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61. 发明授权

US4102996A Method of preparing hepatitis B core antigen 失效
标题翻译：乙型肝炎核心抗原的制备方法
公开(公告)号：US4102996A
公开(公告)日：1978-07-25
申请号：US789033
申请日：1977-04-20
申请人： William J. McAleer , William J. Miller , Edward H. Wasmuth
发明人： William J. McAleer , William J. Miller , Edward H. Wasmuth
IPC分类号： A61K39/29 , A61K39/00 , A61K39/42 , C07K14/02 , G01N33/576 , A61K39/12 , C12K7/00
CPC分类号： C07K14/005 , G01N33/5762 , A61K39/00 , C12N2730/10122 , Y10S435/961
摘要： HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
摘要翻译： HBcAg通过用HBsAg阳性供体的流体的等压条带分离来分离丹烷颗粒，任选但优选地颗粒化丹麦颗粒，然后通过使丹烷颗粒与具有约15至约35个氧化乙烯单元的非离子表面活性剂接触来除去表面抗原存在还原剂如巯基乙醇。分离的核心抗原用作诊断和免疫剂。

62. 发明授权

US3997176A Expansible mandrel 失效
标题翻译：可扩展心轴
公开(公告)号：US3997176A
公开(公告)日：1976-12-14
申请号：US614999
申请日：1975-09-19
申请人： James A. Wyckoff , William J. Miller
发明人： James A. Wyckoff , William J. Miller
IPC分类号： B23B31/40
CPC分类号： B23B31/406 , Y10T279/1058
摘要： An expansible mandrel constructed to radially expand equally comprising a generally truncated polyhedron-shaped core member and a plurality of wedge members defining a cylinder, the core member being axially movable relative to the wedge members. Elastic means surrounding the wedge members maintain the wedge members in position relative to the core member.
摘要翻译：可扩展心轴被构造为径向膨胀，包括大体截面的多面体形状的芯构件和限定圆柱体的多个楔形构件，所述芯构件可相对于楔构件轴向移动。围绕楔形构件的弹性装置将楔形构件保持在相对于芯构件的位置。

63. 发明申请

US20100105148A1 MULTI-CHANNEL SWEPT WAVELENGTH OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 失效
标题翻译：多信道切换波长光学系统及其使用方法
公开(公告)号：US20100105148A1
公开(公告)日：2010-04-29
申请号：US12256852
申请日：2008-10-23
申请人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
发明人： Stephen J. Caracci , Michael J. Dailey, JR. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
IPC分类号： G01N21/00 , G01N21/45 , G01N21/41
CPC分类号： G01N21/253 , G01N21/39 , G01N21/45
摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.
摘要翻译：本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

64. 发明申请

US20090202205A1 Adjustable optical tap 有权
公开(公告)号：US20090202205A1
公开(公告)日：2009-08-13
申请号：US12069213
申请日：2008-02-08
申请人： Mark E. Conner , David R. Kozischek , Frances D. Carter , Daniel A. Nolan , William J. Miller , William T. Sawyer
发明人： Mark E. Conner , David R. Kozischek , Frances D. Carter , Daniel A. Nolan , William J. Miller , William T. Sawyer
IPC分类号： G02B6/26
CPC分类号： G02B6/4201 , G02B6/4287 , G02B6/4291
摘要： An adjustable optical tap for adjusting input power, output power and drop power in a communications network includes an enclosure having a plurality of connector assemblies being configured for interconnecting input and output cables; a cover attachable to the enclosure, the cover including a plurality of drop cable ports; and a tunable splitter disposed in the enclosure in communication with the input cable and the drop cable ports, the tunable splitter being configured for adjustment to affect attenuation in a broad wavelength band.

65. 发明授权

US07492998B2 Fiber bundles and methods of making fiber bundles 有权
标题翻译：纤维束和纤维束的制造方法
公开(公告)号：US07492998B2
公开(公告)日：2009-02-17
申请号：US10930294
申请日：2004-08-31
申请人： William J. Miller , M. Heath Rasmussen , Luis A. Zenteno
发明人： William J. Miller , M. Heath Rasmussen , Luis A. Zenteno
IPC分类号： G02B6/04 , G02B6/06
CPC分类号： G02B6/06 , C03C25/1061 , G02B6/04
摘要： The present invention relates to fiber bundles and methods for making fiber bundles. According to one embodiment of the invention, at the endface of the fused fiber bundle, the ratio of the cross-sectional area of the endface to the cross sectional area of the plurality of optical fibers is at least about 2.5. According to another embodiment of the invention, a fused fiber bundle includes a plurality of optical fibers, and a glass tube surrounding the terminal segments of the optical fibers, wherein the refractive index of the glass tube is less than the refractive index of the claddings of the optical fibers. Other embodiments of the present invention provide methods for making fused bundles.
摘要翻译：本发明涉及纤维束和纤维束的制造方法。根据本发明的一个实施例，在熔融纤维束的端面处，端面的横截面积与多根光纤的横截面积之比至少为2.5。根据本发明的另一个实施例，熔融纤维束包括多个光纤，以及围绕光纤的端子段的玻璃管，其中玻璃管的折射率小于玻璃管的折射率光纤。本发明的其它实施方案提供了制备熔融束的方法。

