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61. 发明授权

US5733525A Method of EII using a water insoluble particulate agent 失效
标题翻译：使用水不溶性颗粒剂的EII方法
公开(公告)号：US5733525A
公开(公告)日：1998-03-31
申请号：US828530
申请日：1997-03-31
申请人： Jo Klaveness
发明人： Jo Klaveness
IPC分类号： A61B5/05 , A61B5/053 , A61K49/00 , A61B5/055
CPC分类号： A61B5/0536 , A61K49/0002 , Y10S514/974 , Y10T436/24
摘要： The invention relates to a method of electrical impedance imaging of a human or animal subject which method comprises parenterally administering to the subject an EII contrast agent and generating an electrical impedance image of at least part of said subject. The contrast agent may be optionally dissolved or dispersed in a physiologically tolerable liquid carrier medium. The contrast agent is capable on dispersion in water of yielding a fluid having an electrical impedance different to that of water and being a water-insoluble particulate material.
摘要翻译：本发明涉及一种人或动物对象的电阻抗成像方法，该方法包括向对象肠胃外施用EII造影剂并产生所述受试者的至少一部分的电阻抗图像。造影剂可以任选地溶解或分散在生理上可耐受的液体载体介质中。造影剂能够在水中分散，产生具有与水不同的电阻抗的流体，并且是水不溶性颗粒材料。

62. 发明授权

US5718884A Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells 失效
标题翻译：具有交联和还原蛋白质壳的基于微泡的造影剂
公开(公告)号：US5718884A
公开(公告)日：1998-02-17
申请号：US397065
申请日：1995-05-04
申请人： Jo Klaveness , Pal Rongved , John Henrik Johansen , Per Antonius Foss , Anders H.o slashed.gset , Anne Marie Hvoslef
发明人： Jo Klaveness , Pal Rongved , John Henrik Johansen , Per Antonius Foss , Anders H.o slashed.gset , Anne Marie Hvoslef
IPC分类号： A61K49/00 , A61K49/18 , A61K49/22 , A61K49/04
CPC分类号： A61K49/1821 , A61K49/18 , A61K49/223
摘要： The present invention pertains to proteinaceous gas- or gas precursor-containing microbubble contrast agents for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g., a dialdehyde such as glutaraldehyde or an .alpha.,.beta.-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH. The contrast agents exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.
摘要翻译： PCT No.PCT / GB93 / 01861 Sec。 371日期：1995年5月4日 102（e）日期1995年5月4日PCT提交1993年9月3日PCT公布。出版物WO94 / 06477 日期：1994年3月31日本发明涉及用于超声和/或MR成像的含蛋白质气体或气体前体的微泡造影剂，其中蛋白质基质通过与双官能醛反应而交联（例如，二醛如作为戊二醛或α，β-不饱和醛如丙烯醛）在水性介质中基本上为中性pH。造影剂表现出改善的体内和储存稳定性，特别是如果基质也与席夫碱还原剂如硼氢化钠反应。这种交联的含蛋白质气体的造影剂的尺寸分布的修改，例如，为了减少微泡的平均尺寸，进一步提高了它们的稳定性并且允许制备具有特别窄的微泡尺寸分布的新型造影剂。

63. 发明授权

US5676925A Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons 失效
公开(公告)号：US5676925A
公开(公告)日：1997-10-14
申请号：US478034
申请日：1995-06-07
申请人： Jo Klaveness , P.ang.l Rongved , Jan Solberg , Per Strande , Unni Nordby Wiggen , Keith Redford
发明人： Jo Klaveness , P.ang.l Rongved , Jan Solberg , Per Strande , Unni Nordby Wiggen , Keith Redford
IPC分类号： A61K49/18 , A61K49/22 , C08G63/00 , A61K9/14
CPC分类号： A61K49/223 , A61K49/1821 , Y10T436/24
摘要： Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula --(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n -- (wherein R.sup.1 and R.sup.2 each represent hydrogen or a carbon-attached monovalent organic group or together form a carbon-attached divalent organic group, and m and n are each independently zero or one) may be used in diagnostic applications such as ultrasound and MR imaging.

