专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20100256097A1 INHIBITORS OF JANUS KINASES 有权
公开(公告)号：US20100256097A1
公开(公告)日：2010-10-07
申请号：US12665045
申请日：2008-06-16
申请人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
发明人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号： A61K31/675 , C07D409/14 , A61K31/4439 , A61K31/4436 , C07D413/14 , A61K31/5377 , C07D409/12 , A61K31/501 , C07F9/28 , C07D417/14 , A61K31/541
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

62. 外观设计

USD622434S1 Light fixture 有权
标题翻译：灯具
公开(公告)号：USD622434S1
公开(公告)日：2010-08-24
申请号：US29339188
申请日：2009-06-25
申请人： Patrick Ward , Ben Schilling , Kevin Wilson
设计人： Patrick Ward , Ben Schilling , Kevin Wilson
CPC分类号： F21S8/04 , F21S8/026 , F21S8/033 , F21V5/00 , F21V9/08 , F21V11/00 , F21V21/02 , F21V21/04 , F21W2131/301 , F21Y2115/10

63. 发明申请

US20100193720A1 SOLENOID VALVE 有权
标题翻译：电磁阀
公开(公告)号：US20100193720A1
公开(公告)日：2010-08-05
申请号：US12760970
申请日：2010-04-15
申请人： Brian M. Cripps , Dennis Mudge , Kevin Wilson
发明人： Brian M. Cripps , Dennis Mudge , Kevin Wilson
IPC分类号： F16K31/06 , B23P11/00
CPC分类号： F16K31/0655 , F16K27/003 , Y10T29/49826
摘要： A valve flow-directing vessel (42) comprising a sleeve (44) having a threaded installation portion (84) for connection to a receiving member, a plunger (46) movable within the sleeve (44) between a closed position and an opened position, and an orifice insert (48/50) fixedly attached to the sleeve (44). The orifice insert (48/50) defines an orifice (132) that is sealed when the plunger (46) is in the closed position and unsealed when the plunger (46) is in the opened position. The orifice (132) is the entrance to a passageway (130) having an exit (134) communicating with a delivery passage of the receiving member, and this exit (134) is positioned beyond the threaded installation portion (84) of the sleeve (44).
摘要翻译：一种阀导流容器（42），其包括套筒（44），所述套筒（44）具有用于连接到接收构件的螺纹安装部分（84），在所述套筒（44）内可在闭合位置和打开位置以及固定地附接到套筒（44）的孔口插入件（48/50）。孔口插入件（48/50）限定了当柱塞（46）处于关闭位置时被密封并且当柱塞（46）处于打开位置时被开封的孔口132。孔口（132）是具有与接收构件的输送通道连通的出口（134）的通道（130）的入口，并且该出口（134）位于套筒的螺纹安装部分（84） 44）。

64. 外观设计

USD606228S1 Light fixture 有权
公开(公告)号：USD606228S1
公开(公告)日：2009-12-15
申请号：US29307843
申请日：2008-05-14
申请人： Patrick Ward , Ben Schilling , Kevin Wilson
设计人： Patrick Ward , Ben Schilling , Kevin Wilson

65. 发明申请

US20090268474A1 Adjustable Light Fixture 有权
标题翻译：可调节灯具
公开(公告)号：US20090268474A1
公开(公告)日：2009-10-29
申请号：US12429006
申请日：2009-04-23
申请人： Patrick Ward , Kevin Wilson , Matthew Gates
发明人： Patrick Ward , Kevin Wilson , Matthew Gates
IPC分类号： F21V15/00
CPC分类号： F21V21/30 , F21S8/02 , F21V21/04
摘要： Disclosed is an adjustable light fixture. The light fixture can include a housing assembly comprising an outer housing surrounding a central opening; a first adjustment mechanism configured to tilt the light source comprising a first rotating member; and a second adjustment mechanism configured to rotate the light source comprising a second rotating member, where the first and second rotating members are substantially parallel to one another. The light fixture can also include a biasing member that will return the housing assembly to a first tilted position from a second titled position.
摘要翻译：公开了一种可调节的灯具。灯具可以包括壳体组件，其包括围绕中心开口的外壳; 第一调节机构，其构造成使包括第一旋转构件的光源倾斜; 以及第二调节机构，其被配置为旋转包括第二旋转构件的光源，其中第一和第二旋转构件基本上彼此平行。灯具还可以包括偏置构件，该偏压构件将使壳体组件从第二标题位置返回到第一倾斜位置。

66. 发明申请

US20090105264A1 Substituted Nicotinamide Compounds 审中-公开
标题翻译：取代的烟酰胺化合物
公开(公告)号：US20090105264A1
公开(公告)日：2009-04-23
申请号：US12084272
申请日：2006-10-30
申请人： Christopher Hamblett , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Kevin Wilson
发明人： Christopher Hamblett , Dawn M. Mampreian , Joey L. Methot , Thomas Miller , David L. Sloman , Matthew G. Stanton , Kevin Wilson
IPC分类号： A61K31/496 , C07D401/04 , C07D241/36 , A61P35/00 , C07D409/14 , A61K31/497
CPC分类号： C07D213/56 , C07D239/28 , C07D401/12 , C07D487/08
摘要： The present invention relates to a novel class of substituted nicotinamides. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新型的取代烟酰胺。这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。

