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61. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

62. 发明授权

US06269264B1 Method for measuring impedance in the body 有权
标题翻译：测量身体阻抗的方法
公开(公告)号：US06269264B1
公开(公告)日：2001-07-31
申请号：US09325312
申请日：1999-06-03
申请人： Robert R. Weyant , Jason A. Sholder , Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Said Mortazavi
发明人： Robert R. Weyant , Jason A. Sholder , Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Said Mortazavi
IPC分类号： A61B505
CPC分类号： A61N1/36521
摘要： Methods and apparatus are provided for measuring the impedance of a patient's body. Pulse generating circuitry within a rate-responsive pacemaker is used to generate an impedance measurement signal that is applied to the body of the patient with conventional pacemaker leads. The impedance measurement signal contains a series of multiphasic impedance measurement waveforms, which have no net DC value and zero value after second integration. The impedance measurement signal allows the impedance of the body to be measured without interfering with external cardiac monitoring equipment such as electrocardiogram machines.
摘要翻译：提供了用于测量患者身体阻抗的方法和装置。速率响应起搏器内的脉冲发生电路用于产生用常规起搏器引线施加到患者身体的阻抗测量信号。阻抗测量信号包含一系列多相阻抗测量波形，其在第二次积分后不具有净DC值和零值。阻抗测量信号允许测量身体的阻抗，而不会干扰外部心脏监测设备，如心电图仪。

63. 发明授权

US08175707B1 Enhancement of rate responsive IEGM-based AV/PV and VV delay algorithms 有权
标题翻译：增强基于速率的基于IEGM的AV / PV和VV延迟算法
公开(公告)号：US08175707B1
公开(公告)日：2012-05-08
申请号：US11951928
申请日：2007-12-06
申请人： Connie Wright , Xiaoyi Min , Euljoon Park , Scott Simon
发明人： Connie Wright , Xiaoyi Min , Euljoon Park , Scott Simon
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/3682 , A61N1/3684
摘要： An exemplary method includes delivering a cardiac resynchronization therapy using an atrio-ventricular delay and an interventricular delay, monitoring patient activity, optimizing the atrio-ventricular delay and the interventricular delay for a plurality of patient activity states to generate a plurality of optimal atrio-ventricular delays and a plurality of optimal interventricular delays, storing the optimal atrio-ventricular delays and the optimal interventricular delays in association with corresponding patient activity states, detecting a change in patient activity, adjusting an atrial pacing rate in response to the detected change in patient activity based at least in part on a heart failure status and setting the atrio-ventricular delay and the interventricular delay, in response to the detected change in patient activity, using a stored optimal atrio-ventricular delay that corresponds to the patient activity and a stored optimal interventricular delay that corresponds to the patient activity. Other exemplary technologies are also disclosed.
摘要翻译：示例性方法包括使用心室延迟和心室间延迟来递送心脏再同步治疗，监测患者活动，优化多个患者活动状态的心房延迟和室间延迟以产生多个最佳心房室延迟和多个最佳心室间延迟，存储与相应的患者活动状态相关联的最佳心室延迟和最佳心室延迟，检测患者活动的变化，响应于检测到的患者活动变化来调整心房起搏速率至少部分地基于心力衰竭状态，并且响应于检测到的患者活动的变化来设置心室延迟和室间延迟，使用存储的对应于患者活动的最佳心室延迟和存储的最佳室间延迟对应于pa 活跃。还公开了其它示例性技术。

64. 发明授权

US07844333B1 Pacing therapy for transient ischemia treatment 有权
标题翻译：起搏治疗短暂性脑缺血治疗
公开(公告)号：US07844333B1
公开(公告)日：2010-11-30
申请号：US11736155
申请日：2007-04-17
申请人： Steve Koh , Euljoon Park , Eric Falkenberg
发明人： Steve Koh , Euljoon Park , Eric Falkenberg
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/365
摘要： Embodiments include methods and devices for detecting ischemia in a patient and treating the ischemia with a pacing therapy that increases cardiac efficiency, output, or both, without substantially increasing myocardial oxygen consumption. Such therapy may also be used to mitigate the adverse effects of decreased blood flow to the ischemic tissue by increasing the blood flow an oxygenation thereto.
摘要翻译：实施方案包括用于检测患者局部缺血的方法和装置，并且通过起搏治疗来治疗缺血，其提高心脏效率，输出或两者，而不显着增加心肌耗氧量。这种治疗也可用于通过增加血流对其的氧合来减轻血液流向缺血组织的不利影响。

