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61. 发明授权

US06344276B1 Non-dissolvable amorphous Ti-Ca-P coating for implant application 有权
标题翻译：用于植入物应用的不溶性无定形Ti-Ca-P涂层
公开(公告)号：US06344276B1
公开(公告)日：2002-02-05
申请号：US09314155
申请日：1999-05-19
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Shinn-Jyh Ding
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Shinn-Jyh Ding
IPC分类号： B32B1504
CPC分类号： A61C8/0013 , A61C8/0012 , B32B15/01 , C23C14/06 , C23C14/3414
摘要： A medical implant coated with an amorphous hydroxyapatite/titanium coating layer having both high coating-substrate bond strength and a low dissolution rate of the coating. The medical implant of the present invention includes a substrate and a surface coating deposited onto the substrate from a composite target comprising 10-75% by volume of titanium and 90-25% by volume of hydroxyapatite.
摘要翻译：涂有无定形羟基磷灰石/钛涂层的医用植入物，其具有涂层 - 涂层 - 粘合强度高和涂层溶解速度低的特点。本发明的医用植入物包括从包含10-75体积％的钛和90-25体积％的羟基磷灰石的复合靶材沉积到基底上的基底和表面涂层。

62. 发明授权

US09782210B2 Method and apparatus for delivering cement paste into a bone cavity 有权
公开(公告)号：US09782210B2
公开(公告)日：2017-10-10
申请号：US14735343
申请日：2015-06-10
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju
IPC分类号： A61B17/88 , B65B3/12 , B65B3/00
CPC分类号： A61B17/8833 , A61B17/8816 , A61B17/8822 , B65B3/003 , B65B3/12
摘要： A technique for simultaneously forming a plurality of paste filled tunnels. The plurality of paste filled tunnels are connected to a surgical tube directly or indirectly and emptied one after another, until a desired amount of the paste is injected into a bone cavity, organ or a tissue via the surgical tube. The paste may be a bone cement paste, a drug powder paste, viscous fluid or gel. The injected bone cement paste will set in the bone cavity to act as a medical implant.

63. 发明授权

US09445855B2 Method and apparatus for delivering cement paste into a bone cavity 有权
公开(公告)号：US09445855B2
公开(公告)日：2016-09-20
申请号：US14088919
申请日：2013-11-25
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju
IPC分类号： B65B3/00 , A61B17/88 , B65B3/12
CPC分类号： A61B17/8833 , A61B17/8816 , A61B17/8822 , B65B3/003 , B65B3/12
摘要： The present invention is related to a technique for simultaneously forming a plurality of paste filled tunnels. The plurality of paste filled tunnels are connected to a surgical tube directly or indirectly and emptied one after another, until a desired amount of the paste is injected into a bone cavity, organ or a tissue via the surgical tube. The paste may be a bone cement paste, a drug powder paste, viscous fluid or gel. The injected bone cement paste will set in the bone cavity to act as a medical implant.

64. 发明授权

US08784551B2 Bone cement formula and bioresorbable hardened bone cement composites prepared with the same 有权
标题翻译：骨水泥配方和生物可吸收硬化骨水泥复合材料制备
公开(公告)号：US08784551B2
公开(公告)日：2014-07-22
申请号：US12907091
申请日：2010-10-19
申请人： Chien-Ping Ju , Jiin-Huey Chern Lin
发明人： Chien-Ping Ju , Jiin-Huey Chern Lin
IPC分类号： C04B11/00 , C04B41/50 , A61L24/00 , A61L27/46 , C04B28/34 , C04B41/00 , C04B111/00
CPC分类号： C04B28/34 , A61L24/0063 , A61L27/46 , A61L2430/02 , C04B28/346 , C04B41/009 , C04B41/5092 , C04B2111/00836 , C04B22/062 , C04B22/143 , C04B22/16 , C04B24/06 , C04B38/02
摘要： The present invention provides a bone cement formula having a powder component and a setting liquid component, wherein the powder component includes a calcium sulfate source and a calcium phosphate source with a weight ratio of the calcium sulfate source less than 65%, based on the total weight of the calcium sulfate source and the calcium phosphate source, and the setting liquid component comprises ammonium ion (NH4+) in a concentration of about 0.5 M to 4 M, wherein the calcium phosphate source includes tetracalcium phosphate (TTCP) and dicalcium phosphate in a molar ratio of TTCP to dicalcium phosphate of about 0.5 to about 2.5, and the calcium sulfate source is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), or anhydrous calcium sulfate.
摘要翻译：本发明提供了一种具有粉末成分和凝固液成分的骨水泥配方，其中粉末组分包括硫酸钙源和磷酸钙源，其硫酸钙源的重量比小于65％，基于总计硫酸钙源和磷酸钙源的重量，凝固液成分包含浓度为约0.5M至4M的铵离子（NH 4 +），其中磷酸钙源包括磷酸四钙（TTCP）和磷酸二钙 TTCP与磷酸二钙的摩尔比为约0.5至约2.5，硫酸钙源为半水合硫酸钙（CSH），脱硫酸钙（CSD）或无水硫酸钙。

