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61. 发明申请

US20120220612A1 PHARMACEUTICAL COMPRISING PPAR AGONIST 审中-公开
标题翻译：药物包装PPAR激动剂
公开(公告)号：US20120220612A1
公开(公告)日：2012-08-30
申请号：US13406990
申请日：2012-02-28
申请人： Yoshikuni NAKAMURA , Ikuko Hanano , Jun Inoue
发明人： Yoshikuni NAKAMURA , Ikuko Hanano , Jun Inoue
IPC分类号： A61K31/505 , A61K31/216 , A61K31/426 , A61P27/02
CPC分类号： C07D239/47 , A61K31/216 , A61K31/426 , A61K31/505 , C07D277/26
摘要： An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.
摘要翻译：本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂，含有PPARα或δ激动剂作为活性成分。

62. 发明授权

US08052225B2 Bicycle wheel securing structure 有权
标题翻译：自行车轮固定结构
公开(公告)号：US08052225B2
公开(公告)日：2011-11-08
申请号：US12968468
申请日：2010-12-15
申请人： Jun Inoue , Takanori Kanehisa
发明人： Jun Inoue , Takanori Kanehisa
IPC分类号： B60B27/00
CPC分类号： B62K25/02 , B62K23/06 , B62K2206/00 , B62M25/04
摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.
摘要翻译：自行车车轮固定结构包括自行车叉，适配器和保持构件。自行车叉具有间隔开的用于在其间接纳自行车轮毂的两个轴支撑部分。适配器设置在一个轴支撑部分中的适配器接收孔中。适配器包括一个螺纹轴安装孔。保持构件通过适配器可操作地联接在适配器和轴支撑部分中的一个之间。当保持构件处于保持位置时，保持构件防止适配器相对于自行车叉的旋转运动和适配器相对于自行车叉沿着轴安装开口的轴线的轴向运动。当保持构件处于释放位置时，适配器可在适配器容纳孔内旋转，而不相对于自行车叉轴向移动。

63. 发明授权

US08042881B2 Bicycle wheel securing structure 有权
公开(公告)号：US08042881B2
公开(公告)日：2011-10-25
申请号：US12268469
申请日：2008-11-11
申请人： Jun Inoue , Takanori Kanehisa
发明人： Jun Inoue , Takanori Kanehisa
IPC分类号： B60B27/00
CPC分类号： B62K25/02 , B62K23/06 , B62K2206/00 , B62M25/04
摘要： A bicycle wheel securing structure includes a bicycle fork, an adapter and a holding member. The bicycle fork has two axle support portions that are spaced apart for receiving a bicycle hub therebetween. The adapter is disposed in an adapter receiving bore in one of the axle support portions. The adapter includes a threaded axle mounting opening. The holding member is operatively coupled between the adapter and the one of the axle support portions with the adapter. The holding member prevents both rotational movement of the adapter with respect to the bicycle fork and axial movement of the adapter with respect to the bicycle fork along an axis of the axle mounting opening when the holding member is in a retaining position. The adapter is rotatable within the adapter receiving bore without moving axially with respect to the bicycle fork when the holding member is in a releasing position.

64. 发明申请

US20100105868A1 METHOD FOR DETECTING NEUROBLASTOMA 有权
标题翻译：检测神经元的方法
公开(公告)号：US20100105868A1
公开(公告)日：2010-04-29
申请号：US12568569
申请日：2009-09-28
申请人： Johji Inazawa , Issei Imoto , Jun Inoue
发明人： Johji Inazawa , Issei Imoto , Jun Inoue
IPC分类号： C07K14/435 , C12Q1/68 , C12N5/02 , C07H21/04
CPC分类号： G01N33/57407 , A61K38/00 , C12Q1/6886 , C12Q2600/154
摘要： The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.
摘要翻译：本发明旨在提供一种判断神经母细胞瘤的恶性程度及其自发消退的方法。本发明提供一种检测癌症的方法，其包括检测样品中溶酶体相关蛋白多能跨膜5（LAPTM5）基因的活化或失活以及MYCN基因的扩增，以评估标本的恶性程度和自发回归的进展。

65. 发明申请

US20090237652A1 APPARATUS FOR INSPECTING DEFECTS OF HONEYCOMB STRUCTURE 有权
标题翻译：检测蜂窝结构缺陷的装置
公开(公告)号：US20090237652A1
公开(公告)日：2009-09-24
申请号：US12403599
申请日：2009-03-13
申请人： Takayoshi Akao , Hiroyuki Shindo , Jun Inoue , Keita Oikawa
发明人： Takayoshi Akao , Hiroyuki Shindo , Jun Inoue , Keita Oikawa
IPC分类号： G01N21/88
CPC分类号： G01N21/95692 , G01N15/088 , G01N21/47 , G01N2015/0846
摘要： According to an apparatus for inspecting defects of a honeycomb structure that is provided with a current plate and an air current formation means (air source and a header tube), fine defects or defects taking place in the vicinity of an outer periphery of the honeycomb structure can be detected with high sensitivity.
摘要翻译：根据用于检查设置有电流板和气流形成装置（空气源和集管）的蜂窝结构体的缺陷的装置，在蜂窝结构体的外周附近发生细小的缺陷或缺陷可以高灵敏度地检测。

