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61. 发明授权

US4267295A Polymeric compositions and hydrogels formed therefrom 失效
标题翻译：由此形成的聚合物组合物和水凝胶
公开(公告)号：US4267295A
公开(公告)日：1981-05-12
申请号：US10992
申请日：1979-02-09
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/083 , A61K9/20 , A61L27/16 , A61L33/06 , B01D71/40 , B29D11/02 , C08F220/28 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/083 , A61K9/2027 , A61L27/16 , A61L33/064 , B01D71/40 , B29D11/02 , Y10S528/92
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
摘要翻译：本发明提供了新的水凝胶形成材料，其包括由亲水性丙烯酸酯或甲基丙烯酸二羟烷基酯，基本上不溶于水的丙烯酸烷基酯或甲基丙烯酸烷基酯，一种或多种另外的亲水共聚单体共聚形成的合成的，亲水的，不溶于水的聚合物网络，所述共聚单体选自乙烯基单体，丙烯酸酯和甲基丙烯酸酯，以及交联剂。水凝胶优选用于形成隐形眼镜，但也可用于药物和农药递送装置; 透析，超滤和反渗透膜; 手术和牙科植入物; 等等。

62. 发明授权

US08956311B2 Methods for diagnosing meibomian gland dysfunction 有权
标题翻译：睑板腺功能障碍诊断方法
公开(公告)号：US08956311B2
公开(公告)日：2015-02-17
申请号：US13271768
申请日：2011-10-12
申请人： Donald R. Korb , Caroline Blackie , Christy Stevens
发明人： Donald R. Korb , Caroline Blackie , Christy Stevens
IPC分类号： A61B5/103 , A61B5/00 , A61B3/10
CPC分类号： A61B5/4261 , A61B3/10
摘要： Methods of diagnosing meibomian gland dysfunction are disclosed. The methods may be standardized and provide an accurate diagnosis of whether meibomian gland dysfunction exists. In one embodiment, a method is provided that utilizes an evaluation tool to apply a force for a preselected period of time to at least one of a plurality of meibomian glands in two or more regions of a plurality of regions of an eyelid. A grade is assigned to the at least one meibomian gland of the plurality of meibomian glands in each of the two or more regions based on any secretion that is expressed from each meibomian gland. In this manner, a plurality of meibomian gland secretion grades is obtained. The plurality of meibomian gland secretion grades is indicative of the presence of meibomian gland dysfunction.
摘要翻译：公开了睑板腺功能障碍诊断方法。方法可以被标准化，并提供是否存在睑板腺功能障碍的准确诊断。在一个实施例中，提供了一种利用评估工具将预定时间段的力施加到眼睑多个区域的两个或更多个区域中的多个睑板腺中的至少一个的方法。基于从每个睑板腺表达的任何分泌，将等级分配给两个或更多个区域中的每一个中的多个睑板腺中的至少一个睑板腺。以这种方式，获得多个睑板腺分泌等级。多个睑板腺分泌级别表示睑板腺功能障碍的存在。

63. 发明授权

US5851543A Skin care preparation and method 失效
公开(公告)号：US5851543A
公开(公告)日：1998-12-22
申请号：US978538
申请日：1997-11-26
申请人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
发明人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
IPC分类号： A61K9/06 , A61K8/37 , A61K8/55 , A61K9/08 , A61K9/107 , A61K9/12 , A61K31/23 , A61K31/661 , A61K47/44 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/375 , A61K8/553 , A61Q19/007 , Y10S514/844 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/937
摘要： A composition and method for treatment of skin. The composition comprises a pharmaceutically acceptable carrier containing a bilayer component having one or more polar terminus groups and one or more non-polar terminus groups separated from said polar terminus groups capable of penetrating the outer surface of the skin to form an aligned bilayer within the stratum corneum. The bilayer assists in the formation of bilayer lamellae that is believed to replicate the bilayer lamellae present in healthy skin. The composition is topically applied to the skin as often as is required.

