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61. 发明授权

US07579340B2 Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists 失效
标题翻译：苯二胺尿激肽素受体拮抗剂和CCR-9拮抗剂
公开(公告)号：US07579340B2
公开(公告)日：2009-08-25
申请号：US11895069
申请日：2007-08-22
申请人： Ronald Biediger , Jie Chen , Daxin Gao , Robert Market , Chengde Wu
发明人： Ronald Biediger , Jie Chen , Daxin Gao , Robert Market , Chengde Wu
IPC分类号： A61K31/5375 , A61K31/4523 , A61K31/4025 , A61K31/381 , C07D413/10 , C07D409/10
CPC分类号： C07D207/16 , A61K31/16 , A61K31/40 , A61K31/445 , A61K31/497 , C07D209/08 , C07D209/44 , C07D213/74 , C07D237/08 , C07D239/26 , C07D241/42 , C07D295/135 , C07D333/38 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
摘要翻译：本发明涉及尿素调节素II受体拮抗剂，CCR-9拮抗剂，含有它们的药物组合物及其应用。

62. 发明申请

US20090149638A1 SYSTEMS AND METHODS FOR PURIFYING PROTEINS 审中-公开
标题翻译：净化蛋白质的系统和方法
公开(公告)号：US20090149638A1
公开(公告)日：2009-06-11
申请号：US12238797
申请日：2008-09-26
申请人： Arthur C. Ley , Jie Chen
发明人： Arthur C. Ley , Jie Chen
IPC分类号： C07K1/34 , C12M1/00
CPC分类号： B01D15/3804 , B01D15/1871 , B01D15/305 , B01D15/327 , B01D15/34 , B01D15/361 , C07K1/36
摘要： Described herein are novel systems and downstream protein purification (DSP) processes that provide high quality product rapidly, and on a large scale. Many of the processes enable one chromatography step to follow another chromatography step without an intermediate ultrafiltration/diafiltration (UFDF) step. These optimized processes allow for automation on the manufacture plant floor, permitting the use of a multi-cycling strategies that can utilize smaller, less expensive columns. The processes can provide considerable advantage on production efficiency, cost saving and on waste disposal.
摘要翻译：本文描述的是新型系统和下游蛋白质纯化（DSP）方法，其快速，大规模地提供高质量的产品。许多方法使得一个色谱步骤能够进行另一个色谱步骤，而无需中间超滤/渗滤（UFDF）步骤。这些优化的过程允许在制造车间的自动化，允许使用可以利用更小，更便宜的柱的多循环策略。这些过程可以在生产效率，成本节约和废物处理方面提供相当大的优势。

63. 发明申请

US20080320379A1 Method for Generating and Opening Computer Forme File 审中-公开
标题翻译：生成和打开计算机表格文件的方法
公开(公告)号：US20080320379A1
公开(公告)日：2008-12-25
申请号：US12165409
申请日：2008-06-30
申请人： Jie Chen
发明人： Jie Chen
IPC分类号： G06F17/00
CPC分类号： G06F17/2205 , G06F16/93
摘要： The present invention relates to a method for generating and opening computer forme file. The method for generating the computer forme file includes the following steps. A content of the printer spool file of the word processing document under the current environment is transformed into a picture; forme file information which describes correlative information including a picture quantity, a picture format and a storage position is generated; said picture and said forme file information are encapsulated into a forme file. This method provides two kinds of the generating modes, including: the forme file storing only the picture and the forme file storing the document data and the picture. The method for opening the computer forme file includes the following steps. The information of the document head is read in; the total number of pages of the document is obtained; the picture in the forme file is read in and displayed according to parsing said information of the document head and the total number of pages of the document. This method provides two kinds of the opening modes, including: opening the forme file in the read-only manner and in the editing manner. Said forme file has the practical functions, for example searching the content, looking up and locating the page number, editing or consulting the content and so on.
摘要翻译：本发明涉及一种生成和打开计算机格式文件的方法。生成计算机格式文件的方法包括以下步骤。当前环境下的文字处理文件的打印机假脱机文件的内容被转换为图片; 生成描述包括图像数量，图像格式和存储位置的相关信息的格式文件信息; 所述图片和所述格式文件信息被封装到格式文件中。该方法提供两种生成模式，包括：仅存储图像的格式文件和存储文档数据和图像的格式文件。打开计算机格式文件的方法包括以下步骤。读入文件头的信息; 获得文档的总页数; 根据解析文档头的所述信息和文档的总页数，读取并显示格式文件中的图片。该方法提供两种打开模式，包括：以只读方式和编辑方式打开forme文件。所述forme文件具有实用功能，例如搜索内容，查找和查找页码，编辑或咨询内容等。

