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61. 发明授权

US07700618B2 Sulfonyl benzimidazole derivatives 失效
标题翻译：磺酰基苯并咪唑衍生物
公开(公告)号：US07700618B2
公开(公告)日：2010-04-20
申请号：US12280586
申请日：2007-02-23
申请人： Tomoki Kato , Kana Kon-I , Yohei Yuki , Kazuo Ando
发明人： Tomoki Kato , Kana Kon-I , Yohei Yuki , Kazuo Ando
IPC分类号： A61K31/437 , A61K31/4184 , C07D471/04 , C07D235/08
CPC分类号： C07D235/08 , C07D235/12 , C07D405/12 , C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, m and n are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, COPD, cryptogenic fibrosing alveolitis and bronchitis.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3，R 4，R 5，m和n各自如本文所述，和含有这些化合物的组合物，治疗由CB2受体活性介导的病症，例如但不限于炎症性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛，神经病，神经痛，糖尿病性神经病，HIV相关神经病，神经损伤，类风湿关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，咳嗽，支气管收缩，肠易激综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，呕吐如癌症化疗诱发的呕吐，类风湿性关节炎，哮喘，克罗恩病溃疡性结肠炎，哮喘，皮炎，季节性过敏性鼻炎，GERD，便秘，腹泻，功能性胃肠道疾病，肠易激综合征，皮肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球性肾炎，肾缺血，肾炎，肝炎，脑中风，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合征，COPD，隐源性纤维化肺泡炎和支气管炎。

62. 发明申请

US20090137584A1 SULFONYL BENZIMIDAZOLE DERIVATIVES 失效
标题翻译：磺酰苯并咪唑衍生物
公开(公告)号：US20090137584A1
公开(公告)日：2009-05-28
申请号：US12280586
申请日：2007-02-23
申请人： Tomoki Kato , Kana Kon-I , Yohei Yuki , Kazuo Ando
发明人： Tomoki Kato , Kana Kon-I , Yohei Yuki , Kazuo Ando
IPC分类号： A61K31/5377 , C07D235/08 , C07D413/12 , A61P25/00 , A61K31/4184
CPC分类号： C07D235/08 , C07D235/12 , C07D405/12 , C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, m and n are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, COPD, cryptogenic fibrosing alveolitis and bronchitis.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3，R 4，R 5，m和n各自如本文所述，和含有这些化合物的组合物，治疗由CB2受体活性介导的病症，例如但不限于炎症性疼痛，伤害性疼痛，神经性疼痛，纤维肌痛，慢性腰痛，内脏痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，疱疹后神经痛，神经病，神经痛，糖尿病性神经病，HIV相关神经病，神经损伤，类风湿关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经变性疾病，咳嗽，支气管收缩，肠易激综合征（IBS），炎性肠病（IBD），结肠炎，脑血管缺血，呕吐如癌症化疗诱发的呕吐，类风湿性关节炎，哮喘，克罗恩病溃疡性结肠炎，哮喘，皮炎，季节性过敏性鼻炎，GERD，便秘，腹泻，功能性胃肠道疾病，肠易激综合征，皮肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球性肾炎，肾缺血，肾炎，肝炎，脑中风，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合征，COPD，隐源性纤维化肺泡炎和支气管炎。

63. 发明申请

US20080293767A1 1-Isopropyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide Derivatives Having 5-Ht4 Receptor Agonistic Activity 失效
标题翻译：具有5-Ht4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
公开(公告)号：US20080293767A1
公开(公告)日：2008-11-27
申请号：US10597480
申请日：2005-01-18
申请人： Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
发明人： Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
IPC分类号： A61K31/4545 , A61P3/00 , A61P25/00 , A61P1/00 , A61P9/00 , C07D405/14 , C07D401/12
CPC分类号： C07D401/12 , C07D405/14
摘要： This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
摘要翻译：本发明提供式（I）化合物：其中R 1表示具有1至4个碳原子的烷基或卤原子，R 2表示具有1至4个碳原子的烷基，R 3表示氢原子或羟基基团，A表示氧原子或式-C（R4）（R5） - （其中R4表示氢原子或具有1至4个碳原子的烷基，R5表示羟基或式具有1至4个碳原子的烷氧基）或其药学上可接受的盐。这些化合物具有5-HT 4受体激动活性，因此可用于治疗哺乳动物特别是人类的胃食管反流病，非溃疡性消化不良，功能性消化不良，肠易激综合征等。

64. 发明申请

US20080269211A1 Indazole Derivatives 失效
标题翻译：吲唑衍生物
公开(公告)号：US20080269211A1
公开(公告)日：2008-10-30
申请号：US11995179
申请日：2006-07-14
申请人： Asako Ishibashi , Tomoki Kato , Kiyoshi Kawamura , Sachiko Mihara , Mikio Morita
发明人： Asako Ishibashi , Tomoki Kato , Kiyoshi Kawamura , Sachiko Mihara , Mikio Morita
IPC分类号： A61K31/416 , A61P1/00 , A61P25/00 , A61P9/00 , C07D401/12 , C07D405/14 , A61K31/5377 , C07D403/12 , C07D413/14 , C07D401/14 , A61K31/454
CPC分类号： C07D401/12 , C07D403/12 , C07D405/14
摘要： This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， A和m各自如本文所述，含有这些化合物的组合物和这些化合物在治疗由5-HT 4激动剂活性介导的病症中的用途，例如但不限于胃食管反流疾病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默氏病，认知障碍，呕吐，偏头痛，神经疾病，疼痛，心血管疾病，心力衰竭，心律失常，糖尿病和呼吸暂停综合征。

