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61. 发明授权

US07596406B2 Device for recording electrophysiological signals and for displaying the signals or signal information elements which are derived therefrom 失效
标题翻译：用于记录电生理信号并显示从其导出的信号或信号信息元素的装置
公开(公告)号：US07596406B2
公开(公告)日：2009-09-29
申请号：US11347549
申请日：2006-02-03
申请人： Jan Boese , Martin Kleen , Norbert Rahn
发明人： Jan Boese , Martin Kleen , Norbert Rahn
IPC分类号： A61B5/44
CPC分类号： A61B5/044 , A61B5/0422
摘要： Device for recording electrophysiological signals and for displaying the signals or signal information elements which are derived therefrom, comprising a catheter which includes a plurality of electrodes arranged in a distributed manner for signal recording and a rendition device for displaying the signals or the individual signal information elements which relate to the respective electrodes and are derived from the signals, wherein the signals or the signal information elements can be displayed in a display which is modeled on the geometric arrangement of the electrodes at the catheter or on the geometric arrangement of the electrodes during the signal recording.
摘要翻译：用于记录电生理信号并用于显示由其导出的信号或信号信息元素的装置，包括导管，该导管包括以分布式布置用于信号记录的多个电极，以及用于显示信号或各个信号信息元素的再现装置其涉及各个电极并且从信号导出，其中信号或信号信息元素可以显示在显示器中，该显示器被建模在导管处的电极的几何排列上或在电极的几何排列期间信号记录。

62. 发明申请

US20080212858A1 Method for image registration processes and X-ray angiography system 有权
标题翻译：图像配准过程和X射线血管造影系统的方法
公开(公告)号：US20080212858A1
公开(公告)日：2008-09-04
申请号：US12070484
申请日：2008-02-19
申请人： Jan Boese , Jorn Justiz , Andreas Meyer , Marcus Pfister
发明人： Jan Boese , Jorn Justiz , Andreas Meyer , Marcus Pfister
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , A61B2090/364 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/30004 , G06T2207/30012 , G06T2207/30048
摘要： Registration of preoperatively acquired MRI images of soft parts to intraoperatively acquired X-ray images of soft parts is not possible. The invention shows a way of nevertheless using such preoperatively acquired images for superimposition with 2D projections of the soft parts, taking an indirect route via 3D/3D registration of images of the spinal column. For this purpose, 3D image data sets of the spinal column must be obtained separately on the one hand using MRI and on the other using the X-ray imaging system so that the 3D/3D registration produces a mapping rule which then also applies to the preoperatively acquired images of the soft part if the soft part images and the spinal images are acquired without intervening change in the patient position in the MRI scanner.
摘要翻译：将软件部分术前获取的MRI图像注册到软组件的术中获得的X射线图像是不可能的。本发明示出了一种使用这种预先获取的图像与软部件的2D投影叠加的方式，通过经脊柱的图像的3D / 3D对准进行间接路线。为此，必须使用MRI单独获得脊柱的3D图像数据集，另一方面必须使用X射线成像系统获得脊柱的3D图像数据集，使得3D / 3D注册产生映射规则，其然后也适用于如果获取软部分图像和脊柱图像而不在MRI扫描仪中的患者位置的中间改变，则在术前获取软部分的图像。