64. 发明授权

US5567412A Contrast agents consisting of galactose particles and an amphilic carboxylic acid 失效
标题翻译：由半乳糖颗粒和双亲羧酸组成的造影剂
公开(公告)号：US5567412A
公开(公告)日：1996-10-22
申请号：US256150
申请日：1994-09-29
申请人： Jo Klaveness , P.ang.l Rongved , Lars Stubberud
发明人： Jo Klaveness , P.ang.l Rongved , Lars Stubberud
IPC分类号： A61K47/12 , A61K47/36 , A61K49/00 , A61K49/22
CPC分类号： A61K49/223 , A61K49/226
摘要： The present invention relates to contrast agents comprising microbubble-generating carbohydrate microparticles in admixture with an amphiphilic organic acid containing in excess of 20 carbon atoms. The contrast agents exhibit good stability and/or enhanced contrast effect and may be used in diagnostic applications such as ultrasound and MR imaging.
摘要翻译： PCT No.PCT / EP93 / 00026 Sec。 371日期1994年9月29日 102（e）1994年9月29日PCT PCT 1993年1月8日PCT公布。公开号WO93 / 13802 日期1993年7月22日本发明涉及包含产生微泡的碳水化合物微粒与含有超过20个碳原子的两亲性有机酸混合的造影剂。造影剂表现出良好的稳定性和/或增强的对比效果，并且可用于诸如超声和MR成像的诊断应用中。

65. 发明授权

US5242683A Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI 失效
标题翻译：包含参考物质和用于X射线和MRI的碘化物的对比媒体
公开(公告)号：US5242683A
公开(公告)日：1993-09-07
申请号：US778054
申请日：1991-12-10
申请人： Jo Klaveness
发明人： Jo Klaveness
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , A61K49/08
CPC分类号： A61K49/10 , A61K49/0495 , A61K49/085 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The contrast medium can be used for both X-ray and magnetic resonance imaging of the gastro-intestinal tract but overcomes or greatly reduces the side effects experienced by mannitol-containing prior art contrast media.

66. 发明授权

US5208324A Paramagnetic compounds 失效
标题翻译：参考化合物
公开(公告)号：US5208324A
公开(公告)日：1993-05-04
申请号：US548994
申请日：1990-07-26
申请人： Jo Klaveness , Pal Rongved , Per Strande
发明人： Jo Klaveness , Pal Rongved , Per Strande
IPC分类号： G01R33/28 , A61B5/055 , A61K31/785 , A61K49/00 , A61K49/04 , A61K49/08 , A61K49/10 , A61K49/12 , A61K51/00 , A61P9/06 , A61P39/02 , C08B37/00 , C08L101/02 , C09K3/00
CPC分类号： A61K49/085 , A61K49/126 , Y10T436/24
摘要： There are provided paramagnetic compounds comprising a paramagnetic metal species chelated by a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a macromolecule, wherein said linker group provides a carbon chain of at least 2 atoms between said amide group and said ester group. The novel compounds are particularly suitable as contrast agents, e.g. in magnetic resonance imaging.

