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61. 发明申请

US20120211763A1 NITRIDE SEMICONDUCTOR SUBSTRATE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：氮化物半导体衬底及其制造方法
公开(公告)号：US20120211763A1
公开(公告)日：2012-08-23
申请号：US13352987
申请日：2012-01-18
申请人： Akira Yoshida , Jun Komiyama , Yoshihisa Abe , Hiroshi Oishi , Kenichi Eriguchi , Shunichi Suzuki
发明人： Akira Yoshida , Jun Komiyama , Yoshihisa Abe , Hiroshi Oishi , Kenichi Eriguchi , Shunichi Suzuki
IPC分类号： H01L29/20 , H01L21/20
CPC分类号： H01L21/0237 , H01L21/02458 , H01L21/02505 , H01L21/0254 , H01L21/0262 , H01L29/2003 , H01L29/7787
摘要： A nitride semiconductor substrate suitable for a normally-off type high breakdown-voltage device and a method of manufacturing the substrate are provided allowing both a higher threshold voltage and improvement in current collapse.In a nitride semiconductor substrate 10 having a substrate 1, a buffer layer 2 formed on one principal plane of the substrate 1, an intermediate layer 3 formed on the buffer layer 2, an electron transport layer 4 formed on the intermediate layer 3, and an electron supply layer 5 formed on the electron transport layer 4, the intermediate layer 3 has a thickness of 200 nm to 1500 nm and a carbon concentration of 5×1016 atoms/cm3 to 1×1018 atoms/cm3 and is of AlxGa1-xN (0.05≦x≦0.24), and the electron transport layer 4 has a thickness of 5 nm to 200 nm and is of AlyGa1-yN (0≦y≦0.04).
摘要翻译：提供了适用于常关型高击穿电压装置的氮化物半导体衬底和制造衬底的方法，其允许更高的阈值电压和电流崩溃的改善。在具有衬底1的氮化物半导体衬底10中，形成在衬底1的一个主平面上的缓冲层2，形成在缓冲层2上的中间层3，形成在中间层3上的电子传输层4和形成在电子输送层4上的电子供给层5，中间层3的厚度为200nm〜1500nm，碳浓度为5×1016原子/ cm3〜1×1018原子/ cm3，为AlxGa1-xN（ 0.05＆nlE; x＆lt; L; 0.24），电子传输层4的厚度为5nm〜200nm，为Al y Ga 1-y N（0＆nl E; y＆nlE; 0.04）。

62. 发明申请

US20110081678A1 METHOD FOR PRODUCING BETA-ALANYL-AMINO ACID OR DERIVATIVE THEREOF 审中-公开
标题翻译：生产β-氨基酸或其衍生物的方法
公开(公告)号：US20110081678A1
公开(公告)日：2011-04-07
申请号：US12943509
申请日：2010-11-10
申请人： Rie Takeshita , Yasuaki Takakura , Shunichi Suzuki , Kenzo Yokozeki
发明人： Rie Takeshita , Yasuaki Takakura , Shunichi Suzuki , Kenzo Yokozeki
IPC分类号： C12P21/02 , C07H21/04 , C12N9/00 , C12N5/10
CPC分类号： C12P21/02 , C07K5/0202 , C12N9/48
摘要： The present invention provides a method for efficiently producing a β-alanyl-amino acid (e.g., carnosine) or derivative thereof. Specifically, it provides a method for producing a β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof, by reacting a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof in the presence of an enzyme or an enzyme-containing product that has an ability to form the β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof from the β-alanyl ester or the β-alanyl amide and the amino acid (e.g., histidine) or derivative thereof. The present invention also provides a protein which is able to catalyze production of a β-alanyl-amino acid or derivative thereof from a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof, and a polynucleotide encoding said protein.
摘要翻译：本发明提供了一种有效生产β-丙氨酰 - 氨基酸（如肌肽）或其衍生物的方法。具体地说，本发明提供了一种通过使β-丙氨酰基酯或一种 - 丙氨酰基酰胺与氨基酸或氨基酸反应生产β-丙氨酰 - 氨基酸（例如， - 丙氨酰 - 组氨酸）或其衍生物的方法其衍生物在酶或含酶产物的存在下具有从丙氨酰酯形成β-淀粉氨基酸（例如，β-丙氨酰 - 组氨酸）或其衍生物的能力，或丙氨酰酰胺和氨基酸（如组氨酸）或其衍生物。本发明还提供一种蛋白质，其能够催化β-氨基丙氨酰 - 氨基酸或其衍生物从β-丙氨酰酯或其 - 氨基酸或其衍生物及其衍生物的产生，以及多核苷酸编码所述蛋白质。