65. 发明授权

US10276637B2 Organic EL multi-color light-emitting device 有权
公开(公告)号：US10276637B2
公开(公告)日：2019-04-30
申请号：US14114880
申请日：2012-05-09
申请人： Toshiki Matsumoto , Tadahiko Yoshinaga , Tomoki Kato , Tetsuya Inoue , Mitsunori Ito , Kei Yoshida , Kiyoshi Ikeda , Mitsuru Eida
发明人： Toshiki Matsumoto , Tadahiko Yoshinaga , Tomoki Kato , Tetsuya Inoue , Mitsunori Ito , Kei Yoshida , Kiyoshi Ikeda , Mitsuru Eida
IPC分类号： H01L27/32 , H01L51/00 , C09K11/06 , H05B33/10 , H01L51/50
摘要： An organic EL multi-color emitting device including a substrate, and a first light-emitting element and a second light-emitting element arranged on the surface of the substrate; the first light-emitting element including, between an anode and a cathode, a first organic layer, a second organic layer and a third organic layer in this sequence in a direction perpendicular to the surface of the substrate; the second light-emitting element including, between an anode and a cathode, a second organic layer and a third organic layer in this sequence in a direction perpendicular to the surface of the substrate; the first organic layer including a first light-emitting dopant; the third organic layer including a second light-emitting dopant; the second organic layer including any of (A) a compound including an arylamine site, and a furan site or a thiophene site, (B) a compound including an arylamine site and a site comprising a nitrogen-containing six-membered ring structure, (C) a compound including a carbazole site, and a furan site or a thiophene site, and (D) a compound including a carbazole site and a site including a nitrogen-containing six-membered ring structure.

66. 发明授权

US09564595B2 Bis-carbazole derivative and organic electroluminescent element using same 有权
标题翻译：双咔唑衍生物和使用其的有机电致发光元件
公开(公告)号：US09564595B2
公开(公告)日：2017-02-07
申请号：US14006514
申请日：2012-03-21
申请人： Tomoki Kato , Nobuhiro Yabunouchi , Takahiro Fujiyama
发明人： Tomoki Kato , Nobuhiro Yabunouchi , Takahiro Fujiyama
IPC分类号： H01L51/54 , C09K11/06 , H01L51/00 , C07D209/86 , C07D209/88 , H01L51/50
CPC分类号： H01L51/0052 , C07D209/86 , C07D209/88 , H01L51/0072 , H01L51/0085 , H01L51/0086 , H01L51/0087 , H01L51/0088 , H01L51/5016
摘要： A biscarbazole derivative represented by formula (1): wherein A1, A2, L1, L2, R1 to R4, and a to d are as defined in the specification, is useful as a material for forming organic EL devices and the organic EL devices including the derivative is capable of driving at a low voltage and has a long lifetime.
摘要翻译：由式（1）表示的双咔唑衍生物：其中A 1，A 2，L 1，L 2，R 1至R 4和a至d如说明书中所定义，可用作形成有机EL器件的材料并且包括该衍生物的有机EL器件能够在低电压下驱动并且具有长的寿命。

67. 发明授权

US09527814B2 Aromatic amine derivative, organic device material and hole-injection/transport material and organic electroluminescent element material each comprising the derivative, and organic electroluminescent element 有权
标题翻译：芳族胺衍生物，有机器件材料和空穴注入/输送材料和各自包含衍生物的有机电致发光元件材料和有机电致发光元件
公开(公告)号：US09527814B2
公开(公告)日：2016-12-27
申请号：US13496400
申请日：2011-02-15
申请人： Tomoki Kato , Mitsuru Eida , Masami Watanabe , Akinori Yomogita , Takushi Shiomi
发明人： Tomoki Kato , Mitsuru Eida , Masami Watanabe , Akinori Yomogita , Takushi Shiomi
IPC分类号： H01L51/50 , C07D209/86 , C07D307/91 , C07D407/14 , C09K11/06 , H01L51/00 , H05B33/14
CPC分类号： C07D209/86 , C07D307/91 , C07D407/14 , C09K11/06 , C09K2211/1029 , H01L51/0072 , H01L51/5012 , H01L51/5048 , H05B33/14
摘要： An aromatic amine derivative represented by the following formula (1), wherein L is a linking group, Z is a group represented by the following formula (2) and A1 and A2 are independently a monovalent group represented by the following formula (3):
摘要翻译：由下式（1）表示的芳香族胺衍生物，其中L为连接基团，Z为下式（2）表示的基团，A1和A2分别为下式（3）表示的一价基团：