65. 发明申请

US20100042173A1 SYSTEM AND METHOD FOR EVALUATING AND OPTIMIZING THE CONTRIBUTION OF PARTICULAR HEART CHAMBERS TO THE OVERALL EFFICACY OF CARDIAC PACING THERAPY 审中-公开
标题翻译：用于评估和优化特定心脏瓣膜对心脏瓣膜治疗的总体效果的系统和方法
公开(公告)号：US20100042173A1
公开(公告)日：2010-02-18
申请号：US12603829
申请日：2009-10-22
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/368 , A61N1/08 , A61N1/365
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3688
摘要： Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.
摘要翻译：提供技术来评估和优化特定心室对起搏功效的贡献。简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。起搏器然后根据起搏模式的改变以及起搏功效的任何短暂变化来评估特定心室对起搏功效的贡献。此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

66. 发明授权

US07620448B1 Methods and devices for monitoring myocardial mechanical stability 有权
标题翻译：监测心肌机械稳定性的方法和装置
公开(公告)号：US07620448B1
公开(公告)日：2009-11-17
申请号：US11421915
申请日：2006-06-02
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于基于指示患者心脏对于多个连续节拍的机械功能的信号来监测心肌机械稳定性。某些实施例使用时域技术，而其他实施例使用频域技术来监测心肌机械稳定性。在某些实施例中，使用重复每N次跳动的图案化起搏序列来对患者的心脏进行起搏。在其他实施例中，患者的心脏不需要起搏。本摘要不是对本发明的完整描述或限制本发明的范围。

67. 发明申请

US20090270936A1 IMPLANTABLE MEDICAL DEVICE WITH COORDINATED VENTRICULAR OVERDRIVE AND TRIGGER MODE PACING 审中-公开
标题翻译：具有协调的心脏超声和触发模式的可植入医疗装置
公开(公告)号：US20090270936A1
公开(公告)日：2009-10-29
申请号：US12111876
申请日：2008-04-29
申请人： Michael E. Benser , Euljoon Park
发明人： Michael E. Benser , Euljoon Park
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： A method and system are provided for providing coordinated ventricular overdrive and triggered pacing through an implantable system. A lead senses signals from a heart to obtain sensed signals representative of tachycardia occurring in at least one chamber of the heart. The lead includes an electrode. A control module detects tachycardia in at least one chamber of the heart and based thereon, initiates an overdrive pacing mode and a triggered pacing mode. The control module controls delivery of overdrive pacing pulses through the electrode to a first chamber of the heart in accordance with the overdrive pacing mode. The control module controls delivery of a triggered pacing pulse through the electrode to the first chamber of the heart in accordance with the triggered pacing mode. The triggered pacing pulse is temporally interspersed with the overdrive pacing pulses. The triggered pacing pulse may be delivered at a time that is independent of, and unrelated to, the timing of the overdrive pacing pulses.
摘要翻译：提供了一种方法和系统，用于通过可植入系统提供协调的心室过度驱动和触发起搏。引线感测来自心脏的信号以获得代表在心脏的至少一个腔室中发生的心动过速的感测信号。引线包括电极。控制模块在心脏的至少一个室中检测心动过速，并且基于此，启动过速起搏模式和触发的起搏模式。控制模块根据超速起搏模式控制过驱动起搏脉冲通过电极传递到心脏的第一腔室。控制模块根据触发的起搏模式控制触发的起搏脉冲通过电极传递到心脏的第一腔室。触发起搏脉冲在时间上散布着超速起搏脉冲。触发的起搏脉冲可以在与过速起搏脉冲的定时无关并且不相关的时间被传送。

