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61. 发明申请

US20090192556A1 SLEEP STAGE DETECTION 有权
标题翻译：睡眠阶段检测
公开(公告)号：US20090192556A1
公开(公告)日：2009-07-30
申请号：US12238105
申请日：2008-09-25
申请人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
发明人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/4812 , A61B5/0031 , A61B5/01 , A61B5/02055 , A61B5/024 , A61B5/04014 , A61B5/04015 , A61B5/0402 , A61B5/0478 , A61B5/048 , A61B5/1116 , A61B5/1118 , A61B5/4082 , A61B5/4839 , A61M5/1723 , A61M21/02 , A61M2005/1726 , A61M2021/0072 , A61M2205/3523 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/36078 , A61N1/36139 , G06F19/3481 , G16H40/63
摘要： Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
摘要翻译：可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化。可以基于睡眠阶段确定来选择或修改治疗程序。根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

62. 发明申请

US20090082691A1 FREQUENCY SELECTIVE MONITORING OF PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：频率选择性监测生理信号
公开(公告)号：US20090082691A1
公开(公告)日：2009-03-26
申请号：US12237868
申请日：2008-09-25
申请人： Timothy J. Denison , Randy M. Jensen , Wesley A. Santa
发明人： Timothy J. Denison , Randy M. Jensen , Wesley A. Santa
IPC分类号： A61B5/04
CPC分类号： A61B5/04004 , A61B5/04018 , A61B5/048 , A61B5/4082 , A61B5/4094
摘要： In general, the disclosure is directed to a frequency selective monitor and methods for monitoring physiological signals in one or more selected frequency bands. A frequency selective monitor may utilize a heterodyning, chopper-stabilized amplifier architecture to convert a selected frequency band to a baseband for analysis. The frequency selective monitor may be useful in a variety of therapeutic and/or diagnostic applications. As examples, a frequency selective signal monitor may be provided within a medical device or within a sensor coupled to a medical device. The physiological signal may be analyzed in one or more selected frequency bands to trigger delivery of patient therapy and/or recording of diagnostic information.
摘要翻译：通常，本发明涉及一种频率选择性监测器和用于监测一个或多个所选频带中的生理信号的方法。频率选择性监视器可以利用外差斩波稳定的放大器架构将所选择的频带转换为基带用于分析。频率选择性监测器可用于各种治疗和/或诊断应用。作为示例，可以在医疗装置内或耦合到医疗装置的传感器内提供频率选择信号监视器。可以在一个或多个所选频带中分析生理信号以触发患者治疗的传递和/或记录诊断信息。

63. 发明申请

US20080180278A1 Chopper-stabilized instrumentation amplifier for wireless telemetry 有权
标题翻译：用于无线遥测的斩波稳定仪表放大器
公开(公告)号：US20080180278A1
公开(公告)日：2008-07-31
申请号：US11700738
申请日：2007-01-31
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： G08C19/16
CPC分类号： H03F3/393 , A61B5/0031 , A61B5/7203 , A61B5/7228 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device. The amplifier may be used for physiological signal sensing, impedance sensing, telemetry or other test and measurement applications.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于低功率系统，例如可植入医疗设备。放大器可用于生理信号感测，阻抗检测，遥测或其他测试和测量应用。

64. 发明授权

US07391257B1 Chopper-stabilized instrumentation amplifier for impedance measurement 有权
标题翻译：用于阻抗测量的斩波稳定仪表放大器
公开(公告)号：US07391257B1
公开(公告)日：2008-06-24
申请号：US11700405
申请日：2007-01-31
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： H03F1/02
CPC分类号： H03F3/387 , A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7217 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定的仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

