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61. 发明授权

US5612022A Pulverulent hair bleach of peroxygen oxidizer and polyoxyethylene/polyoxypropylene copolymer 失效
标题翻译：过氧化氧化剂的粉状漂白剂和聚氧乙烯/聚氧丙烯共聚物
公开(公告)号：US5612022A
公开(公告)日：1997-03-18
申请号：US683104
申请日：1996-07-16
申请人： Caroline Tricaud , Jean-Marie Millequant , Henri Sebag
发明人： Caroline Tricaud , Jean-Marie Millequant , Henri Sebag
IPC分类号： A61K8/00 , A61K8/22 , A61K8/23 , A61K8/25 , A61K8/72 , A61K8/86 , A61K8/90 , A61Q5/08 , A61K7/07 , A61K7/135
CPC分类号： A61K8/90 , A61Q5/08 , A61K2800/31
摘要： A process for preparing a pulverulent, anhydrous hair bleaching composition comprises mixing in a non-solvent medium at room temperature a dry bleaching powder of a peroxygen compound oxidizing agent and at least one anhydrous block and/or random polyoxyethylene/polyoxypropylene copolymer which is liquid and water-soluble at room temperature.
摘要翻译：制备粉状，无水的脱毛组合物的方法包括在室温下在非溶剂介质中混合过氧化合物氧化剂的干漂白粉和至少一种无水块和/或无规聚氧乙烯/聚氧丙烯共聚物，其是液体和在室温下溶于水。

62. 发明授权

US5411742A Compositions for the treatment of acne containing a derivative of salicylic acid and derivatives of salicylic acid 失效
标题翻译：用于治疗含有水杨酸衍生物和水杨酸衍生物的粉刺的组合物
公开(公告)号：US5411742A
公开(公告)日：1995-05-02
申请号：US110174
申请日：1993-08-23
申请人： Henri Sebag , Alain Ribier , Pascal Simon , Laurence Sebillotte
发明人： Henri Sebag , Alain Ribier , Pascal Simon , Laurence Sebillotte
IPC分类号： A61K8/11 , A61K8/00 , A61K8/14 , A61K8/33 , A61K8/34 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/73 , A61K8/92 , A61K31/60 , A61Q19/00 , C07C65/40 , A61K9/127
CPC分类号： A61K8/37 , A61K31/60 , A61K8/14 , A61K8/368 , A61Q19/00 , C07C65/40 , Y10T428/2984
摘要： Composition for the treatment of acne containing a dispersion of vesicles of ionic or non-ionic amphiphilic lipids, the vesicles containing in the lipid phase at least one salicylic acid derivative of formula (I): ##STR1## in which R represents a linear or branched C.sub.11 -C.sub.17 alkyl radical; R'.sub.1, R'.sub.2, R'.sub.3, which are identical or different, represent a C.sub.1 -C.sub.18 alkyl or hydroxyalkyl radical, it being possible for one of the radicals R'.sub.1, R'.sub.2 or R'.sub.3 to be a benzyl radical. The derivative of formula (I) serves both as charged lipid and as anti-acne active ingredient. The derivatives of formula (I) in which, when R represents a C.sub.13 -C.sub.17 alkyl radical, R'.sub.1, R'.sub.2, R'.sub.3, when they are identical, do not represent a hydroxyethyl radical.
摘要翻译：用于治疗含有离子或非离子两亲性脂质的囊泡分散体的粉刺的组合物，所述囊泡在脂质相中含有至少一种式（I）的水杨酸衍生物：其中R表示直链或支链C11-C17烷基; R'1，R'2，R'3相同或不同，表示C1-C18烷基或羟烷基，基团R'1，R'2或R'3之一可能为苄基。式（I）的衍生物既用作带电脂质又用作抗痤疮活性成分。式（I）的衍生物，其中当R表示C13-C17烷基时，R'1，R'2，R'3，当它们相同时，不表示羟乙基。

