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61. 发明申请

US20180085554A1 DEVICES, SYSTEMS, AND METHODS USEFUL TO ENGAGE TISSUE USING SUCTION AND TO PERFORM MEDICAL PROCEDURES DURING SUCTIONAL ENGAGEMENT 审中-公开
公开(公告)号：US20180085554A1
公开(公告)日：2018-03-29
申请号：US15821825
申请日：2017-11-23
申请人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
发明人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
IPC分类号： A61M25/00 , A61B17/34
CPC分类号： A61M25/0067 , A61B17/00491 , A61B17/3401 , A61B17/3403 , A61B17/3415 , A61B17/3478 , A61B18/02 , A61B18/14 , A61B2017/00026 , A61B2017/00044 , A61B2017/00084 , A61B2017/00247 , A61B2017/308 , A61B2018/00291 , A61M25/0026 , A61M25/0084 , A61M25/06 , A61M25/09 , A61M2025/0057
摘要： Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during sectional engagement. The present disclosure includes disclosure of a tension apparatus, comprising an elongated portion; and a head portion at a distal end of the elongated portion, the head portion comprising one or more arms, whereby a suction lumen extending along the elongated portion and the one or more arms terminates at one or more suction openings at each of the one or more arms.

62. 发明授权

US08738121B2 Method and apparatus for distinguishing epileptic seizure and neurocardiogenic syncope 有权
标题翻译：用于区分癫痫发作和神经心源性晕厥的方法和装置
公开(公告)号：US08738121B2
公开(公告)日：2014-05-27
申请号：US12861178
申请日：2010-08-23
申请人： Nathalie Virag , H. Toby Markowitz , Rolf Vetter
发明人： Nathalie Virag , H. Toby Markowitz , Rolf Vetter
IPC分类号： A61B5/0456 , A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0456 , A61B5/4094 , A61B5/7282 , A61N1/365 , A61N1/3702 , A61N1/37247
摘要： A system and method for distinguishing an epileptic event from a syncope event that includes sensing a signal, generating sensed intervals in response to the sensed signal, generating an indication signal in response to an occurrence of an event, determining a marginality in response to the generated indication signal and the sensed intervals, and determining the event as being one of the epileptic event and the syncope event in response to the determined marginality.
摘要翻译：一种用于区分癫痫事件与晕厥事件的系统和方法，其包括感测信号，响应于感测到的信号产生感测间隔，响应于事件的发生而产生指示信号，响应所产生的边界指示信号和所感测的间隔，并且响应于所确定的边际，将事件确定为癫痫事件和晕厥事件之一。

63. 发明授权

US08364252B2 Identifying a structure for cannulation 有权
标题翻译：识别插管的结构
公开(公告)号：US08364252B2
公开(公告)日：2013-01-29
申请号：US12424007
申请日：2009-04-15
申请人： H. Toby Markowitz , Brent Chelgren , Noelle Christine Hurtig , Marie P. Smith , Phillip Falkner , Lane A. Phillips
发明人： H. Toby Markowitz , Brent Chelgren , Noelle Christine Hurtig , Marie P. Smith , Phillip Falkner , Lane A. Phillips
IPC分类号： A61B5/04
CPC分类号： G06T19/003 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B5/066 , A61B5/068 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/102 , A61B2034/105 , A61B2034/2051 , A61B2034/2068 , A61B2034/2072 , A61B2090/061 , A61B2090/063 , A61B2090/371 , A61B2090/376 , A61B2090/378
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

64. 发明授权

US08355774B2 System and method to evaluate electrode position and spacing 有权
标题翻译：评估电极位置和间距的系统和方法
公开(公告)号：US08355774B2
公开(公告)日：2013-01-15
申请号：US12609734
申请日：2009-10-30
申请人： H. Toby Markowitz , Shangqian Peter Zhang
发明人： H. Toby Markowitz , Shangqian Peter Zhang
IPC分类号： A61B5/05 , A61B19/00 , A61N1/00
CPC分类号： A61N1/37 , A61B5/0422 , A61B5/06 , A61B5/063 , A61B34/20 , A61B2034/2051 , A61B2034/2072 , A61N1/372
摘要： A method and apparatus for tracking and illustrating the location of leads positioned within the volume is disclosed. For example, the lead electrodes can be positioned within a heart of a patient that can be tracked over time. The lead electrodes can be tracked with an electrode potential or bioimpedance tracking system to determine the position of the lead electrodes. A method and apparatus is disclosed to analyze the position information for analyzing the selected position of the lead electrodes.
摘要翻译：公开了一种用于跟踪和示出位于体积内的引线的位置的方法和装置。例如，引线电极可以位于可以随时间跟踪的患者的心脏内。可以用电极电位或生物阻抗跟踪系统跟踪引线电极以确定引线电极的位置。公开了分析用于分析引线电极的选定位置的位置信息的方法和装置。

