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61. 发明授权

US08498693B2 Intracorporeal marker and marker delivery device 有权
标题翻译：体内标记和标记物递送装置
公开(公告)号：US08498693B2
公开(公告)日：2013-07-30
申请号：US13082463
申请日：2011-04-08
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B5/00
CPC分类号： A61B19/54 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： An elongated intracorporeal remotely detectable marker includes a core of bioabsorbable fibers. An outer jacket of bioabsorbable fibers is disposed around at least part of the core. In one embodiment, for example, the core has a longitudinal extent and a pair of opposed ends, and the outer jacket is disposed around the longitudinal extent of the core, with the pair of opposed ends being exposed.
摘要翻译：细长的体内可远程检测标记包括生物可吸收纤维的核心。生物可吸收纤维的外护套设置在芯的至少一部分周围。在一个实施例中，例如，芯具有纵向范围和一对相对的端部，并且外护套围绕芯的纵向延伸部设置，其一对相对的端部露出。

62. 发明申请

US20120310032A1 METHODS FOR ASYMMETRICAL IRRADIATION OF A BODY CAVITY 有权
标题翻译：一种身体不对称辐射的方法
公开(公告)号：US20120310032A1
公开(公告)日：2012-12-06
申请号：US13571495
申请日：2012-08-10
申请人： Paul Lubock , Michael L. Jones , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Frank R. Louw
IPC分类号： A61M36/12
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如，活检或癌症。一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射（例如健康组织）。

63. 发明授权

US08326401B2 MRI detectable obturator 有权
标题翻译： MRI可检测的闭孔器
公开(公告)号：US08326401B2
公开(公告)日：2012-12-04
申请号：US11985997
申请日：2007-11-19
申请人： Paul Lubock , Michael L. Jones , Ethan Broadaway , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Ethan Broadaway , Frank R. Louw
IPC分类号： A61B5/05
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

64. 发明申请

US20120253189A1 CAVITY-FILLING BIOPSY SITE MARKERS 有权
公开(公告)号：US20120253189A1
公开(公告)日：2012-10-04
申请号：US13495408
申请日：2012-06-13
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

65. 发明申请

US20120071705A1 BRACHYTHERAPY DEVICE FOR ASYMMETRICAL IRRADIATION OF A BODY CAVITY 有权
标题翻译：一种身体不对称辐射的BRACHYTHERAPY装置
公开(公告)号：US20120071705A1
公开(公告)日：2012-03-22
申请号：US13302086
申请日：2011-11-22
申请人： Paul Lubock , Michael L. Jones , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Frank R. Louw
IPC分类号： A61N5/00
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如，活检或癌症。一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射（例如健康组织）。

66. 发明申请

US20120029262A1 TREATMENT OF A BODY CAVITY 审中-公开
标题翻译：治疗身体的空间
公开(公告)号：US20120029262A1
公开(公告)日：2012-02-02
申请号：US13252579
申请日：2011-10-04
申请人： Paul Lubock , Michael L. Jones
发明人： Paul Lubock , Michael L. Jones
IPC分类号： A61M36/00
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are provided for controlled application of a treatment to tissue adjacent a body cavity, such as after removal of tissue, e.g. cancer. A device embodying features of the invention includes one or more radiation shielding components to control emitted radiation from a radiation source to minimize radiation damage to healthy portions of the body cavity. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location therein to seal the passageway leading to the body cavity. Methods for treating a body cavity include methods for delivering a radiation source to a body cavity while minimizing damaging irradiation of healthy tissue.
摘要翻译：提供了设备和方法，用于控制对身体周围的组织进行治疗，例如在去除组织后，例如，癌症。体现本发明特征的装置包括一个或多个辐射屏蔽组件，用于控制来自辐射源的辐射，以最小化对体腔健康部分的辐射损伤。体现本发明特征的装置可以包括密封构件，该密封构件位于装置的轴的位置处，靠近其中的处理位置以密封通向体腔的通道。用于治疗体腔的方法包括将辐射源递送到体腔的方法，同时最小化对健康组织的损伤性照射。

67. 发明申请

US20110166448A1 MARKER DELIVERY DEVICE WITH RELEASABLE PLUG 有权
标题翻译：具有可释放插头的标记传送设备
公开(公告)号：US20110166448A1
公开(公告)日：2011-07-07
申请号：US13037971
申请日：2011-03-01
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61M25/00
CPC分类号： A61B5/064 , A61B5/055 , A61B5/062 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61K49/12 , A61K49/18 , A61K2123/00 , A61M5/007 , A61M37/0069
摘要： A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.
摘要翻译：标记输送装置包括细长的输送套管，其具有与内腔连通的远端部分中的远端部分，内腔和排出口。至少一个细长的纤维标记物体可滑动地设置在细长的输送套管的内腔内。所述至少一个细长的纤维标记物主体包括多个生物可吸收的聚合物链。股线被压缩成压缩构型并且在插入细长的输送套管之前用压缩构型与聚合物粘合剂结合在一起。可释放插塞设置在内腔的远侧部分内并且远离至少一个细长纤维标记体，以至少部分地封闭远端部分中的排出口。

68. 发明申请

US20100324416A1 CAVITY-FILLING BIOPSY SITE MARKERS 有权
公开(公告)号：US20100324416A1
公开(公告)日：2010-12-23
申请号：US12852286
申请日：2010-08-06
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

69. 发明申请

US20090287078A1 Marker or filler forming fluid 审中-公开
标题翻译：标记或填料成型液
公开(公告)号：US20090287078A1
公开(公告)日：2009-11-19
申请号：US12214947
申请日：2008-06-24
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61M5/00
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.
摘要翻译：用于形成体内部位的标记物或填充剂块的溶液。该溶液含有极性的水溶性非水溶剂如二甲基亚砜和生物可吸收的，基本上不溶于水的聚合物如聚乳酸，或乳酸和乙醇酸的共聚物。溶液可以通过合适的注射器和输送管递送到活检部位。输送管优选地设置在远端上的可释放的不透射线元件，其可以在形成于活检腔内的聚合物标记块内释放。

70. 发明申请

US20080281142A1 Methods for asymmetrical irradiation of a body cavity 有权
标题翻译：体腔不对称照射方法
公开(公告)号：US20080281142A1
公开(公告)日：2008-11-13
申请号：US12151153
申请日：2008-05-02
申请人： Paul Lubock , Michael L. Jones , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Frank R. Louw
IPC分类号： A61N5/00
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如，活检或癌症。一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射（例如健康组织）。

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