63. 发明授权

US5362494A Cosmetic, dermo-pharmaceutical or vesicle-containing composition including clycerol-derived compounds 失效
标题翻译：含有甘油衍生化合物的化妆品，皮肤药物或含囊泡的组合物
公开(公告)号：US5362494A
公开(公告)日：1994-11-08
申请号：US910174
申请日：1992-07-14
申请人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
发明人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/64 , A61K8/72 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/97 , A61K8/98 , A61K9/10 , A61K9/107 , A61K9/127 , A61K47/10 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C41/26 , C07C43/11 , C07C43/13 , C07C43/178 , C07C43/23 , C07C69/33 , C07C323/12 , C07D317/22 , A61K7/40
CPC分类号： C07D317/22 , A61K8/14 , A61K8/39 , A61Q19/00 , C07C323/12 , C07C43/11 , C07C43/135 , C07C43/178 , C07C43/23 , C07C69/33 , A61Q1/06 , A61Q17/04 , A61Q19/002 , A61Q19/04 , A61Q19/08 , Y10S514/846 , Y10S514/847 , Y10S514/941 , Y10S514/944 , Y10S516/01 , Y10T428/2984
摘要： ##STR1## Non-ionic amphiphilic, glycerol-derived compounds having formula (I), where R is a radical selected from the group consisting of C
4-28 branched or linear alkenyl or alkyl radicals or mixtures thereof, or is a --CH
2 A grouping in which A is --OR', --SR, (II) where R' is a saturated or unsaturated hydrocarbonated radical and n represents an average statistical value n greater than 1 and equal to or less than 6; and, when R' is a --CH
2 A radical, n is also 2. These compounds are surface-active agents and some may form vesicles.
摘要翻译：（I）（II）具有式（I）的非离子两亲性甘油衍生化合物，其中R是选自C4-28支链或直链烯基或烷基或基团的基团或者是其中A是-OR'，-SR，（II）的-CH 2 A基团，其中R'是饱和或不饱和的烃基，n表示大于1且等于或小于6的平均统计值n ; 当R'是-CH 2 A基团时，n也是2.这些化合物是表面活性剂，一些可以形成囊泡。

64. 发明授权

US5298242A Polyfluoroalkylthiopoly(ethylimidazolium) compounds, preparation process and their use as biocidal agents 失效
标题翻译：多氟烷基硫代聚（乙基咪唑）化合物，其制备方法及其用作杀生物剂
公开(公告)号：US5298242A
公开(公告)日：1994-03-29
申请号：US903023
申请日：1992-06-23
申请人： Guy Vanlerberghe , Eric Bollens , Claude Mahieu , Henri Sebag
发明人： Guy Vanlerberghe , Eric Bollens , Claude Mahieu , Henri Sebag
IPC分类号： A01N43/50 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/20 , A61K8/34 , A61K8/40 , A61K8/46 , A61K8/49 , A61K8/70 , A61K8/89 , A61K8/891 , A61K8/92 , A61K31/415 , A61P17/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q19/00 , C07D233/60 , C07D403/12 , C07D521/00 , C08F226/06 , A61K31/74 , C07D233/00
CPC分类号： C07D249/08 , A01N43/50 , A61K8/70 , A61Q19/00 , A61Q3/00 , A61Q5/00 , A61Q5/006 , C07D231/12 , C07D233/56 , A61Q15/00 , A61Q5/02
摘要： The invention relates to compounds of formula: ##STR1## in which: w is 0, 1 or 2;x is between 2 and 10;y is between 0 and 5;R denotes a methyl, ethyl, hydroxyethyl or benzyl radical;X.crclbar. denotes an inorganic or organic anion; andn is an integer or decimal number between 1 and 15;the [C.sub.5 H.sub.6 N.sub.2 R.sup.+ ] group representing the following structures, taken as a mixture or individually: ##STR2## as well as their use as a biocidal agent or preservative.
摘要翻译：本发明涉及式（I）化合物，其中：w为0,1或2; x在2到10之间; y在0和5之间; R表示甲基，乙基，羟乙基或苄基; X（ - ）表示无机或有机阴离子; n是1到15之间的整数或十进制数; 代表以下结构的[C5H6N2R +]基团作为混合物或单独使用：以及它们作为杀生物剂或防腐剂的用途。

65. 发明授权

US5198470A Lipid compounds derived from sphingosines, process for preparing these and their applications, in particular in cosmetics and in the pharmacy of skin conditions 失效
标题翻译：衍生自鞘氨醇的脂质化合物，其制备方法及其应用，特别是在化妆品和皮肤病症药物中
公开(公告)号：US5198470A
公开(公告)日：1993-03-30
申请号：US904503
申请日：1992-06-25
申请人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
发明人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
IPC分类号： A61K8/14 , A61K8/68 , A61K9/127 , A61K47/18 , A61Q19/00 , C07C271/16
CPC分类号： A61Q5/00 , A61K47/18 , A61K8/14 , A61K8/68 , A61K9/0014 , A61K9/1272 , A61Q19/00 , C07C271/16 , Y10S514/844 , Y10S514/852 , Y10S514/88
摘要： The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use or pharmaceutical use for skin conditions containing this compound.
摘要翻译：本发明涉及式（I）的脂质化合物：其中R 1表示C 11至C 21烷基或烯基，R 2表示直链或支链C 8至C 30烃基，饱和或带有一个或多个烯属不饱和键，以及其制备方法和用于化妆品用途的组合物或含有该化合物的皮肤病症的药物用途。