65. 发明申请

US20130138114A1 CALCIUM-BASED BONE CEMENT FORMULA WITH ENHANCED NON-DISPERSIVE ABILITY 有权
标题翻译：基于钙的骨水泥配方，具有增强的非分散能力
公开(公告)号：US20130138114A1
公开(公告)日：2013-05-30
申请号：US13339704
申请日：2011-12-29
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju
IPC分类号： A61B17/68 , A61K6/083 , A61K33/42
CPC分类号： A61L24/0063 , A61L27/425 , A61L2400/06 , A61L2430/02
摘要： A calcium-based bone cement formula having a powder component and a setting liquid component with a liquid to powder ratio of 0.20 ml/g to 0.50 ml/g is provided, wherein the powder component includes tetracalcium phosphate. The bone cement formula further contains, based on the total weight of the bone cement formula, 0.01-1% of poly(acrylic acid) having a repeating unit of —(CH2—C(COOH)H)n-, wherein n=50-50000.
摘要翻译：提供了具有粉末成分和液体/粉末比为0.20ml / g至0.50ml / g的凝固液体组分的钙基骨水泥配方，其中粉末组分包括磷酸四钙。骨水泥配方还含有基于骨水泥配方总重量的0.01-1％具有重复单元为 - （CH 2 -C（COOH）H）n - 的聚（丙烯酸），其中n = 50 -50000。

66. 发明申请

US20120330365A1 In-Situ Deformable Mini-Bone Plate 有权
标题翻译：原位可变形小骨板
公开(公告)号：US20120330365A1
公开(公告)日：2012-12-27
申请号：US13531710
申请日：2012-06-25
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Jing-Wei Lee
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Jing-Wei Lee
IPC分类号： A61B17/80
CPC分类号： A61B17/8085
摘要： A bone plate provided in the present invention has an elongated strip, and a series of repeating units are provided on the elongated strip. Each repeating unit has two crowns, two necks, and four bridges, wherein the two crowns and the two necks are connected by the four bridges to from a symmetrical ring structure, and wherein a width of the bridge (BW) is greater than a width of the crown (CW), a maximum distance between inner sides of the two crowns (ID) is greater than a width of the neck (NW), a maximum distance between outer sides of two opposite bridges of the four bridges (OD) is greater than a unit length between two adjacent repeating units (UL), and the crown width (CW) is 0.1-1.0 mm, so that the bone plate can be deformed in-situ by a surgeon.
摘要翻译：在本发明中提供的骨板具有细长带，并且在细长带上设置一系列重复单元。每个重复单元具有两个冠部，两个颈部和四个桥梁，其中两个冠部和两个颈部通过四个桥连接到对称的环形结构，并且其中桥梁（BW）的宽度大于宽度冠部（CW）的两个冠部（ID）的内侧之间的最大距离大于颈部宽度（NW）时，四个桥梁（OD）的两个相对桥梁的外侧之间的最大距离为大于两个相邻重复单元（UL）之间的单位长度，并且冠部宽度（CW）为0.1-1.0mm，使得骨板可以由外科医生原位变形。

