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61. 发明授权

US07718769B2 Tri-peptide hepatitis C serine protease inhibitors 有权
标题翻译：三肽丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US07718769B2
公开(公告)日：2010-05-18
申请号：US11602586
申请日：2006-11-20
申请人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Zhe Wang , Yat Sun Or
发明人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Zhe Wang , Yat Sun Or
IPC分类号： A61K38/00
CPC分类号： C07K5/0808 , A61K38/00
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

62. 发明授权

US07672540B2 Nonrigid registration of cardiac perfusion MR images using adaptive local template matching 失效
标题翻译：使用自适应局部模板匹配的心脏灌注MR图像的非刚性注册
公开(公告)号：US07672540B2
公开(公告)日：2010-03-02
申请号：US11365273
申请日：2006-03-01
申请人： Ying Sun , Gareth Funka-Lea
发明人： Ying Sun , Gareth Funka-Lea
IPC分类号： G06K9/32 , G06K9/00
CPC分类号： G06T7/20 , G06T7/0012 , G06T2207/30048
摘要： Motion of the heart during contrast enhancement is modeled at two hierarchical levels: global translation and local deformation. Large-scale, i.e., global, translational motion is identified using global template matching, while the local deformation of a portion of the object (e.g., the left ventricle where the object is a heart) is obtained using an adaptive local template matching scheme which adapts to the local edge distributions by varying the height and the width of the template as well as the location of the template followed by spatial regularization. To address the difficulty of rapid intensity changes across the image sequence as the contrast agent perfuse into the tissue, an edge-based similarity measure is used for template matching.
摘要翻译：在对比度增强过程中心脏的运动被建模在两个层次上：全局平移和局部变形。使用全局模板匹配来确定大规模，即全局，平移运动，而使用自适应局部模板匹配方案获得对象部分（例如，对象是心脏的左心室）的局部变形，通过改变模板的高度和宽度以及模板的位置跟随空间正则化来适应局部边缘分布。为了解决造影剂灌注到组织中的图像序列之间的快速强度变化的难度，使用基于边缘的相似性度量来进行模板匹配。

63. 发明申请

US20090290775A1 Method and System for Selecting the Number of Gaussian Modes for the Segmentation of Cardiac Magnetic Resonance (MR) Images 有权
标题翻译：用于选择心脏磁共振（MR）图像分割的高斯模式数的方法和系统
公开(公告)号：US20090290775A1
公开(公告)日：2009-11-26
申请号：US12393097
申请日：2009-02-26
申请人： Ying Sun , Marie-Pierre Jolly , Jens Gühring
发明人： Ying Sun , Marie-Pierre Jolly , Jens Gühring
IPC分类号： G06K9/00
CPC分类号： G06T7/143 , G06T7/11 , G06T7/136 , G06T2207/10088 , G06T2207/30048
摘要： A method for automatically selecting a number of Gaussian modes for segmentation of a cardiac magnetic resonance (MR) image, including: identifying a left ventricle (LV) in a cardiac MR image slice; quantifying the LV blood pool; obtaining a mask for the LV blood pool; generating a ring mask for a myocardium of the LV from the LV blood pool mask; fitting three Gaussian modes to a histogram of the image slice to obtain a corresponding homogeneity image for the myocardium; computing a quality of fitting (QOF) measure for the three Gaussian modes based on the corresponding homogeneity image; repeating the fitting and computing steps for four and five Gaussian modes; and selecting the homogeneity image of the number of Gaussian modes with the largest QOF measure as the homogeneity image for processing.
摘要翻译：一种用于自动选择用于分割心脏磁共振（MR）图像的多个高斯模式的方法，包括：识别心脏MR图像切片中的左心室（LV）; 量化LV血液池; 获得LV血液的面罩; 从LV血液屏障中产生LV的心肌的环形掩模; 将三个高斯模式拟合到图像切片的直方图，以获得心肌的相应的均匀图像; 基于相应的均匀图像计算三种高斯模式的拟合质量（QOF）度量; 重复四种和五种高斯模式的拟合和计算步骤; 并选择具有最大QOF测量的高斯模式数量的均匀图像作为用于处理的均匀性图像。