68. 发明授权

US09260390B2 Aromatic amine derivatives and organic electroluminescent elements using same 有权
标题翻译：芳族胺衍生物和使用其的有机电致发光元件
公开(公告)号：US09260390B2
公开(公告)日：2016-02-16
申请号：US13399412
申请日：2012-02-17
申请人： Tomoki Kato
发明人： Tomoki Kato
IPC分类号： H01L51/54 , C07D405/12 , C07D403/12 , C07D409/12 , C07D209/86 , C07D307/91 , C07D333/76 , C09K11/06 , H01L51/00 , H05B33/14 , H01L51/50
CPC分类号： H01L51/006 , C07D209/86 , C07D307/91 , C07D333/76 , C07D405/12 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1022 , C09K2211/1029 , C09K2211/1088 , H01L51/0052 , H01L51/0058 , H01L51/0061 , H01L51/0072 , H01L51/0073 , H01L51/5012 , H01L51/5056 , H01L51/5072 , H01L51/5088 , H05B33/14
摘要： Provided are an organic EL device material that reduce the driving voltage of an organic EL device and increase the lifetime of the device as compared with a conventional organic EL device material. Also provided are organic electroluminescence devices containing the organic EL device material.
摘要翻译：提供了一种有机EL器件材料，其与传统的有机EL器件材料相比降低了有机EL器件的驱动电压并增加了器件的寿命。还提供了含有有机EL器件材料的有机电致发光器件。

69. 发明授权

US09184395B2 Aromatic amine derivative and organic electroluminescent element using same 有权
标题翻译：芳香族胺衍生物和使用其的有机电致发光元件
公开(公告)号：US09184395B2
公开(公告)日：2015-11-10
申请号：US13979075
申请日：2012-01-13
申请人： Tomoki Kato , Nobuhiro Yabunouchi , Takahiro Fujiyama
发明人： Tomoki Kato , Nobuhiro Yabunouchi , Takahiro Fujiyama
IPC分类号： H01L51/50 , H01L51/00 , C07C211/61 , C09K11/06 , G03G5/06 , H05B33/10 , C09B57/00
CPC分类号： H01L51/006 , C07C211/61 , C07C2603/18 , C07C2603/26 , C07C2603/94 , C09B57/00 , C09B57/008 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , G03G5/0614 , H01L51/5012 , H01L51/5056 , H05B33/10
摘要： To provide an organic EL element material that is capable of enhancing the light emission efficiency and the lifetime of the element as compared to an ordinary organic EL element material, and an organic EL element using the same. Specifically, to provide an aromatic amine derivative represented by Ar1Ar2Ar3N, and an organic EL element using the same. Representative compounds include the following.
摘要翻译：提供一种与普通有机EL元件材料相比能够提高元件的发光效率和使用寿命的有机EL元件以及使用其的有机EL元件。具体地，提供由Ar 1 Ar 2 Ar 3 N表示的芳族胺衍生物和使用其的有机EL元件。代表性化合物包括以下。

70. 发明授权

US09145363B2 Aromatic amine derivative and organic electroluminescent element 有权
标题翻译：芳香胺衍生物和有机电致发光元件
公开(公告)号：US09145363B2
公开(公告)日：2015-09-29
申请号：US13201785
申请日：2010-02-16
申请人： Nobuhiro Yabunouchi , Tomoki Kato
发明人： Nobuhiro Yabunouchi , Tomoki Kato
IPC分类号： H01L51/50 , C07D209/86 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , H01L51/00
CPC分类号： C07D209/86 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , H01L51/006 , H01L51/0061 , H01L51/0081 , H01L51/5048 , H01L51/5088
摘要： Provided are a long-lifetime organic electroluminescence device which can be fabricated in an improved yield owing to suppressed crystallization of molecules, and an aromatic amine derivative that realizes the device, i.e., a novel aromatic amine derivative having a specific structure. Specifically provided are an organic electroluminescence device, including an organic thin film layer formed of one or more layers including at least a light emitting layer, the organic thin film layer being interposed between a cathode and an anode, and an aromatic amine derivative for at least one layer of the organic thin film layer, in particular, a hole transporting layer, the derivative having at least one such structure that a substituent in which two or more specific heterocycles are linked to each other, in particular, a substituent in which two or more specific heterocycles are linked through an aryl group is bonded to an amine through an aryl group.
摘要翻译：提供一种长寿命有机电致发光器件，其由于分子的抑制结晶而能够以提高的产率制造，以及实现该器件的芳族胺衍生物，即具有特定结构的新颖芳族胺衍生物。具体地提供了一种有机电致发光器件，其包括由至少包括发光层的一层或多层形成的有机薄膜层，有机薄膜层介于阴极和阳极之间，并且至少有芳族胺衍生物有机薄膜层的一层，特别是空穴传输层，该衍生物具有至少一个这样的结构，即其中两个或多个特定杂环彼此连接的取代基，特别是其中两个或多个通过芳基连接的更具体的杂环通过芳基键合到胺上。

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