
公开(公告)号：US20110238789A1
公开(公告)日：2011-09-29
申请号：US12887476
申请日：2010-09-21
申请人： Michael G. Luby , Mark Watson , Lorenzo Vicisano , Payam Pakzad , Bin Wang , Ying Chen , Thomas Stockhammer
发明人： Michael G. Luby , Mark Watson , Lorenzo Vicisano , Payam Pakzad , Bin Wang , Ying Chen , Thomas Stockhammer
IPC分类号： G06F15/16
CPC分类号： H04L65/601 , H04L65/4084 , H04L65/602 , H04L65/604 , H04L65/607 , H04L65/80 , H04L67/02 , H04N21/23106 , H04N21/23406 , H04N21/234327 , H04N21/235 , H04N21/2401 , H04N21/25808 , H04N21/2662 , H04N21/435 , H04N21/44004 , H04N21/440227 , H04N21/44209 , H04N21/84 , H04N21/8456
摘要： A block-request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server. The system might include controlling the sequence, timing and construction of block requests, time based indexing, variable block sizing, optimal block partitioning, control of random access point placement, including across multiple presentation versions, dynamically updating presentation data, and/or efficiently presenting live content and time shifting.
摘要翻译：块请求流系统提供了这样的系统的用户体验和带宽效率的改进，通常使用以传统文件服务器（HTTP，FTP等）服务的形式生成数据的摄取系统，其中摄取系统进入内容，并将其准备为由文件服务器提供的文件或数据元素。该系统可以包括控制块请求的序列，时序和结构，基于时间的索引，可变块大小，最佳块分割，随机接入点布置的控制，包括跨多个呈现版本，动态地更新呈现数据，和/或有效地呈现实时内容和时间转移。

65. 发明申请

US20110231569A1 ENHANCED BLOCK-REQUEST STREAMING USING BLOCK PARTITIONING OR REQUEST CONTROLS FOR IMPROVED CLIENT-SIDE HANDLING 有权
标题翻译：使用块分割或请求控制来改善客户端处理的增强块请求流
公开(公告)号：US20110231569A1
公开(公告)日：2011-09-22
申请号：US12887483
申请日：2010-09-21
申请人： Michael G. Luby , Mark Watson , Lorenzo Vicisano , Payam Pakzad , Bin Wang
发明人： Michael G. Luby , Mark Watson , Lorenzo Vicisano , Payam Pakzad , Bin Wang
IPC分类号： G06F15/16
CPC分类号： H04L65/604 , H04L65/4084 , H04L65/602 , H04L65/607 , H04L65/80 , H04N21/23106 , H04N21/23406 , H04N21/234327 , H04N21/235 , H04N21/2401 , H04N21/25808 , H04N21/2662 , H04N21/435 , H04N21/44004 , H04N21/440227 , H04N21/44209 , H04N21/84 , H04N21/8456
摘要： A block-request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server. A client device can be adapted to take advantage of the ingestion process. The client device might be configured to optimize use of resources, given the information available to it from the ingestion system. This may include configurations to determine the sequence, timing and construction of block requests based on monitoring buffer size and rate of change of buffer size, use of variable sized requests, mapping of block requests to underlying transport connections, flexible pipelining of requests, and/or use of whole file requests based on statistical considerations.
摘要翻译：块请求流系统提供了这样的系统的用户体验和带宽效率的改进，通常使用以传统文件服务器（HTTP，FTP等）服务的形式生成数据的摄取系统，其中摄取系统进入内容，并将其准备为由文件服务器提供的文件或数据元素。客户端设备可以适应于摄取过程的优点。考虑到从摄取系统可用的信息，客户端设备可能被配置为优化资源的使用。这可以包括基于监视缓冲区大小和缓冲区大小的改变速率来确定块请求的顺序，时间和结构的配置，使用可变大小的请求，将块请求映射到底层传输连接，请求的灵活流水线化和/ 或基于统计考虑使用整个文件请求。

