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    • 61. 发明申请
    • HIGH THROUGHPUT SCREENING SYSTEM AND METHOD
    • 高通量筛选系统和方法
    • US20090035220A1
    • 2009-02-05
    • US11832658
    • 2007-08-02
    • Kevin Jones
    • Kevin Jones
    • A61K49/00A61P43/00C12M1/00
    • C12M23/12A61K49/0008B01L3/5085B01L2300/0829B01L2400/0415C12M35/02
    • A high throughput screening method for determining the pharmacological effect of a given agent, the method comprising, providing an assay plate with at least one sample well, where at least one well contains a volume of media and at least one zebrafish, introducing at least one agent to at least one of the wells with the media and zebrafish and incubating for a given amount of time, providing an electrical stimulus to the plate so as to promote a locomotor response in the zebrafish, and detecting the locomotor response of the zebrafish in response to the electrical stimulus in each well an agent was added to relative to a control well. Also disclosed is an assay plate that includes a first electrode located substantially at the center of the bottom portion of the well and a second electrode located substantially around the circumference of the well wall.
    • 用于确定给定试剂的药理作用的高通量筛选方法,所述方法包括:向所述测定板提供至少一个样品孔,其中至少一个孔含有一定体积的培养基和至少一种斑马鱼,引入至少一种 向至少一个具有培养基和斑马鱼的孔中培养并孵育给定量的时间,向板提供电刺激,以促进斑马鱼的运动反应,并检测斑马鱼的运动反应。 对于每个孔中的电刺激,相对于对照孔添加剂。 还公开了一种测定板,其包括基本上位于阱的底部的中心的第一电极和基本上围绕阱壁的圆周设置的第二电极。