64. 发明授权

US4914088A Dry eye treatment solution and method 失效
标题翻译：干眼治疗溶液及方法
公开(公告)号：US4914088A
公开(公告)日：1990-04-03
申请号：US111874
申请日：1987-10-23
申请人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
发明人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
IPC分类号： A61K31/685 , A61K9/00 , A61K31/683 , A61K38/00 , A61P27/02
CPC分类号： A61K31/685 , A61K9/0048
摘要： A method and composition for treating dry eye. The method comprises addition of a positively or negatively charged, complex phospholipid to the ocular surface of the eye. The phospholipid is desirably added in a treatment composition, preferably in the form of an aqueous emulsion. It is believed that the phospholipid component of the treatment composition permits replication of a tear film.
摘要翻译：一种治疗干眼症的方法和组合物。该方法包括向眼睛的眼表面添加带正电荷或带负电荷的复合磷脂。优选将磷脂加入到处理组合物中，优选以水乳液的形式加入。认为处理组合物的磷脂成分允许复制泪液膜。

65. 发明授权

US4056496A Hydrogels and articles made therefrom 失效
标题翻译： HYDROGELS AND ARTICLES THEEFROM
公开(公告)号：US4056496A
公开(公告)日：1977-11-01
申请号：US685996
申请日：1976-05-13
申请人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
发明人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
IPC分类号： A61K6/083 , A61K9/20 , B01D71/40 , C08F220/28 , G02B1/04 , C08F220/14 , G02C7/04
CPC分类号： C08F220/28 , A61K6/083 , A61K9/2027 , B01D71/40 , G02B1/043 , Y10S521/905 , Y10S524/916 , Y10S528/92
摘要： This invention relates to polymers and hydrogels of polymers formed from a hydrophilic monomer of the group of dihydroxyalkyl acrylates and methacrylates, a substantially water insoluble monomer from the group of alkyl acrylates and methacrylates and preferably a minor amount of a water insoluble epoxidized alkyl acrylate or methacrylate. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices: dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry, and the like.

66. 发明授权

US09161531B2 High alcohol content sanitizer 有权
标题翻译：高酒精消毒剂
公开(公告)号：US09161531B2
公开(公告)日：2015-10-20
申请号：US13403259
申请日：2012-02-23
申请人： Donald R. Korb , Hridaya N. Bhargava
发明人： Donald R. Korb , Hridaya N. Bhargava
IPC分类号： A01N31/00 , A01N31/02 , A61K8/34 , A61K8/55 , A61Q17/00
CPC分类号： A01N31/02 , A01N25/04 , A61K8/34 , A61K8/37 , A61K8/553 , A61K8/97 , A61K2800/48 , A61K2800/49 , A61K2800/596 , A61K2800/74 , A61Q17/005 , A61Q19/007 , A01N25/30 , A01N2300/00
摘要： This invention relates to an antimicrobial sanitizing composition in the form of a gel or cream that contains an alcohol in an amount of at least 55% by weight. The sanitizer is capable of disinfecting and providing prolonged antimicrobial property to a variety of surfaces, including the skin, without causing, drying, cracking, redness or irritation. In addition to alcohol, the sanitizer contains an anionic phospholipid in a controlled concentration as well as components conventionally found in skin creams and gels such as emulsifiers, emollients, moisturizers, rheology modifiers, and neutralizers. The anionic phospholipid enables use of the composition without the user experiencing dryness or irritation and the feeling of a greasy and unpleasant residue on the skin following use.
摘要翻译：本发明涉及含有至少55重量％的醇的凝胶或乳膏形式的抗微生物消毒组合物。消毒剂能够消毒并提供长时间的抗菌性能到各种表面，包括皮肤，而不会引起，干燥，开裂，发红或刺激。除了酒精之外，消毒剂含有受控浓度的阴离子磷脂以及通常在皮肤霜和凝胶如乳化剂，润肤剂，保湿剂，流变改性剂和中和剂中常见的组分。阴离子磷脂能够使用组合物，而不会使用者在使用后经历干燥或刺激以及皮肤上油腻和不愉快的残留物的感觉。

