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61. 发明授权

US07279564B2 Expression in filamentous fungi of protease inhibitors and variants thereof 有权
标题翻译：蛋白酶抑制剂及其变体的丝状真菌中的表达
公开(公告)号：US07279564B2
公开(公告)日：2007-10-09
申请号：US10971596
申请日：2004-10-22
申请人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
发明人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
IPC分类号： C07H21/02 , C12N15/00 , C12N1/15
CPC分类号： C12N15/80 , C07K14/811
摘要： Described herein are protease inhibitors, variants thereof and methods for their production.
摘要翻译：本文描述的是蛋白酶抑制剂，其变体及其制备方法。

62. 发明授权

US06685748B1 Enzymatic bleaching of natural non-cotton cellulosic fibers 有权
标题翻译：天然非棉纤维素纤维的酶促漂白
公开(公告)号：US06685748B1
公开(公告)日：2004-02-03
申请号：US09542311
申请日：2000-04-04
申请人： Anthony G. Day , Scott D. Power , Doreen Victoria , Deborah S. Winetzky
发明人： Anthony G. Day , Scott D. Power , Doreen Victoria , Deborah S. Winetzky
IPC分类号： D06Q102
CPC分类号： D06L4/40
摘要： A method is provided for bleaching a non-cotton cellulosic fiber, yarn or fabric by contacting said fiber, yarn or fabric with a hemicellulase enzyme for a time and under conditions suitable to produce a whitening of said fiber, yarn or fabric.
摘要翻译：提供了一种通过使纤维，纱线或织物与半纤维素酶接触一段时间并在适于产生所述纤维，纱线或织物的美白的条件下漂白非棉纤维素纤维，纱线或织物的方法。

63. 发明授权

US06590078B2 DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi 有权
标题翻译：用于在丝状真菌中分泌多肽的DNA序列，载体和融合多肽
公开(公告)号：US06590078B2
公开(公告)日：2003-07-08
申请号：US09912733
申请日：2001-07-23
申请人： Michael Ward , Scott D. Power
发明人： Michael Ward , Scott D. Power
IPC分类号： C07K100
CPC分类号： C12N15/80 , C07K2319/036 , C07K2319/20 , C07K2319/42 , C12N15/625
摘要： The invention includes novel fusion nucleic acids encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides. The fusion nucleic acids comprise four nucleic acids which encode a fusion polypeptide comprising first, second, third and fourth amino acid sequences. The first nucleic acid encodes a signal polypeptide functional as a secretory sequence in a first filamentous fungus. The second nucleic acid encodes a secreted polypeptide or functional portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third nucleic acid encodes a cleavable linker while the fourth nucleic acid comprises at least two nucleic acids encoding desired polypeptides.
摘要翻译：本发明包括编码融合多肽的新型融合核酸，其在丝状真菌中表达时导致融合多肽的表达。融合核酸包含编码包含第一，第二，第三和第四氨基酸序列的融合多肽的四个核酸。第一核酸编码在第一丝状真菌中作为分泌序列起作用的信号多肽。第二核酸编码通常由相同的丝状真菌或第二丝状真菌分泌的分泌的多肽或其功能部分。第三核酸编码可切割的接头，而第四核酸包含编码所需多肽的至少两个核酸。

64. 发明授权

US06265204B1 DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi 失效
标题翻译：用于在丝状真菌中分泌多肽的DNA序列，载体和融合多肽
公开(公告)号：US06265204B1
公开(公告)日：2001-07-24
申请号：US08785668
申请日：1997-01-17
申请人： Michael Ward , Scott D. Power
发明人： Michael Ward , Scott D. Power
IPC分类号： C12N115
CPC分类号： C12N15/80 , C07K2319/036 , C07K2319/20 , C07K2319/42 , C12N15/625
摘要： The invention includes novel fusion nucleic acids encoding fusion polypeptides which when expressed in a filamentous fungus result in the expression of fusion polypeptides. The fusion nucleic acids comprise four nucleic acids which encode a fusion polypeptide comprising first, second, third and fourth amino acid sequences. The first nucleic acid encodes a signal polypeptide functional as a secretory sequence in a first filamentous fungus. The second nucleic acid encodes a secreted polypeptide or functional portion thereof which is normally secreted from the same filamentous fungus or a second filamentous fungus. The third nucleic acid encodes a cleavable linker while the fourth nucleic acid comprises at least two nucleic acids encoding desired polypeptides.
摘要翻译：本发明包括编码融合多肽的新型融合核酸，其在丝状真菌中表达时导致融合多肽的表达。融合核酸包含编码包含第一，第二，第三和第四氨基酸序列的融合多肽的四个核酸。第一核酸编码在第一丝状真菌中作为分泌序列起作用的信号多肽。第二核酸编码通常由相同的丝状真菌或第二丝状真菌分泌的分泌的多肽或其功能部分。第三核酸编码可切割的接头，而第四核酸包含编码所需多肽的至少两个核酸。

65. 发明授权

US5411873A Process for producing heterologous polypeptides 失效
标题翻译：用于产生异源多肽的方法
公开(公告)号：US5411873A
公开(公告)日：1995-05-02
申请号：US928697
申请日：1992-08-11
申请人： Robin M. Adams , Scott D. Power , David B. Powers , James A. Wells , Daniel G. Yansura
发明人： Robin M. Adams , Scott D. Power , David B. Powers , James A. Wells , Daniel G. Yansura
IPC分类号： C11D3/386 , C12N9/54 , C12N15/10 , C12N15/52 , C12N15/75 , C12P21/02
CPC分类号： C12N15/52 , C11D3/386 , C12N15/102 , C12N15/75 , C12N9/54 , C12R1/07
摘要： Processes for producing various heterologous polypeptides which when expressed are either incorrectly processed and hence asssociated with the surface of the host cell or are not processed to mature form. More specifically, processes for the production of heterologous non-human carbonyl hydrolases expressed either in host cells incapable of producing enzymatically active endoprotease or host cells deficient in enzymatically active extracellular endoprotease are disclosed. Such non-human carbonyl hydrolases generally are incapable of autoproteolytic maturation and become associated with the surface of expression hosts which are deficient in enzymatically active extracellular endoprotease. Processes for preparing non-human carbonyl hydrolase and heterologous polypeptides which are expressed as part of a fusion polypeptide are also disclosed, as well as non-human carbonyl hydrolases which are substantially free of the host cell membrane with which they are normally associated.
摘要翻译：用于产生各种异源多肽的方法，当被表达时，它们被错误地加工并因此与宿主细胞的表面相结合或者不被加工成成熟形式。更具体地，公开了在不能产生酶促活性内切蛋白酶的宿主细胞中表达的异源非人羰基水解酶的生产方法或在酶活性细胞外内蛋白酶中缺乏的宿主细胞。这种非人羰基水解酶通常不能自身蛋白水解成熟，并且与酶活性细胞外内蛋白酶缺陷的表达宿主的表面相关联。还公开了制备非人羰基水解酶和作为融合多肽的一部分表达的异源多肽的方法，以及基本上不含与它们通常结合的宿主细胞膜的非人羰基水解酶。

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