66. 发明授权

US5182407A Solubilizing and/or dispersant compounds, preparation process and compositions containing them 失效
标题翻译：溶解和/或分散化合物，制备方法和包含它们的组合物
公开(公告)号：US5182407A
公开(公告)日：1993-01-26
申请号：US731441
申请日：1991-07-17
申请人： Henri Sebag
发明人： Henri Sebag
IPC分类号： A61K8/30 , A61K8/00 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/73 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K8/98 , A61K47/20 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/10 , A61Q7/00 , A61Q19/00 , B01F17/00 , B01F17/18 , B01F17/22 , C07C305/06 , C07C309/30 , C07C323/52 , C07C323/60 , C11D1/00 , C11D1/90 , D06P1/649
CPC分类号： C11D1/90 , A61K8/46 , A61Q19/00 , A61Q3/00 , A61Q5/00 , B01F17/0057 , C07C323/60 , A61Q5/006 , A61Q5/02 , A61Q5/065 , A61Q7/00
摘要： The present invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, denote a methyl or ethyl radical;R.sub.3 denotes a methyl, ethyl or hydroxyethyl radical;A denotes a ##STR2## radical or ##STR3## R denotes H or CH.sub.3 ; X denotes Cl.sup.-, BR.sup.-, I.sup.-, CH.sub.3 OSO.sub.3.sup.-, CH.sub.3 SO.sub.3.sup.-, ##STR4## p and q, which are identical or different, denote integers such that 1.ltoreq.p.ltoreq.15, 0.ltoreq.q.ltoreq.13 and 2.ltoreq.p+q.ltoreq.20;n denotes an integer equal to 2 or 3;m denotes 0 or 1, and m+q.noteq.0;as well as the salts from neutralization by bases, their preparation process and their utilization as an additive in compositions for treatment of keratinous materials.
摘要翻译：本发明涉及式（I）化合物：其中：R 1和R 2相同或不同，表示甲基或乙基; R3表示甲基，乙基或羟乙基; A表示基团，或者 R表示H或CH 3; X表示相同或不同的Cl-，BR-，I - ，CH 3 OSO 3 - ，CH 3 SO 3 - ， p和q，表示整数，使得1≤n≤15,0≤q< / = 13和2

67. 发明授权

US5008406A Hemiacetal compounds and the applications thereof 失效
标题翻译：半缩醛化合物及其应用
公开(公告)号：US5008406A
公开(公告)日：1991-04-16
申请号：US340754
申请日：1989-04-20
申请人： Guy Vanlerberghe , Alexandre Zysman , Henri Sebag
发明人： Guy Vanlerberghe , Alexandre Zysman , Henri Sebag
IPC分类号： A61K8/14 , A61K9/127 , A61K47/48 , A61Q19/00 , B01F17/32 , B01J13/02 , C07B41/00 , C07B43/00 , C07C43/04 , C07C43/11 , C07C43/13 , C07C43/178 , C07C43/305 , C07C217/08 , C07C323/12 , C07D319/06 , C07D319/12 , C07D321/08 , C07K16/00
CPC分类号： A61Q19/00 , A61K47/48238 , A61K47/48815 , A61K8/14 , A61K9/1272 , C07C217/08 , C07C323/00 , C07C323/12 , C07C43/11 , C07C43/135 , C07C43/178 , C07D319/12 , C07D321/08 , A61K2800/57 , Y10S424/812 , Y10S530/81 , Y10T428/2984
摘要： The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:--C.sub.2 H.sub.4 O--.sub.rand/or--C.sub.3 H.sub.5 (OH)O--.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.