65. 发明授权

US07078916B2 Linearity enhancement for capacitive sensors 有权
标题翻译：电容式传感器的线性增强
公开(公告)号：US07078916B2
公开(公告)日：2006-07-18
申请号：US10818863
申请日：2004-04-06
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： G01R27/26
CPC分类号： G01P15/131 , G01D5/2417 , G01L1/144 , G01L9/12 , G01P15/125
摘要： A method for enhancing the linearity of a differential capacitive sensor as a function of beam displacement. An ac-modulated feedback connection from a sensor output terminal to a movable beam electrode is provided through a fix-up capacitor. The output terminal signal is inverted in the feedback connection so that the fix-up capacitor reduces the capacitance from the fixed electrodes to the beam electrode. When the fix-up capacitor value is chosen approximately equal to the fixed capacitance of the differential capacitor, the feedback circuit compensates for the effect of this fixed capacitance. The linearity of the output as a function of the displacement of the beam is improved. Thus, the signal-to-noise ratio of devices such as accelerometers may be increased by allowing sensors to employ a large displacement range. The invention may be used in differential accelerometers and in other types of differential capacitive sensors.
摘要翻译：一种用于增强差分电容传感器作为光束位移的函数的线性度的方法。通过固定电容器提供从传感器输出端子到可移动光束电极的交流调制反馈连接。输出端子信号在反馈连接中反转，使得固定电容器将电容从固定电极减小到光束电极。当固定电容值被选择为近似等于差分电容器的固定电容时，反馈电路补偿该固定电容的影响。作为光束位移的函数的输出的线性度得到改善。因此，可以通过允许传感器采用大的位移范围来增加诸如加速度计之类的装置的信噪比。本发明可以用于差分加速度计和其他类型的差动电容式传感器。

66. 发明授权

US06673615B2 Characterization of individual polymer molecules based on monomer-interface interactions 有权
标题翻译：基于单体界面相互作用的单个聚合物分子的表征
公开(公告)号：US06673615B2
公开(公告)日：2004-01-06
申请号：US10079178
申请日：2002-02-20
申请人： Timothy J. Denison , Alexis Sauer , Jene Golovchenko , Amit Meller , Eric Brandin , Daniel Branton
发明人： Timothy J. Denison , Alexis Sauer , Jene Golovchenko , Amit Meller , Eric Brandin , Daniel Branton
IPC分类号： G01N33483
CPC分类号： G01N33/48721 , B82Y15/00 , B82Y30/00 , C07K14/705 , C12N9/1241 , C12Q1/6816 , C12Q1/6827 , C12Q1/6869 , G01N33/68 , Y10S977/795 , Y10S977/88 , Y10S977/953 , Y10S977/957 , Y10S977/958 , C12Q2565/631 , C12Q2523/307 , C12Q2565/607
摘要： The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of a double-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acid polymer in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the single-stranded nucleic acid polymer passes through the channel so as to differentiate between nucleotide monomers that are hybridized to another nucleotide monomer before entering the channel and nucleotide monomers that are not hybridized to another nucleotide monomer before entering the channel.
摘要翻译：本发明涉及一种用于通过（1）在两个池之间提供两个独立的相邻的介质池和界面来检测核酸中的双链区域的方法，所述界面具有如此尺寸以允许顺序单体单链核酸但不是双链核酸的单体通过从一个池到另一个池; （2）将核酸聚合物置于两个池中的一个中; 和（3）测量，因为单链核酸聚合物的每个核苷酸单体通过通道，以便在进入通道之前与另一个核苷酸单体杂交的核苷酸单体与未杂交的核苷酸单体区分进入通道之前的另一种核苷酸单体。

67. 发明授权

US06570432B2 Integrator topology for continuous integration 失效
公开(公告)号：US06570432B2
公开(公告)日：2003-05-27
申请号：US10133682
申请日：2002-04-26
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： G06G719
CPC分类号： G06G7/1865
摘要： Provided are integrator circuit topologies that enable continuous integration without reset of the integrator circuit. One such integrator circuit includes a first integrator and a second integrator, each of the two integrators having a non-inverting terminal. Each of the non-inverting terminals is connected to an input node to alternately receive an input current for continuous integrator circuit integration without integrator circuit reset. The inverting terminal of the second integrator can be connected to an inverting terminal of the first integrator. The non-inverting terminal of the second integrator can be connected to an output of the first integrator through a first capacitor, and an output of the second integrator can be connected to a non-inverting terminal of the first integrator through a second capacitor. With such a capacitor connection, the capacitors alternately charge and discharge, based on integrator input current that is alternately directed between the non-inverting terminals of the integrators.