67. 发明申请

US20120214878A1 High Alcohol Content Sanitizer 有权
标题翻译：高酒精消毒液
公开(公告)号：US20120214878A1
公开(公告)日：2012-08-23
申请号：US13403259
申请日：2012-02-23
申请人： Donald R. Korb , Hridaya N. Bhargava
发明人： Donald R. Korb , Hridaya N. Bhargava
IPC分类号： A01N31/02 , A01P1/00
CPC分类号： A01N31/02 , A01N25/04 , A61K8/34 , A61K8/37 , A61K8/553 , A61K8/97 , A61K2800/48 , A61K2800/49 , A61K2800/596 , A61K2800/74 , A61Q17/005 , A61Q19/007 , A01N25/30 , A01N2300/00
摘要： This invention relates to an antimicrobial sanitizing composition in the form of a gel or cream that contains an alcohol in an amount of at least 55% by weight. The sanitizer is capable of disinfecting and providing prolonged antimicrobial property to a variety of surfaces, including the skin, without causing, drying, cracking, redness or irritation. In addition to alcohol, the sanitizer contains an anionic phospholipid in a controlled concentration as well as components conventionally found in skin creams and gels such as emulsifiers, emollients, moisturizers, rheology modifiers, and neutralizers. The anionic phospholipid enables use of the composition without the user experiencing dryness or irritation and the feeling of a greasy and unpleasant residue on the skin following use.
摘要翻译：本发明涉及含有至少55重量％的醇的凝胶或乳膏形式的抗微生物消毒组合物。消毒剂能够消毒并提供长时间的抗菌性能到各种表面，包括皮肤，而不会引起，干燥，开裂，发红或刺激。除了酒精之外，消毒剂含有受控浓度的阴离子磷脂以及通常在皮肤霜和凝胶如乳化剂，润肤剂，保湿剂，流变改性剂和中和剂中常见的组分。阴离子磷脂能够使用组合物，而不会使用者在使用后经历干燥或刺激以及皮肤上油腻和不愉快的残留物的感觉。

68. 发明授权

US5278151A Dry eye treatment solution 失效
标题翻译：干眼治疗溶液
公开(公告)号：US5278151A
公开(公告)日：1994-01-11
申请号：US898380
申请日：1992-06-09
申请人： Donald R. Korb , Thomas Glonek , Jack Greiner
发明人： Donald R. Korb , Thomas Glonek , Jack Greiner
IPC分类号： A61K9/00 , A61K31/685
CPC分类号： A61K31/685 , A61K9/0048 , Y10S514/912
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a finely divided oil in water emulsion.
摘要翻译：一种用于减少水层从眼表的蒸发的方法和组合物。该方法包括在眼睛上施用带电磷脂和非极性油的混合物，优选以细碎的水包油乳液的形式。

69. 发明授权

US4401372A Contact lens 失效
公开(公告)号：US4401372A
公开(公告)日：1983-08-30
申请号：US101981
申请日：1979-12-10
申请人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
发明人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
IPC分类号： A61K9/20 , G02C7/04
CPC分类号： G02C7/04 , A61K9/2027
摘要： This invention concerns a minus prescription hydrogel contact lens that permits oxygen diffusion to the cornea in sufficient quantity to avoid the effects of oxygen deprivation; avoids the physiological complications arising from damage to the bulbar conjunctivia due to compression of the limbal capillaries; and avoids corneal scleral or wetting deficiencies. These advantages are accomplished through a combination of lens design and hydrogel properties.

70. 发明授权

US4313355A Method and apparatus for manufacturing plastic lenses 失效
标题翻译：塑料镜片制造方法及装置
公开(公告)号：US4313355A
公开(公告)日：1982-02-02
申请号：US86470
申请日：1979-10-19
申请人： Ronald K. Becker , Donald R. Korb
发明人： Ronald K. Becker , Donald R. Korb
IPC分类号： B24B13/04 , B23B1/00 , B23B5/40
CPC分类号： B24B13/046 , Y10T82/10 , Y10T82/148
摘要： The method of making plastic lenses ready for fitting to the contour of the wearer's eye comprising supporting a blank of plastic at one end for rotation about a predetermined axis, turning the blank down to a predetermined diameter, making an annular face cut at the distal end of the blank of predetermined radial width, making a spherically concave base cut at said distal end of predetermined depth relative to said annular face cut, reversing the blank end-for-end, making a first spherically convex cut at said end of the blank of a predetermined radius such that the distance between the inner and outer surfaces is of a predetermined thickness and making a flange cut at the marginal edge of the outer convex surface of lesser radius of curvature; and apparatus for carrying out the method.
摘要翻译：制造适合佩戴者眼睛轮廓的塑料透镜的方法包括：在一端支撑塑料坯料以绕预定轴线旋转，将坯料向下转动到预定直径，从而在远端切割环形面的预定径向宽度的坯料，在相对于所述环形面切割的预定深度的所述远端处切割球形凹形基底，使坯件端部端部反向，在坯料的所述端部处形成第一球形切口使得内表面和外表面之间的距离为预定厚度并使凸缘在较小曲率半径的外凸表面的边缘处切割成预定半径; 以及用于执行该方法的装置。

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