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61. 发明授权

US4857553A Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents 失效
标题翻译：用某些取代苯基烷基氨基（和氨基酸）衍生物和其他5-羟色胺消耗剂治疗恶心和呕吐的方法
公开(公告)号：US4857553A
公开(公告)日：1989-08-15
申请号：US230487
申请日：1988-08-10
申请人： John W. Ward , William L. Smith
发明人： John W. Ward , William L. Smith
IPC分类号： A61K31/135 , A61K31/195 , A61K31/215
CPC分类号： A61K31/135 , A61K31/195 , A61K31/215
摘要： A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: ##STR1## wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R.sup.1 and R.sup.2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.
摘要翻译：一种用于治疗哺乳动物呕吐的方法，该方法包括向所述哺乳动物施用呕吐抑制量的消耗哺乳动物脑中5-羟色胺的化合物; 其中是具有下式的化合物：其中R选自氢，低级烷基，三氟甲基，羧基或低级烷氧基羰基; R1和R2是氢或低级烷基; Z是三氟甲基或卤素; 其光学异构体及其药学上可接受的盐; 两种本发明优选的化合物是芬氟拉明和佛非氟胺。

62. 发明授权

US4717563A 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs 失效
标题翻译： 2-烷氧基-N-（1-氮杂双环（2.2.2）辛-3-基）苯甲酰胺和硫代苯甲酰胺在减轻由非铂抗癌药引起的呕吐的方法中
公开(公告)号：US4717563A
公开(公告)日：1988-01-05
申请号：US836518
申请日：1986-03-05
申请人： Reevis S. Alphin , William L. Smith , Harry R. Munson, Jr. , Robert F. Boswell
发明人： Reevis S. Alphin , William L. Smith , Harry R. Munson, Jr. , Robert F. Boswell
IPC分类号： A61K31/435 , A61P1/08 , C07D453/02 , A61K31/44
CPC分类号： C07D453/02 , A61K31/435 , Y10S514/872
摘要： A method of controlling emesis caused by non-platinum anti-cancer drugs with 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is loweralkyl; and R.sub.2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

63. 发明授权

US4547514A Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity 失效
标题翻译：丙烯酰氧基-N-（氨基烷基）-1-吡咯烷和哌啶甲酰胺和具有抗心律失常活性的硫代酰胺
公开(公告)号：US4547514A
公开(公告)日：1985-10-15
申请号：US557885
申请日：1983-12-05
申请人： Pershottam P. Mathur , William L. Smith
发明人： Pershottam P. Mathur , William L. Smith
IPC分类号： A61K31/40 , A61K31/445 , A61P9/06 , C07D207/12 , C07D211/40 , C07D211/42 , C07D211/46 , A61K31/385 , A61K31/495 , A61K31/535
CPC分类号： C07D211/40 , C07D207/12 , C07D211/42 , C07D211/46 , Y10S514/821
摘要： Pharmaceutical compositions comprised of aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides are provided of the formula: ##STR1## wherein Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2,3-dihydro-1H-inden-4-yl, 2,3-dihydro-1H-inden-5-yl, phenyl, substituted phenyl wherein the substituents are selected from lower alkyl of from 1 to 8 carbon atoms, lower alkyloxy of from 1 to 8 carbon atoms, halogen and trifluoromethyl; m and n are 1 or 2 but are never 2 at the same time; p is 1, 2, 3 or 4; R is selected from hydrogen or lower alkyl of from 1 to 3 carbon atoms; R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl of from 1 to 8 carbon atoms, phenyl, phenyl lower alkyl of from 7 to 9 carbon atoms, and cycloalkyl of from 3 to 8 carbon atoms, and R.sup.1 and R.sup.2 taken together with the adjacent atom may form a heterocyclic residue selected from 4-morpholino, 1-pyrrolidino, 1-piperidino, 1-piperazino and 4-lower alkyl piperazin-1-yl; X is oxygen or sulfur; and the pharmaceutically acceptable acid addition salts thereof having antiarrhythmic activity.
摘要翻译：由芳氧基-N-（氨基烷基）-1-吡咯烷和哌啶甲酰胺和硫代酰胺组成的药物组合物由下式提供：其中Ar选自1-萘基，2-萘基，二氢-1H-茚-4-基，2,3-二氢-1H-茚-5-基，苯基，取代苯基，其中取代基选自1至8个碳原子的低级烷基，低级烷氧基为1至 8个碳原子，卤素和三氟甲基; m和n是1或2，但从不同时2; p为1,2,3或4; R选自氢或1至3个碳原子的低级烷基; R1和R2选自氢，1至8个碳原子的低级烷基，苯基，7至9个碳原子的苯基低级烷基和3至8个碳原子的环烷基，以及R1和R2与相邻的原子可以形成选自4-吗啉代，1-吡咯烷子基，1-哌啶子基，1-哌嗪基和4-低级烷基哌嗪-1-基的杂环残基; X是氧或硫; 及其药学上可接受的酸加成盐具有抗心律不齐活性。