68. 发明授权

US06380790B1 Integrator topplogy for continuous integration 失效
标题翻译：用于连续集成的积分器地形学
公开(公告)号：US06380790B1
公开(公告)日：2002-04-30
申请号：US09502134
申请日：2000-02-11
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： G06G718
CPC分类号： G06G7/1865
摘要： An apparatus includes a switching circuit, an integrator circuit having an input for receiving a first signal from the switching circuit, a sensing circuit having an input for receiving a second signal from the integrator circuit, and a control circuit having an input for receiving a third signal from the sensing circuit and an output for sending a fourth signal to the switching circuit. In certain applications, the integrator circuit includes a first integrator and a second integrator having an inverting terminal connected to an inverting terminal of the first integrator. The second integrator also includes a non-inverting terminal connected to an output of the first integrator through a first capacitor, and an output connected to a non-inverting terminal of the first integrator through a second capacitor.
摘要翻译：一种装置包括开关电路，具有用于接收来自开关电路的第一信号的输入端的积分器电路，具有用于从积分电路接收第二信号的输入端的感测电路，以及具有用于接收第三信号的输入端的控制电路来自感测电路的信号和用于向切换电路发送第四信号的输出。在某些应用中，积分器电路包括第一积分器和第二积分器，其具有连接到第一积分器的反相端子的反相端子。第二积分器还包括通过第一电容器连接到第一积分器的输出的非反相端子，以及通过第二电容器连接到第一积分器的非反相端的输出端。

69. 发明授权

US06362002B1 Characterization of individual polymer molecules based on monomer-interface interactions 有权
标题翻译：基于单体界面相互作用的单个聚合物分子的表征
公开(公告)号：US06362002B1
公开(公告)日：2002-03-26
申请号：US09457959
申请日：1999-12-09
申请人： Timothy J. Denison , Alexis Sauer , Jene Golovchenko , Amit Meller , Eric Brandin , Daniel Branton
发明人： Timothy J. Denison , Alexis Sauer , Jene Golovchenko , Amit Meller , Eric Brandin , Daniel Branton
IPC分类号： G01N33483
CPC分类号： G01N33/48721 , B82Y15/00 , B82Y30/00 , C07K14/705 , C12N9/1241 , C12Q1/6816 , C12Q1/6827 , C12Q1/6869 , G01N33/68 , Y10S977/795 , Y10S977/88 , Y10S977/953 , Y10S977/957 , Y10S977/958 , C12Q2565/631 , C12Q2523/307 , C12Q2565/607
摘要： The invention relates to a method for detecting a double-stranded region in a nucleic acid by (1) providing two separate, adjacent pools of a medium and a interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage of a single-stranded nucleic acid, but not of a double-stranded nucleic acid, from one pool to the other pool; (2) placing a nucleic acid polymer in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the single-stranded nucleic acid polymer passes through the channel so as to differentiate between nucleotide monomers that are hybridized to another nucleotide monomer before entering the channel and nucleotide monomers that are not hybridized to another nucleotide monomer before entering the channel.
摘要翻译：本发明涉及一种用于通过（1）在两个池之间提供两个独立的相邻的介质池和界面来检测核酸中的双链区域的方法，所述界面具有如此尺寸以允许顺序单体单链核酸但不是双链核酸的单体通过从一个池到另一个池; （2）将核酸聚合物置于两个池中的一个中; 和（3）测量，因为单链核酸聚合物的每个核苷酸单体通过通道，以便在进入通道之前与另一个核苷酸单体杂交的核苷酸单体与未杂交的核苷酸单体区分进入通道之前的另一种核苷酸单体。

70. 发明授权

US09888861B2 Method and apparatus for detecting a biomarker in the presence of electrical stimulation 有权
公开(公告)号：US09888861B2
公开(公告)日：2018-02-13
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/0488 , A61B5/0496
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

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