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    • 62. 发明授权
    • Flow control technique for assay devices
    • 测定装置的流量控制技术
    • US08124421B2
    • 2012-02-28
    • US12968366
    • 2010-12-15
    • Shawn Ray FeasterKaiyuan Yang
    • Shawn Ray FeasterKaiyuan Yang
    • G01N33/543G01N33/00C08B1/00
    • G01N33/558G01N33/52
    • A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
    • 提供了一种用于控制采用膜的测定装置中的流体流动的方法。 具体地,通过对膜进行溶剂处理,在膜中形成一个或多个凹陷区域。 基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。 例如,醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。 在与溶剂处理接触时,形成可以用于与流量控制有关的各种不同功能的凹陷区域。 在一个具体实施方案中,凹陷区域可用作计量通道,其能够在测定开始时将受控体积的测试样品递送到检测区域。
    • 68. 发明申请
    • Flow control technique for assay devices
    • 测定装置的流量控制技术
    • US20060246597A1
    • 2006-11-02
    • US11119394
    • 2005-04-29
    • Shawn FeasterKaiyuan Yang
    • Shawn FeasterKaiyuan Yang
    • G01N31/22
    • G01N33/558G01N33/52
    • A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
    • 提供了一种用于控制采用膜的测定装置中的流体流动的方法。 具体地,通过对膜进行溶剂处理,在膜中形成一个或多个凹陷区域。 基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。 例如,醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。 在与溶剂处理接触时,形成可以用于与流量控制有关的各种不同功能的凹陷区域。 在一个具体实施方案中,凹陷区域可用作计量通道,其能够在测定开始时将受控体积的测试样品递送到检测区域。