65. 发明申请

US20120271341A1 Method and Apparatus for Treating a Mitral Valve Prolapse and Providing Embolic Protection 审中-公开
标题翻译：用于治疗二尖瓣止痛和提供栓塞保护的方法和装置
公开(公告)号：US20120271341A1
公开(公告)日：2012-10-25
申请号：US13093233
申请日：2011-04-25
申请人： Alexander J. Hill , Thomas M. Castellano , H. Toby Markowitz
发明人： Alexander J. Hill , Thomas M. Castellano , H. Toby Markowitz
IPC分类号： A61F2/01 , A61N1/00
CPC分类号： A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61N1/39
摘要： A method and apparatus for treating a mitral valve prolapse and providing embolic protection in a patient is disclosed. An embolic protection filter is delivered to the left atrium and placed in the blood flow exiting the left atrium of the heart. The filter is secured in the heart of a patient. A shaping member is delivered to the mitral valve of the heart and secured in the heart.
摘要翻译：公开了一种用于治疗二尖瓣脱垂并在患者中提供栓塞保护的方法和装置。栓塞保护过滤器被输送到左心房并且放置在离开心脏左心房的血流中。过滤器固定在患者的心脏中。成形构件被递送到心脏的二尖瓣并固定在心脏中。

66. 发明申请

US20120190993A1 LOCATING AN INDICATOR 有权
标题翻译：定位指标
公开(公告)号：US20120190993A1
公开(公告)日：2012-07-26
申请号：US13424857
申请日：2012-03-20
申请人： H. Toby Markowitz , Pooja Mehta , Ioana Fleming , Phillip Falkner , Eduardo N. Warman
发明人： H. Toby Markowitz , Pooja Mehta , Ioana Fleming , Phillip Falkner , Eduardo N. Warman
IPC分类号： A61B5/02
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： A system to determine and illustrate a location of position element within a volume is disclosed. The position element can be used to determine the position of a portion of an instrument. The instrument can include one or both of a cannulated member and a lead member passed through the cannula.
摘要翻译：公开了一种用于确定和说明体内位置元素的位置的系统。位置元件可用于确定仪器的一部分的位置。仪器可以包括穿过插管的插管构件和引导构件中的一个或两个。

67. 发明授权

US08208991B2 Determining a material flow characteristic in a structure 失效
标题翻译：确定结构中的材料流动特性
公开(公告)号：US08208991B2
公开(公告)日：2012-06-26
申请号：US12422658
申请日：2009-04-13
申请人： H. Toby Markowitz , Phillip Falkner
发明人： H. Toby Markowitz , Phillip Falkner
IPC分类号： A61B5/05
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

68. 发明授权

US07991467B2 Remotely enabled pacemaker and implantable subcutaneous cardioverter/defibrillator system 有权
标题翻译：远程启动心脏起搏器和植入式皮下心律转复/除颤器系统
公开(公告)号：US07991467B2
公开(公告)日：2011-08-02
申请号：US11114474
申请日：2005-04-26
申请人： H. Toby Markowitz , Douglas A. Hettrick , William J. Combs , Todd J. Sheldon , David L. Thompson , Raja N. Ghanem , Kevin A. Wanasek
发明人： H. Toby Markowitz , Douglas A. Hettrick , William J. Combs , Todd J. Sheldon , David L. Thompson , Raja N. Ghanem , Kevin A. Wanasek
IPC分类号： A61B5/02 , A61N1/362
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心脏复律除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的外科手术入侵患者体内，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

69. 发明申请

US20110160557A1 TESTING COMMUNICATION DURING IMPLANTATION 有权
标题翻译：植入过程中的测试通讯
公开(公告)号：US20110160557A1
公开(公告)日：2011-06-30
申请号：US12732403
申请日：2010-03-26
申请人： Can Cinbis , H. Toby Markowitz
发明人： Can Cinbis , H. Toby Markowitz
IPC分类号： A61B5/04
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for testing communication through a patient during implantation using telemetry coupling electrodes on a delivery catheter. In one example, at least two telemetry coupling electrodes may be placed on or within a delivery catheter to test conductive communication with external body electrodes during implantation. In some instances, the telemetry coupling electrodes of the delivery catheter may approximate the spacing of telemetry electrodes on an IMD. In this manner, testing conductively coupled communication with telemetry coupling electrodes of the catheter may be used to mimic the telemetry electrodes on the IMD and determine a target position and/or orientation of an electrode or electrodes of the IMD for successful conductive communication through the body.
摘要翻译：描述了一种用于在植入期间通过患者使用传送导管上的遥测耦合电极来测试通信的系统和方法。在一个示例中，至少两个遥测耦合电极可以放置在输送导管上或内部，以在植入期间测试与外部身体电极的导电连通。在一些情况下，输送导管的遥测耦合电极可以接近IMD上遥测电极的间距。以这种方式，测试与导管的遥测耦合电极的导电耦合通信可以用于模拟IMD上的遥测电极，并且确定IMD的电极或电极的目标位置和/或取向以通过身体成功地导电连通。

70. 发明申请

US20110054293A1 Combination Localization System 有权
公开(公告)号：US20110054293A1
公开(公告)日：2011-03-03
申请号：US12844065
申请日：2010-07-27
申请人： H. Toby Markowitz , Kenneth Gardeski , Jean Carver , Kendra Yasger , Michael R. Neldert , Lane A. Phillips , Laurent Verard , Steven L. Hartmann , Andrew Bzostek , Bradley A. Jascob
发明人： H. Toby Markowitz , Kenneth Gardeski , Jean Carver , Kendra Yasger , Michael R. Neldert , Lane A. Phillips , Laurent Verard , Steven L. Hartmann , Andrew Bzostek , Bradley A. Jascob
IPC分类号： A61B6/00
CPC分类号： G01S5/0263 , A61B18/1492 , A61B34/20 , A61B2017/00725 , A61B2034/2051 , A61B2034/2053 , A61B2090/0818
摘要： A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.

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