63. 发明申请

US20080208040A1 Method for three-dimensional localization of an instrument for an interventional access and associated device 有权
标题翻译：用于介入和相关设备的仪器的三维定位方法
公开(公告)号：US20080208040A1
公开(公告)日：2008-08-28
申请号：US12070479
申请日：2008-02-19
申请人： Jan Boese
发明人： Jan Boese
IPC分类号： A61B6/00
CPC分类号： A61B6/02 , A61B6/12 , A61B34/20 , A61B90/36 , A61B2090/376
摘要： The invention relates to a method for three-dimensional localization of an instrument for an interventional access, comprising: creating a three-dimensional image recording covering a region of the intervention and surroundings; determining local attenuation values of the three-dimensional image recording by x-ray absorption characteristics; recording a two-dimensional image recording covering the region of the intervention and surroundings; determining an x-ray intensity at an x-ray sensor arranged on the instrument; localizing the x-ray sensor in the two-dimensional image recording based on the x-ray intensity; summing the local attenuation values along a virtual x-ray path passing through the x-ray sensor in the three-dimensional image recording; identifying a point on the virtual x-ray path where the attenuation sum corresponds to the x-ray intensity at the x-ray sensor; and determining a three-dimensional position of the point corresponding to the three-dimensional position of the x-ray sensor on the instrument.
摘要翻译：本发明涉及一种用于介入入口的仪器的三维定位的方法，包括：创建覆盖干预和周围区域的三维图像记录; 通过x射线吸收特性确定三维图像记录的局部衰减值; 记录覆盖干预和周围地区的二维图像记录; 确定布置在所述仪器上的x射线传感器的x射线强度; 基于x射线强度将x射线传感器定位在二维图像记录中; 在三维图像记录中沿着穿过x射线传感器的虚拟x射线路径对局部衰减值求和; 识别虚拟x射线路径上的点，其中衰减和对应于x射线传感器处的x射线强度; 并且确定与所述仪器上的x射线传感器的三维位置相对应的点的三维位置。

64. 发明申请

US20080137936A1 Method for providing a 3D X-ray image dataset of a patient's heart 有权
标题翻译：用于提供患者心脏的3D X射线图像数据集的方法
公开(公告)号：US20080137936A1
公开(公告)日：2008-06-12
申请号：US11980229
申请日：2007-10-30
申请人： Jan Boese , Joachim Hornegger , Gunter Lauritsch , Marcus Prummer
发明人： Jan Boese , Joachim Hornegger , Gunter Lauritsch , Marcus Prummer
IPC分类号： A61B6/00
CPC分类号： G06T7/20 , A61B5/7289 , A61B6/032 , A61B6/466 , A61B6/503 , A61B6/5288 , G06T2207/30048 , Y10S378/901
摘要： X-ray images are recorded of a patient's heart and the heartbeat phase is registered as that is done. The heartbeat phases are coarsely divided into intervals and all X-ray images that have been assigned heartbeat phase from the interval are used for reconstructing a 3D image dataset. The movement fields of the other 3D image datasets are then calculated for one of said 3D image datasets. Movement fields are vector fields indicating the movements of similar structures from one local area to the other. A departure is then made from the coarse interval division, and for each heartbeat phase a movement field is interpolated individually or at least for fairly short intervals from the movement fields determined in advance, which field is used for generating a deformed 3D image dataset that has been imaged onto a reference heartbeat phase. The deformed 3D image datasets are then added together.
摘要翻译：记录患者心脏的X射线图像，并记录心跳阶段。将心跳阶段粗略地划分为间隔，并且已经从间隔分配了心跳相位的所有X射线图像用于重建3D图像数据集。然后针对所述3D图像数据集之一计算其它3D图像数据集的运动场。运动场是指示类似结构从一个局部区域到另一个局部区域的运动的向量场。然后从粗间隔划分出发，并且对于每个心跳阶段，移动场单独或至少相对于预先确定的运动场的相当短的间隔进行内插，该场用于生成变形的3D图像数据集，其具有被成像到参考心跳期。然后将变形的3D图像数据集加在一起。

65. 发明申请

US20080119901A1 Method and system for patient-specific production of a cardiac electrode 有权
标题翻译：用于患者特异性生产心脏电极的方法和系统
公开(公告)号：US20080119901A1
公开(公告)日：2008-05-22
申请号：US11600976
申请日：2006-11-17
申请人： Norbert Rahn , Jan Boese
发明人： Norbert Rahn , Jan Boese
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N2001/0585
摘要： In a method and system for patient-specific production of a cardiac electrode, such as for use in a biventricular pacing system, a 3D representation of the coronary sinus vessel tree is segmented to indicate the interior surface thereof an a representative line from an opening of the coronary sinus vessel tree to an implantation site for the electrode, and a computerized model of the electrode is generated. A computerized virtual implantation of the electrode through the 3D representation of the coronary sinus vessel tree is implemented using the model and the internal surface and the representative line. From the virtual implantation, a determination is made as to whether an electrode conforming to the model can be guided to and implanted at the implantation site in a medically acceptable manner. If so, an actual electrode conforming to the model is then produced. If not, the model generation and the virtual implantation are iteratively modified until a satisfactory implantation result is achieved according to the virtual implantation.
摘要翻译：在用于患者特异性生产心脏电极的方法和系统中，例如用于双心室起搏系统中，冠状窦血管树的3D表示被分割以指示其内表面与来自开口的代表性线将冠状窦血管树移植到电极的植入部位，生成电极的电脑模型。通过冠状窦血管树的3D表示，通过模型和内表面和代表线来实现电极的电脑虚拟植入。从虚拟植入中，确定符合模型的电极是否可以以医学上可接受的方式被引导到植入部位并植入。如果是这样，则产生符合该模型的实际电极。如果不是，则模型生成和虚拟植入被迭代地修改，直到根据虚拟植入实现令人满意的植入结果。