64. 发明授权

US06831080B2 Cinnamide derivatives as KCNQ potassium channel modulators 有权
标题翻译：桂酰胺衍生物作为KCNQ钾通道调节剂
公开(公告)号：US06831080B2
公开(公告)日：2004-12-14
申请号：US10160582
申请日：2002-05-31
申请人： Yong-Jin Wu , Li-Quang Sun , Jie Chen , Huan He , Alexandre L'Heureux , Pierre Dextraze , Jean-Paul Daris , Gene G. Kinney , Steven I. Dworetzky , Piyasena Hewawasam
发明人： Yong-Jin Wu , Li-Quang Sun , Jie Chen , Huan He , Alexandre L'Heureux , Pierre Dextraze , Jean-Paul Daris , Gene G. Kinney , Steven I. Dworetzky , Piyasena Hewawasam
IPC分类号： C07C23720
CPC分类号： C07D213/40 , C07C233/11 , C07C235/34 , C07D209/08 , C07D213/56 , C07D215/04 , C07D215/12 , C07D217/06 , C07D239/26 , C07D241/12 , C07D265/30 , C07D265/36 , C07D295/135 , C07D307/79 , C07D311/58 , C07D317/58 , C07D317/60 , C07D319/18 , C07D333/24 , C07D407/12 , C07D491/08
摘要： There is provided novel cinnamide derivatives of Formula I: wherein R is C1-4 alkyl or trifluoromethyl; R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl in which said substituted phenyl is substituted with one or two substituents each independently selected-from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy and nitro; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, and halogen; R4 is selected from the group consisting of di(C1-4 alkyl)amino, trifluoromethoxy and optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl with one or two substituents in which said substituent is independently selected from the group consisting of C1-4 alkyl, aminomethyl, hydroxymethyl, chloro or fluoro; R5 is hydrogen, chloro or fluoro; or R4 and R5 taken together are —CH═CH—CH═CH— or —X(CH2)mY— in which X and Y are each independently selected from the group consisting of CH2, (CH2)nN(R9)— and O, wherein m is 1 or 2; n is 0 or 1; and R6, R7, and R8 are each independently selected from hydrogen, chloro and fluoro; and R9 is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxyethyl, C1-4 alkoxyethyl, cyclopropylmethyl, —CO2(C1-4alkyl), and —CH2CH2NR10R11 in which R10 and R11 are each independently hydrogen or C1-4 alkyl, which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
摘要翻译：提供式I的新颖的肉桂酰胺衍生物：其中R是C 1-4烷基或三氟甲基; R 1选自吡啶基，喹啉基，噻吩基，呋喃基，1,4-苯并二恶烷基，1,3-苯并二恶唑基，苯并二氢吡喃基，茚满基，联苯基，苯基和取代的苯基，其中所述取代的苯基被一个或两个各自独立地选自卤素，C 1-4烷基，C 1-4烷氧基，三氟甲基，三氟甲氧基和硝基的取代基; R 2和R 3各自独立地选自氢，C 1-4烷基和卤素; R 4选自二（C 1-4烷基）氨基，三氟甲氧基和任选取代的吗啉-4-基，吡啶基，嘧啶基，哌嗪基和吡嗪基，其中一个或两个取代基独立地选自所述取代基由C1-4烷基，氨基甲基，羟甲基，氯或氟组成的基团; R 5是氢，氯或氟; 或R 4和R 5一起为-CH = CH-CH = CH-或-X（CH 2）mY-，其中X和Y各自独立地选自CH 2，（CH 2）n N （R 9） - 和O，其中m为1或2; n为0或1; 和R 6，R 7和R 8各自独立地选自氢，氯和氟; 并且R 9选自氢，C 1-4烷基，羟乙基，C 1-4烷氧基乙基，环丙基甲基，-CO 2（C 1-4烷基）和-CH 2 CH 2 NR 10 R 11， 10>和R 11各自独立地是氢或C 1-4烷基，其是KCNQ钾通道的开放剂，并且可用于治疗对开放KCNQ钾通道有响应的病症。

