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61. 发明授权

US4586026A Infrared gas analyzer using count quadrature sampling 失效
标题翻译：红外气体分析仪采用计数正交采样
公开(公告)号：US4586026A
公开(公告)日：1986-04-29
申请号：US549411
申请日：1983-11-07
申请人： James R. Braig , Max D. Liston
发明人： James R. Braig , Max D. Liston
IPC分类号： G01N21/25 , G01N21/35
CPC分类号： H03M1/48 , G01N21/256 , G01N21/3504
摘要： The percentage gas concentration within a sample as measured in a conventional optical bench is derived from the composite signal of the reference beam and sample beam transmitted through a sample cell in the optical bench. The primary source, which generates the reference beam and the secondary source which generates the sample beam are driven ninety degrees out of phase. The composite signal derived from the detector in the optical bench is digitized and then integrated according to the quadrature of the primary component of the composite signal derived from the reference beam, and is also integrated according to the quadrature of the secondary component of the composite signal derived from the sample beam. What is obtained is the integral of the absolute value of the secondary component and the integral of the absolute value of the primary component of the composite signal over one cycle of the reference beam and sample beam. The ratio of these component signals is computed to obtain a signal which is related to the percentage concentration of reference gas contained within the sample.
摘要翻译：在常规光学平台中测量的样品中的气体浓度百分比是从参考光束和通过光学平台中的样品池传输的样品光束的复合信号导出的。产生参考光束的主光源和产生采样光束的次光源相位驱动九十度。从光台上的检测器导出的复合信号被数字化，然后根据从参考光束导出的复合信号的主分量的正交积分，并且还根据复合信号的次分量的正交积分源自样品束。获得的是二次分量的绝对值的积分和复合信号的主要分量的绝对值的积分在参考光束和样本光束的一个周期上。计算这些分量信号的比率以获得与样品中包含的参考气体的浓度百分比相关的信号。

62. 发明申请

US20110306856A1 SYSTEMS AND METHODS FOR MEASURING MULTIPLE ANALYTES IN A SAMPLE 有权
标题翻译：用于在样品中测量多个分析物的系统和方法
公开(公告)号：US20110306856A1
公开(公告)日：2011-12-15
申请号：US13156295
申请日：2011-06-08
申请人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
IPC分类号： A61B5/157 , A61B6/00
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
摘要翻译：提供了用于分析流体样品的多个组分的系统和方法。在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分的样品分离后。

63. 发明授权

US07972296B2 Fluid component analysis system and method for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US07972296B2
公开(公告)日：2011-07-05
申请号：US12249831
申请日：2008-10-10
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M31/00
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

64. 发明申请

US20100234786A1 System and Method for Detection of Disconnection in an Extracorporeal Blood Circuit 有权
标题翻译：体外循环检测系统和方法
公开(公告)号：US20100234786A1
公开(公告)日：2010-09-16
申请号：US12705054
申请日：2010-02-12
申请人： Barry Neil Fulkerson , James R. Braig
发明人： Barry Neil Fulkerson , James R. Braig
IPC分类号： A61M1/14
CPC分类号： A61M1/3653 , A61M1/3639 , A61M1/3656 , A61M1/3659 , A61M2230/06
摘要： The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.
摘要翻译：本发明涉及一种具有断开监视器的透析系统，用于确定与患者的血液线路连接是否已断开。它包括与患者流体连通的血液回路和透析电路，用于产生指示血液回路中脉冲信号的信号的压力传感器，用于产生指示患者脉搏和断开的信号的心脏参考信号发生器监控。断开监视器包括：压力传感器数据接收器，用于接收指示血液回路中的脉冲信号的信号;心脏参考信号接收器，用于接收指示患者脉搏的信号;以及处理器，用于将指示脉搏信号和指示患者脉搏的信号，以产生指示与患者的血液线路连接断开的数据。

