专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US4513675A Presser foot automatic lifting device 失效
标题翻译：压脚自动提升装置
公开(公告)号：US4513675A
公开(公告)日：1985-04-30
申请号：US487744
申请日：1983-04-22
申请人： Horst Meyer , Gunter Landwehr
发明人： Horst Meyer , Gunter Landwehr
IPC分类号： D05B27/02 , D05B27/14 , D05B29/00 , D05B29/06 , D05B27/06 , D05B29/02
CPC分类号： D05B27/14 , D05B29/06
摘要： A sewing machine with a workpiece feed comprises a feed dog positioned below the workpiece providing a four-motion feed movement. A presser foot is fixed to a presser foot bar and can be raised from the workpiece during the stitching cycle by a lifting gear to ensure turning of the workpiece. This makes it possible to follow complicated seam patterns. The lifting gear is constructed in such a way that the presser foot is raised from the workpiece while the needle perforates the material, during its downwardly directed movement approximately up to its bottom dead center position.
摘要翻译：具有工件进给的缝纫机包括位于工件下方的进给爪，其提供四运动进给运动。压脚固定到压脚杆上，并且可以在缝合循环期间通过起重工具从工件上升起来，以确保工件的转动。这使得可以跟随复杂的缝合图案。提升齿轮构造成使得压脚从工件升起，同时针在其向下指向的运动期间穿过材料时大致直到其下死点位置。

62. 发明授权

US4053614A 1,2-Pentamethylene-1,4-dihydropyridine derivatives 失效
标题翻译： 1,2-二戊烯-1,4-二氢吡啶衍生物
公开(公告)号：US4053614A
公开(公告)日：1977-10-11
申请号：US604352
申请日：1975-08-13
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： A61K31/395 , A61K31/44 , C07D455/02 , C07D471/04 , C07D498/04 , C07D513/04 , A61K31/455
CPC分类号： C07D471/04 , A61K31/395 , A61K31/44 , C07D455/02 , C07D513/04
摘要： 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are anti-hypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.

63. 发明授权

US4024261A Compositions and methods employing tetrahydroindolizine derivatives 失效
标题翻译：使用四氢吲哚啉衍生物的组合物和方法
公开(公告)号：US4024261A
公开(公告)日：1977-05-17
申请号：US604257
申请日：1975-08-13
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： A61K31/395 , A61K31/44 , C07D455/02 , C07D471/04
CPC分类号： C07D471/04 , A61K31/395 , A61K31/44 , C07D455/02 , Y10S514/929
摘要： 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are anti-hypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.
摘要翻译：在3-位和5-位具有羰基官能团的1,4-二氢吡啶，任选被6位的低级烷基取代，在4-位被低级烷基，苯基，取代的苯基或杂环基取代，和通过1-位和2-位融合成五，六或七元环烷基环，其中一个亚甲基可以被硫，氧亚氨基或烷基亚氨基取代，是抗高血压剂和冠状血管扩张剂。其中6-甲基-4-（3-硝基苯基）-1,2-戊烯-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯的代表性实施例是通过缩合的亚乙酰乙酸酯和环状氨基羰基衍生物。

