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61. 发明授权

US6119952A Device and method for dosing fluid 有权
标题翻译：用于计量流体的装置和方法
公开(公告)号：US6119952A
公开(公告)日：2000-09-19
申请号：US384357
申请日：1999-08-27
申请人： Andreas Kappel , Randolf Mock , Hans Meixner
发明人： Andreas Kappel , Randolf Mock , Hans Meixner
IPC分类号： F02M51/06 , F02M61/08 , F02D1/06 , B05B9/00 , F02M47/02 , F02M61/00
CPC分类号： F02M61/08 , F02M51/0603 , F01L2009/0413 , F02M2200/703 , F02M2200/705
摘要： A device and method for dosing fluid has a housing enclosing a lifting element and a primary drive hydraulically operable on the lifting element via a hydraulic chamber. The lifting element is disposed within a borehole with a leakage permitting fit. A fluid chamber in communication with the borehole contains a fluid to be dispensed in a dosed manner by controlled axial movement of the primary drive and lifting element.
摘要翻译：用于计量流体的装置和方法具有壳体，其包围提升元件和主驱动器，其通过液压室在提升元件上液压地操作。提升元件设置在钻孔内，泄漏允许配合。与钻孔连通的流体室包含通过受控的主驱动和提升元件的轴向移动以剂量方式分配的流体。

62. 发明授权

US5875764A Apparatus and method for valve control 失效
标题翻译：阀门控制装置及方法
公开(公告)号：US5875764A
公开(公告)日：1999-03-02
申请号：US78078
申请日：1998-05-13
申请人： Andreas Kappel , Randolf Mock , Hans Meixner , Edward-James Hayes
发明人： Andreas Kappel , Randolf Mock , Hans Meixner , Edward-James Hayes
IPC分类号： F02M47/02 , F02M59/46 , F02M63/00 , F02M41/00
CPC分类号： F02M63/0035 , F02M47/027 , F02M59/46 , F02M63/0026 , F02M63/0036 , F02M2200/706
摘要： An easily controllable primary drive (5) guided in a first bore (3), for example a piezo actuator, transmits its stroke by a piston-hydraulic stroke transmission with a hydraulic chamber (2) onto a stroke element (70) of the secondary side guided in a second bore (4). The pressure in a valve chamber (9) is controlled via the stroke element (7) of the secondary side.
摘要翻译：在第一孔（3）中引导的容易控制的主驱动器（5）例如压电致动器通过具有液压室（2）的活塞液压冲程变速器将其行程传递到次级的冲程元件（70）上在第二孔（4）中引导。通过次级侧的行程元件（7）控制阀室（9）中的压力。

63. 发明授权

US5850109A Magnetostrictive actuator 失效
标题翻译：磁致伸缩致动器
公开(公告)号：US5850109A
公开(公告)日：1998-12-15
申请号：US913402
申请日：1997-09-12
申请人： Randolf Mock , Hans Meixner , Andreas Kappel
发明人： Randolf Mock , Hans Meixner , Andreas Kappel
IPC分类号： F04B17/00 , H01L41/12 , H04R15/00
CPC分类号： H04R15/00 , F04B17/003 , H01L41/12
摘要： Drive elements whose physical volume is considerably smaller than piezoelectric actuators for comparable mechanical characteristics and actuation travels can be developed on the basis of the magnetostrictive material Tb.sub.x Dy.sub.1-x Fe.sub.2 (Terfenol). Despite these characteristics, magnetostrictive actuators have until now been used only where no rapid switching processes or actuation movements are required. An actuator of compact construction responds to an electrical drive signal very quickly and can produce large actuation forces. The actuator typically contains N.apprxeq.100 drive elements (1, 1') which are arranged one above the other in the form of a stack, are each of layered construction, and are provided with electrical connections. The drive elements (1, 1') each have a small metal plate (4, 4'), which is arranged between two insulators (2, 2', 3, 3'), and an actuator element (5, 5') which is manufactured from Terfenol. When current flows through it, the small metal plate (4, 4'), which is slotted in a U-shape, acts as a planar annular coil whose magnetic field passes through the actuator element (5, 5') and causes magnetostriction there.
摘要翻译： PCT No.PCT / DE96 / 00384 Sec。 371日期：1997年9月12日 102（e）日期1997年9月12日PCT提交1996年3月5日PCT公布。公开号WO96 / 29748 日期1996年9月26日可以在磁致伸缩材料TbxDy1-xFe2（Terfenol）的基础上开发物理体积远小于压电致动器的相当的机械特性和致动行程的驱动元件。尽管有这些特征，但是迄今为止，只有在不需要快速切换过程或致动运动的地方才使用磁致伸缩致动器。紧凑结构的致动器非常快速地响应电驱动信号并且可以产生大的致动力。致动器通常包含以堆叠的形式彼此排列的N个大约100个驱动元件（1,1'），每个都是分层结构，并且设置有电连接。驱动元件（1,1'）各自具有设置在两个绝缘体（2,2'，3,3'）和致动器元件（5,5'）之间的小金属板（4,4'），它是由Terfenol制造的。当电流流过其中时，开槽为U形的小金属板（4,4'）起到平面环形线圈的作用，其中磁场通过致动器元件（5,5'）并在其中引起磁致伸缩。