64. 外观设计

USD267242S Stackable unit for a seed germinating device 失效
公开(公告)号：USD267242S
公开(公告)日：1982-12-14
申请号：US108568
申请日：1979-12-31
申请人： William L. Smith , Robert B. Whitson
设计人： William L. Smith , Robert B. Whitson

65. 发明授权

US4170960A Additive supply and control device 失效
标题翻译：添加剂供应和控制装置
公开(公告)号：US4170960A
公开(公告)日：1979-10-16
申请号：US921484
申请日：1978-07-03
申请人： Walter F. Germack , William L. Smith
发明人： Walter F. Germack , William L. Smith
IPC分类号： F02B51/00 , F02M25/00 , F02B77/00
CPC分类号： F02M25/00 , F02B51/00 , F02F2007/0092
摘要： There is disclosed an engine additive supply and control device, for supplying a fuel supplement in small amounts which will have many desirable effects on operation of the vehicle or apparatus which is being driven by an engine to which the additive is being supplied along with the fuel and air mixture, the quantity of supply being controlled in response to manifold vacuum conditions and flow of additive through the device being controlled by passage way, opening and fluid line sizes, in the device, which are coordinated to prevent surging, flooding and to minimize consumption, while providing adequate quantities to produce the desired interaction with the fuel/air mixture, a container, a body with suitable wells and passages and interconnections being provided.
摘要翻译：公开了一种发动机添加剂供应和控制装置，用于少量供应燃料补充剂，这将对由正在与燃料一起供应添加剂的发动机驱动的车辆或设备的操作产生许多期望的影响和空气混合物，供应量根据歧管真空条件进行控制，并且通过装置的添加剂的流动由装置中的通道，开口和流体管线尺寸控制，其被协调以防止浪涌，溢流和最小化消耗，同时提供足够的量以产生与燃料/空气混合物的期望的相互作用，容器，具有合适的井的主体和通道以及互连。

66. 发明公开

US20240023667A1 DYNAMIC CUSHIONING SYSTEM FOR SHOES OR INSOLES 审中-公开
公开(公告)号：US20240023667A1
公开(公告)日：2024-01-25
申请号：US17813529
申请日：2022-07-19
申请人： William L. Smith
发明人： William L. Smith
IPC分类号： A43B13/18
CPC分类号： A43B13/189
摘要： Provided are dynamic cushioning systems (e.g., for use in insoles, orthoses, shoes, etc.), comprising: a fluid chamber (e.g., 100, 200) having at least one flexible fluid reservoir cell in each of a hindfoot and a forefoot portion, and having at least one main fluid transfer channel spanning a midfoot portion and connecting, in fluid exchange communication, the at least one hindfoot fluid reservoir cell with the at least one forefoot fluid reservoir cell to provide a reactive network of hindfoot and/or forefoot fluid reservoir cells in fluid exchange communication. The interconnected multi-reservoir networks provide optimal reactivity and dynamic positional cushioning by controlling fluid transfer rate(s) between and among the fluid reservoir cells. Also provided are methods for making the fluid chambers, along with insoles, orthoses, shoes, and other footwear, etc., comprising same.

67. 发明申请

US20190017880A1 TEMPERATURE SENSOR ASSEMBLY 审中-公开
公开(公告)号：US20190017880A1
公开(公告)日：2019-01-17
申请号：US15651025
申请日：2017-07-17
申请人： William L. Smith
发明人： William L. Smith
IPC分类号： G01K7/18 , G01D11/24 , G01K1/08 , G01K1/16
摘要： A temperature sensor assembly is described that includes a sensor probe including a probe head and a probe shaft. At least a tip of the sensor probe includes a material with a thermal conductivity proportionality constant greater than stainless steel. A temperature sensor is positioned within the probe shaft adjacent to the tip. A nose piece is positioned on the probe shaft opposite the probe head. The nose piece includes a material with a thermal conductivity proportionality constant greater than stainless steel. The temperature sensor assembly also includes a collar positioned around the probe shaft between the probe head and the nose piece, the collar is capable of rotating relative to the probe shaft during installation of the sensor assembly.