66. 发明申请

US20080064974A1 Method and medical imaging system for acquisition of image data 有权
标题翻译：用于获取图像数据的方法和医学成像系统
公开(公告)号：US20080064974A1
公开(公告)日：2008-03-13
申请号：US11900834
申请日：2007-09-13
申请人： Jan Boese , Andreas Meyer , Norbert Rahn
发明人： Jan Boese , Andreas Meyer , Norbert Rahn
IPC分类号： A61B5/0402
CPC分类号： A61B6/541 , A61B5/0402 , A61B6/4441
摘要： The invention relates to a method and a medical imaging system for acquisition of image data of the heart using a medical imaging procedure during an intervention on the heart, while the heart is stimulated by a pacing signal from an external heart pacemaker, the acquisition and/or reconstruction of the image data being controlled, in particular triggered, by the pacing signal.
摘要翻译：本发明涉及一种用于在心脏介入期间使用医学成像程序获取心脏的图像数据的方法和医学成像系统，同时心脏由来自外部心脏起搏器的起搏信号刺激，采集和/ 或通过起搏信号来重构被特别触发的图像数据。

67. 发明申请

US20070083108A1 Method for visually supporting an invasive examination or therapy of the heart with the aid of an invasive instrument 有权
标题翻译：借助于侵入性仪器视觉上支持侵入性检查或治疗心脏的方法
公开(公告)号：US20070083108A1
公开(公告)日：2007-04-12
申请号：US11524611
申请日：2006-09-21
申请人： Jan Boese , Norbert Rahn
发明人： Jan Boese , Norbert Rahn
IPC分类号： G01N23/04 , A61B5/05
CPC分类号： A61B6/12 , A61B5/7285 , A61B6/541 , A61B8/543 , A61B34/20 , A61B90/36 , A61B2017/00243 , A61B2090/376
摘要： To visually support a catheter ablation in the heart, three-dimensional image data have been used prior to the intervention. During ablation, the position of the catheter is pinpointed by an orientation system. The orientation system acquires electroanatomical 3D mapping data. the two-dimensional image data is assigned to the 3D mapping data in the correct position and dimensions which is a time-consuming step. The invention makes provision for the orientation system being in a fixed location relative to the X-ray system so that a positionally and dimensionally correct alignment of the X-ray image data set with the 3D mapping data is no longer required. An image or surface based 3D-3D alignment of the three-dimensional data acquired prior to the intervention with the three-dimensional X-ray image data is considerably less time-consuming than alignment thereof with the 3D mapping data and is more reliable because more structures is recognized in the three-dimensional X-ray image data.
摘要翻译：为了可视地支持心脏中的导管消融，在干预之前已经使用三维图像数据。在消融期间，导管的位置由定位系统精确定位。取向系统获取电解剖3D绘图数据。将二维图像数据分配给三维映射数据，该数据是正确的位置和尺寸，这是耗时的步骤。本发明提供了相对于X射线系统的定位系统在固定位置的设置，使得不再需要X射线图像数据集与3D映射数据的位置和尺寸校正对准。在三维X射线图像数据的干预之前获取的三维数据的图像或基于表面的3D-3D对准与3D映射数据的对准相比，耗时更少，并且更可靠，因为更多在三维X射线图像数据中识别结构。