67. 发明申请

US20090069250A1 Inhibitors of Histone Deacetylase 有权
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US20090069250A1
公开(公告)日：2009-03-12
申请号：US12224466
申请日：2007-02-23
申请人： Jonathan B. Grimm , Jed L. Hubbs , Thomas Miller , Karin M. Otte , Phieng Siliphaivanh , Matthew G. Stanton , Kevin Wilson , David Witter , Hua Zhou
发明人： Jonathan B. Grimm , Jed L. Hubbs , Thomas Miller , Karin M. Otte , Phieng Siliphaivanh , Matthew G. Stanton , Kevin Wilson , David Witter , Hua Zhou
IPC分类号： A61K38/05 , C07D213/56 , A61K31/4406 , A61K31/381 , C07D333/24 , C07D409/12 , A61K31/397
CPC分类号： C07C237/42 , C07D333/20
摘要： The present invention relates to a novel class of compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and sale dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新颖的化合物。这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统疾病（CNS），例如神经退行性疾病本发明还提供包含本发明化合物和这些药物组合物的销售给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的这些化合物。

68. 发明申请

US20070130673A1 Protective headgear 审中-公开
标题翻译：保护性头饰
公开(公告)号：US20070130673A1
公开(公告)日：2007-06-14
申请号：US11302093
申请日：2005-12-12
申请人： Stan Wasserkrug , Kevin Wilson
发明人： Stan Wasserkrug , Kevin Wilson
IPC分类号： A42B3/00
CPC分类号： A42B3/324 , A42B1/08 , A42B3/003 , A42B3/06 , A42B3/12
摘要： Described is a protective headgear for sports and recreational activities. The protective headgear is designed to provide a user protection against impact or collision due to a fall or contact with a static or moving object, while at the same time providing the user the maximum amount of comfort and style. The headgear may comprise an inner, intermediate, and outer section. The inner section is formed of a material providing ventilation and/or shock absorption, the intermediate section is formed of a hardened material, and the outer section is formed of a fabric material intended to give the headgear an aesthetically pleasing appearance.
摘要翻译：描述的是运动和娱乐活动的保护性头饰。保护性头饰设计用于防止由于与静态或运动物体的跌落或接触而造成的冲击或碰撞，同时为用户提供最大的舒适度和风格。头带可以包括内部，中间和外部部分。内部部分由提供通风和/或减震的材料形成，中间部分由硬化材料形成，外部部分由织物材料形成，以使头饰具有美观的外观。

69. 发明申请

US20060148809A1 Pyridazine derivatives as ligands for gaba receptors 失效
标题翻译：哒嗪衍生物作为gaba受体的配体
公开(公告)号：US20060148809A1
公开(公告)日：2006-07-06
申请号：US10524006
申请日：2003-08-04
申请人： Stephen Fletcher , Angus Macleod , Monique Van Niel , Kevin Wilson
发明人： Stephen Fletcher , Angus Macleod , Monique Van Niel , Kevin Wilson
IPC分类号： C07D403/02 , A61K31/501
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/04 , C07D471/04
摘要： A class of pyridazine derivatives, substituted in the 4-position by an optionally substituted heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
摘要翻译：一类由任选取代的杂芳环在4-位取代的哒嗪衍生物是GABA A受体的选择性配体，特别是对α2和/或α3和/或其α5亚基具有高亲和力，因此有益于治疗和/或预防中枢神经系统的不良状况，包括焦虑，抽搐和认知障碍。

70. 发明申请

US20060059425A1 Method and apparatus for enabling a user to select hierarchically arranged data in a graphical user interface 审中-公开
标题翻译：用于使用户能够在图形用户界面中选择分层排列的数据的方法和装置
公开(公告)号：US20060059425A1
公开(公告)日：2006-03-16
申请号：US10941223
申请日：2004-09-14
申请人： Mark Anspach , Evelyn Williams , Kevin Wilson
发明人： Mark Anspach , Evelyn Williams , Kevin Wilson
IPC分类号： G06F17/00
CPC分类号： G06F3/0482
摘要： A method of selecting options arranged in a hierarchy including a first level and at least one additional level is described. The method includes displaying a hierarchical-selection visual object. A selection action of the hierarchical-selection visual object may cause a display list, containing at least one hierarchy item and possibly selectable items, to be shown. Detecting a pointing action at a hierarchy item may cause a lower level display list to be displayed. Lower level display lists may include selectable items, hierarchy items, or both. Multiple levels of hierarchy may be displayed in this manner. With the display lists shown, a second selection action may cause the selected item to be displayed in an information area of the hierarchical-selection visual object. Other embodiments comprise a computer readable medium having stored thereon computer instructions, and a computer system for executing the computer instructions to perform the method of selecting options.
摘要翻译：描述了选择以包括第一级别和至少一个附加级别的层次结构排列的选项的方法。该方法包括显示分级选择视觉对象。分级选择视觉对象的选择动作可能导致显示包含至少一个层级项目和可能可选项目的显示列表。检测层次结构项目上的指点动作可能导致显示较低级别的显示列表。较低级别的显示列表可以包括可选项目，层级项目或两者。可以以这种方式显示多层次结构。利用所示的显示列表，第二选择动作可以使所选择的项目显示在分层选择视觉对象的信息区域中。其他实施例包括其上存储有计算机指令的计算机可读介质，以及用于执行计算机指令以执行选择选项的方法的计算机系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式