68. 发明授权

US4963535A Nonirritant cosmetic compositions containing a foaming surfactant and a nonionic surfactant containing two fatty chains 失效
标题翻译：含有发泡表面活性剂的非刺激性化妆品组合物和含有两个脂肪链的非离子表面活性剂
公开(公告)号：US4963535A
公开(公告)日：1990-10-16
申请号：US151462
申请日：1988-02-02
申请人： Henri Sebag , Guy Vanlerberghe
发明人： Henri Sebag , Guy Vanlerberghe
IPC分类号： A61K8/00 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q1/02 , A61Q1/14 , A61Q5/02 , A61Q19/10 , B01F17/42 , C07C41/03 , C07C41/26 , C07C43/13 , C11D1/72
CPC分类号： C11D1/72 , A61K8/39 , A61K8/442 , A61K8/463 , A61K8/604 , A61Q1/14 , A61Q19/10 , A61Q5/02 , A61K2800/596 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/941
摘要： Cosmetic compositions for cleaning hair, the skin or for removing make-up from the face or from the eyes, containing (a) a foaming surface-active agent, (b) an aqueous, hydroalcoholic or oily carrier and (c) a nonfoaming, nonionic product, poorly soluble in water, of general formula (I):R--O--[C.sub.2 H.sub.3 --CH.sub.2 R.sub.1 --O].sub.p [C.sub.2 H.sub.3 O--CH.sub.2 OH].sub.n H (I)in which R denotes a C.sub.8 -C.sub.20 alkyl radical, R.sub.1 denotes a C.sub.7 -C.sub.17 alkyl radical or an alkoxy radical containing from 8 to 20 carbon atoms, R+R.sub.1 containing from 21 to 31 carbon atoms and preferably from 23 to 27, p denotes the exact value of 1 or a statistical mean value of between 1 and 2, and n denotes a statistical mean value of between 2 and 10 and preferably between 2.5 and 7.The presence of the component (c) improves the compatibility of the foaming surface-active agents (a) with the skin and the mucosa.
摘要翻译：包含（a）发泡表面活性剂，（b）含水，水醇或油性载体的化妆品组合物，用于清洁头发，皮肤或从脸部或眼睛中除去化妆品，和（c） RO- [C 2 H 3 -CH 2 R 1 -O] p [C 2 H 3 O-CH 2 OH] n H（I）的非离子产物，其中R表示C8-C20烷基，R1表示C7- C17烷基或含有8至20个碳原子的烷氧基，含有21至31个碳原子，优选23至27的R + R1，p表示1的精确值或1和2之间的统计平均值，并且＆lt; upbar＆n表示2和10之间的统计平均值，优选在2.5和7之间。组分（c）的存在改善了发泡表面活性剂（a）与皮肤和粘膜的相容性。

69. 发明授权

US4940575A 4-hydroxyisoxazole derivatives, method of preparing same, and cosmetic and pharmaceutical compositions containing them 失效
标题翻译： 4-羟基异恶唑衍生物，其制备方法，以及含有它们的化妆品和药物组合物
公开(公告)号：US4940575A
公开(公告)日：1990-07-10
申请号：US371058
申请日：1989-06-26
申请人： Alexandre Zysman , Henri Sebag
发明人： Alexandre Zysman , Henri Sebag
IPC分类号： A61K8/49 , A61K31/42 , A61Q17/04 , C07D261/18
CPC分类号： A61Q17/04 , A61K8/49 , C07D261/18
摘要： 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
摘要翻译：对应于下式的4-羟基异恶唑衍生物：其中：R表示具有1至23个碳原子的直链或支链烷基或羟烷基，具有2至23个碳原子的直链或支链烯基，苯基或苄基，R 1表示OR 2，-NHR 3或-NH-NHR 4，R 2表示氢原子或碳原子数1〜24的烷基，R 3表示氢原子，碳原子数1〜20的烷基原子或基团，其中n为2至3，并且r'和r“相同或不同，表示氢原子或低级烷基，或当形成杂环时，如吗啉，哌啶或哌嗪，R 4表示氢原子或苄基，和式（I）化合物的盐。这些衍生物适用于治疗和美容领域，特别是抵消太阳的有害影响。

70. 发明授权

US4940573A Cationic surface-active compounds 失效
标题翻译：阳离子表面活性化合物
公开(公告)号：US4940573A
公开(公告)日：1990-07-10
申请号：US282321
申请日：1988-12-09
申请人： Henri Sebag , Guy Vanlerberghe
发明人： Henri Sebag , Guy Vanlerberghe
IPC分类号： C11D1/62 , A61K8/00 , A61K8/04 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q5/00 , A61Q5/02 , B01F17/18 , B01F17/42 , C07C67/00 , C07C213/00 , C07C217/04 , C07C217/08 , C07C217/28 , C07C239/00 , C07C239/12 , C07C291/04 , C07C301/00 , C07C303/22 , C07C303/32 , C07C309/13 , C07C309/14 , C07D295/08 , C07D295/088 , C07D295/22 , C08G65/32 , C08G65/329 , C11D1/88 , C11D3/46
CPC分类号： C07D295/088 , A61K8/45 , A61Q1/14 , A61Q19/00 , A61Q19/10 , A61Q5/02 , C07C291/04 , C08G65/329
摘要： Cationic surface-active products of the formula: ##STR1## in which R.sub.1 =C.sub.4 -C.sub.20 aliphatic radical, R.sub.2 =C.sub.4 -C.sub.20 alkyl, alkoxymethyl or alkenyloxy radical, p=1-2.5, n=2-20 and G denotes an amine or amine oxide group, and their salts are disclosed for use principally in cosmetics.

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