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61. 发明授权

US5989271A Flexible tip rheolytic thrombectomy catheter and method of constructing same 失效
标题翻译：柔性尖端溶解性血栓切除术导管及其构建方法
公开(公告)号：US5989271A
公开(公告)日：1999-11-23
申请号：US188631
申请日：1998-11-09
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Cindy M. Setum , Robert C. Dutcher , William J. Drasler
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Cindy M. Setum , Robert C. Dutcher , William J. Drasler
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22045
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. The rheolytic thrombectomy catheter has a first tube with a distal open end and a second tube aligned within the first tube and having a flexible tip assembly. A tapered and flexible tip follows a guidewire within and along tortuous and difficult vasculature paths to the site of thrombus. The flexible tip assembly, includes a soft flexible tip and also includes a hard plastic shell offering structural integrity and rigid alignment between a toroidal loop and an inner body to prevent lever arm distortion and to maintain spray gap alignment for saline jet flow emanating from the toroidal loop. Saline jets dislodge, entrain, and break thrombus into pieces which are evacuated through the dual lumen tube. A construction method is also included for mounting of the toroidal loop within the hard plastic shell and attachment of the soft tapered and flexible tip with sufficient bond strength to function as intended for use.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。所述溶解性血栓切除术导管具有第一管，所述第一管具有远端开口端，所述第二管在所述第一管内对准并且具有柔性末端组件。锥形和柔性的尖端跟随导线，并沿着曲折和困难的脉管系统通向血栓部位。柔性尖端组件包括软柔性尖端并且还包括硬塑料外壳，其在环形环和内部主体之间提供结构完整性和刚性对准，以防止杠杆臂变形并且保持喷射间隙对准用于从环形管发出的盐水喷射流循环。盐水喷射器移动，夹带并将血栓破坏成通过双腔管排出的碎片。还包括用于将环形环安装在硬塑料外壳内的结构方法，以及软的锥形和挠性端部的附着，其具有足够的粘合强度，以达到预期的目的。

62. 发明授权

US5674433A High efficiency microbubble aeration 失效
标题翻译：高效微泡曝气
公开(公告)号：US5674433A
公开(公告)日：1997-10-07
申请号：US519125
申请日：1995-08-24
申请人： Michael J. Semmens , Charles J. Gantzer , Michael J. Bonnette
发明人： Michael J. Semmens , Charles J. Gantzer , Michael J. Bonnette
IPC分类号： B01F3/04
CPC分类号： B01F3/04241 , B01F3/04269 , B01F2003/04319 , Y10S261/75
摘要： An aeration device disperses microbubbles into a liquid and maintains efficient transfer of gas to the liquid. The aeration device uses a number of sealed end, hollow fiber membranes that are hydrophobic and provided with pores in the walls of the tubular fibers that range from about 0.01 to 1.0 microns, so that very small bubbles are formed on the outside surface of the hollow fiber membranes. Gas pressures above the bubble point of the fiber membranes are used, and a cloud of microbubbles is expelled into the liquid as it is forced to flow past the fibers. These microbubbles provide a large surface area for the effective dissolution of gases into the liquid. The length of the hollow fiber membranes is controlled in order to obtain efficient small bubble formation.
摘要翻译：曝气装置将微泡分散在液体中并保持气体有效转移到液体中。曝气装置使用多个密封端的中空纤维膜，其是疏水性的并且在管状纤维的壁中具有范围为约0.01至1.0微米的孔，使得在中空的外表面上形成非常小的气泡纤维膜。使用高于纤维膜泡点的气体压力，并且当其被迫流过纤维时，微泡云被排出到液体中。这些微泡为气体有效溶解到液体中提供了大的表面积。控制中空纤维膜的长度以获得有效的小气泡形成。

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