专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US07919628B2 CXCR2 inhibitors 有权
标题翻译： CXCR2抑制剂
公开(公告)号：US07919628B2
公开(公告)日：2011-04-05
申请号：US11771958
申请日：2007-06-29
申请人： Stephanie Hachtel , Juergen Dedio , Holger Heitsch , Werngard Czechtizky , Sven Grueneberg , Stephen J. Shimshock , Raymond W. Kosley, Jr. , Carolina L. Lanter , Hui Li , Rosy Sher , Aleksandra Weichsel
发明人： Stephanie Hachtel , Juergen Dedio , Holger Heitsch , Werngard Czechtizky , Sven Grueneberg , Stephen J. Shimshock , Raymond W. Kosley, Jr. , Carolina L. Lanter , Hui Li , Rosy Sher , Aleksandra Weichsel
IPC分类号： C07D277/64 , A61K31/426
CPC分类号： C07D213/68 , C07D207/325 , C07D213/30 , C07D213/65 , C07D213/69 , C07D215/14 , C07D217/26 , C07D231/12 , C07D233/64 , C07D249/06 , C07D249/08 , C07D249/18 , C07D261/08 , C07D263/32 , C07D271/12 , C07D277/24 , C07D277/64 , C07D307/42 , C07D317/54 , C07D319/20 , C07D333/56 , C07D333/70 , C07D409/12 , C07D417/12 , C07D495/04
摘要： The invention relates to compounds of the formula I: in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.
摘要翻译：本发明涉及式I化合物：其中R1，R2，X，A，B，D和Y1至Y4具有权利要求中所示的含义，和/或其药学上可接受的盐和/或前药。由于其作为趋化因子受体的抑制剂的特性，特别是作为CXCR2抑制剂，式I化合物及其药学上可接受的盐和前药适用于预防和治疗趋化因子介导的疾病。

62. 发明申请

US20110027856A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权
公开(公告)号：US20110027856A1
公开(公告)日：2011-02-03
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： C12N9/99
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

63. 发明申请

US20110016005A1 PROVIDING ADVERTISEMENTS FROM RELATED SEARCH QUERIES 审中-公开
标题翻译：从相关搜索查询提供广告
公开(公告)号：US20110016005A1
公开(公告)日：2011-01-20
申请号：US12511752
申请日：2009-07-29
申请人： Hui Li , Yong Zhang , Gangjiang Li , Boon-Lock Yeo
发明人： Hui Li , Yong Zhang , Gangjiang Li , Boon-Lock Yeo
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0256 , G06F16/248 , G06F16/9535 , G06Q30/02 , G06Q30/0251 , G06Q30/0277
摘要： Methods, systems and apparatus for identifying advertisements previously presented when processing related search queries related to a submitted search query, and providing the advertisements identified from the related search queries for presentation on a search results page for the submitted search query.
摘要翻译：用于识别当处理与所提交的搜索查询有关的相关搜索查询时先前呈现的广告的方法，系统和装置，以及提供从相关搜索查询识别的广告，以便在所提交的搜索查询的搜索结果页上呈现。

64. 发明授权

US07834024B2 Compositions and methods for inhibition of the JAK pathway 有权
标题翻译：用于抑制JAK途径的组合物和方法
公开(公告)号：US07834024B2
公开(公告)日：2010-11-16
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译：本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。

65. 发明授权

US07825116B2 N2, N4-bis-aryl-5-fluoro-2,4-pyrimidinediamines 有权
标题翻译： N 2，N 4 - 双 - 芳基-5-氟-2,4-嘧啶二亚胺
公开(公告)号：US07825116B2
公开(公告)日：2010-11-02
申请号：US11539101
申请日：2006-10-05
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： C07D239/48 , C07D403/12 , A61K31/506
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译：本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。

66. 发明授权

US07812669B2 Predistortion apparatus, system, and method 有权
标题翻译：预失真装置，系统和方法
公开(公告)号：US07812669B2
公开(公告)日：2010-10-12
申请号：US12485456
申请日：2009-06-16
申请人： Hui Li , Zhan Shi , Jianmin Zhou
发明人： Hui Li , Zhan Shi , Jianmin Zhou
IPC分类号： H03F1/26
CPC分类号： H03F1/3247 , H03F2201/3233
摘要： The present invention discloses a predistortion apparatus, a predistortion system and a predistortion method. The predistorter comprises a modular value calculating section, for performing modular arithmetic on an information source input signal inputted from an information source; an orthogonal lookup table value acquiring section, for searching N stored lookup tables orthogonal to one another, finding out corresponding output of each lookup table in accordance with the modular value of the information source input signal, and acquiring N lookup table values, wherein N is an integer greater than 1; a multiplying section, for multiplying the N lookup table values acquired by the orthogonal lookup table value acquiring section with N amplitude adjustment factors to obtain N amplitude adjustment values, and multiplying the N lookup table values with N phase adjustment factors to obtain N phase adjustment values; and a summating section, for summating the N amplitude adjustment values to obtain an amplitude predistortion value, and summating the N phase adjustment values to obtain a phase predistortion value.
摘要翻译：本发明公开了一种预失真装置，预失真系统和预失真方法。预失真器包括模块值计算部分，用于对从信息源输入的信息源输入信号进行模数运算; 正交查找表值获取部分，用于搜索彼此正交的N个存储的查找表，根据信息源输入信号的模块值找出每个查找表的相应输出，并获取N个查找表值，其中N是大于1的整数; 乘法部分，用于将由正交查找表值获取部分获取的N个查找表值与N个幅度调整因子相乘以获得N个幅度调整值，并将N个查找表值与N个相位调整因子相乘以获得N个相位调整值 ; 以及求和部分，用于对N个振幅调整值进行求和以获得幅度预失真值，并且对N个相位调整值进行求和以获得相位预失真值。