67. 发明授权

US07976874B2 Injectable calcium phosphate cements and the preparation and use thereof 有权
标题翻译：可注射的磷酸钙水泥及其制备和应用
公开(公告)号：US07976874B2
公开(公告)日：2011-07-12
申请号：US11129029
申请日：2005-05-13
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： A61K33/42 , A61P19/00
CPC分类号： A61L24/02 , A61C5/62 , A61K6/0008 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K33/42 , A61L24/001 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B14/366 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B20/008 , C04B40/0272 , C04B40/0218 , C04B40/0263 , C04B20/1014 , C04B22/064 , C04B22/126 , C04B20/023 , C04B20/107 , A61K6/087 , C08L89/00
摘要： A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
摘要翻译：公开了一种适用于牙齿和骨假体的磷酸钙骨水泥，其包括直径为0.05至100微米的磷酸钙颗粒，其中表面上的所述磷酸钙颗粒具有宽度范围为1至100的晶须或细晶体 nm，长度范围为1〜1000nm。

68. 发明授权

US07959684B2 Method for forming a bioresorbable composite implant in a bone 有权
标题翻译：在骨中形成生物可再吸收复合植入物的方法
公开(公告)号：US07959684B2
公开(公告)日：2011-06-14
申请号：US12230828
申请日：2008-09-05
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Pong-Jeu Lu
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Pong-Jeu Lu
IPC分类号： A61F2/28
CPC分类号： A61B17/70 , A61B17/7095 , A61B17/8805 , A61B17/8811 , A61B2017/564
摘要： A method for forming a composite implant in a bone cavity is disclosed, which includes i) forming a first bone filler in a bone cavity; and ii) inserting a second bone filler into an unfilled space in the bone cavity, wherein the first bone filler has a higher compressive strength and slower bioresorption rate in comparison with the second bone filler.
摘要翻译：公开了一种用于在骨腔中形成复合植入物的方法，其包括：i）在骨腔中形成第一骨填充物; 以及ii）将第二骨填料插入所述骨腔中的未填充空间中，其中所述第一骨填料与所述第二骨填料相比具有较高的抗压强度和较慢的生物再吸收速率。

69. 发明授权

US07186294B2 Process for affecting the setting and working time of bioresorbable calcium phosphate cements 失效
公开(公告)号：US07186294B2
公开(公告)日：2007-03-06
申请号：US11137112
申请日：2005-05-25
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： C04B28/34
CPC分类号： C04B28/346 , A61K6/0643 , A61L24/0063 , A61L24/02 , C04B12/025 , C04B28/34 , C04B2103/10 , C04B2111/00836 , C04B2111/70 , C04B40/0082 , C04B22/064 , C04B2103/0099 , C04B22/062 , C04B22/16 , C04B22/143 , C04B22/165
摘要： A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5–2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.

70. 发明授权

US07182895B2 Dual function prosthetic bone implant and method for preparing the same 失效
标题翻译：双功能假体骨植入物及其制备方法
公开(公告)号：US07182895B2
公开(公告)日：2007-02-27
申请号：US11055373
申请日：2005-02-10
申请人： Jiin-Huey Chern Lin , Chien-Ping Ju , Chih-Hung Tsai
发明人： Jiin-Huey Chern Lin , Chien-Ping Ju , Chih-Hung Tsai
IPC分类号： A61F2/28 , B29C39/02 , B29C39/12
CPC分类号： C04B28/346 , A61F2/28 , A61F2/4644 , A61F2002/30535 , A61F2250/0058 , A61L27/46 , A61L27/56 , C04B2111/00836 , C04B22/082 , C04B22/10 , C04B38/04 , C04B40/0028 , C04B40/0259 , C04B40/0286 , C04B22/16 , C04B24/04 , C04B22/06 , C04B40/0263
摘要： The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.
摘要翻译：本发明公开了一种由具有磷灰石相作为主相的硬化磷酸钙骨水泥制成的假体骨植入物，其包括承载大部分负荷的致密皮层部分和允许快速血液/体液渗透和组织的多孔松质骨部分向内生长

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