66. 发明申请

US20080003147A1 Fluid handling system for flow-through assay 审中-公开
标题翻译：用于流通测定的流体处理系统
公开(公告)号：US20080003147A1
公开(公告)日：2008-01-03
申请号：US11824420
申请日：2007-06-29
申请人： William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
发明人： William J. Miller , Mark L. Morrell , Todd M. Roswech , Po Ki Yuen
IPC分类号： B01L3/02
CPC分类号： G01N35/1072 , B01L3/5027 , G01N35/1074
摘要： A fluid handling system for transferring fluids is disclosed. The fluid handling system incorporates a plurality of transfer units for dispensing and/or collecting fluids as part of a closed analytical system. The plurality of transfer units are capable of functioning independently and/or collectively when assembled in a unitary array format. Methods of making and using the fluid handling system are also disclosed. The fluid handling system allows a sub-array of transfer units to shift in a vertical direction independent from a position of another sub-array of transfer units that are assembled within the same fluid head. Therefore, the fluid handling system facilitates multi-port fluid delivery and collection in an array format. Further, the fluid handling system aligned with a sensing surface enables label-free detection assays to be performed in an analytical system.
摘要翻译：公开了一种用于输送流体的流体处理系统。流体处理系统包括用于分配和/或收集流体作为封闭分析系统的一部分的多个转运单元。当以单一阵列格式组装时，多个传送单元能够独立地和/或共同地起作用。还公开了制造和使用流体处理系统的方法。流体处理系统允许传送单元的子阵列在垂直方向上移动，独立于组装在同一流体头内的另一传送单元子阵列的位置。因此，流体处理系统便于以端口流体输送和以阵列格式收集。此外，与感测表面对准的流体处理系统使得能够在分析系统中进行无标记检测分析。

67. 发明授权

US06925839B2 Method for making capillary splice 失效
标题翻译：毛细管接头的制作方法
公开(公告)号：US06925839B2
公开(公告)日：2005-08-09
申请号：US10185936
申请日：2002-06-28
申请人： Hoa Dempsey , James G. Fagan , William J. Miller , Stephen R. Ormbsy , Terry L. Taft
发明人： Hoa Dempsey , James G. Fagan , William J. Miller , Stephen R. Ormbsy , Terry L. Taft
IPC分类号： C03B23/045 , C03B23/047 , C03B23/07 , G02B6/255 , C03B23/08
CPC分类号： G02B6/2551 , C03B23/045 , C03B23/047 , C03B23/07
摘要： A method of making a capillary splice includes applying pressure to a bore in a tube, applying heat to a portion of the tube to soften the portion of the tube, and forming a bubble within the bore in the heated portion under the influence of the pressure and heat. While forming the bubble, a diameter of the bore at the heated portion is measured to determine when the bubble has enlarged to a target size. When the bubble has enlarged to the target size, a force is applied along an axial axis of the tube to shape the bubble to a desired size.
摘要翻译：制造毛细管接头的方法包括向管中的孔施加压力，向管的一部分施加热量以软化管的该部分，并且在压力的影响下在加热部分的孔内形成气泡和热量。在形成气泡的同时，测量加热部分处的孔的直径以确定气泡何时扩大到目标尺寸。当气泡扩大到目标尺寸时，沿着管的轴向施加力以将气泡成形为期望的尺寸。