64. 发明申请

US20090240136A9 Contrast-invariant registration of cardiac and renal magnetic resonance perfusion images 有权
标题翻译：心脏和肾脏磁共振灌注图像的对比不变记录
公开(公告)号：US20090240136A9
公开(公告)日：2009-09-24
申请号：US11078035
申请日：2005-03-11
申请人： Ying Sun , Marie-Pierre Jolly , Jose Moura
发明人： Ying Sun , Marie-Pierre Jolly , Jose Moura
IPC分类号： A61B5/05
CPC分类号： A61B5/055
摘要： A system and method are provided for contrast-invariant registration of images, the system including a processor, an imaging adapter or a communications adapter for receiving an image data sequence, a user interface adapter for selecting a reference frame from the image sequence or cropping a region of interest (ROI) from the reference frame, a tracking unit for tracking the ROI across the image sequence, and an estimation unit for segmenting the ROI in the reference frame or performing an affine registration for the ROI; and the method including receiving an image sequence, selecting a reference frame from the image sequence, cropping a region of interest (ROI) from the reference frame, tracking the ROI across the image sequence, segmenting the ROI in the reference frame, and performing an affine registration for the ROI.
摘要翻译：提供了用于对比度不变的图像配准的系统和方法，所述系统包括处理器，成像适配器或用于接收图像数据序列的通信适配器，用于从图像序列中选择参考帧的用户接口适配器或裁剪来自参考帧的感兴趣区域（ROI），用于跟踪跨越图像序列的ROI的跟踪单元，以及用于在参考帧中分割ROI或对ROI执行仿射注册的估计单元; 并且所述方法包括接收图像序列，从所述图像序列中选择参考帧，从所述参考帧裁剪感兴趣区域（ROI），沿所述图像序列跟踪所述ROI，在所述参考帧中分割所述ROI，以及执行 ROI的仿射注册。

65. 发明授权

US07575542B1 Apparatus for changing bits of machine tool 失效
标题翻译：用于更换机床位的装置
公开(公告)号：US07575542B1
公开(公告)日：2009-08-18
申请号：US12229018
申请日：2008-08-19
申请人： Ying Sun , Chi Sun
发明人： Ying Sun , Chi Sun
IPC分类号： B23Q3/157
CPC分类号： B23Q3/15706 , B23Q3/15534 , B23Q5/347 , Y10S483/90 , Y10T483/1755 , Y10T483/1795
摘要： A machine tool is provided with a bit-changing apparatus including a cam, a rocker, a roller, a linkage, a pulling element, a disc and clips. The cam is attached to the machine tool. The roller is attached to the rocker and movable against the cam. The linkage includes at least one track attached to the machine tool, a sliding element attached to another end of the rocker and movable on the track, and a connecting rod formed with an end pivotally connected to the machine tool and another end pivotally connected to the rocker. The pulling element is provided between the rocker and the machine tool so that the roller is kept against the cam. The disc is rotationally supported on the rocker. Each of the clips is attached to the disc and used to clip a holder for holding a bit so that a selected bit can be engaged with a bit-driving unit of the machine tool.
摘要翻译：一种机床设置有包括凸轮，摇杆，滚子，连杆机构，牵引元件，圆盘和夹子的位移装置。凸轮连接到机床上。滚轮安装在摇臂上，可抵靠凸轮移动。连杆包括附接到机床的至少一个轨道，附接到摇臂的另一端并可在轨道上移动的滑动元件，以及形成有可枢转地连接到机床的端部的连接杆，以及可枢转地连接到机床的另一端摇杆牵引元件设置在摇杆和机床之间，使得辊保持抵靠凸轮。盘被旋转地支撑在摇杆上。每个夹子连接到盘上，并用于夹持保持器以保持位，使得所选择的位可以与机床的位驱动单元接合。