63. 发明授权

US07851610B2 Transporter protein 失效
标题翻译：转运蛋白
公开(公告)号：US07851610B2
公开(公告)日：2010-12-14
申请号：US11946113
申请日：2007-11-28
申请人： Shunichi Suzuki , Kenzo Yokozeki , Peter Henderson
发明人： Shunichi Suzuki , Kenzo Yokozeki , Peter Henderson
IPC分类号： C07K1/00 , C07H21/04 , A61K39/00
CPC分类号： C07K14/195
摘要： A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to uptake hydantoin compounds is obtained by introducing and expressing the novel gene, called mhp, using gene recombination techniques.
摘要翻译：描述了具有转运乙内酰脲化合物的活性的新型蛋白质，以及表达该转运蛋白的重组体。从微型液化酵母菌株AJ3912开始，发现了一种能够转运乙内酰脲化合物的蛋白质的新基因。通过使用基因重组技术引入和表达新的基因，称为mhp，获得具有优异吸收乙内酰脲化合物能力的重组体。

64. 发明申请

US20090253168A1 Novel Transporter Protein 失效
标题翻译：新型运载蛋白
公开(公告)号：US20090253168A1
公开(公告)日：2009-10-08
申请号：US11946113
申请日：2007-11-28
申请人： Shunichi Suzuki , Kenzo Yokozeki , Peter Henderson
发明人： Shunichi Suzuki , Kenzo Yokozeki , Peter Henderson
IPC分类号： C12P21/02 , C12N15/31 , C12N1/21 , C12P13/04
CPC分类号： C07K14/195
摘要： A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to uptake hydantoin compounds is obtained by introducing and expressing the novel gene, called mhp, using gene recombination techniques.
摘要翻译：描述了具有转运乙内酰脲化合物的活性的新型蛋白质，以及表达该转运蛋白的重组体。从微型液化酵母菌株AJ3912开始，发现了一种能够转运乙内酰脲化合物的蛋白质的新基因。通过使用基因重组技术引入和表达新的基因，称为mhp，获得具有优异吸收乙内酰脲化合物能力的重组体。

65. 发明授权

US07368757B2 Compound semiconductor and compound semiconductor device using the same 有权
标题翻译：化合物半导体和使用其的化合物半导体器件
公开(公告)号：US07368757B2
公开(公告)日：2008-05-06
申请号：US11298490
申请日：2005-12-12
申请人： Jun Komiyama , Yoshihisa Abe , Shunichi Suzuki , Hideo Nakanishi
发明人： Jun Komiyama , Yoshihisa Abe , Shunichi Suzuki , Hideo Nakanishi
IPC分类号： H01L31/0312
CPC分类号： H01L29/452 , H01L21/02381 , H01L21/02433 , H01L21/02447 , H01L21/02458 , H01L21/02461 , H01L21/02502 , H01L21/02516 , H01L21/0254 , H01L21/0262 , H01L29/045 , H01L29/1608 , H01L29/2003 , H01L29/267 , H01L33/007
摘要： A back electrode 6 is formed in the back of a Si single crystal substrate 2 of a compound semiconductor in which an n-type 3C-SiC single crystal buffer layer 3 having a thickness of 0.05-2 μm, a carrier concentration of 1016-1021/cm3, a hexagonal InwGaxAl1-w-xN single crystal buffer layer 4 (0≦w
摘要翻译：背面电极6形成在化合物半导体的Si单晶衬底2的背面，其中厚度为0.05-2μm的n型3C-SiC单晶缓冲层3，载流子浓度为10 ^{16×10 21 / cm 3，六方晶系Al x 厚度为0.01-0.5μm的1-wx N单晶缓冲层4（0 <= w <1,0 <= x <1，w + x <1）和n型六方晶系在Al 3 O 3中，单晶层5（0 <= y <1,0 3 <！ - SIPO - >面，并且在六方晶系的表面上形成表面电极7，单晶层5，以提供化合物s 导致少量能量损失并且允许高效率和高击穿电压的半导体器件。}

66. 发明授权

US07361490B2 DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, transformed cell, method of producing protein and method of producing optically active amino acid 失效
标题翻译：编码乙内酰脲的DNA，编码N-氨基甲酰-L-氨基酸水解酶的DNA，重组DNA，转化细胞，产生蛋白质的方法和产生旋光氨基酸的方法
公开(公告)号：US07361490B2
公开(公告)日：2008-04-22
申请号：US11476572
申请日：2006-06-29
申请人： Yasuhiro Takenaka , Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
发明人： Yasuhiro Takenaka , Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
IPC分类号： C12P13/22 , C12P13/04 , C12N9/86
CPC分类号： C12N9/80 , C12N9/86 , C12P13/04 , C12P41/009 , C12Y305/01077 , C12Y305/02002
摘要： The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically active amino acids from a microorganism of the genus Microbacterium having the above ability and by improving gene amplification and transcriptional and translational activities thereby preparing a recombinant wherein the amount of the desired enzymes produced is increased. The hydantoinase gene is, for example, a DNA encoding for a protein having a hydantoinase activity, which has the nucleotide sequence set forth in SEQ ID NO:1 in the Sequence. The N-carbamyl-L-amino acid hydrolase gene is, for example, a DNA encoding for a protein having an N-carbamyl-L-amino acid hydrolase activity, which has the nucleotide sequence set forth in SEQ ID NO:3 in the Sequence.
摘要翻译：本发明提供了一种通过分离涉及将5-取代的乙内酰脲或N-氨基甲酰基氨基酸转化成5-取代的乙内酰脲或N-氨基甲酰基氨基酸的能力的乙内酰脲酶基因和N-氨基甲酰基-L-氨基酸水解酶基因从5-取代的乙内酰脲生产旋光性氨基酸的方法具有上述能力的微杆菌属的微生物的旋光活性氨基酸，通过改善基因扩增和转录和翻译活性，从而制备重组体，其中产生的所需酶的量增加。乙内酰脲酶基因是例如编码具有乙内酰脲酶活性的蛋白质的DNA，其具有序列中SEQ ID NO：1所示的核苷酸序列。 N-氨基甲酰基-L-氨基酸水解酶基因是例如编码具有N-氨基甲酰基-L-氨基酸水解酶活性的蛋白质的DNA，其具有SEQ ID NO：3所示的核苷酸序列序列。

