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61. 发明授权

US09770411B2 Methods of using gas-filled microvesicles covalently bound to an antigen 有权
公开(公告)号：US09770411B2
公开(公告)日：2017-09-26
申请号：US13996034
申请日：2011-12-21
申请人： Gilles Bioley , Blaise Corthesy , Philippe Bussat , Anne Lassus , Michel Schneider
发明人： Gilles Bioley , Blaise Corthesy , Philippe Bussat , Anne Lassus , Michel Schneider
IPC分类号： A61K39/395 , A61K9/00 , A61K39/385 , A61K47/48 , A61K39/00
CPC分类号： A61K9/0087 , A61K39/385 , A61K47/6925 , A61K2039/60
摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.

62. 发明授权

US09211348B2 Targeted gas-filled microvesicles 有权
标题翻译：靶向充气微泡
公开(公告)号：US09211348B2
公开(公告)日：2015-12-15
申请号：US13814329
申请日：2011-08-09
申请人： Thierry Bettinger , Philippe Bussat , Samir Cherkaoui , Irene Guilbert-Brigger , Bernard Lamy
发明人： Thierry Bettinger , Philippe Bussat , Samir Cherkaoui , Irene Guilbert-Brigger , Bernard Lamy
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K38/178 , A61K49/221 , A61K49/222 , A61K49/227
摘要： Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.
摘要翻译：与包含氨基酸序列的多肽相关的充气微泡，所述序列对选择素特别是对选择素具有结合亲合力。充气微泡可用于超声成像。

63. 发明申请

US20130156706A1 TARGETED GAS-FILLED MICROVESICLES 有权
标题翻译：目标气体填充微波
公开(公告)号：US20130156706A1
公开(公告)日：2013-06-20
申请号：US13814329
申请日：2011-08-09
申请人： Thierry Bettinger , Philippe Bussat , Samir Cherkaoui , Irene Guilbert-Brigger , Bernard Lamy
发明人： Thierry Bettinger , Philippe Bussat , Samir Cherkaoui , Irene Guilbert-Brigger , Bernard Lamy
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K38/178 , A61K49/221 , A61K49/222 , A61K49/227
摘要： Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.
摘要翻译：与包含氨基酸序列的多肽相关的充气微泡，所述序列对选择素特别是对选择素具有结合亲合力。充气微泡可用于超声成像。

64. 发明申请

US20120093731A9 GAS-FILLED MICROVESICLES WITH TARGETING LIGAND OR THERAPEUTIC AGENT 审中-公开
标题翻译：具有指定配体或治疗剂的气体填充微血管
公开(公告)号：US20120093731A9
公开(公告)日：2012-04-19
申请号：US12448374
申请日：2007-12-19
申请人： Eric Allemann , Thierry Bettinger , Philippe Bussat
发明人： Eric Allemann , Thierry Bettinger , Philippe Bussat
IPC分类号： A61K49/22 , A61K9/00 , A61P43/00 , A61K49/00 , G01N33/566 , C07K16/00 , A61K39/395
CPC分类号： A61K49/223
摘要： Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging.
摘要翻译：气体填充的微泡包含含有气体的边界包膜，其中所述微泡包含： - 与所述包膜结合的第一组分，对抗体的Fc区具有结合亲和力; 和包含通过所述Fc区结合到所述第一组分的抗体的Fc区的第二组分，所述第二组分包含靶向配体或治疗剂。所述微泡的水性悬浮液在增强超声成像的对比中是特别有用的。