64. 发明授权

US4004014A 2-Amino-6-dialkylaminodihydropyridines, their production, pharmaceutical compositions and methods of use thereof 失效
标题翻译： 2-氨基-6-二烷基氨基二氢吡啶，它们的制备，药物组合物及其使用方法
公开(公告)号：US4004014A
公开(公告)日：1977-01-18
申请号：US545202
申请日：1975-01-29
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： A61K31/4427 , A61K31/455 , A61P1/00 , A61P3/06 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/04 , C07D211/90 , C07D401/04 , C07D211/00 , C07D401/00
CPC分类号： C07D211/90
摘要： 2-Amino-6-dialkylaminodihydropyridines exist in tautomeric form and are represented by the formulae ##STR1## WHEREIN R.sub.1 and R.sub.3 are the same or different and each is straight, branched or cyclic alkyl, alkenyl or alkynyl or said alkyl, alkenyl or alkynyl interrupted by 1 or 2 oxygen atoms;R.sub.2 is a saturated, partially unsaturated or unsaturated straight, branched or cyclic hydrocarbon; aryl unsubstituted or substituted by 1, 2 or 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, azido, halo, cyano, nitro, trifluoromethyl, carbalkoxy and SO.sub.n -alkyl wherein n is 0, 1 or 2; naphthyl; quinolyl; isoquinolyl; pyridyl; pyrimidyl; thenyl; or furyl; andR.sub.4 and R.sub.5 are each lower alkyl; benzyl; or, together with the nitrogen atom to which they are attached, a 4- to 7-membered ring. These compounds are useful for their coronary-vessel-dilating effect, their antihypertensive effect, their anti-fibrillation effect, their vascular-spasmolytic effect and their muscular-spasmolytic effect.
摘要翻译： 2-氨基-6-二烷基氨基二氢吡啶以互变异构形式存在并由下式表示：其中R 1和R 3相同或不同，并且各自为直链，支链或环状烷基，烯基或炔基或所述被1或2个氧原子间隔的烷基，烯基或炔基; R2是饱和的，部分不饱和的或不饱和的直链，支链或环状烃; 未取代的或被1,2或3个相同或不同的选自烷基，烷氧基，叠氮基，卤素，氰基，硝基，三氟甲基，烷氧基和其中n为0,1或2的烷基的取代基取代的芳基; 萘基; 喹啉基异喹啉基吡啶基嘧啶基茶碱或呋喃基; 且R 4和R 5各自为低级烷基; 苄基; 或者与它们所连接的氮原子一起形成4-至7-元环。这些化合物可用于其冠状血管扩张作用，其抗高血压作用，其抗纤维化作用，其血管解痉作用及其肌肉 - 解痉作用。

65. 发明授权

US4002762A 2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension 失效
标题翻译：用于影响冠状动脉血管扩张和治疗高血压的2-氨基-3,4-二氢吡啶
公开(公告)号：US4002762A
公开(公告)日：1977-01-11
申请号：US544934
申请日：1975-01-28
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： C07D211/90 , A61K31/455
CPC分类号： C07D211/90 , Y10S514/929
摘要： 3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20.degree. C to 200.degree. C. The compounds, of which 2-amino-3,6-dimethyl-4-phenyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a typical embodiment, possess antihypertensive and coronary dilating properties.
摘要翻译： 3-取代的2-氨基-3,4-二氢吡啶-3-羧酸酯是通过2-氨基-1,4-二氢吡啶-3-羧酸酯与烷基化剂在惰性有机溶剂的存在下反应来制备的温度为20℃至200℃。其中2-氨基-3,6-二甲基-4-苯基-3,4-二氢吡啶-3,5-二羧酸二乙酯是其典型的实例，具有抗高血压和冠状动脉扩张性能。

66. 发明授权

US4001235A 2-Amino-1,4-dihydropyridine derivatives 失效
标题翻译： 2-氨基-1,4-二氢吡啶衍生物
公开(公告)号：US4001235A
公开(公告)日：1977-01-04
申请号：US503345
申请日：1974-09-05
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： C07D211/90 , C07D215/54 , C07D401/04 , C07D405/04 , C07D409/04 , C07D239/26
CPC分类号： C07D401/04 , C07D211/90 , C07D215/54 , C07D405/04 , C07D409/04
摘要： 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

67. 发明授权

US3983151A Process for the preparation of 4-hydroxy-3-methoxy-phenylacetonitrile 失效
标题翻译： 4-羟基-3-甲氧基 - 苯乙腈的制备方法
公开(公告)号：US3983151A
公开(公告)日：1976-09-28
申请号：US634126
申请日：1975-11-21
申请人： Horst Meyer
发明人： Horst Meyer
IPC分类号： C07C255/37 , C07C67/00 , C07C253/00 , C07C255/53 , C07C121/75
CPC分类号： C07C255/53
摘要： 3-Methoxy-4-hydroxyphenylacetonitrile, which is a known chemical intermediate, is obtained from the reaction of an N-(lower alkyl) 3-methoxy-4-hydroxybenzylamine with hydrogen cyanide.
摘要翻译：由N-（低级烷基）3-甲氧基-4-羟基苄胺与氰化氢的反应得到作为已知化学中间体的3-甲氧基-4-羟基苯基乙腈。