67. 发明申请

US20070292916A1 MUTANT PROTEIN HAVING THE PEPTIDE-SYNTHESIZING ACTIVITY 审中-公开
标题翻译：具有肽合成活性的突变蛋白
公开(公告)号：US20070292916A1
公开(公告)日：2007-12-20
申请号：US11765926
申请日：2007-06-20
申请人： Isao ABE , Rie Takeshita , Seiichi Hara , Sonoko Suzuki , Kenzo Yokozeki , Masakazu Sugiyama , Shunichi Suzuki , Kunihiko Watanabe , Nobuhisa Shimba , Takefumi Nakamura , Uno Tagami , Yuya Kodama , Hiromi Onoye , Reiko Yuuji , Eiichiro Suzuki , Tatsuki Kashiwagi , Ningchun Xu , Yuko Kai
发明人： Isao ABE , Rie Takeshita , Seiichi Hara , Sonoko Suzuki , Kenzo Yokozeki , Masakazu Sugiyama , Shunichi Suzuki , Kunihiko Watanabe , Nobuhisa Shimba , Takefumi Nakamura , Uno Tagami , Yuya Kodama , Hiromi Onoye , Reiko Yuuji , Eiichiro Suzuki , Tatsuki Kashiwagi , Ningchun Xu , Yuko Kai
IPC分类号： C12P21/06 , C12N9/64 , C07H21/04
CPC分类号： C07K14/00 , C07K14/195 , C12N9/93
摘要： The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208
摘要翻译：本发明的目的在于提供优异的肽合成蛋白质和有效生产肽的方法。在下列（I）和（II）所示的至少一种蛋白质存在下，使胺组分和羧基组分反应合成肽。（I）具有包含SEQ ID NO：2的氨基酸序列中的任何突变1至68和突变239至290和324至377的一个或多个突变的氨基酸序列的突变蛋白。（II）具有包含SEQ ID NO：208的氨基酸序列中的任何突变L1至L335和M1至M642的一个或多个突变的氨基酸序列的突变蛋白

68. 发明授权

US07262485B2 Substrate for growing electro-optical single crystal thin film and method of manufacturing the same 失效
标题翻译：用于生长电光单晶薄膜的基板及其制造方法
公开(公告)号：US07262485B2
公开(公告)日：2007-08-28
申请号：US11174610
申请日：2005-07-06
申请人： Yoshihisa Abe , Shunichi Suzuki , Hideo Nakanishi , Jun Komiyama
发明人： Yoshihisa Abe , Shunichi Suzuki , Hideo Nakanishi , Jun Komiyama
IPC分类号： H01L29/30 , H01L29/04 , H01L31/036
CPC分类号： G02F1/03
摘要： A substrate 1 for growing an electro-optical single crystal thin film in which two or more layers of buffer layers 3, 4, and 5 for buffering lattice mismatch between Si and BTO are formed on an Si (001) substrate 2 is provided as a substrate for growing an electro-optical single crystal thin film which can obtain an electro-optical single crystal thin film of BTO single crystal thin film 6 etc. with a large size and a very high quality.
摘要翻译：在Si（001）基板2上形成用于生长用于缓冲Si和BTO之间的晶格失配的两层或多层缓冲层3,4和5的电光单晶薄膜的衬底1，作为用于生长可以获得具有大尺寸和非常高质量的BTO单晶薄膜6等的电光单晶薄膜的电光单晶薄膜的基板。

69. 发明申请

US20060246553A1 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids 失效
公开(公告)号：US20060246553A1
公开(公告)日：2006-11-02
申请号：US11484680
申请日：2006-07-12
申请人： Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
发明人： Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
IPC分类号： C12P13/22
CPC分类号： C12P13/22 , C12N9/90 , C12P41/009
摘要： The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the racemase, and processes for producing optically active amino acids.

70. 发明授权

US07112431B2 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids 失效
公开(公告)号：US07112431B2
公开(公告)日：2006-09-26
申请号：US10863245
申请日：2004-06-09
申请人： Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
发明人： Shunichi Suzuki , Norimasa Onishi , Kenzo Yokozeki
IPC分类号： C12N9/90 , C12P41/00
CPC分类号： C12P13/22 , C12N9/90 , C12P41/009
摘要： The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the racemase, and processes for producing optically active amino acids.

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