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61. 外观设计

USD518857S1 Animated electroluminescent sign 有权
标题翻译：动画电致发光标志
公开(公告)号：USD518857S1
公开(公告)日：2006-04-11
申请号：US29219024
申请日：2004-12-10
申请人： Christopher Miller
设计人： Christopher Miller

62. 发明申请

US20060074128A1 Substituted 2-phenyl benzofurans as estrogenic agents 审中-公开
标题翻译：取代的2-苯基苯并呋喃酮作为雌激素剂
公开(公告)号：US20060074128A1
公开(公告)日：2006-04-06
申请号：US11247361
申请日：2005-10-11
申请人： Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
发明人： Christopher Miller , Michael Collini , David Kaufman , Robert Morris , Robert Singhaus , John Ullrich , Heather Harris , James Keith , Leo Albert , Rayomand Unwalla
IPC分类号： A61K31/343 , C07D307/87
CPC分类号： C07D307/80 , C07D405/06 , C07D413/04
摘要： This invention provides estrogen receptor modulators of formula 1, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式1的雌激素受体调节剂，其具有其中R，R'，A，A'，X，Y和Y如说明书中所定义的结构或其药学上可接受的盐。

63. 发明申请

US20060030612A1 Indazoles useful in treating cardiovascular diseases 失效
标题翻译：吲唑可用于治疗心血管疾病
公开(公告)号：US20060030612A1
公开(公告)日：2006-02-09
申请号：US11194263
申请日：2005-08-01
申请人： Robert Steffan , Edward Matelan , Stephen Bowen , John Ullrich , Jay Wrobel , Edouard Zamaratski , Lars Kruger , Annabel Hedemyr , Aiping Cheng , Tomas Hansson , Rayomand Unwalla , Christopher Miller , Patrik Rhonnstad
发明人： Robert Steffan , Edward Matelan , Stephen Bowen , John Ullrich , Jay Wrobel , Edouard Zamaratski , Lars Kruger , Annabel Hedemyr , Aiping Cheng , Tomas Hansson , Rayomand Unwalla , Christopher Miller , Patrik Rhonnstad
IPC分类号： C07D231/56 , A61K31/4162
CPC分类号： C07D403/04 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D491/10
摘要： This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.
摘要翻译：本发明提供式（I）或（Ia）化合物：其可用于治疗或抑制LXR介导的疾病。

64. 发明申请

US20060010513A1 Oligonucleotide arrays to monitor gene expression and methods for making and using same 审中-公开
标题翻译：用于监测基因表达的寡核苷酸阵列及其制备和使用方法
公开(公告)号：US20060010513A1
公开(公告)日：2006-01-12
申请号：US11128049
申请日：2005-05-11
申请人： Mark Melville , Timothy Charlebois , William Mounts , Louane Hann , Martin Sinacore , Mark Leonard , Eugene Brown , Christopher Miller , Gene Lee
发明人： Mark Melville , Timothy Charlebois , William Mounts , Louane Hann , Martin Sinacore , Mark Leonard , Eugene Brown , Christopher Miller , Gene Lee
IPC分类号： A01H1/00 , C12N15/82
CPC分类号： C07K14/47 , C12Q1/6837 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention.
摘要翻译：本发明提供了能够鉴定涉及通过细胞系诱导特定表型的基因和相关途径的寡核苷酸阵列，例如涉及通过细胞系诱导转基因表达的基因和相关途径。当关于正在研究的细胞系的基因组的信息很少或没有信息时，本发明是特别有用的，因为它提供了用于鉴定已知和先前未被发现的基因的共有序列的方法，以及为所识别的共有序列设计寡核苷酸探针。另外，当该阵列用于确定由细胞系表达转基因的最佳条件时，本发明教导了将阵列中的转基因序列包含寡核苷酸探针的方法。本发明还提供了使用该阵列鉴定涉及诱导特定细胞系表型的基因和相关途径的方法。本发明还提供未被发现的基因的新型多核苷酸（即，未被测序和/或显示由CHO细胞表达的基因）和参与特定细胞表型诱导的新型多核苷酸，例如当在下面生长时增加的存活压力培养条件，转基因表达增加，抗原产生减少等。这些新型多核苷酸分别被称为新的CHO序列和差异CHO序列。本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子提供反义和RNAi分子。本发明还提供使用本发明的多核苷酸的方法。

65. 发明申请

US20060004087A1 Tetracyclic compounds as estrogen ligands 审中-公开
标题翻译：四环化合物作为雌激素配体
公开(公告)号：US20060004087A1
公开(公告)日：2006-01-05
申请号：US11170017
申请日：2005-06-29
申请人： Christopher Miller , Michael Collini , Robert Morris , Robert Singhaus
发明人： Christopher Miller , Michael Collini , Robert Morris , Robert Singhaus
IPC分类号： A61K31/353 , A61K31/343 , C07D493/04
CPC分类号： C07D493/04 , C07D307/77 , C07D307/93
摘要： This invention provides estrogen receptor modulators having the structure: wherein R1, R2, R3, R4, Q, n, R8, R9, R10, and R11 have been defined in the specification; or a pharmaceutically acceptable salt thereof. The invention further provides methods for the preparation and use of the compounds.
摘要翻译：本发明提供具有以下结构的雌激素受体调节剂：其中R 1，R 2，R 3，R 4，，Q，n，R 8，R 9，R 10和R 11已经在规范; 或其药学上可接受的盐。本发明还提供了制备和使用化合物的方法。

