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61. 发明授权

US07688111B1 Level-shifting circuit with bipolar junction transistor 有权
标题翻译：具有双极结型晶体管的电平移位电路
公开(公告)号：US07688111B1
公开(公告)日：2010-03-30
申请号：US12195725
申请日：2008-08-21
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： H03K19/082 , H03K19/0175
CPC分类号： H03K19/017509
摘要： A level-shifting circuit includes an input node, a first output transistor, a second output transistor, a pull-up transistor, and an output node. The input node receives an input signal. The first output transistor turns on when the input signal is at a first voltage level and couples an output node to a positive supply voltage when turned on. The second output transistor, a bipolar junction transistor (BJT), couples the output node to a negative supply voltage when turned on. The pull-up transistor turns on when the input signal is at a second voltage level and generates a voltage at a base terminal of the second output transistor that turns the second output transistor on. Additionally, the level-shifting circuit generates, at the output node, an output signal with a voltage swing that includes a positive voltage range and a negative voltage range.
摘要翻译：电平移动电路包括输入节点，第一输出晶体管，第二输出晶体管，上拉晶体管和输出节点。输入节点接收输入信号。当输入信号处于第一电压电平时，第一输出晶体管导通，并且当导通时将输出节点耦合到正电源电压。第二输出晶体管，双极结型晶体管（BJT）在导通时将输出节点耦合到负电源电压。当输入信号处于第二电压电平时，上拉晶体管导通，并在第二输出晶体管的基极端产生电压，使第二输出晶体管导通。此外，电平移动电路在输出节点产生具有包括正电压范围和负电压范围的电压摆幅的输出信号。

62. 发明申请

US20100056496A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：US20100056496A1
公开(公告)日：2010-03-04
申请号：US12439771
申请日：2007-09-04
申请人： Naresh Kumar , Kirandeep Kaur , Yogesh D. Shejul , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
发明人： Naresh Kumar , Kirandeep Kaur , Yogesh D. Shejul , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
IPC分类号： A61K31/55 , C07D223/14 , A61P1/00 , A61P11/00 , A61P3/00
CPC分类号： C07D221/24 , C07D209/12 , C07D209/14
摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors. Formula (I) or a pharmaceutically accepted salt, pharmaceutically acceptable solvate, enantiomers, diastereomer, polymorph or N-oxide thereof, wherein X is.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。式（I）或其药学上可接受的盐，药学上可接受的溶剂合物，对映异构体，非对映体，多晶型物或N-氧化物，其中X为。

63. 发明申请

US20090306129A1 SUBSTITUTED PYRAZOLO [3,4-B] PYRIDINES AS PHOSPHODIESTERASE INHIBITORS 有权
标题翻译：取代的吡唑并[3,4-B]吡啶作为磷酸酯酶抑制剂
公开(公告)号：US20090306129A1
公开(公告)日：2009-12-10
申请号：US12067013
申请日：2006-09-11
申请人： Venkata P. Palle , Sarala Balachandran , Nidhi Gupta , Vinayak Vasantrao Khairnar , Mandadapu Raghuramaiah , Abhijit Ray , Sunanda Ghose Dastidar
发明人： Venkata P. Palle , Sarala Balachandran , Nidhi Gupta , Vinayak Vasantrao Khairnar , Mandadapu Raghuramaiah , Abhijit Ray , Sunanda Ghose Dastidar
IPC分类号： A61K31/415 , C07D231/10 , C07D471/04 , A61K31/437 , A61P11/06 , A61P25/00 , A61P17/00 , A61P29/00 , A61P19/02
CPC分类号： C07D471/04
摘要： The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV Formula (XIV).
摘要翻译：本发明涉及磷酸二酯酶（PDE）IV型选择性抑制剂。提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为PDE IV型选择性抑制剂的用途。制备的化合物对应于结构XIV式（XIV）。

64. 发明申请

US20090221664A1 PHARMACEUTICAL COMPOSITIONS OF MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：药物受体拮抗剂的药物组合物
公开(公告)号：US20090221664A1
公开(公告)日：2009-09-03
申请号：US12090805
申请日：2006-10-19
申请人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Shivani Malhotra
发明人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Shivani Malhotra
IPC分类号： A61K31/403
CPC分类号： A61K31/401
摘要： Provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists (“MRA”), and at least one additional active ingredients selected from one or more β2-agonists, p38 MAP kinase inhibitors, PDE-IV inhibitors, corticosteroids or a mixture thereof and optionally one or more pharmaceutically acceptable carriers, excipients or diluents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.
摘要翻译：本文提供包含一种或多种毒蕈碱受体拮抗剂（“MRA”）和至少一种选自一种或多种β-激动剂，p38MAP激酶抑制剂，PDE-IV抑制剂，皮质类固醇或其混合物的另外的活性成分的药物组合物，任选的一种或多种药学上可接受的载体，赋形剂或稀释剂。此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