67. 发明授权

US07812029B1 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds 有权
标题翻译：用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法
公开(公告)号：US07812029B1
公开(公告)日：2010-10-12
申请号：US12028581
申请日：2008-02-08
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： C07D239/42
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译：本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。

68. 发明授权

US07801895B2 Method and apparatus for organizing nodes in a network 有权
标题翻译：用于组织网络中的节点的方法和装置
公开(公告)号：US07801895B2
公开(公告)日：2010-09-21
申请号：US11605162
申请日：2006-11-28
申请人： Dietmar Hepper , Hui Li , Meinolf Blawat
发明人： Dietmar Hepper , Hui Li , Meinolf Blawat
IPC分类号： G06F17/30
CPC分类号： G06F3/0635 , G06F3/0605 , G06F3/067 , G06F17/30194 , H04L67/1097 , H04L69/329
摘要： In current Distributed Storage Systems, applications may determine the device on which data shall be stored. The invention provides a method for automatically selecting an individual storage device within a DSS. A method for automatically classifying a node in a network comprises determining data classes, automatically classifying data of said data classes stored on a node, determining the amount of stored data per data class, calculating data dominance values for each of the data classes, receiving a request that indicates a data type according to one of said data classes, and providing said dominance value according to the requested data class.Further, a method for automatically organizing nodes in a network comprises receiving a request for storing data of a particular data type, transmitting the request to storage nodes, receiving from the storage nodes respective dominance values, and selecting the node with the highest dominance value for storing the data.
摘要翻译：在当前的分布式存储系统中，应用程序可以确定要存储数据的设备。本发明提供了一种在DSS内自动选择单个存储设备的方法。一种用于自动分类网络中的节点的方法包括：确定数据类别，自动分类存储在节点上的所述数据类别的数据，确定每个数据类别存储的数据量，计算每个数据类别的数据优势值，根据所述数据类别之一指示数据类型的请求，并根据请求的数据类提供所述优势值。此外，用于在网络中自动组织节点的方法包括：接收存储特定数据类型的数据的请求，将请求发送到存储节点，从存储节点接收各自的优势值，并且选择具有最高优势值的节点存储数据。

69. 发明授权

US07792116B2 Method and device for interworking between internet protocol networks 有权
标题翻译：互联网协议网络互通的方法和设备
公开(公告)号：US07792116B2
公开(公告)日：2010-09-07
申请号：US11703709
申请日：2007-02-08
申请人： Hui Li , Yajuan Wu
发明人： Hui Li , Yajuan Wu
IPC分类号： H04L12/56 , H04J3/16
CPC分类号： H04L29/06027 , H04L65/1006 , H04L65/1016 , H04L65/1043 , H04L69/08 , H04L69/16 , H04L69/167 , H04L69/24
摘要： Embodiments of the present invention provide a method and device for interworking between Internet Protocol (IP) networks of. The method includes: judging whether the home network of a called UE supports the IP version of a calling UE, and forwarding a message sent from the calling UE to a home calling state control device of the called UE if yes, otherwise, performing an IP version transformation of the message and sending the message to the home calling state control device of the called UE; judging whether the called UE supports the IP version of the message, forwarding the message to the called UE if yes, otherwise, performing an IP version transformation of the message and sending the message to the called UE. The method and device can reduce unnecessary transformation between different IP versions and improve the interworking between IP networks when the IP Multimedia Subsystem (IMS) is employed.
摘要翻译：本发明的实施例提供了一种在互联网协议（IP）网络之间进行互通的方法和装置。该方法包括：判断被叫UE的归属网络是否支持主叫用户的IP版本，如果是，则将从主叫UE发送的消息转发给被叫方的归属呼叫状态控制设备，否则执行IP 消息的版本转换，并将消息发送到被叫UE的归属呼叫状态控制装置; 判断被叫UE是否支持消息的IP版本，如果是，则将消息转发给被叫UE，否则执行消息的IP版本变换，并向被叫UE发送消息。该方法和设备可以减少不同IP版本之间的不必要的转换，并且当采用IP多媒体子系统（IMS）时，可以改善IP网络之间的互通。

70. 发明授权

US07754714B2 Cycloalkyl substituted pyrimidinediamine compounds and their uses 有权
公开(公告)号：US07754714B2
公开(公告)日：2010-07-13
申请号：US11133419
申请日：2005-05-18
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim M. V. Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim M. V. Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式