68. 发明授权

US3981893A 2-Amino-4 H-pyrane 失效
标题翻译： 2-氨基-4H-吡喃
公开(公告)号：US3981893A
公开(公告)日：1976-09-21
申请号：US578465
申请日：1975-05-19
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： A61K31/35 , C07D309/22 , C07D409/04
CPC分类号： C07D309/22 , A61K31/35 , C07D409/04
摘要： 2-Amino-4 H-pyrane derivatives of the formula ##SPC1##WhereinR.sup.1 and R.sup.2 are the same or different and each is hydrogen or straight- or branched-chain alkyl;R.sup.3 is straight- or branched-chain alkyl, phenyl or --COOR' wherein R' is a straight, branched or cyclic saturated or unsaturated aliphatic hydrocarbon;R.sup.4 is straight, branched or cyclic alkyl or alkenyl, aryl unsubstituted or substituted by 1, 2 or 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy, and --SO.sub.n alkyl wherein n is 0, 1 or 2, orR.sup.4 is naphthyl, quinolyl, pyridyl, thienyl or furyl unsubstituted or substituted by alkyl, alkoxy or halogen;R.sup.5 is straight, branched or cyclic alkyl or --OR" wherein R" is a straight, branched or cyclic hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; andR.sup.6 is hydrogen or alkyl;Are useful for their strong coronary action and as antihypertensive agents.
摘要翻译：式WHEREIN R1和R2的2-氨基-4H-吡喃衍生物相同或不同，各自为氢或直链或支链烷基; R3是直链或支链烷基，苯基或-COOR'，其中R'是直链，支链或环状的饱和或不饱和脂族烃; R4是直链，支链或环状的烷基或链烯基，未被取代或被1,2或3个相同或不同的选自烷基，烷氧基，卤素，硝基，氰基，三氟甲基，烷氧羰基和-SOn 烷基，其中n为0,1或2，或R4为萘基，喹啉基，吡啶基，噻吩基或呋喃基，未取代或被烷基，烷氧基或卤素取代; R5是直链，支链或环状烷基或-OR“，其中R”是直链，支链或环状烃或被1或2个氧原子间断的所述烃; R6为氢或烷基; 有用于其强大的冠状动脉和抗精神病药。

69. 发明授权

US3974275A 1,4-Dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives 失效
标题翻译：可用作冠状血管扩张剂和抗高血压药物的1,4-二氢吡啶羧酸酯
公开(公告)号：US3974275A
公开(公告)日：1976-08-10
申请号：US548395
申请日：1975-02-10
申请人： Friedrich Bossert , Horst Meyer , Wulf Vater
发明人： Friedrich Bossert , Horst Meyer , Wulf Vater
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/535
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , Y10S514/929
摘要： Certain 1,4-dihydropyridine carboxylic acid esters or their pharmaceutically acceptable non toxic salts are useful as coronary vessel dilators and antihypertensives.
摘要翻译：某些1,4-二氢吡啶羧酸酯或其药学上可接受的无毒盐可用作冠状血管扩张剂和抗高血压药。

70. 发明授权

US3951994A Tetrahydroindolizine derivatives 失效
标题翻译：四氢吲哚啉衍生物
公开(公告)号：US3951994A
公开(公告)日：1976-04-20
申请号：US468458
申请日：1974-05-09
申请人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
发明人： Horst Meyer , Friedrich Bossert , Wulf Vater , Kurt Stoepel
IPC分类号： A61K31/395 , A61K31/44 , C07D455/02 , C07D471/04 , C07D213/57
CPC分类号： C07D471/04 , A61K31/395 , A61K31/44 , C07D455/02 , Y10S514/929
摘要： 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.
摘要翻译：在3-位和5-位具有羰基官能团的1,4-二氢吡啶，任选被6位的低级烷基取代，在4-位被低级烷基，苯基，取代的苯基或杂环基取代，和通过1-和2-位融合成五，六或七元环烷基环，其中一个亚甲基可以被硫，氧亚氨基或烷基亚氨基取代，是抗高血压剂和冠状血管扩张剂。其中6-甲基-4-（3-硝基苯基）-1,2-戊烯-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯的代表性实施例是通过缩合的亚乙酰乙酸酯和环状氨基羰基衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式