66. 发明授权

US07586522B2 Image processing device 失效
公开(公告)号：US07586522B2
公开(公告)日：2009-09-08
申请号：US11704467
申请日：2007-02-09
申请人： Jun Inoue , Osamu Inagaki , Shinichi Nakajima , Hiroki Shibasaki
发明人： Jun Inoue , Osamu Inagaki , Shinichi Nakajima , Hiroki Shibasaki
IPC分类号： H04N5/228 , H04N9/09 , H04N5/225
CPC分类号： H04N7/066 , H04N5/217 , H04N5/772 , H04N9/7973 , H04N9/8042
摘要： In short, the image processing device for obtaining a single image by using a plurality of image-pickup elements comprises a plurality of image-pickup signal processing circuits that are provided for each of the image-pickup elements, an image arrangement conversion circuit which converts the read-out order of the images corresponding to the respective image-pickup elements that are output from the image-pickup signal processing circuits, an image splitting processing circuit for performing image splitting on the image that is output from the image arrangement conversion circuit, an image processing circuit for performing image processing in parallel on each of the split images, and an image compression circuit for compressing in parallel each of the split images that are output from the image processing circuit.

67. 发明授权

US07572833B2 Drug composition comprising dipeptidyl aldehyde derivative 失效
标题翻译：药物组合物包含二肽基醛衍生物
公开(公告)号：US07572833B2
公开(公告)日：2009-08-11
申请号：US10415295
申请日：2001-09-27
申请人： Jun Inoue , Masazumi Yamaguchi
发明人： Jun Inoue , Masazumi Yamaguchi
IPC分类号： A61K31/18
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/0048 , A61K9/127 , A61K9/4858 , A61K31/18 , A61K31/404 , A61K47/02 , A61K47/24 , A61K47/54
摘要： The present invention provides a preparation containing a compound of the formula (I) wherein R1 is an alkyl group having 1 to 4 carbon atoms or an optionally substituted aryl group having 6 to 10 carbon atoms; R2 and R3 are the same or different and each is hydrogen or an alkyl group having 1 to 4 carbon atoms, or R2 and R3 in combination form a ring having 3 to 7 carbon atoms; and R4 is a lower alkyl group optionally substituted by aryl, cycloalkyl or aromatic heterocyclic residue, or a pharmaceutically acceptable salt thereof together with a lipid. The preparation shows improved stability and improved absorption and penetration into tissue.
摘要翻译：本发明提供含有式（I）的化合物的制备方法，其中R 1为碳原子数为1〜4的烷基或可具有取代基的碳原子数6〜10的芳基。 R2和R3相同或不同，各自为氢或具有1至4个碳原子的烷基，或R2和R3组合形成具有3至7个碳原子的环; 并且R 4是任选被芳基，环烷基或芳族杂环残基或其药学上可接受的盐与脂质取代的低级烷基。该制剂显示改进的稳定性和改善的吸收和渗透到组织中。

68. 发明申请

US20080108061A1 Method for detecting cancer and a method for suppressing cancer 审中-公开
标题翻译：癌症检测方法及癌症抑制方法
公开(公告)号：US20080108061A1
公开(公告)日：2008-05-08
申请号：US11591487
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
IPC分类号： C12Q1/68 , C12N15/87
CPC分类号： C12N15/113 , A61K38/00 , A61K48/005 , C12N15/86 , C12N2310/11 , C12N2760/18843 , C12Q1/6886 , C12Q2600/112
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in brain tumor as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译：本发明的目的是找到用作检测细胞癌变和癌症恶性程度的指标的癌症相关基因，以提供使用癌症相关基因作为指标检测癌症的方法，以及提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。根据本发明，已经共同发现了与正常细胞相比在脑肿瘤中扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。

69. 发明申请

US20070161019A1 Method for detecting cancer and a method for suppressing cancer 审中-公开
标题翻译：癌症检测方法及癌症抑制方法
公开(公告)号：US20070161019A1
公开(公告)日：2007-07-12
申请号：US11591637
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in lung cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译：本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。根据本发明，已经共同发现在肺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。

70. 发明申请

US20070004643A1 Alpha-ketoamide derivative, and production method and use thereof 有权
标题翻译： α-酮酰胺衍生物及其制备方法和用途
公开(公告)号：US20070004643A1
公开(公告)日：2007-01-04
申请号：US10582015
申请日：2004-12-08
申请人： Yoshihisa Shirasaki , Hiroyuki Miyashita , Masayuki Nakamura , Jun Inoue
发明人： Yoshihisa Shirasaki , Hiroyuki Miyashita , Masayuki Nakamura , Jun Inoue
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07D213/30 , C07C271/22 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07D295/215 , C07D307/20 , C07D309/12
摘要： The present invention provides a compound represented by the formula (I): (wherein R1 is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic group; R2 is a lower alkyl optionally substituted by a phenyl; and R3 is a lower alkyl optionally substituted by a halogen, a lower alkoxy or a phenyl, or a fused polycyclic hydrocarbon group), which is well absorbed orally, exhibits durability of good blood level and has potent calpain inhibitory activity.
摘要翻译：本发明提供由式（I）表示的化合物：其中R 1是被低级烷氧基或杂环基或杂环基取代的低级烷基; R 2， / SUP>是任选被苯基取代的低级烷基; R 3是任选被卤素，低级烷氧基或苯基或稠合多环烃基取代的低级烷基，其是良好的口腔吸收，具有良好的血液水平的耐久性，并具有强大的钙蛋白酶抑制活性。

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