68. 发明授权

US06244323B1 Method for stripping coatings from optical fibers 有权
标题翻译：剥离光纤涂层的方法
公开(公告)号：US06244323B1
公开(公告)日：2001-06-12
申请号：US09616204
申请日：2000-07-13
申请人： William J. Miller
发明人： William J. Miller
IPC分类号： B32B3500
CPC分类号： G02B6/125 , G02B6/245 , G02F1/3132 , Y10T156/1137 , Y10T156/1153 , Y10T156/1168 , Y10T156/1972
摘要： A method and apparatus are provided for removing protective coating material from a fiber optic cable including one or more optical fibers. A stream of hot inert gas is directed onto the cable to soften the protective coating material and blow it from the cable. The stream can be moved relative to the cable until the desired length of coating material has been removed.
摘要翻译：提供一种用于从包括一根或多根光纤的光纤电缆去除保护涂层材料的方法和装置。将热惰性气体流引导到电缆上，以软化保护涂层材料并将其从电缆中吹出。流可以相对于电缆移动，直到所需长度的涂层材料被去除。

69. 发明授权

US5995539A Method and apparatus for signal transmission and reception 失效
标题翻译：用于信号发送和接收的方法和装置
公开(公告)号：US5995539A
公开(公告)日：1999-11-30
申请号：US634179
申请日：1996-04-18
申请人： William J. Miller
发明人： William J. Miller
IPC分类号： H04K1/02 , H04L25/03 , H04L29/14 , H04B1/38 , H04L5/16
CPC分类号： H04K1/02 , H04L25/03343 , H04L69/40
摘要： A method and modem for communicating serial input data over a transmission link. Serial input data is partitioned into parallel data elements prior to rotation by an invertible linear mapping. Resulting frames of parallel signal elements sequentially modulate a carrier, which is then transmitted over the link. After receipt of the modulated carrier from the link, the signal is demodulated and assembled into frames of parallel signal elements which are derotated by an inverse linear mapping. Thresholding the result of the inverse mapping recovers the parallel data elements, which are then re-assembled into serial output data. The linear mapping employs: 1) commuting rotation matrices for convolutionally rotating data vectors into signal vectors and vice-versa; 2) filter bank polyphase rotation matrices; or 3) computationally efficient multi-rate wavelet filter banks. Transmitter pre-emphasis places most of the information in lower baseband frequencies; complimentary de-emphasis occurs in the receiver. Logarithmic amplification of the baseband signal prior to carrier modulation improves modulation gain and transmit channel noise attenuation. Coefficients of the rotation matrix of the receiver are adaptively equalized to correct for transmission path distortion. FM double-side band is employed in systems requiring minimized cost and complexity. FM single-side band is employed in systems in which bandwidth reduction is desirable. AM is also employable.
摘要翻译：一种用于通过传输链路传送串行输入数据的方法和调制解调器。串行输入数据在通过可逆线性映射旋转之前被划分为并行数据元素。并行信号单元的所得帧顺序地调制载波，然后通过链路发送。在从链路接收到调制载波之后，该信号被解调并组合成并行信号元素的帧，其被反向线性映射解旋。对逆映射的结果进行阈值恢复并行数据元素，然后将其重新组合成串行输出数据。线性映射采用：1）将卷积旋转数据向量的旋转矩阵换成信号向量，反之亦然; 2）滤波器组多相旋转矩阵; 或3）计算效率高的多速率小波滤波器组。发射机预加重将大部分信息置于较低的基带频率; 在接收机中发生免费去加重。载波调制之前的基带信号的对数放大提高了调制增益和发射信道噪声衰减。接收机的旋转矩阵的系数被自适应地均衡以校正传输路径失真。 FM双边带用于需要最小化成本和复杂性的系统中。 FM单边带用于需要带宽降低的系统中。 AM也可以使用。

70. 发明授权

US5943458A Mach-Zehnder interferometric devices with composite fibers 失效
标题翻译：具有复合纤维的马赫 - 曾德干涉仪
公开(公告)号：US5943458A
公开(公告)日：1999-08-24
申请号：US870522
申请日：1997-06-06
申请人： William J. Miller
发明人： William J. Miller
IPC分类号： G02B6/12 , G02B6/24 , G02B6/28 , G02B6/34 , G02F1/313 , G02F1/35 , G02B6/26
CPC分类号： G02B6/29352 , G02B6/2835 , G02F1/3136 , G02F1/3517 , G02B2006/12145 , G02B6/243 , G02F1/3131
摘要： A Mach-Zehnder wavelength selective device is made using one or more composite optical fibers each incorporating a phase shift region having one effective refractive index spliced between coupling regions having a different effective refractive index. The optical path length difference or phase delay induced by each such composite fiber is a linear function of the length of the phase shift region.
摘要翻译：使用一个或多个复合光纤制造马赫 - 策德尔波长选择装置，每个复合光纤包括具有在具有不同有效折射率的耦合区域之间接合的一个有效折射率的相移区域。由每个这样的复合光纤引起的光程长度差或相位延迟是相移区域的长度的线性函数。

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