65. 发明申请

US20100086490A1 GAS-FILLED MICROVESICLES WITH TARGETING LIGAND OR THERAPEUTIC AGENT 审中-公开
标题翻译：具有指定配体或治疗剂的气体填充微血管
公开(公告)号：US20100086490A1
公开(公告)日：2010-04-08
申请号：US12448374
申请日：2007-12-19
申请人： Eric Allemann , Thierry Bettinger , Philippe Bussat
发明人： Eric Allemann , Thierry Bettinger , Philippe Bussat
IPC分类号： A61K49/22 , C07K16/00 , A61K9/00 , A61K39/395 , A61K49/00 , G01N33/566 , A61P43/00
CPC分类号： A61K49/223
摘要： Gas-filled microvesicles comprising a boundary envelope containing a gas, wherein said microvesicles comprise: —a first component, bound to said envelope, having binding affinity for an Fc-region of an antibody; and—a second component comprising a Fc-region of an antibody, bound to said first component through said Fc-region, said second component comprising a targeting ligand or a therapeutic agent. Aqueous suspensions of said microvesicles are particularly useful in contrast enhanced ultrasound imaging.
摘要翻译：气体填充的微泡包含含有气体的边界包膜，其中所述微泡包含： - 与所述包膜结合的第一组分，对抗体的Fc区具有结合亲和力; 和包含通过所述Fc区结合到所述第一组分的抗体的Fc区的第二组分，所述第二组分包含靶向配体或治疗剂。所述微泡的水性悬浮液在增强超声成像的对比中是特别有用的。

66. 发明授权

US06403057B1 Microcapsules, method of making and their use 失效
标题翻译：微胶囊，制作方法及其用途
公开(公告)号：US06403057B1
公开(公告)日：2002-06-11
申请号：US09599576
申请日：2000-06-23
申请人： Michel Schneider , Philippe Bussat
发明人： Michel Schneider , Philippe Bussat
IPC分类号： A61K4900
CPC分类号： A61K9/0065 , A61K9/5015 , A61K49/223
摘要： The invention relates to microcapsules to a microcapsule with a mean size from a fraction of micrometer to 1000 micrometers having a biodegradable membrane encapsulating a gas core. The membrane comprising one or more biodegradable water insoluble lipids or mixtures thereof and optionally mixtures of the lipids with up to 75% by weight of biodegradable polymers encapsulates the core which is filled with air or a gas. Microcapsules disclosed, may be non-coalescent, dry and instantly dispersible, when in suspension in a physiologically acceptable carrier are useful as delivery vehicles for therapeutically active agents and/or as contrast agents for echographic imaging of organs of human or animal body. The microcapsules of the invention are made by a method in which a water-in-oil emulsion is made from an organic solution comprising dissolved a mono-, di-, triglyceride preferably tripalmitin or tristearin and optionally therapeutically active substance and an aqueous solution containing a surfactant, optionally evaporating part of the solvent, adding a redispersing agent and freeze drying the mixture. The freeze dried mixture is then redispersed in an aqueous carrier to separate microcapsules from debris and the semi-spherical or spherical microcapsules are dried.
摘要翻译：本发明涉及到微胶囊的微胶囊，其平均尺寸为千分之一至1000微米，具有封装气芯的可生物降解的膜。所述膜包含一种或多种可生物降解的水不溶性脂质或其混合物，以及脂质与高达75％（重量）可生物降解聚合物的任选混合物包封填充有空气或气体的核心。公开的微胶囊可以是非聚结剂，干燥和即时可分散的，当在生理学上可接受的载体中的悬浮液可用作治疗活性剂的递送载体和/或作为用于人或动物体器官的回波成像的对比剂时。本发明的微胶囊通过一种方法制备，其中油包水乳液由有机溶液制成，该有机溶液包含溶解的甘油单酯，二甘油三酯，优选三棕榈素或三硬脂精和任选的治疗活性物质和含有表面活性剂，任选地蒸发部分溶剂，加入再分散剂并冷冻干燥混合物。然后将冷冻干燥的混合物再分散在水性载体中以将微胶囊与碎片分离，并将半球形或球形微胶囊干燥。