64. 发明授权

US5208611A Arrangement for heating the ink in the write head of an ink-jet printer 失效
标题翻译：用于加热喷墨打印机的写入头中的墨水的布置
公开(公告)号：US5208611A
公开(公告)日：1993-05-04
申请号：US715794
申请日：1991-06-14
申请人： Andreas Kappel , Rudolf Probst
发明人： Andreas Kappel , Rudolf Probst
IPC分类号： B41J2/05
CPC分类号： B41J2/04541 , B41J2/04548 , B41J2/04563 , B41J2/0458 , B41J2002/14379 , B41J2202/11
摘要： A heating device of a write head based on layer technology for an ink jet printer is furnished as a heating resistor (15) in the form of a heating conduit meander directly from an electrically conductive thin film, disposed in the empty spaces on a substrate, and deposited on the base oxide for furnishing the thermal converter and the conductor paths (5, 6). The empty spaces are thereby created by a spacing and a group-like combination and a gathering of the conductor paths (5, 6), wherein part sections of the heating resistors (15) are embedded in the empty spaces. The heating resistor (15) is part of a resistance measurement bridge and is employed simultaneously as a heat source and as a temperature sensor based on processing and evaluation of its electrical resistance values at different points in time.
摘要翻译：作为用于喷墨打印机的基于层技术的写入头的加热装置被设置为加热电阻体（15），该加热电阻器直接由导电薄膜弯曲，设置在基板上的空白空间中，并沉积在基底氧化物上，用于提供热转换器和导体路径（5,6）。由此通过间隔和组合组合以及导体路径（5,6）的集合来产生空的空间，其中加热电阻器（15）的部分部分嵌入在空的空间中。加热电阻器（15）是电阻测量桥的一部分，并且同时用作热源，并且作为基于在不同时间点对其电阻值的处理和评估的温度传感器。

65. 发明授权

US08906639B2 Method of determining factor XIII with the aid of plasma-based reference material 有权
标题翻译：借助于基于等离子体的参考材料确定因子XIII的方法
公开(公告)号：US08906639B2
公开(公告)日：2014-12-09
申请号：US13498923
申请日：2010-06-17
申请人： Gerlinde Christ , Andreas Kappel , Lena Pechmann , Frank Vitzhum , Norbert Zander
发明人： Gerlinde Christ , Andreas Kappel , Lena Pechmann , Frank Vitzhum , Norbert Zander
IPC分类号： C12Q1/56 , G01N33/573 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/56 , G01N33/5735
摘要： The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method.
摘要翻译：本发明涉及体外诊断领域，涉及借助于基于等离子体的参考材料来确定凝血因子XIII（因子XIII，F XIII）的方法，以及用于进行血液凝固因子方法。

66. 发明申请

US20120190053A1 Method of determining factor XIII with the aid of plasma-based reference material 有权
标题翻译：借助于基于等离子体的参考材料确定因子XIII的方法
公开(公告)号：US20120190053A1
公开(公告)日：2012-07-26
申请号：US13498923
申请日：2010-06-17
申请人： Gerlinde Christ , Andreas Kappel , Lena Pechmann , Frank Vitzhum , Norbert Zander
发明人： Gerlinde Christ , Andreas Kappel , Lena Pechmann , Frank Vitzhum , Norbert Zander
IPC分类号： C12Q1/48
CPC分类号： G01N33/86 , C12Q1/56 , G01N33/5735
摘要： The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method.
摘要翻译：本发明涉及体外诊断领域，涉及借助于基于等离子体的参考材料来确定凝血因子XIII（因子XIII，F XIII）的方法，以及用于进行血液凝固因子方法。