66. 发明申请

US20090047248A1 TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS 失效
标题翻译：三唑基大环内酯类抗坏血酸C蛋白酶抑制剂
公开(公告)号：US20090047248A1
公开(公告)日：2009-02-19
申请号：US11835657
申请日：2007-08-08
申请人： Ying Sun , Deqiang Niu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Deqiang Niu , Yat Sun Or , Zhe Wang
IPC分类号： A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61P31/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K38/21 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.
摘要翻译：本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过向受试者施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

67. 发明申请

US20080152622A1 QUINOXALINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS 有权
标题翻译：喹诺酮类大环内酯类抗生素C丝氨酸蛋白酶抑制剂
公开(公告)号：US20080152622A1
公开(公告)日：2008-06-26
申请号：US12043421
申请日：2008-03-06
申请人： Suanne Nakajima , Zhenwei Miao , Ying Sun , Datong Tang , Guoyou Xu , Brian Porter , Yat Sun Or , Zhe Wang
发明人： Suanne Nakajima , Zhenwei Miao , Ying Sun , Datong Tang , Guoyou Xu , Brian Porter , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/12 , A61K38/21 , C07K5/12 , A61P31/12
CPC分类号： C07K5/0802 , A61K38/212 , A61K38/215 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性的式I或II化合物或其药学上可接受的盐，酯或前药。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

68. 发明授权

US07387600B1 Tool support device for machine tool 有权
标题翻译：机床刀具支撑装置
公开(公告)号：US07387600B1
公开(公告)日：2008-06-17
申请号：US11879849
申请日：2007-07-18
申请人： Ying Sun , Chi Sun
发明人： Ying Sun , Chi Sun
IPC分类号： B23Q3/157
CPC分类号： B23Q3/15706 , B23Q3/15534 , Y10T483/1755 , Y10T483/1795
摘要： A tool support device for a machine tool includes a housing disposed beside a tool spindle, a tool storage rack having a shaft rotatably attached to the housing, a plate secured to the shaft and rotatably received in the housing, a number of rollers disposed on the plate, an axle rotatably disposed in the housing and having a rotary member which includes a helical groove for engaging with the rollers and for rotating the plate and the shaft and the tool storage rack relative to the tool spindle, the tool support device includes a compact structure for suitably shielding and protecting the tool support device and for preventing the tool support device from being contaminated and damaged by dirt and cut chips.
摘要翻译：一种用于机床的工具支撑装置包括：设置在工具主轴旁边的壳体，具有可旋转地附接到壳体的轴的工具存储架，固定到轴上并可旋转地容纳在壳体中的板，设置在壳体上的多个辊板，可旋转地设置在壳体中并具有旋转构件的旋转构件，该旋转构件包括用于与辊接合并用于相对于工具主轴旋转板和轴以及工具存储架的螺旋槽，工具支撑装置包括紧凑型用于适当地屏蔽和保护工具支撑装置的结构，并且用于防止工具支撑装置被污物和切屑所污染并损坏。

69. 发明申请

US20080038225A1 TRIAZOLYL ACYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：三唑乙酰胆碱酯酶蛋白酶抑制剂
公开(公告)号：US20080038225A1
公开(公告)日：2008-02-14
申请号：US11835157
申请日：2007-08-07
申请人： Ying Sun , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Yat Sun Or , Zhe Wang
IPC分类号： A61K31/425 , A61K31/41 , A61K31/44 , A61K31/7056 , A61K38/21 , A61P31/12 , C07D249/04 , C07D277/30 , C07D401/12
CPC分类号： C07K5/0804 , A61K38/00 , C07D207/24 , C07D409/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.
摘要翻译：本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过向受试者施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

70. 发明申请

US20070281885A1 MACROCYLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS 有权
标题翻译：大环氧合酶抑制剂C蛋白酶抑制剂
公开(公告)号：US20070281885A1
公开(公告)日：2007-12-06
申请号：US11759080
申请日：2007-06-06
申请人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/12 , C07K5/12
CPC分类号： A61K38/4886 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/45 , A61K38/52 , C07K5/0804 , C07K5/0812 , C07K7/06 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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