65. 发明申请

US20090221515A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20090221515A1
公开(公告)日：2009-09-03
申请号：US11574465
申请日：2005-08-31
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Venkata P. Palle , Mohammad Salman , Abhijit Ray , Raj Kumar Shirumalla , Abdul Rehaman Abdul Rauf
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Venkata P. Palle , Mohammad Salman , Abhijit Ray , Raj Kumar Shirumalla , Abdul Rehaman Abdul Rauf
IPC分类号： A61K31/7008 , C07H5/04
CPC分类号： C07H15/18
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。

66. 发明申请

US20090054382A1 COMPOSITIONS OF PHOSPHODIESTERASE TYPE IV INHIBITORS 审中-公开
标题翻译：磷酸二酯酶IV型抑制剂的组合物
公开(公告)号：US20090054382A1
公开(公告)日：2009-02-26
申请号：US12090798
申请日：2006-10-19
申请人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
发明人： Abhijit Ray , Sunanda G. Dastidar , Rajkumar Shirumalla , Suman Gupta
IPC分类号： A61K31/573 , A61K31/407 , A61K31/424
CPC分类号： A61K31/41
摘要： Provided herein are pharmaceutical compositions comprising one or more phosphodiesterase inhibitors of type IV (“PDE-IV”), and at least one other active ingredients selected from muscarinic receptor antagonists (MRA), β2-agonists, p38 MAP Kinase inhibitors, and corticosteroids and optionally one or more pharmaceutically acceptable excipients and/or other therapeutic agents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.
摘要翻译：本文提供了包含一种或多种IV型磷酸二酯酶抑制剂（“PDE-IV”）和至少一种选自毒蕈碱受体拮抗剂（MRA），β2-激动剂，p38 MAP激酶抑制剂和皮质类固醇的其它活性成分的药物组合物，以及任选地一种或多种药学上可接受的赋形剂和/或其它治疗剂。此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

67. 发明申请

US20090048247A1 CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE - IV 审中-公开
标题翻译：作为磷酸二酯酶类型的抑制剂的稠度的异构衍生物
公开(公告)号：US20090048247A1
公开(公告)日：2009-02-19
申请号：US11815695
申请日：2006-02-13
申请人： Venkata P. Palle , Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukamal , Mandadapu Raghu Ramaiah , Manoj Kumar Khera , Lailt Kumar Baregama , Vinayak Vasantrao Khairnar , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata P. Palle , Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukamal , Mandadapu Raghu Ramaiah , Manoj Kumar Khera , Lailt Kumar Baregama , Vinayak Vasantrao Khairnar , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/5377 , C07D498/10 , A61K31/424 , A61P31/18
CPC分类号： C07D261/20
摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

68. 发明申请

US20080207659A1 INHIBITORS OF PHOSPHODIESTERASE TYPE 4 审中-公开
标题翻译：磷酸二酯酶类型4的抑制剂
公开(公告)号：US20080207659A1
公开(公告)日：2008-08-28
申请号：US12031842
申请日：2008-02-15
申请人： Asit Kumar Chakraborti , Simi Sarin , Santosh Vijaykumar Rudrawar , Raj Kumar , Sunay Vijaykumar Chankeshwara , Abhijit Ray , Sunanda Ghosh Dastidar
发明人： Asit Kumar Chakraborti , Simi Sarin , Santosh Vijaykumar Rudrawar , Raj Kumar , Sunay Vijaykumar Chankeshwara , Abhijit Ray , Sunanda Ghosh Dastidar
IPC分类号： A61K31/506 , C07D239/20 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04
摘要： The present invention relates to inhibitors of phosphodiesterase (PDE) type 4.Compounds disclosed herein can be useful for treating, preventing, inhibiting or suppressing asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), AIDS, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis or other inflammatory diseases, especially in humans.Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as phosphodiesterase (PDE) type 4 inhibitors are provided.
摘要翻译：本发明涉及类型4的磷酸二酯酶（PDE）抑制剂。本文公开的化合物可用于治疗，预防，抑制或抑制哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性特发性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），艾滋病，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎或其他炎性疾病。提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）4型抑制剂的用途。

69. 发明申请

US20080114031A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20080114031A1
公开(公告)日：2008-05-15
申请号：US11692362
申请日：2007-03-28
申请人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
发明人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
IPC分类号： A61K31/4525 , A61K31/34 , A61P17/00 , A61P29/00 , A61P3/10 , A61P35/00 , A61P37/00 , A61P9/00 , C07D307/20 , C07D405/02 , C07D405/14 , C07D413/02
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥反应，炎症性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

70. 发明申请

US20080021080A1 5-LIPOXYGENASE INHIBITORS 失效
标题翻译： 5-LIPOXYGENASE抑制剂
公开(公告)号：US20080021080A1
公开(公告)日：2008-01-24
申请号：US11685892
申请日：2007-03-14
申请人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
发明人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
IPC分类号： A61K31/41 , A61P11/00 , C07D249/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.
摘要翻译：本发明涉及5-脂氧合酶抑制剂。本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性皮炎，过敏性鼻炎，其他炎性和自身免疫性疾病。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

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