65. 发明申请

US20090101577A1 Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements 审中-公开
标题翻译：使用中央静脉压测量法控制超滤的方法和系统
公开(公告)号：US20090101577A1
公开(公告)日：2009-04-23
申请号：US12238055
申请日：2008-09-25
申请人： Barry N. Fulkerson , James R. Braig , Victor Gura
发明人： Barry N. Fulkerson , James R. Braig , Victor Gura
IPC分类号： B01D61/34 , A61B5/02
CPC分类号： A61M1/3653 , A61B5/02152 , A61B5/412 , A61M1/3659 , A61M1/3661 , A61M2230/30 , B01D61/22 , B01D61/32
摘要： The volume of fluid removed from a patient during ultrafiltration is controlled automatically on the basis of central venous pressure (CVP) measurements. In one embodiment, a central venous catheter (CVC) is used for accessing blood during dialysis. A sensor located at the tip of the catheter or inside the dialysis machine is used to periodically measure CVP. CVP feedback data helps prevent the excessive removal of fluids from the patient.
摘要翻译：基于中心静脉压（CVP）测量自动控制在超滤期间从患者移除的流体体积。在一个实施例中，中心静脉导管（CVC）用于在透析期间接近血液。位于导管尖端或透析机内部的传感器用于定期测量CVP。 CVP反馈数据有助于防止患者过度去除液体。

66. 发明授权

US07480032B2 Device and method for in vitro determination of analyte concentrations within body fluids 有权
标题翻译：用于体外测定体液中分析物浓度的装置和方法
公开(公告)号：US07480032B2
公开(公告)日：2009-01-20
申请号：US11337943
申请日：2006-01-23
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

67. 发明授权

US07122154B1 Apparatus for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的装置，区分肺泡和上呼吸道酒精
公开(公告)号：US07122154B1
公开(公告)日：2006-10-17
申请号：US08363615
申请日：1994-12-23
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

68. 发明授权

US06771993B2 Sample adapter 失效
标题翻译：样品适配器
公开(公告)号：US06771993B2
公开(公告)日：2004-08-03
申请号：US10219996
申请日：2002-08-15
申请人： Peter Rule , James R. Braig , Philip C. Hartstein , Jennifer H. Gable
发明人： Peter Rule , James R. Braig , Philip C. Hartstein , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.
摘要翻译：适配器将诸如全血的体液样品（包括分析物）提供给非侵入性监测器的分析器窗口。适配器包括包括第一侧和第二侧的基材。适配器还包括在基材的第二侧的开口和基材的第一侧中的开口之间延伸的样品容纳体积。

69. 发明授权

US5095913A Shutterless optically stabilized capnograph 失效
标题翻译：无光闸光学稳定的星座
公开(公告)号：US5095913A
公开(公告)日：1992-03-17
申请号：US522208
申请日：1990-05-11
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/083 , G01J1/24 , G01J5/12 , G01N21/31 , G01N21/35
CPC分类号： G01N21/3504 , A61B5/083 , G01J1/24 , G01J5/12 , G01N2021/3166 , G01N2201/126
摘要： Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of optically filtered thermopiles in series and processing the resulting differential pair.
摘要翻译：公开了用于构造光学稳定的无闸门红外捕集仪的方法和装置。本发明的血氧监护仪提供了患者的呼吸气流的成分的绝对浓度，而没有通常与热电堆检测器相关的热漂移问题，从而提供高精度的装置。本发明不需要机械快门来调制入射的红外光束和调制源的需要，从而增加所公开的设备的可靠性和响应时间。基本上不受其工作环境温度变化影响的测井仪通过串联连接成对的光学过滤的热电堆并处理所得的差分对来提供。

70. 发明授权

US08535522B2 System and method for detection of disconnection in an extracorporeal blood circuit 有权
标题翻译：用于检测体外血液回路断开的系统和方法
公开(公告)号：US08535522B2
公开(公告)日：2013-09-17
申请号：US12705054
申请日：2010-02-12
申请人： Barry Neil Fulkerson , James R. Braig
发明人： Barry Neil Fulkerson , James R. Braig
IPC分类号： B01D61/32 , B01D61/28 , B01D61/30 , A61M1/14
CPC分类号： A61M1/3653 , A61M1/3639 , A61M1/3656 , A61M1/3659 , A61M2230/06
摘要： The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.
摘要翻译：本发明涉及一种具有断开监视器的透析系统，用于确定与患者的血液线路连接是否已断开。它包括与患者流体连通的血液回路和透析电路，用于产生指示血液回路中脉冲信号的信号的压力传感器，用于产生指示患者脉搏和断开的信号的心脏参考信号发生器监控。断开监视器包括：压力传感器数据接收器，用于接收指示血液回路中的脉冲信号的信号;心脏参考信号接收器，用于接收指示患者脉搏的信号;以及处理器，用于将指示脉搏信号和指示患者脉搏的信号，以产生指示与患者的血液线路连接断开的数据。

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