67. 发明授权

US6123922A Resilient deformable microballoons for echographic imaging 失效
标题翻译：用于回波成像的弹性变形微球
公开(公告)号：US6123922A
公开(公告)日：2000-09-26
申请号：US929274
申请日：1997-09-12
申请人： Daniel Bichon , Philippe Bussat , Michel Schneider
发明人： Daniel Bichon , Philippe Bussat , Michel Schneider
IPC分类号： A61B8/00 , A61B20060101 , A61K20060101 , A61K9/107 , A61K9/127 , A61K9/16 , A61K9/50 , A61K47/30 , A61K49/00 , A61K49/22 , B01J13/02 , B01J13/04 , B01J13/06
CPC分类号： A61K49/223
摘要： Air or gas filled microballoons bounded by an interfacially deposited polymer membrane which can be dispersed in aqueous carrier liquids to be injected into living organisms or administered orally, rectally and urethrally for therapeutic or diagnostic purposes (echography). The properties of the polymeric membrane of the microballoons (elasticity, permeability, biodegradability) can be controlled at will depending on the selected polymer, the interfacial deposition conditions, and the polymer additives.
摘要翻译：由界面沉积的聚合物膜界定的空气或气体填充的微球，其可以分散在水性载体液体中以被注射到活生物体中，或者以口服，直肠和尿道给药以用于治疗或诊断目的（回波图）。根据所选择的聚合物，界面沉积条件和聚合物添加剂，可以随意控制微球聚合物膜的性质（弹性，渗透性，生物降解性）。

68. 发明授权

US6110443A Dry stable formation to produce microbubble suspension for ultrasound 失效
标题翻译：干稳定形成以产生超声波微泡悬浮液
公开(公告)号：US6110443A
公开(公告)日：2000-08-29
申请号：US853936
申请日：1997-05-09
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22 , A61B8/13
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
摘要翻译：在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。它们含有层状表面活性剂和任选的亲水稳定剂。层状表面活性剂可以是脂质体的形式。通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

69. 发明授权

US6060040A Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients 失效
标题翻译：用于增加患者消化道可视化MRI对比度的交联聚合物组合物
公开(公告)号：US6060040A
公开(公告)日：2000-05-09
申请号：US997453
申请日：1997-12-23
申请人： Herve Tournier , Philippe Bussat
发明人： Herve Tournier , Philippe Bussat
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C233/20 , C07C237/08 , C07C237/10 , C07C327/06 , C07C327/10 , C07D257/02 , C08F20/00 , C08F20/36 , C08F20/38 , C08F20/52 , C08F22/10 , A61B5/055
CPC分类号： C08F22/105 , A61K49/06 , C07C229/16 , C07C237/10 , C07D257/02 , C08F20/36 , Y10S514/836
摘要： The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--Z--A (1) and/or C(R.sup.1 R.sup.2).dbd.CR.sup.3 --O--Z--A--Z--CO--CR.sup.3 .dbd.C(R.sup.1 R.sup.2) (2) in monomer, oligomer, homopolymer and copolymer forms, in which the R.sup.1, R.sup.2 and R.sup.3 represent H or saturated or unsaturated C.sub.1-10 aliphatic radicals optionally substituted by one or more OH groups; Z is a covalent bond or a linker spacer and A is a moiety capable of fixing a paramagnetic metal by chelation. Compounds of type (1) useful in the present invention are, for instance the polyalkylene-aminopolycaboxylic acids such as NTA, EDTA, DTPA, DOTA and like structures, possibly involving additional substituents; an example is the compound BOPTA which is a DTPA derivative carrying a benzyloxypropyl group.
摘要翻译：本发明提供作为消化道MR成像中的对比信号发生器，式C（R1R2）= CR3-CO-ZA（1）和/或C（R1R2）= CR3-OZAZ-的新型丙烯酸化合物的顺磁性金属螯合物， CO-CR 3 = C（R 1 R 2）（2）在单体，低聚物，均聚物和共聚物形式中，其中R 1，R 2和R 3表示H或任选被一个或多个OH基团取代的饱和或不饱和C 1-10脂族基团; Z是共价键或连接基团，A是通过螯合固定顺磁性金属的部分。可用于本发明的（1）型化合物是例如可能涉及另外的取代基的聚亚烷基 - 氨基多羧酸如NTA，EDTA，DTPA，DOTA等结构; 作为具有苄氧基丙基的DTPA衍生物的化合物BOPTA的实例。

70. 发明授权

US5658551A Stable microbubbles suspensions injectable into living organisms 失效
公开(公告)号：US5658551A
公开(公告)日：1997-08-19
申请号：US456385
申请日：1995-06-01
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22 , A61B8/13
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

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