65. 发明授权

US5994306A Fine-tuned protegrins 失效
标题翻译：微调整合素
公开(公告)号：US5994306A
公开(公告)日：1999-11-30
申请号：US752852
申请日：1996-11-21
申请人： Conway C. Chang , Chee Liang Gu , Jie Chen , Deborah A. Steinberg , Robert I. Lehrer , Sylvia S.L. Harwig, deceased
发明人： Conway C. Chang , Chee Liang Gu , Jie Chen , Deborah A. Steinberg , Robert I. Lehrer , Sylvia S.L. Harwig, deceased
IPC分类号： A61K38/00 , A01N63/02 , A61K38/10 , A61K38/17 , A61P31/00 , A61P31/04 , C07K4/00 , C07K7/00 , C07K7/08 , C07K14/00 , C07K16/18 , C12N15/12 , A61K38/04 , A01N25/00 , C12N15/13
CPC分类号： C07K7/08 , A01N63/02 , A61K38/10 , A61K38/17 , C07K16/18
摘要： The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections.
摘要翻译：本发明涉及与天然存在的整合素肽相关的抗微生物肽，以及在各种情况下使用肽的方法，包括治疗或预防感染。

66. 发明授权

US5887024A Matched filter 失效
标题翻译：匹配过滤器
公开(公告)号：US5887024A
公开(公告)日：1999-03-23
申请号：US780145
申请日：1996-12-26
申请人： Xiaoling Qin , Kunihiko Suzuki , Guoliang Shou , Changming Zhou , Jie Chen
发明人： Xiaoling Qin , Kunihiko Suzuki , Guoliang Shou , Changming Zhou , Jie Chen
IPC分类号： H03H11/04 , H03H17/02 , H04B15/00 , H04K1/00 , H04L27/30
CPC分类号： H03H11/04 , H03H17/02
摘要： The present invention provides a matched filter which can refresh an entire while keeping the speed of a calculation comparable to a small sized circuit. The first and second addition circuits of a matched filter of the present invention are classified into a plurality of groups, the first and second auxiliary adders replace functions for the groups of the first and second adders respectively. The outputs of the first and second adders are then inputted to the first and second subtractors, respectively, and the refreshing means appropriately refreshes the groups replaced by the first and second auxiliary adders. Further, the present invention decreases the number of auxiliary sapling and holding circuits to be used, and decides the refreshing intervals by considering the change of the voltage caused by leakage and other permissible errors of output voltage.
摘要翻译：本发明提供了一种匹配滤波器，其可以保持与小尺寸电路相当的计算速度的整体刷新。本发明的匹配滤波器的第一和第二加法电路分为多个组，第一和第二辅助加法器分别代替第一和第二加法器的组的功能。然后，第一和第二加法器的输出分别输入到第一和第二减法器，并且刷新装置适当地刷新由第一和第二辅助加法器替换的组。此外，本发明减少了要使用的辅助树苗和保持电路的数量，并且通过考虑由漏电引起的电压的变化和输出电压的其他允许误差来决定刷新间隔。

67. 外观设计

USD998378S1 Shelf 有权
公开(公告)号：USD998378S1
公开(公告)日：2023-09-12
申请号：US29893660
申请日：2023-06-01
申请人： Jie Chen
设计人： Jie Chen
摘要： FIG. 1 is a front perspective view of a shelf, showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof;
FIG. 8 is a bottom view thereof; and,
FIG. 9 is a usage state view thereof.
The broken lines in the drawings illustrate the portions of the shelf, which form no part of the claimed design.