66. 发明申请

US20110078278A1 METHOD AND SYSTEM AND PROCESSING HTTP REQUESTS 有权
标题翻译：方法和系统和处理HTTP请求
公开(公告)号：US20110078278A1
公开(公告)日：2011-03-31
申请号：US12868891
申请日：2010-08-26
申请人： Jie Cui , Bin Wang , Zhe Xiang , Jian Ming Zhang
发明人： Jie Cui , Bin Wang , Zhe Xiang , Jian Ming Zhang
IPC分类号： G06F15/16
CPC分类号： G06F17/30887 , G06F17/30861 , G06F17/30873 , H04L29/12613 , H04L29/12679 , H04L61/00 , H04L61/15 , H04L61/1511 , H04L61/301 , H04L61/3045 , H04L61/35 , H04L67/02 , H04L67/142 , H04L69/329
摘要： A method and a system for processing an HTTP request. There is provided a method for processing an HTTP request, including: receiving an original HTTP request for accessing an instance of an application; modifying a domain name to be accessed; and sending the new HTTP request to a server of the application so as to access the instance of the application, wherein the domain name to be accessed by the original HTTP request and the new domain name correspond to a same IP address. This avoids various problems such as data confusion, data error, and use inconvenience in the related art occurring when a plurality of service instances of a same application run in a same hypertext transfer protocol session. A system for carrying out the above method is also provided.
摘要翻译：一种用于处理HTTP请求的方法和系统。提供了一种用于处理HTTP请求的方法，包括：接收用于访问应用的实例的原始HTTP请求; 修改要访问的域名; 并将新的HTTP请求发送到应用的服务器，以访问应用的实例，其中由原始HTTP请求访问的域名和新域名对应于相同的IP地址。这避免了在相同应用程序的多个服务实例在相同的超文本传输协议会话中运行时出现的各种问题，例如数据混淆，数据错误和使用相关技术中的不便。还提供了一种用于执行上述方法的系统。

67. 发明申请

US20110070317A1 PYRROLOPYRIDINES AS KINASE INHIBITORS 有权
标题翻译：吡咯啉作为激酶抑制剂
公开(公告)号：US20110070317A1
公开(公告)日：2011-03-24
申请号：US12992468
申请日：2009-05-13
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K33/24 , A61P35/00 , C07D471/04 , A61K31/437 , A61K31/7068 , A61K31/4745 , A61K31/513 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/498 , A61K31/5377 , A61K31/55
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式（I）的化合物可用于抑制CHK1和/或CHK2。公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

68. 发明申请

US20110068488A1 HUMIDIFIER WITH FIELD RECONFIGURABLE BYPASS FEATURE 有权
标题翻译：带现场可重复旁路功能的加湿器
公开(公告)号：US20110068488A1
公开(公告)日：2011-03-24
申请号：US12565706
申请日：2009-09-23
申请人： XinHua Cao , Stephane Joseph Pierre Beland , Bin Wang , Jason Ableitner , Brad Terlson , Evelyne Tremblay , Vincent Boutin
发明人： XinHua Cao , Stephane Joseph Pierre Beland , Bin Wang , Jason Ableitner , Brad Terlson , Evelyne Tremblay , Vincent Boutin
IPC分类号： B01F3/04 , F24F6/02 , F23L13/00
CPC分类号： F24F6/043 , F24F11/0008 , F24F11/30 , F24F2110/20 , Y10S261/15
摘要： A humidifier for adding humidity to an air stream of an HVAC system includes a housing configured to be mounted to a surface of an HVAC duct. A back side of the housing may be positioned adjacent to an opening in the surface of the HVAC duct, and the housing may be configured to hold a humidifier pad in an operating position. The housing may define a first air flow path from a first side of the humidifier pad to the opening in the surface of the HVAC duct when the housing is mounted to the surface of the HVAC duct. The housing may further define a second air flow path from a second side of the humidifier pad to a bypass aperture. At least part of the second air flow path may be defined by a bypass duct member. The bypass duct member may be field-reconfigurable between at least a first position resulting in the bypass aperture being located at a first location, and a second position resulting in the bypass aperture being located at a second location. In some cases, the first and second locations are on the left and right sides, respectively, of the humidifier housing.
摘要翻译：用于向HVAC系统的空气流添加湿度的加湿器包括构造成安装到HVAC管道的表面的壳体。壳体的后侧可以邻近于HVAC管道的表面中的开口定位，并且壳体可以被配置为将加湿器垫保持在操作位置。当壳体安装到HVAC管道的表面时，壳体可以限定从加湿器衬垫的第一侧到HVAC管道的表面中的开口的第一空气流动路径。壳体还可以限定从加湿器垫的第二侧到旁路孔的第二空气流动路径。第二气流路径的至少一部分可以由旁路管道构件限定。旁路管道构件可以在导致旁路孔位于第一位置的至少第一位置和导致旁路孔位于第二位置的第二位置之间进行场重新配置。在一些情况下，第一和第二位置分别位于加湿器壳体的左侧和右侧。