68. 发明授权

US07596410B1 Tiered antitachycardia pacing and pre-pulsing therapy 有权
标题翻译：分层抗心动过速起搏和预脉冲治疗
公开(公告)号：US07596410B1
公开(公告)日：2009-09-29
申请号：US11413772
申请日：2006-04-28
申请人： Mark W. Kroll , Michael Benser , Euljoon Park
发明人： Mark W. Kroll , Michael Benser , Euljoon Park
IPC分类号： A61N1/368
CPC分类号： A61N1/3962 , A61N1/0563 , A61N1/36071 , A61N1/3622
摘要： An implantable system applies tiered antitachycardia pacing (ATP) that may be combined with pre-pulsing therapy in order to reduce pain. In one implementation, an exemplary system applies a progression of increasingly potent pacing vectors, progressing in an initial tier from small electrodes inside the heart to later tiers that increasingly use a large electrode surface outside the heart. In the latter tiers, a pre-pulse may be added prior to each ATP pulse to reduce the sensation of pain.
摘要翻译：植入式系统应用分层抗心动过速起搏（ATP），可与预脉冲治疗相结合，以减轻疼痛。在一个实施方案中，示例性系统应用越来越有效的起搏向量的进展，在初始层级内从心脏内的小电极进行到越来越多地使用心脏外的大电极表面的后续层级。在后一级，可以在每个ATP脉冲之前加入预脉冲以减少疼痛的感觉。

69. 发明授权

US07460909B1 Implantable device for monitoring hemodynamic profiles 有权
标题翻译：用于监测血液动力学特征的植入式装置
公开(公告)号：US07460909B1
公开(公告)日：2008-12-02
申请号：US11205694
申请日：2005-08-16
申请人： Steve Koh , Euljoon Park
发明人： Steve Koh , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3925 , A61N1/3962
摘要： An exemplary method includes providing a filling pressure parameter, providing a perfusion parameter, determining a hemodynamic profile based at least in part on the filling pressure parameter and the perfusion parameter and adjusting a stimulation parameter of an implantable cardiac therapy device based at least in part on the hemodynamic profile. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括提供填充压力参数，提供灌注参数，至少部分地基于填充压力参数和灌注参数确定血液动力学分布，并且至少部分地基于至少部分地调节可植入心脏治疗装置的刺激参数血流动力学特征。还公开了其它示例性方法，装置，系统等。

70. 发明授权

US07430447B2 Evoked response and impedance measures for monitoring heart failure and respiration 有权
标题翻译：用于监测心力衰竭和呼吸的诱发反应和阻抗措施
公开(公告)号：US07430447B2
公开(公告)日：2008-09-30
申请号：US11149058
申请日：2005-06-06
申请人： Xiaoyi Min , Euljoon Park , Malin Öhlander
发明人： Xiaoyi Min , Euljoon Park , Malin Öhlander
IPC分类号： A61N1/00
CPC分类号： A61B5/0535 , A61B5/0402 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61N1/3601 , A61N1/365 , A61N1/36521 , A61N1/371
摘要： An exemplary method includes acquiring impedance values over one or more respiratory cycles, determining an impedance span based on the impedance values and, based at least in part on the impedance span, determining cardiac condition or respiratory condition. Another exemplary method includes acquiring IEGMs over one or more respiratory cycles, determining evoked response measure values based on the IEGMs, determining an evoked response span based on the evoked response measure values and, based at least in part on the evoked response span, determining cardiac condition or respiratory condition. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括：通过一个或多个呼吸周期获取阻抗值，基于阻抗值确定阻抗跨度，并且至少部分地基于阻抗跨度，确定心脏状况或呼吸状况。另一示例性方法包括通过一个或多个呼吸周期获取IEGM，基于IEGM确定诱发的应答测量值，基于诱发的响应测量值确定诱发的应答跨度，并且至少部分地基于诱发的响应跨度，确定心脏病情或呼吸状况。还公开了其它示例性方法，装置，系统等。

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