68. 发明申请

US20170351232A1 SYSTEM AND METHOD FOR ELECTRICAL COMPONENT MANAGEMENT 审中-公开
公开(公告)号：US20170351232A1
公开(公告)日：2017-12-07
申请号：US15609780
申请日：2017-05-31
申请人： Jie Chen , Ali Razban , Stanley Yung-Ping Chien , Amin Amini , Mustafa Saad Abdulwahhab Kamoona , Hamid Reza Piroozi
发明人： Jie Chen , Ali Razban , Stanley Yung-Ping Chien , Amin Amini , Mustafa Saad Abdulwahhab Kamoona , Hamid Reza Piroozi
IPC分类号： G05B15/02
CPC分类号： G05B15/02 , G05B13/00 , G05B15/00 , G05B19/00
摘要： A system for managing performance of one or more electrical components in real-time is disclosed. The system includes one or more sensors coupled to one or more energy consuming devices and adapted to provide working conditions of the one or more energy consuming devices. The system further includes one or more actuators coupled to and configured to control the one or more energy consuming devices. Additionally, the system includes a computing device in electrical communication with the one or more sensors and the one or more actuators. The system also includes a database capable of retaining an instruction program for the computing device. The computing device includes a processor that is configured to receive data from the one or more sensors, analyze data from the one or more sensors, and execute the instruction program received from the database in order to optimize operation of the one or more energy consuming devices based on one or more criteria.

69. 发明授权

US09121628B2 Heat pumps with unequal cooling and heating capacities for climates where demand for cooling and heating are unequal, and method of adapting and distributing such heat pumps 有权
标题翻译：对于冷却和加热需求不平等的气候，对不同冷却和加热能力的热泵以及适配和分配这种热泵的方法
公开(公告)号：US09121628B2
公开(公告)日：2015-09-01
申请号：US13035761
申请日：2011-02-25
申请人： Jie Chen , Allan J. Reifel , David L. Koesterer , Siegfried J. Weigl
发明人： Jie Chen , Allan J. Reifel , David L. Koesterer , Siegfried J. Weigl
IPC分类号： F25B30/02 , F25B49/02
CPC分类号： F25B30/02 , F25B49/025 , F25B2600/025 , F25B2600/0253 , F25B2600/11 , Y02B30/741 , Y10T29/49359
摘要： Heat pumps for climates where demand for cooling and heating are unequal and methods of adapting and distributing heat pumps for such climates. Heat pumps include a compressor, compressor motor, variable speed drive, and controller. In a number of embodiments, non-volatile memory stores sets of constant speeds for cooling and heating, and a person can select, via an input device, different sets of speeds for cooling and heating to provide the different cooling and heating capacities. The controller then operates the unit at the selected speeds, selecting from within the set based on demand for cooling or heating. In some embodiments, different sets of speeds may have the same minimum speed but different maximum speeds. Identical heat pumps can be configured to have different capacity ratings and different advertised efficiencies for different climates.
摘要翻译：用于冷却和加热需求不平等的气候的热泵以及适应和分配这种气候的热泵的方法。热泵包括压缩机，压缩机电机，变速驱动器和控制器。在多个实施例中，非易失性存储器存储用于冷却和加热的恒定速度的组，并且人员可以经由输入设备选择用于冷却和加热的不同速度的组合以提供不同的冷却和加热能力。然后，控制器以所选择的速度操作单元，基于对冷却或加热的需求从组内进行选择。在一些实施例中，不同的速度组可以具有相同的最小速度但是不同的最大速度。相同的热泵可以配置为具有不同的容量额定值和不同的气候条件下不同的广告效率。

70. 发明授权

US09096648B2 Methods of reducing level of one or more impurities in a sample during protein purification 有权
标题翻译：在蛋白质纯化期间降低样品中一种或多种杂质水平的方法
公开(公告)号：US09096648B2
公开(公告)日：2015-08-04
申请号：US13565463
申请日：2012-08-02
申请人： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
发明人： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC分类号： A23J1/00 , C07K1/00 , C07K14/00 , C07K17/00 , C07K1/36 , B01D15/36 , B01J20/282 , C07K1/16 , C07K1/20 , B01D15/12 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K16/00 , B01D15/18 , B01D15/38
CPC分类号： C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
摘要： The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
摘要翻译：本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。

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