69. 发明申请

US20100189030A1 MULTIPLE ANTENNA MODE CONTROL METHOD BASED ON STATION 有权
标题翻译：基于站点的多天线模式控制方法
公开(公告)号：US20100189030A1
公开(公告)日：2010-07-29
申请号：US12442945
申请日：2007-09-18
申请人： Feng Li , Li Zhang , Bin Wang
发明人： Feng Li , Li Zhang , Bin Wang
IPC分类号： H04W4/00 , H04L1/02
CPC分类号： H04B7/0691 , H04B7/0628 , H04B7/0689 , H04B7/0874
摘要： The present invention provides a multiple antenna mode control method based on Station, including the steps: step 1 the Station reports a multiple antenna mode set or subset supported by the Station to the Access Point; step 2, the Access Point returns a multiple antenna mode set or subset supported by the Access Point to the Station, or returns directly a multiple antenna mode set or subset supported by both the Station and the Access Point to the Station; and step 3, a multiple antenna mode is chosen from a multiple antenna mode set or subset supported by both the Station and the Access Point for communicating between the Station and the Access Point. Thereby, a best transmission quality can be achieved during data transmission, and furthermore, the retransmission times and the error frame rate are reduced, and the network throughput is decreased.
摘要翻译：本发明提供一种基于站的多天线模式控制方法，包括以下步骤：步骤1，台站向接入点报告站点支持的多天线模式集或子集; 步骤2，接入点将接入点支持的多天线模式集或子集返回到站，或直接返回站和接入点支持的多天线模式集或子集到站; 并且步骤3，从站和接入点所支持的多天线模式集或子集中选择多天线模式，以在站和接入点之间进行通信。因此，在数据传输期间可以实现最佳的传输质量，此外，重传次数和错误帧速率降低，网络吞吐量降低。

70. 发明申请

US20100143401A1 VACCINE PREVENTING AND/OR TREATING AUTOIMMUNE DISEASES 审中-公开
标题翻译：疫苗预防和/或治疗自身免疫性疾病
公开(公告)号：US20100143401A1
公开(公告)日：2010-06-10
申请号：US12532643
申请日：2008-03-19
申请人： Bin Wang , Huali Jin , Youmin Kang , Wenjuan Zhang , Yang Yu , Jinyao Li
发明人： Bin Wang , Huali Jin , Youmin Kang , Wenjuan Zhang , Yang Yu , Jinyao Li
IPC分类号： A61K39/00 , A61P37/04 , A61P3/10
CPC分类号： A61K39/0008 , A01K2267/0325 , A61K2039/53 , A61K2039/545
摘要： The present invention discloses a vaccine preventing and/or treating autoimmune diseases. Its active component is: the mixture consisting of a protein antigen causing an autoimmune disease or the epitope polypeptides thereof, and the recombinant eukaryotic vector with the coding genes of an autoantigen or the epitope polypeptides thereof inserted into multiple cloning sites. The autoantigen is insulin, glutamic acid decarboxylase or heat shock protein, myelin oligodendrocyte glycoprotein, two myelin antigens, zona pellucida 3, myoglobulin, type II collagen, thyroglobulin, cell membrane surface antigen, type II colloid antigen, acetylcholine receptor, thyrocyte cell surface antigen, salivary gland duct antigen, thyroglobulin, superantigen, or interphotoreceptor retinoid binding protein. The vaccine can inhibit the proliferation of T cells of immune animals and humans, induce the occurrence of immune suppression, as well as prevent and/or treat autoimmune diseases effectively.
摘要翻译：本发明公开了一种预防和/或治疗自身免疫疾病的疫苗。其活性组分是：由引起自身免疫疾病的蛋白质抗原或其表位多肽组成的混合物和具有插入到多个克隆位点中的自身抗原或其表位多肽的编码基因的重组真核载体。自身抗原是胰岛素，谷氨酸脱羧酶或热休克蛋白，髓鞘少突胶质细胞糖蛋白，两种髓鞘抗原，透明带3，肌球蛋白，II型胶原，甲状腺球蛋白，细胞膜表面抗原，II型胶体抗原，乙酰胆碱受体，甲状腺细胞表面抗原，唾液腺导管抗原，甲状腺球蛋白，超抗原或视网膜受体类视黄醇结合蛋白。疫苗可以抑制免疫动物和人类的T细胞的增殖，诱导免疫抑制的发生，以及有效地预防和/或治疗自身免疫性疾病。

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