68. 发明申请

US20070066899A1 Medical treatment device and associated method of operation 有权
标题翻译：医疗器械及相关操作方法
公开(公告)号：US20070066899A1
公开(公告)日：2007-03-22
申请号：US11526177
申请日：2006-09-22
申请人： Jan Boese , Norbert Rahn
发明人： Jan Boese , Norbert Rahn
IPC分类号： A61B8/00 , A61B18/18
CPC分类号： A61B18/1492 , A61B8/12 , A61B2017/00119 , A61B2017/00123 , A61B2018/00678 , A61B2018/00702 , A61B2018/00791 , A61B2090/376 , A61B2090/378
摘要： Medical treatment device with an ablation catheter and a visualization device for joint display of the ablation catheter and the anatomy of a part of a patient's body to be treated, whereby the visualization device is embodied for detection of areas of risk of the part of the body to be treated and for displaying the areas of risk jointly with the ablation catheter and the anatomy.
摘要翻译：具有消融导管和用于联合显示消融导管和待治疗的患者身体的一部分的解剖结构的可视化装置的医疗处理装置，由此可视化装置被实施用于检测身体部分的风险区域被治疗并与消融导管和解剖结构联合显示风险区域。

69. 发明申请

US20070066889A1 Method for localizing a medical instrument introduced into the body of an examination object 有权
标题翻译：将引入到检查对象体内的医疗器械定位的方法
公开(公告)号：US20070066889A1
公开(公告)日：2007-03-22
申请号：US11524665
申请日：2006-09-21
申请人： Jan Boese , Bernhard Sandkamp
发明人： Jan Boese , Bernhard Sandkamp
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B5/06 , A61B5/063 , A61B5/7207 , A61B6/12 , A61B2034/2053 , A61B2562/17
摘要： A method for localizing a medical instrument, in particular a catheter or guide wire, introduced into the body of an examination object, comprising the steps: arrangement of at least four electrodes on the body of the examination object, recording of three-dimensional image data of a body region of the examination object that is of interest by means of an imaging medical examination device, determination of a model of the electrical conductivity of the examination object as a function of the recorded three-dimensional image data, determination of the electric field distribution when a voltage and/or current is/are applied for at least three different electrode pairs formed from the four electrodes as a function of the conductivity model and the spatial positions of the electrodes, not all the electrodes lying in one plane, application of a voltage and/or a current at each electrode pair and determination of a voltage value at an electrode of the medical instrument for the at least three electrode pairs and determination of the spatial position of the medical instrument as the point of intersection of the equipotential surfaces assigned to the at least three voltage values at the electrode of the medical instrument.
摘要翻译：一种将被引入检查对象体内的医疗器械，特别是导管或引导线定位的方法，包括以下步骤：在检查对象的身体上布置至少四个电极，记录三维图像数据通过成像医疗检查装置感兴趣的检查对象的身体区域，根据记录的三维图像数据确定检查对象的电导率的模型，确定电场当对由四个电极形成的至少三个不同的电极对施加电压和/或电流作为电导率模型和电极的空间位置的函数（并非所有电极位于一个平面中）时，分布应用每个电极对处的电压和/或电流以及用于至少三次的医疗器械的电极处的电压值的确定 e电极对以及将医疗器械的空间位置确定为在医疗器械的电极处分配给至少三个电压值的等电位面的交点。

70. 发明申请

US20070049908A1 Apparatus for automatic replacement of instruments during minimally invasive procedures 有权
标题翻译：用于在微创手术期间自动更换仪器的装置
公开(公告)号：US20070049908A1
公开(公告)日：2007-03-01
申请号：US11453611
申请日：2006-06-15
申请人： Jan Boese , Reinmar Killmann
发明人： Jan Boese , Reinmar Killmann
IPC分类号： A61B17/00
CPC分类号： A61B90/10 , A61B34/73 , A61B90/00 , A61B2017/00243 , A61B2017/00362 , A61B2017/3445
摘要： The invention relates to an apparatus for automatic replacement of instruments during minimally invasive procedures, comprising a housing, an outlet element for an instrument, a selection unit and a guide element.
摘要翻译：本发明涉及一种在微创手术过程中自动更换仪器的装置，包括一个外壳，一个仪器出口元件，一个选择单元和一个导向元件。

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