66. 发明申请

US20050004464A1 Method and apparatus for forming multiple beams 有权
标题翻译：用于形成多个梁的方法和装置
公开(公告)号：US20050004464A1
公开(公告)日：2005-01-06
申请号：US10800125
申请日：2004-03-12
申请人： Christopher Miller
发明人： Christopher Miller
IPC分类号： H01Q25/00 , A61B8/00
CPC分类号： G01S15/8909 , G01S7/5209 , H01Q25/00
摘要： An apparatus and associated method are disclosed which form a multiple beam forming network using time division multiplexing. Instead of having several parallel sets of beam forming network hardware running at a given sampling clock rate, a simpler, single piece of hardware is run at a faster rate equal to the given sampling clock rate times the number of beams to be formed. Each sample received from each element is time division multiplexed into a bit stream, one for each beam. These time division multiplex element samples are weighted to apply the desired phase shift/time delay per element. Each weighted resultant is delayed in a cascade delay pipeline and then combined with the cascade combiner to form a beam at a given time division instant. This process is repeated for the next set of time division multiplexed samples and weights from each element of the array at a given time to form the next beam. The process is repeated for all beams until the sampling time interval ends.
摘要翻译：公开了一种使用时分复用形成多波束形成网络的装置和相关方法。代替具有以给定采样时钟速率运行的多个并行的波束形成网络硬件集合，以更快的速率运行更简单的单个硬件，该速率等于给定采样时钟速率乘以要形成的波束的数量。从每个元件接收的每个样本被时分复用为比特流，每个波束一个。这些时分多路复用元件样本被加权以应用每个元件所需的相移/时间延迟。每个加权结果在级联延迟流水线中延迟，然后与级联组合器组合以在给定的时分瞬间形成波束。对于在给定时间的阵列的每个元素的下一组时分复用采样和权重重复该过程以形成下一个波束。对于所有光束重复该过程，直到采样时间间隔结束为止。

67. 外观设计

USD485749S1 Dispenser 失效
公开(公告)号：USD485749S1
公开(公告)日：2004-01-27
申请号：US29158028
申请日：2002-03-28
申请人： Issac Zaksenberg , Christopher Miller
设计人： Issac Zaksenberg , Christopher Miller

68. 外观设计

USD478280S1 Dispenser 失效
公开(公告)号：USD478280S1
公开(公告)日：2003-08-12
申请号：US29158021
申请日：2002-03-28
申请人： Christopher Miller , Issac Zaksenberg
设计人： Christopher Miller , Issac Zaksenberg

69. 发明授权

US5012460A RAM head positioning and tracking system 失效
标题翻译： RAM头定位跟踪系统
公开(公告)号：US5012460A
公开(公告)日：1991-04-30
申请号：US739514
申请日：1985-05-31
申请人： Steve S. Popovich , Russell A. Meyer , William J. Stanis , Christopher Miller , Gary R. Mitchell
发明人： Steve S. Popovich , Russell A. Meyer , William J. Stanis , Christopher Miller , Gary R. Mitchell
IPC分类号： G11B7/09 , G11B20/12 , G11B20/14 , G11B21/08 , G11B27/30
CPC分类号： G11B7/09 , G11B20/1217 , G11B20/1403 , G11B21/085 , G11B27/3027 , G11B2020/1282 , G11B2220/20 , G11B2220/2537
摘要： A method and apparatus for positioning and tracking a Random Access Memory (RAM) optical head over an information storage media having a plurality of tracks formed by optically readable deformations ("pits") in the media including, a central controller, a laser diode optical-system carrying head which is movable transversely of the tracks in incremental steps for coarse positioning of the head over a selected band of tracks and a servomechanism which positions the laser's objective lens over a specifically addressed track and maintains it there until another track is addressed. Also discussed is a unique method of generating a tracking error signal as an input to the servomechanism which includes the asynchronous detection of a sector mark and the generation of an independent clocking signal from the synchronous detection of off-track pairs of pits spaced uniformly between other data in the track to produce the tracking error signal.
摘要翻译：一种用于在具有多个轨道的信息存储介质上定位和跟踪随机存取存储器（RAM）光学头的方法和装置，所述多个轨道由介质中的光学可读变形（“凹坑”）形成，包括：中央控制器，激光二极管光学系统承载头可以以递增的步长横向移动，以便在选定的轨道带上粗略地定位头部，以及伺服机构，其将激光器的物镜定位在专门寻址的轨道上，并将其保持在那里，直到另一个轨道被寻址。还讨论了产生跟踪误差信号作为伺服机构的输入的唯一方法，该方法包括扇区标记的异步检测和来自在其它区域之间均匀间隔的偏离轨道对的同步检测的独立时钟信号的产生轨道中的数据产生跟踪误差信号。

70. 外观设计

USD1028180S1 Sewer hose elbow cap 有权
公开(公告)号：USD1028180S1
公开(公告)日：2024-05-21
申请号：US29789197
申请日：2021-09-08
申请人： Jeffrey Robert Russell , Brandon Wayne Blakely , Christopher Miller
设计人： Jeffrey Robert Russell , Brandon Wayne Blakely , Christopher Miller
摘要： FIG. 1 is a top, front, right side perspective view of a sewer hose elbow cap showing our new design;
FIG. 2 is a bottom, rear, left side perspective view thereof;
FIG. 3 is a top plan view thereof;
FIG. 4 is a bottom plan view thereof; and,
FIG. 5 is a right side elevational view thereof, the left side elevational view, front elevational view, and rear elevational view all being a mirror image thereof.

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