专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20060167004A1 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders 失效
标题翻译： 4（苯基 - 哌嗪基 - 甲基）苯甲酰胺衍生物及其用于治疗疼痛或胃肠道疾病的用途
公开(公告)号：US20060167004A1
公开(公告)日：2006-07-27
申请号：US10533744
申请日：2003-11-05
申请人： Willliam Brown , Andrew Griffin , Niklas Plobeck , Christopher Walpole
发明人： Willliam Brown , Andrew Griffin , Niklas Plobeck , Christopher Walpole
IPC分类号： A61K31/496 , A61K31/495 , C07D417/02 , C07D409/02 , C07D403/02
CPC分类号： C07D295/155 , C07D307/52
摘要： Compounds of general formula: wherein R1 and R2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译：制备其中R 1和R 2的化合物如说明书中所定义，以及其盐，对映异构体和包含该化合物的药物组合物。它们可用于治疗，特别是治疗疼痛。

62. 发明授权

US07008952B2 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
标题翻译： 4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病
公开(公告)号：US07008952B2
公开(公告)日：2006-03-07
申请号：US10477636
申请日：2002-05-16
申请人： William Brown , Andrew Griffin , Christopher Walpole
发明人： William Brown , Andrew Griffin , Christopher Walpole
IPC分类号： A61K31/55 , C07D211/58
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06 , C07D417/06
摘要： Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
摘要翻译：通式Ⅰ化合物[化学式应在此插入。 R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种。其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基，烷氧基，氯，氟，溴和碘。苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

63. 发明授权

US06756387B2 Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain 失效
标题翻译：羟苯基 - 哌啶-4-亚基 - 甲基 - 苯甲酰胺衍生物用于治疗疼痛
公开(公告)号：US06756387B2
公开(公告)日：2004-06-29
申请号：US10240038
申请日：2003-01-16
申请人： William Brown , Christopher Walpole , Zhongyong Wei
发明人： William Brown , Christopher Walpole , Zhongyong Wei
IPC分类号： A61K314545
CPC分类号： C07D401/06 , C07D211/70 , C07D405/06 , C07D409/06 , C07D417/06
摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译：通式IR 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，三唑基和噻唑基中的任一个;其中每个R 1苯环和R 1杂芳环可以任选和独立地进一步被取代选自直链和支链C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴和碘的1,2或3个取代基。苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行;在本申请中公开和要求保护的，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在痛苦的管理中。

64. 发明授权

US08022074B2 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
标题翻译： 4-（苯基 - 哌嗪基 - 甲基）苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病的用途
公开(公告)号：US08022074B2
公开(公告)日：2011-09-20
申请号：US12911167
申请日：2010-10-25
申请人： William Brown , Christopher Walpole , Niklas Plobeck
发明人： William Brown , Christopher Walpole , Niklas Plobeck
IPC分类号： A61K31/496
CPC分类号： C07D295/155 , C07D233/24 , C07D307/52 , C07D333/20
摘要： The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R1 phenyl and R1 heteroaromatic ring may optionally and independently be substituted by 1, 2 or 3 substituents selected from CF3, methyl, iodo, bromo, fluoro, and chloro; R2 is independently selected from ethyl and isopropyl; R3 is hydrogen or fluoro; R4 is —NH2 or —NHSO2R5; and R5 is hydrogen, —CF3, or C1-C6 alkyl, or pharmaceutically acceptable salts thereof; at least one process for making at least one compound in accordance with Formula I; at least one method for treating at least one δ receptor associated condition with at least one compound in accordance with Formula I; and at least one pharmaceutical composition comprising at least one compound in accordance with Formula I.
摘要翻译：本发明涉及至少一种通式I的化合物，其中R 1是苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基或吡啶N-氧化物，其中每个R 1苯基和R 1杂芳环可任选地和独立地是被1,2或3个选自CF 3，甲基，碘，溴，氟和氯的取代基取代; R2独立地选自乙基和异丙基; R3是氢或氟; R4是-NH2或-NHSO2R5; 和R 5是氢，-CF 3或C 1 -C 6烷基，或其药学上可接受的盐; 至少一种制备根据式I的至少一种化合物的方法; 用至少一种根据式I的化合物治疗至少一种δ受体相关病症的方法; 和包含至少一种根据式I的化合物的至少一种药物组合物。

65. 发明申请

US20110039858A1 Novel Compounds 失效
标题翻译：新型化合物
公开(公告)号：US20110039858A1
公开(公告)日：2011-02-17
申请号：US12911167
申请日：2010-10-25
申请人： William Brown , Christopher Walpole , Niklas Plobeck
发明人： William Brown , Christopher Walpole , Niklas Plobeck
IPC分类号： A61K31/497 , A61P25/00
CPC分类号： C07D295/155 , C07D233/24 , C07D307/52 , C07D333/20
摘要： The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R1 phenyl and R1 heteroaromatic ring may optionally and independently be substituted by 1, 2 or 3 substituents selected from CF3, methyl, iodo, bromo, fluoro, and chloro; R2 is independently selected from ethyl and isopropyl; R3 is hydrogen or fluoro; R4 is —NH2 or —NHSO2R5; and R5 is hydrogen, —CF3, or C1-C6 alkyl, or pharmaceutically acceptable salts thereof; at least one process for making at least one compound in accordance with Formula I; at least one method for treating at least one δ receptor associated condition with at least one compound in accordance with Formula I; and at least one pharmaceutical composition comprising at least one compound in accordance with Formula I.
摘要翻译：本发明涉及至少一种通式I的化合物，其中R 1是苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基或吡啶N-氧化物，其中每个R 1苯基和R 1杂芳环可任选地和独立地是被1,2或3个选自CF 3，甲基，碘，溴，氟和氯的取代基取代; R2独立地选自乙基和异丙基; R3是氢或氟; R4是-NH2或-NHSO2R5; 和R 5是氢，-CF 3或C 1 -C 6烷基，或其药学上可接受的盐; 至少一种制备根据式I的至少一种化合物的方法; 用至少一种根据式I的化合物治疗至少一种δ受体相关病症的方法; 和包含至少一种根据式I的化合物的至少一种药物组合物。

