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    • 62. 发明授权
    • Agitation stabilizer in solid-phase peptide synthesizer
    • 固相肽合成仪中的搅拌稳定剂
    • US5344613A
    • 1994-09-06
    • US9080
    • 1993-01-26
    • Kiyoshi NokiharaRintaro YamamotoMakoto HazamaShin Nakamura
    • Kiyoshi NokiharaRintaro YamamotoMakoto HazamaShin Nakamura
    • B01J19/00B01L99/00C07K1/04C08F2/00C40B40/10C40B60/14C07K5/00
    • B01L99/00B01J19/0046C07K1/045B01J2219/00286B01J2219/00288B01J2219/005B01J2219/0059B01J2219/00596B01J2219/00725C40B40/10C40B60/14
    • In an automated solid-phase peptide synthesizing apparatus comprising at least one reaction vessel containing particulate resin as an insoluble support matrix which anchors elongating peptide chains yielded through coupling-assembly formation of peptide bonds, mixing agitation of reagents, as well as circulation agitation of washing solvents flushing the coupling-associated reaction solutions, introduced in peptide chain-assembly process steps into the reaction vessel, is effected by the bubbling of an inert gas forcibly passed through the reagents or washing solvent via a drainage port of the reaction vessel, in order to promote peptide synthesis. A removable agitation stabilizer is inserted into the reaction vessel as a barrier for inhibiting extra-vessel escape, due to action of the bubbling inert gas, of the reagents as well as the washing solvents, and of the support matrix anchoring the elongating peptide chains. The stabilizer also breaks clumping and coagulative skinning of elongated peptides bound to the support matrix, as effects further consequent of the action of the bubbling inert gas and levitated thereby toward the mouth of the reaction vessel during peptide synthesis. The stabilizer additionally acts as a baffle furthering mixing agitation, to promote dispersive mixing of the peptidyl resin with the reagents and washing solvents during peptide chain assembly; and It also serves to distribute washing solvents evenly along the inner surface of the reaction vessel.
    • 在一种自动化固相肽合成装置中,包括至少一个含有颗粒状树脂作为不溶性支持基质的反应容器,该反应容器通过肽键的偶联 - 组装形成固定延伸的肽链,混合搅拌试剂以及循环搅拌洗涤 将通过肽链组装工艺步骤引入反应容器的偶联相关反应溶液冲洗到反应容器中,通过以反应容器的排水口强制通过试剂或洗涤溶剂的惰性气体起泡 促进肽合成。 将可移除的搅拌稳定剂插入到反应容器中,作为阻止由于起泡惰性气体的作用以及洗涤溶剂和固定伸长肽链的载体基质而导致的外部容器逸出的屏障。 稳定剂还破坏结合到载体基质上的细长肽的结块和凝结性皮肤剥离,其作用是由于气泡惰性气体的作用而进一步引起,并且由此在肽合成期间悬浮于反应容器口中。 稳定剂另外作为进一步混合搅拌的挡板,以促进肽链组装期间肽基树脂与试剂和洗涤溶剂的分散混合; 并且还用于沿着反应容器的内表面均匀分布洗涤溶剂。
    • 69. 发明授权
    • Storage apparatus and storage apparatus power supply failure management method
    • 存储设备和存储设备电源故障管理方法
    • US07581137B2
    • 2009-08-25
    • US11473032
    • 2006-06-23
    • Naoki OkadaHidehiro NagayaShin Nakamura
    • Naoki OkadaHidehiro NagayaShin Nakamura
    • G06F11/00
    • G06F1/30
    • A storage apparatus according to the present invention can store information related to a power supply abnormality after shutting down the principal functions of a data processing board when a power supply abnormality occurs in a data processing board. A power supply controller of a data processing board mounted in the storage apparatus monitors the operational status of DC/DC power supplies mounted to the data processing board, on the basis of detection signals from a voltage detection circuit. When a power supply abnormality is detected, the power supply controller immediately shuts down the operation of all the DC/DC power supplies. Shutting down the DC/DC power supplies also shuts down the principal functionality of the data processing board. Then, after storing information related to the power supply abnormality in memory, the power supply controller shuts down the auxiliary power supply. The information stored in memory can be transmitted to a management apparatus by way of an intermediary apparatus, which is another data processing board or the like.
    • 根据本发明的存储装置可以在数据处理板中发生电源异常时关闭数据处理板的主要功能之后,存储与电源异常有关的信息。 安装在存储装置中的数据处理板的电源控制器基于来自电压检测电路的检测信号来监视安装到数据处理板的DC / DC电源的操作状态。 当检测到电源异常时,电源控制器立即关闭所有DC / DC电源的操作。 关闭DC / DC电源也会关闭数据处理板的主要功能。 然后,在存储器中存储与电源异常有关的信息之后,电源控制器关闭辅助电源。 存储在存储器中的信息可以通过作为另一数据处理板等的中介装置发送到管理装置。