68. 发明授权

US08457082B2 System and method for providing integrated voice and data services utilizing wired cordless access with unlicensed/unregulated spectrum 有权
标题翻译：使用具有未许可/不受监管频谱的有线无绳接入提供集成语音和数据业务的系统和方法
公开(公告)号：US08457082B2
公开(公告)日：2013-06-04
申请号：US10614737
申请日：2003-07-07
申请人： John A. Hicks, III , Gregory N. Patterson , William L. Smith
发明人： John A. Hicks, III , Gregory N. Patterson , William L. Smith
IPC分类号： H04W4/00
CPC分类号： H04W88/06 , H04M3/42263 , H04M7/0066 , H04M2207/18 , H04M2207/185 , H04W84/12 , H04W84/16
摘要： Methods and systems provide integrated voice and data services utilizing wired cordless access with unlicensed/unregulated connectivity sources. A digital cordless telephone operates over unlicensed/unregulated spectrum in conjunction with one or more wireless access points (WAP) that are installed in homes, businesses, entertainment venues, and the like. The WAPs are connected to a communications service provider's broadband packet data network. A user may use the device when they are in range of another wireless access point in a public or private building that also is connected to their communications service provider's broadband packet data network.
摘要翻译：方法和系统使用具有未许可/不受管制的连接源的有线无绳访问来提供集成的语音和数据服务。数字无绳电话与安装在家庭，商业，娱乐场所等中的一个或多个无线接入点（WAP）结合在非许可/不受监管的频谱上操作。 WAP连接到通信服务提供商的宽带分组数据网络。当用户在公共或私人建筑物中的另一个无线接入点的范围内时，用户也可以使用该设备，该建筑物也连接到他们的通信服务提供商的宽带分组数据网络。

69. 发明授权

US08287755B2 Solid-layered bleach compositions 有权
标题翻译：固体层状漂白剂组合物
公开(公告)号：US08287755B2
公开(公告)日：2012-10-16
申请号：US12620932
申请日：2009-11-18
申请人： William L. Smith , Evan M. Rumberger
发明人： William L. Smith , Evan M. Rumberger
IPC分类号： C01B11/06 , A61Q11/02 , A61Q11/00 , A61K8/20
CPC分类号： C11D3/10 , C11D3/2079 , C11D3/2082 , C11D3/33 , C11D3/349 , C11D3/3761 , C11D3/3776 , C11D3/378 , C11D3/3953 , C11D17/0039 , C11D17/0078
摘要： The present invention provides a solid-layered composition having at least two parts. The first part comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a surfactant, b) a builder, c) an acid, and d) wherein the second part does not contain any oxidant.
摘要翻译：本发明提供具有至少两部分的固体层组合物。第一部分包括a）次氯酸钙，次氯酸镁及其混合物，b）助洗剂，c）水溶性聚合物，d）酸和e）其中第一部分不含次氯酸钠，次氯酸锂，钾次氯酸盐及其混合物。第二部分包括a）表面活性剂，b）助洗剂，c）酸，和d）其中第二部分不含任何氧化剂。

70. 发明申请

US20110059882A1 SOLID-LAYERED BLEACH COMPOSITIONS AND METHODS OF USE 有权
标题翻译：固体漂白组合物及其使用方法
公开(公告)号：US20110059882A1
公开(公告)日：2011-03-10
申请号：US12943185
申请日：2010-11-10
申请人： William L. Smith , Evan Rumberger
发明人： William L. Smith , Evan Rumberger
IPC分类号： A61K8/81 , A61Q11/02 , A61K8/02 , A61K8/84
CPC分类号： C11D3/10 , A61K8/19 , A61K8/20 , A61K8/36 , A61K8/463 , A61K8/466 , A61K8/8147 , A61K8/8152 , A61K8/8176 , A61K8/8188 , A61K2800/88 , A61Q11/02 , C11D1/22 , C11D3/046 , C11D3/2075 , C11D3/2079 , C11D3/2082 , C11D3/33 , C11D3/3454 , C11D3/349 , C11D3/361 , C11D3/3761 , C11D3/3776 , C11D3/378 , C11D3/3953 , C11D17/0078
摘要： The present invention provides a method for cleaning dentures by contacting the dentures with a solid, multi-layered composition having at least two parts in water. The first part of the composition comprises a) calcium hypochlorite, magnesium hypochlorite and mixtures thereof, b) a builder, c) a water-soluble polymer, d) an acid, and e) wherein the first part does not contain sodium hypochlorite, lithium hypochlorite, potassium hypochlorite and mixtures thereof. The second part comprises a) a functional ingredient, b) a builder or filler, and c) wherein the second part does not contain any oxidant.
摘要翻译：本发明提供一种通过使假牙与固体多层组合物接触来清洁义齿的方法，所述组合物在水中具有至少两个部分。组合物的第一部分包括a）次氯酸钙，次氯酸镁及其混合物，b）助洗剂，c）水溶性聚合物，d）酸，和e）其中第一部分不含有次氯酸钠，锂次氯酸盐，次氯酸钾及其混合物。第二部分包括a）功能成分，b）助洗剂或填料，和c）其中第二部分不含任何氧化剂。

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