66. 发明申请

US20080262038A1 Diarylmethylidene Piperidine Derivatives, Preparations Thereof and Uses Thereof 审中-公开
标题翻译：二芳基亚甲基哌啶衍生物，其制备及其用途
公开(公告)号：US20080262038A1
公开(公告)日：2008-10-23
申请号：US10596853
申请日：2005-01-05
申请人： William Brown , Andrew Griffin , Christopher Walpole
发明人： William Brown , Andrew Griffin , Christopher Walpole
IPC分类号： A61K31/4545 , C07D211/00 , C07D401/02 , A61P25/22 , A61P25/00 , A61K31/4535 , A61K31/445
CPC分类号： C07D417/06 , C07D211/70 , C07D401/06
摘要： Compounds of Formula: wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译：其中R 1，R 2和R 3的化合物如说明书中所定义，以及其盐，对映体和制备包含该化合物的药物组合物。它们可用于治疗，特别是治疗疼痛。

67. 发明申请

US20080070946A1 Hydroxymethylbenzothiazoles Amides 审中-公开
标题翻译：羟甲基苯并噻唑酰胺
公开(公告)号：US20080070946A1
公开(公告)日：2008-03-20
申请号：US11576824
申请日：2005-10-05
申请人： Yevgeni Besidski , William Brown , Magali Harter , Yin Hu , Shawn Johnstone , Paul Jones , Denis Labrecque , Alexander Munro , Christopher Walpole
发明人： Yevgeni Besidski , William Brown , Magali Harter , Yin Hu , Shawn Johnstone , Paul Jones , Denis Labrecque , Alexander Munro , Christopher Walpole
IPC分类号： A61K31/428 , A61K31/4436 , A61K31/4535 , A61P11/00 , A61P25/04 , C07D211/06 , C07D213/04 , C07D277/68
CPC分类号： C07D417/12 , C07D277/64
摘要： The present invention relates to new compounds, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新化合物或其盐，溶剂合物或溶剂化盐，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

68. 发明授权

US07229994B2 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders 失效
标题翻译： 4（苯基 - 哌嗪基 - 甲基）苯甲酰胺衍生物及其用于治疗疼痛焦虑或胃肠道疾病的用途
公开(公告)号：US07229994B2
公开(公告)日：2007-06-12
申请号：US10477642
申请日：2002-05-16
申请人： William Brown , Christopher Walpole , Niklas Plobeck
发明人： William Brown , Christopher Walpole , Niklas Plobeck
IPC分类号： A61K31/496 , A61K31/495
CPC分类号： C07D295/155 , C07D233/24 , C07D307/52 , C07D333/20
摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; R2 is independently selected from ethyl and isopropyl; R3 is independently selected from hydrogen and fluoro; R4 is independently selected from —OH, —NH2 and —NHSO2R5; and R5 is independently selected from hydrogen, —CF3 and C1–C6 alkyl, or salts thereof or separate enantiomers and salts thereof; where each R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
摘要翻译：通式I R 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; R 2独立地选自乙基和异丙基; R 3独立地选自氢和氟; R 4独立地选自-OH，-NH 2和-NHSO 2 R 5; 和R 5独立地选自氢，-CF 3 3和C 1 -C 6烷基，或盐或其单独的对映体和盐; 其中每个R 1杂芳环可以任选和独立地被1,2或3个选自直链和支链C 1 -C 6的取代基取代。烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴，和碘。杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的化合物和盐和药物组合物的分开的对映异构体及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

69. 发明授权

US07186733B2 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
标题翻译： 4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病
公开(公告)号：US07186733B2
公开(公告)日：2007-03-06
申请号：US10477633
申请日：2002-05-16
申请人： William Brown , Andrew Griffin , Christopher Walpole
发明人： William Brown , Andrew Griffin , Christopher Walpole
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06 , C07D417/06
摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety or functional gastrointestinal disorders.
摘要翻译：通式I R 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任一种; 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基，烷氧基，氯，氟，溴和碘。苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑或功能性胃肠道疾病中的用途。

70. 发明授权

US07022715B2 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
标题翻译： 4-（苯基 - 哌啶-4-亚基 - 甲基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病
公开(公告)号：US07022715B2
公开(公告)日：2006-04-04
申请号：US10477851
申请日：2002-05-16
申请人： William Brown , Christopher Walpole , Zhongyong Wei
发明人： William Brown , Christopher Walpole , Zhongyong Wei
IPC分类号： A61K31/445 , A61K31/451 , C07D211/08
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06 , C07D417/06
摘要： Compounds of general formula I: R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C?6? alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
摘要翻译：通式I：R 1的化合物选自苯基，吡啶基，吡咯基，噻吩基，呋喃基，咪唑基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; 其中每个R 1苯基环和R 1'杂芳环可以任选地和独立地被1,2或3个选自直链和支链C 1的取代基取代， -C≡6 烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴，和碘。苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式