67. 发明申请

US20120171697A1 Method of Determining Inhibitors of Coagulation 有权
标题翻译：确定凝血抑制剂的方法
公开(公告)号：US20120171697A1
公开(公告)日：2012-07-05
申请号：US13332441
申请日：2011-12-21
申请人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
发明人： Andreas Kappel , Andreas Rechner , Sina Stephan , Thomas Wissel
IPC分类号： G01N33/573 , G01N33/82
CPC分类号： G01N33/86 , C12Q1/56
摘要： A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.
摘要翻译：确定样品中特别是直接凝血酶和因子Xa抑制剂的蛋白水解活性凝血因子（抗凝剂）抑制剂的均匀方法，以及用于该方法的测试试剂盒。使用与蛋白水解活性凝血因子结合但不被后者切割并与抗凝血剂竞争的配体。

68. 发明申请

US20110046455A1 METHODS AND DEVICES FOR EXAMINING A PARTICULAR TISSUE VOLUME IN A BODY, AND A METHOD AND A DEVICE FOR SEGMENTING THE PARTICULAR TISSUE VOLUME 审中-公开
标题翻译：用于检查身体中特定组织体积的方法和装置，以及用于分离特定组织体积的方法和装置
公开(公告)号：US20110046455A1
公开(公告)日：2011-02-24
申请号：US12857919
申请日：2010-08-17
申请人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
发明人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
IPC分类号： A61B5/107 , A61M25/00 , A61B5/055 , A61B5/145 , A61B6/00 , A61B5/053 , A61B6/03
CPC分类号： A61B10/02 , A61B5/055 , A61B5/6852 , A61B10/0045 , A61B10/0283
摘要： A tip of an elongate device is navigated into a particular tissue volume in order to examine the particular tissue volume in a body and part of the tissue volume is analyzed in real-time by way of a biosensor. In at least one embodiment, in the process, either the biosensor can be arranged on the tip of the device or the device includes a catheter, by which a substance to be analyzed is transported out of the tissue volume from the tip to the biosensor arranged at the proximal end of the catheter.
摘要翻译：细长装置的尖端被导航到特定组织体积中以便检查身体中的特定组织体积，并且通过生物传感器实时分析部分组织体积。在至少一个实施例中，在该过程中，生物传感器可以布置在装置的尖端上，或者该装置包括导管，通过该导管将要分析的物质从组织体积从尖端传送到布置的生物传感器在导管的近端。

69. 发明申请

US20100247438A1 IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES 审中-公开
标题翻译：用于诊断肿瘤疾病的体外方法
公开(公告)号：US20100247438A1
公开(公告)日：2010-09-30
申请号：US12731499
申请日：2010-03-25
申请人： Arne Hengerer , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
发明人： Arne Hengerer , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
IPC分类号： A61K49/00 , G01N33/53 , G01N33/573 , G01N33/48 , A61B1/00
CPC分类号： G01N33/57488 , G01N33/57407 , G01N33/57419 , G01N33/57473 , G01N2333/585 , G01N2333/70503 , G01N2333/96486
摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.
摘要翻译：体外方法是用于诊断患者的肿瘤疾病。在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像肿瘤成像方法。

70. 发明授权

US06487505B1 Method for evaluating characteristic values of piezo-mechanical systems 有权
标题翻译：压电机械系统特性值评估方法
公开(公告)号：US06487505B1
公开(公告)日：2002-11-26
申请号：US09581802
申请日：2000-06-16
申请人： Randolf Mock , Eric Chemisky , Andreas Kappel
发明人： Randolf Mock , Eric Chemisky , Andreas Kappel
IPC分类号： H05K700
CPC分类号： G01R29/22 , F02D41/2096 , F02D41/221 , F02D2041/288 , H02N2/06
摘要： For diagnosing coupled piezo-mechanical systems, methods are used which utilize electrical characteristic curves of the piezo-element that is contained in the piezo-mechanical systems. These electrical characteristic curves contain information about the mechanical condition of the overall piezo-mechanical system, which can be interpreted by suitable evaluating methods. It is thus possible to perform a diagnosis in which malfunctions and failures of the piezo-mechanical system can be detected (e.g. wear or failure of particular components). An important field of application is the diagnosis of fuel injectors which are controlled via piezo-actuators.
摘要翻译：为了诊断耦合压电机械系统，使用利用压电机械系统中包含的压电元件的电特性曲线的方法。这些电气特性曲线包含关于整个压电机械系统的机械状态的信息，这可以通过适当的评估方法来解释。因此，可以进行可以检测压电机械系统的故障和故障（例如特定部件的磨损或故障）的诊断。一个重要的应用领域是通过压电致动器控制的燃料喷射器的诊断。

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