67. 发明授权

US5128121A Mixture of a positive and negative contrast agent for magnetic resonance imaging 失效
标题翻译：一种用于磁共振成像的积极和负面对比剂的混合物
公开(公告)号：US5128121A
公开(公告)日：1992-07-07
申请号：US585140
申请日：1990-10-09
申请人： Arne Berg , Jo Klaveness
发明人： Arne Berg , Jo Klaveness
IPC分类号： G01R33/28 , A61B5/055 , A61K20060101 , A61K49/00 , A61K49/18
CPC分类号： G01R33/5601 , A61K49/103 , A61K49/128 , A61K49/1863 , Y10S514/836 , Y10T436/24
摘要： There is provided a method of generating enhanced images of the human or non-human animal body, for example for use in medical diagnosis, which involves administering to the body a positive MRI contrast agent which is body tissue- or body duct-specific following the particular mode of administration and a negative MRI contrast agent which preferably also is body tissue- or body duct-specific. Thereafter a magnetic resonance image is generated of a part of the body containing the negative and positive contrast agents or their paramagnetic, ferromagnetic or superparamagnetic biodegradation products. Contrast media suitable for use in this new image generating method are also provided.
摘要翻译： PCT No.PCT / EP89 / 00376 Sec。 371 1990年10月9日第 102（e）1990年10月9日PCT PCT 1989年4月6日提交PCT公布。第WO89 / 09625号公报提供了一种生成人或非人动物体的增强图像的方法，例如用于医学诊断，其涉及向身体施用作为身体组织的正的MRI造影剂，或身体管道特异性的特定的施用模式和负的MRI造影剂，其优选也是身体组织或体管特异性的。此后，产生包含负和正造影剂或其顺磁性，铁磁性或超顺磁性生物降解产物的身体的一部分的磁共振图像。还提供了适用于该新图像生成方法的对比度介质。

68. 发明授权

US4760173A NMR contrast agents 失效
标题翻译： NMR造影剂
公开(公告)号：US4760173A
公开(公告)日：1988-07-26
申请号：US102533
申请日：1987-09-29
申请人： Jo Klaveness
发明人： Jo Klaveness
IPC分类号： A61B10/00 , A61B5/055 , A61K49/00 , A61K49/06 , C07C237/04 , C07F11/00 , C07F15/02 , G01R33/28 , C07C101/447
CPC分类号： A61K49/06
摘要： There are provided NMR contrast agents comprising water-soluble paramagnetic metal chelates, preferably of Cr(III), Fe(III) or Gd(III), wherein the chelating entity is an anilide group containing organic moiety, preferably a compound of formula I ##STR1## wherein R.sup.1 to R.sup.5 may represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups. The agents are especially suitable for use in NMR imaging of the hepatobiliary system.

69. 发明授权

US09227995B2 Peptides 有权
标题翻译：多肽
公开(公告)号：US09227995B2
公开(公告)日：2016-01-05
申请号：US13064881
申请日：2011-04-22
申请人： Øyvind Jacobsen , Pål Rongved , Jo Klaveness
发明人： Øyvind Jacobsen , Pål Rongved , Jo Klaveness
IPC分类号： A61K38/03 , C07K4/00 , C07K1/107 , C07K5/117 , C07K7/06 , A61K38/00
CPC分类号： C07K5/1024 , A61K38/00 , A61K38/03 , C07K1/107 , C07K1/1072 , C07K1/1075 , C07K4/00 , C07K7/06
摘要： A peptide which can adopt a 310-helical conformation in which the side chains of two amino acid residues in the peptide backbone are linked by a group comprising an aromatic 5-membered ring.
摘要翻译：可以采用310螺旋构象的肽，其中肽主链中两个氨基酸残基的侧链通过包含芳香族5元环的基团连接。

70. 发明申请

US20120226217A1 PHOTOSENSITIZING COMPOSITIONS 有权
标题翻译：光敏组合物
公开(公告)号：US20120226217A1
公开(公告)日：2012-09-06
申请号：US13390404
申请日：2010-08-16
申请人： Jo Klaveness , Anders Hogset
发明人： Jo Klaveness , Anders Hogset
IPC分类号： A61K31/409 , A61M37/00 , C07D487/22
CPC分类号： A61K41/0071
摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.
摘要翻译：本发明涉及两亲性光敏剂的药学上可接受的盐，它们的水溶解度至少为0.5mg / ml，并且它们在光化学内化方法中的用途。这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或由药学上可接受的酸例如磺酸或磺酸衍生物形成。由于其水溶性增加，这些盐特别适合用于制备肠胃外药物制剂，例如，用作注射或输注的溶液。

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